LOCUS       NM_001107664            3893 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus HPS3, biogenesis of lysosomal organelles complex
            2 subunit 1 (Hps3), mRNA.
ACCESSION   NM_001107664 XM_001055734 XM_001055848 XM_001055904 XM_227003
VERSION     NM_001107664.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3893)
  AUTHORS   Di Pietro SM, Falcon-Perez JM and Dell'Angelica EC.
  TITLE     Characterization of BLOC-2, a complex containing the
            Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6
  JOURNAL   Traffic 5 (4), 276-283 (2004)
   PUBMED   15030569
REFERENCE   2  (bases 1 to 3893)
  AUTHORS   Suzuki T, Li W, Zhang Q, Novak EK, Sviderskaya EV, Wilson A,
            Bennett DC, Roe BA, Swank RT and Spritz RA.
  TITLE     The gene mutated in cocoa mice, carrying a defect of organelle
            biogenesis, is a homologue of the human Hermansky-Pudlak syndrome-3
            gene
  JOURNAL   Genomics 78 (1-2), 30-37 (2001)
   PUBMED   11707070
REFERENCE   3  (bases 1 to 3893)
  AUTHORS   Huizing M, Anikster Y, Fitzpatrick DL, Jeong AB, D'Souza M, Rausche
            M, Toro JR, Kaiser-Kupfer MI, White JG and Gahl WA.
  TITLE     Hermansky-Pudlak syndrome type 3 in Ashkenazi Jews and other
            non-Puerto Rican patients with hypopigmentation and platelet
            storage-pool deficiency
  JOURNAL   Am J Hum Genet 69 (5), 1022-1032 (2001)
   PUBMED   11590544
REFERENCE   4  (bases 1 to 3893)
  AUTHORS   Anikster Y, Huizing M, White J, Shevchenko YO, Fitzpatrick DL,
            Touchman JW, Compton JG, Bale SJ, Swank RT, Gahl WA and Toro JR.
  TITLE     Mutation of a new gene causes a unique form of Hermansky-Pudlak
            syndrome in a genetic isolate of central Puerto Rico
  JOURNAL   Nat Genet 28 (4), 376-380 (2001)
   PUBMED   11455388
REFERENCE   5  (bases 1 to 3893)
  AUTHORS   Moore KJ, Swing DA, Copeland NG and Jenkins NA.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473961.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_227003.4, XM_001055904.1, XM_001055734.1, XM_001055848.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3893
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..3893
                     /gene="Hps3"
                     /note="HPS3, biogenesis of lysosomal organelles complex 2
                     subunit 1"
                     /db_xref="GeneID:310288"
                     /db_xref="RGD:1310548"
     exon            1..269
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..3061
                     /gene="Hps3"
                     /note="Hermansky-Pudlak syndrome 3 homolog"
                     /codon_start=1
                     /product="BLOC-2 complex member HPS3"
                     /protein_id="NP_001101134.1"
                     /db_xref="GeneID:310288"
                     /db_xref="RGD:1310548"
                     /translation="MVRLYNLHPFGSQQVVPCQREPEQFCCGGSDALFVASGCKVEAF
                     AVQGAELSRQRCTFSTLGRVLRMAYSEAGDYLVAIEEKNKTVFLRAYVNWRSKRNDNS
                     RVCIRMVGHKMEASFCESFRDQMSIIEMPMSEAPLCISCCPVKGDLLVGCTKKLVLFT
                     LKYDVVNEEFSMLNFERSLIIHINNITPVEISFCVGYVAVMADLEVLLLKLESDPIHG
                     EGVNHHPQESINPLEQTEDVSNETSQLESEDFVICLKPLELFGEKCKQSGISVKLEST
                     GLEDEKVKYLHVQHLLYRRFAPDISFYGLSDNIKLHSLQLLPIHQTGFHPDEKDLSQK
                     KEVPSLFCFFSLPHAGYLYMVVKSVTLLSVYWYPEKSQQAVLTPQFLHVITSQSLQCF
                     TVRCSAAVAHEEDLYMDTTLKACPPVSMDVCALRIQLFIGLKAICHFKNHIILLTKAE
                     PEDIPERRESPKRLLSRKDASVKSRIPHVAEAGWNLYIVNTTAPVQLYKEMVDYSNSY
                     KTVKTESCLHLLSEAHLLVRAALMDVSQLEPAEKAELLEAFKESCGHLGDCYSRLNTE
                     QAHLALPYYKMSGLSLAEVLARVEWTEGNESQKYERGLIFYINHSLYENLDEELSEEL
                     AGKVAQIFHVAEPKQLPHVLSSPSMKNIDPLIALHYLRKLDTCGASPVLVTLTKAAVA
                     LKMGNLDMYRNEMKSHSEMQLVYGFILEPRLLIQQWKGQIVPTELAIDLKETQPGLLV
                     ASVLGLQKNGKIGIEEADSFFKVLCGKDEDMVPQLLVDFWEAQLVACLPDVVLEELFF
                     KLISQYVWRLSKRHCPDTLPLRTAEDLINACSHYGLVYPWVHVLMTSDSLADKNYTED
                     LLKLQSLICSPSLDIVSVIPYLEPLSEDTVAGLSAQVLCHTRLQEYEKCIDTLLERCP
                     EAVIAYANRELKEEHWILWWKKLLPELCHRVKCGGDRYHLHLSLLKETLSVVAVGLDL
                     RDFLNVLPEDGVAAFFLPYLLFCSRKKSLT"
     exon            270..761
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            762..933
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1019
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1209
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1291
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1446
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1555
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1737
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1918
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2152
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2338
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2527
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2635
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2842
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2933
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3893
                     /gene="Hps3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagcaact ctctaagctt gcggaagccg ctcagcggtc cggggcaccg ggatggtgcg
       61 tttgtacaac ctgcacccgt ttgggtcgca gcaggttgtc ccctgccagc gggagcccga
      121 gcagttctgc tgcggcggga gcgacgcgct gttcgtggct tccggctgca aggtggaggc
      181 gtttgctgtt cagggcgcag agctaagccg gcagcgatgc accttctcca cgctaggcag
      241 ggttctgcgc atggcctaca gcgaagccgg agactatctg gtagcaattg aagagaaaaa
      301 caaaactgta ttcctgcgtg cttacgtgaa ttggaggagt aagaggaatg acaactctcg
      361 tgtgtgcatt cgaatggttg ggcacaaaat ggaggcatcc ttctgtgaaa gctttagaga
      421 ccagatgtct ataattgaaa tgccaatgtc cgaggcccct ttgtgcattt catgttgtcc
      481 tgtgaaagga gatctacttg ttggatgtac aaagaagtta gtcttattta ctttgaagta
      541 tgatgtcgtt aatgaggaat tctcaatgtt gaactttgaa cgttcattaa ttatacacat
      601 aaataatatc actcctgttg aaatctcttt ttgtgttgga tatgttgctg tcatggctga
      661 tttagaagtc ttactcctaa aactggagtc agaccctata catggagagg gagttaacca
      721 ccacccacaa gaaagcatca acccattgga acagacagaa gatgtcagta atgaaacttc
      781 acagcttgag tcagaggatt ttgttatctg cctaaaacct ttggaacttt ttggtgaaaa
      841 atgtaaacag tctggaatat ctgttaagct ggagtccaca ggattagaag atgaaaaagt
      901 aaaatattta catgttcagc atctgctgta tagacggttt gctccagata tttcattcta
      961 tggtttgtct gataacatca agttacattc ccttcaactg ctgcccattc accaaactgg
     1021 ttttcatcct gatgaaaaag atttgtctca gaaaaaagag gtgccaagtc tcttctgttt
     1081 cttctcatta ccccatgcgg gctacctgta catggtggtg aagtctgtta cgttactgtc
     1141 agtctattgg tatcctgaga agtctcagca agccgtgctc acaccacaat tcttgcatgt
     1201 catcacaagc caaagcctgc agtgtttcac ggtacgatgc agcgcagcgg tggctcatga
     1261 ggaggaccta tacatggaca ctacactaaa ggcctgccca cctgtcagta tggatgtctg
     1321 tgctctaagg atacagctct tcataggttt gaaagccatc tgtcacttta aaaaccacat
     1381 catacttctg acgaaggcag agcctgagga catcccagag agacgcgagt cacccaagag
     1441 acttctttct agaaaagatg ccagtgttaa gagcaggatc cctcacgtag ctgaggctgg
     1501 atggaatctg tatatcgtga ataccactgc accagttcag ctatacaaag aaatggtaga
     1561 ctatagtaac agctacaaga ctgtgaaaac cgagagctgt ctccacttgc tcagcgaggc
     1621 tcatctgcta gtgagagctg ccctgatgga tgtcagtcag ctagagcctg cagagaaagc
     1681 agagctcctg gaagctttca aagaaagctg cgggcacctt ggagactgtt acagcaggct
     1741 taacactgag caagcccatc tcgccttgcc atactataag atgtctggtt tgtctctggc
     1801 tgaagtcttg gctcgtgtgg aatggacaga agggaatgaa tcacagaaat atgagagagg
     1861 attaatattt tatattaatc attctcttta tgagaacctg gatgaagaat taagtgaaga
     1921 attagctgga aaagtggctc agatatttca tgtggctgag ccgaagcaac tgcctcatgt
     1981 tctctccagt ccgtctatga agaatattga tcctttaatt gccttgcatt acttaaggaa
     2041 gctggacacc tgtggggctt caccagtctt agtgaccttg accaaggctg cagtggcctt
     2101 gaaaatggga aatcttgaca tgtacaggaa tgaaatgaaa agccattcag agatgcagct
     2161 ggtgtatggc ttcattctgg aacctcggct gttaattcaa cagtggaaag gacagattgt
     2221 tcctacggaa cttgcaattg acttgaagga aactcagcct ggattgcttg tggcttcagt
     2281 cctgggctta cagaagaatg gtaaaattgg aatcgaagaa gcagattctt tctttaaggt
     2341 gctgtgtgga aaggatgaag acatggttcc gcagcttttg gtagacttct gggaagctca
     2401 gctcgtagct tgtctcccag atgtggttct tgaggaactc tttttcaagc tcatatctca
     2461 gtacgtctgg aggttatcta agaggcattg tcctgatacc ttaccattga gaacagcaga
     2521 ggatttgata aacgcctgca gtcattatgg cctagtatat ccatgggttc atgtcttaat
     2581 gacgtctgat tccttagctg ataaaaatta cacagaagac cttttgaaac tacagtctct
     2641 catatgtagc ccttcattgg acatagtttc cgttattcca tatctggagc cactctcaga
     2701 agacactgtt gctggcctca gcgctcaagt tctatgtcat acacgcttac aagaatatga
     2761 aaagtgcata gacacattgc tagagagatg cccagaggcg gtcattgcat atgctaaccg
     2821 ggaactgaag gaagagcact ggattctgtg gtggaaaaag ctactgcctg aactctgtca
     2881 cagagtcaag tgtggcggag acagatacca ccttcacctg tcattgctaa aagaaacctt
     2941 gtcggttgtt gctgtgggac tggacctgag ggatttcttg aatgttctcc cagaagatgg
     3001 ggtggcagca ttttttctgc cctacctcct tttctgcagc cggaagaaat cactaacttg
     3061 atggtatcct ttgcagcaca gtggcataag tgactgcgcg ttaaatgctt ggtctcagat
     3121 acagtaaact caaagggttt gtgtttacat gtattgtagc tgctgtaagg gtgcttacct
     3181 taccatgtaa ttgtagccct tggcttaata tataacctga atggatttac ttgtctagaa
     3241 tgtaaaaacc ttcaaaatgt aagatctctt cacatgtatt tatttccttt ggtttttatt
     3301 tttttacgct gtattctgtg tgagcctaga actatgaacc ttgtgctgac ctcaatctat
     3361 gcaaacctcc caagcattat aggtgtgaag agccatgaat gtattttcaa aaccaggcac
     3421 aggcttctgt tgtgagacat agcatggact cggtgctgaa ggcataacaa tcatgtccac
     3481 ccaagccact ggaaggaaat gcattgcaag tatcctcaaa tgccccctta ctcgacaaac
     3541 aatatctcga ttgttacaga tttttcttct gggttactat tttgtatttt tatgtaagta
     3601 tgagaaagat gtaatgtttt actccagtga atacttggcg tgtgagctac ttttgaaact
     3661 catagtgtcc ttctctcaga atcagataaa tggactgttg tctggctgtt aacacttgtt
     3721 taggttacat attttcagcc agagtcttat ttctattttt tatgtgtata tactcctatt
     3781 atttcaaccc acaatataca aaaaaataaa aaattatcat gatgttcata tctgtctttt
     3841 tagtaactaa cttccttgct tatttgtttg gttaatttgt tttattttaa agg
//
