LOCUS       NM_012583               1260 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus hypoxanthine phosphoribosyltransferase 1 (Hprt1),
            mRNA.
ACCESSION   NM_012583 XM_003752155 XM_343829
VERSION     NM_012583.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Jiang,T., Dai,S., Yi,Y., Liu,Y., Zhang,S., Luo,M., Wang,H. and
            Xu,D.
  TITLE     The combination of hprt and gapdh is the best compound reference
            genes in the fetal rat hippocampus
  JOURNAL   Dev Neurobiol 80 (7-8), 229-238 (2020)
   PUBMED   32875725
  REMARK    GeneRIF: The combination of hprt and gapdh is the best compound
            reference genes in the fetal rat hippocampus.
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Wei,X., Das,J., Fragoza,R., Liang,J., Bastos de Oliveira,F.M.,
            Lee,H.R., Wang,X., Mort,M., Stenson,P.D., Cooper,D.N., Lipkin,S.M.,
            Smolka,M.B. and Yu,H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Kawamura,Y., Hayashi,H., Masumura,K., Numazawa,S. and Nohmi,T.
  TITLE     Genotoxicity of phenacetin in the kidney and liver of
            Sprague-Dawley gpt delta transgenic rats in 26-week and 52-week
            repeated-dose studies
  JOURNAL   Toxicology 324, 10-17 (2014)
   PUBMED   25047350
  REMARK    GeneRIF: Report frequency of phenacetin induced gtp point mutations
            in the liver and kidney of gpt transgenic rats.
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Walder,R.Y., Wattiez,A.S., White,S.R., Marquez de Prado,B.,
            Hamity,M.V. and Hammond,D.L.
  TITLE     Validation of four reference genes for quantitative mRNA expression
            studies in a rat model of inflammatory injury
  JOURNAL   Mol Pain 10, 55 (2014)
   PUBMED   25187167
  REMARK    GeneRIF: Thsi study validated the Hprt1, Actb, Mapk6 or B2m and
            showed that any one or combination of two of them are good
            reference genes for normalization of mRNA expression in qPCR
            experiments in the spinal cord and RVM in the CFA model of
            inflammatory injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Nesbitt,M.N., Bakay,B., Gardner,M.B. and Day,C.
  TITLE     Isoenzyme pattern of HPRT in murine erythrocytes: control by an
            autosomal locus
  JOURNAL   Biochem Genet 17 (9-10), 957-964 (1979)
   PUBMED   540025
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Francke,U. and Taggart,R.T.
  TITLE     Assignment of the gene for cytoplasmic superoxide dismutase (Sod-1)
            to a region of chromosome 16 and of Hprt to a region of the X
            chromosome in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 76 (10), 5230-5233 (1979)
   PUBMED   291939
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Holden,J.A. and Kelley,W.N.
  TITLE     Human hypoxanthine-guanine phosphoribosyltransferase. Evidence for
            tetrameric structure
  JOURNAL   J Biol Chem 253 (12), 4459-4463 (1978)
   PUBMED   659426
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   10 (bases 1 to 1260)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098629.1.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_003752155.2, NM_012583.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098629.1, X62085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..1260
                     /gene="Hprt1"
                     /gene_synonym="Hgprtase; Hprt"
                     /note="hypoxanthine phosphoribosyltransferase 1"
                     /db_xref="GeneID:24465"
                     /db_xref="RGD:2826"
     exon            1..93
                     /gene="Hprt1"
                     /gene_synonym="Hgprtase; Hprt"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..723
                     /gene="Hprt1"
                     /gene_synonym="Hgprtase; Hprt"
                     /EC_number="2.4.2.8"
                     /note="hypoxanthine phosphoribosyl transferase; HGPRT;
                     hypoxanthine guanine phosphoribosyl transferase 1"
                     /codon_start=1
                     /product="hypoxanthine-guanine phosphoribosyltransferase"
                     /protein_id="NP_036715.1"
                     /db_xref="GeneID:24465"
                     /db_xref="RGD:2826"
                     /translation="MSTLSPSVVISDDEPGYDLDLFCIPNHYAEDLEKVFIPHGLIMD
                     RTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRL
                     KSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVKQYSPKMVKV
                     ASLLVKRTSRSVGYRPDFVGFEIPDKFVVGYALDYNEHFRDLNHVCVISESGKAKYKA
                     "
     exon            94..200
                     /gene="Hprt1"
                     /gene_synonym="Hgprtase; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            201..384
                     /gene="Hprt1"
                     /gene_synonym="Hgprtase; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            385..450
                     /gene="Hprt1"
                     /gene_synonym="Hgprtase; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            451..468
                     /gene="Hprt1"
                     /gene_synonym="Hgprtase; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            469..551
                     /gene="Hprt1"
                     /gene_synonym="Hgprtase; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            552..598
                     /gene="Hprt1"
                     /gene_synonym="Hgprtase; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            599..675
                     /gene="Hprt1"
                     /gene_synonym="Hgprtase; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1232
                     /gene="Hprt1"
                     /gene_synonym="Hgprtase; Hprt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtagcac ctcctccgcc agcttcctcc tcagaccgct tttcccgcga gccgaccggt
       61 tctgtcatgt cgaccctcag tcccagcgtc gtgattagtg atgatgaacc aggttatgac
      121 ctagatttat tttgcatacc taatcattat gctgaagatt tggaaaaggt gtttattcct
      181 catggactga ttatggacag gactgaaaga cttgctcgag atgtcatgaa ggagatggga
      241 ggccatcaca ttgtggccct ctgtgtgctg aaggggggct ataagttctt tgctgacctg
      301 ctggattaca ttaaagcgct gaatagaaat agtgataggt ccattcctat gactgtagat
      361 tttatcagac tgaagagcta ctgtaatgac cagtcaacgg gggacataaa agttattggt
      421 ggagatgatc tctcaacttt aactggaaag aacgtcttga ttgttgaaga tataattgac
      481 actggtaaaa caatgcagac tttgctttcc ttggtcaagc agtacagccc caaaatggtt
      541 aaggttgcaa gcttgctggt gaaaaggacc tctcgaagtg ttggatacag gccagacttt
      601 gttggatttg aaattccaga caagtttgtt gttggatatg cccttgacta taatgagcac
      661 ttcagggatt tgaatcatgt ttgtgtcatc agcgaaagtg gaaaagccaa gtacaaagcc
      721 taaaagacag cggcaagttg aatctacaag agtcctgttg atgtggccag taaagaacta
      781 gcagacgttc tagtcctgtg gccatctact tagtaaagct tttgcatgaa ccttctatga
      841 attttatggt ttttattttt agaaatgtct gttgctgcgt cccttttgat ttgcactatg
      901 agcctgtagg cagcctaccg tcaggtagat tgtcacttcc cttgtgagac agacagatct
      961 cttaaattac cactgttaaa taataatact gagattgtat ctgtaagaag gatttaaaaa
     1021 gaagctgtat tagtttttta attggtattt taatttttat atattcagga gagaaagatg
     1081 tgatattgtt aatttagaat agtctaaagc gctcagtttc atatcagtaa cagcatctaa
     1141 gaggtttccc cagtggaata aacatgtttc agcagtgtga atcgttgtca accgttcctt
     1201 ttaaatgcaa ataaatacat tctaaaaatt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
