LOCUS       NM_017112               1739 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hepsin (Hpn), mRNA.
ACCESSION   NM_017112
VERSION     NM_017112.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1739)
  AUTHORS   Liu,Y., Qu,H.Q., Chang,X., Qu,J., Mentch,F.D., Nguyen,K., Tian,L.,
            Glessner,J., Sleiman,P.M.A. and Hakonarson,H.
  TITLE     Mutation burden analysis of six common mental disorders in African
            Americans by whole genome sequencing
  JOURNAL   Hum Mol Genet 31 (22), 3769-3776 (2022)
   PUBMED   35642741
REFERENCE   2  (bases 1 to 1739)
  AUTHORS   Heurich,A., Hofmann-Winkler,H., Gierer,S., Liepold,T., Jahn,O. and
            Pohlmann,S.
  TITLE     TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis
            by TMPRSS2 augments entry driven by the severe acute respiratory
            syndrome coronavirus spike protein
  JOURNAL   J Virol 88 (2), 1293-1307 (2014)
   PUBMED   24227843
REFERENCE   3  (bases 1 to 1739)
  AUTHORS   Aljakna,A., Choi,S., Savage,H., Hageman Blair,R., Gu,T.,
            Svenson,K.L., Churchill,G.A., Hibbs,M. and Korstanje,R.
  TITLE     Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that
            affect HDL cholesterol
  JOURNAL   PLoS One 7 (8), e43139 (2012)
   PUBMED   22912808
REFERENCE   4  (bases 1 to 1739)
  AUTHORS   Rosewell,K., Al-Alem,L., Li,F., Kelty,B. and Curry,T.E. Jr.
  TITLE     Identification of hepsin and protein disulfide isomerase A3 as
            targets of gelatinolytic action in rat ovarian granulosa cells
            during the periovulatory period
  JOURNAL   Biol Reprod 85 (4), 858-866 (2011)
   PUBMED   21734266
  REMARK    GeneRIF: Results suggest that hepsin and PDIA3 undergo proteolysis
            by MMP2/9 in ovarian granulosa cells during ovulation and/or
            luteinization.
REFERENCE   5  (bases 1 to 1739)
  AUTHORS   Hanifa,S., Scott,H.S., Crewther,P., Guipponi,M. and Tan,J.
  TITLE     Thyroxine treatments do not correct inner ear defects in tmprss1
            mutant mice
  JOURNAL   Neuroreport 21 (13), 897-901 (2010)
   PUBMED   20683358
REFERENCE   6  (bases 1 to 1739)
  AUTHORS   Zhang,J.L., Zhao,W.G., Wu,K.L., Wang,K., Zhang,X., Gu,C.F., Li,Y.,
            Zhu,Y. and Wu,J.G.
  TITLE     Human hepatitis B virus X protein promotes cell proliferation and
            inhibits cell apoptosis through interacting with a serine protease
            Hepsin
  JOURNAL   Arch Virol 150 (4), 721-741 (2005)
   PUBMED   15614436
REFERENCE   7  (bases 1 to 1739)
  AUTHORS   Hooper,J.D., Campagnolo,L., Goodarzi,G., Truong,T.N., Stuhlmann,H.
            and Quigley,J.P.
  TITLE     Mouse matriptase-2: identification, characterization and
            comparative mRNA expression analysis with mouse hepsin in adult and
            embryonic tissues
  JOURNAL   Biochem J 373 (Pt 3), 689-702 (2003)
   PUBMED   12744720
REFERENCE   8  (bases 1 to 1739)
  AUTHORS   Torres-Rosado,A., O'Shea,K.S., Tsuji,A., Chou,S.H. and Kurachi,K.
  TITLE     Hepsin, a putative cell-surface serine protease, is required for
            mammalian cell growth
  JOURNAL   Proc Natl Acad Sci U S A 90 (15), 7181-7185 (1993)
   PUBMED   8346233
REFERENCE   9  (bases 1 to 1739)
  AUTHORS   Farley,D., Reymond,F. and Nick,H.
  TITLE     Cloning and sequence analysis of rat hepsin, a cell surface serine
            proteinase
  JOURNAL   Biochim Biophys Acta 1173 (3), 350-352 (1993)
   PUBMED   8318546
REFERENCE   10 (bases 1 to 1739)
  AUTHORS   Tsuji,A., Torres-Rosado,A., Arai,T., Le Beau,M.M., Lemons,R.S.,
            Chou,S.H. and Kurachi,K.
  TITLE     Hepsin, a cell membrane-associated protease. Characterization,
            tissue distribution, and gene localization
  JOURNAL   J Biol Chem 266 (25), 16948-16953 (1991)
   PUBMED   1885621
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X70900.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X70900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1739
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1739
                     /gene="Hpn"
                     /note="hepsin"
                     /db_xref="GeneID:29135"
                     /db_xref="RGD:61982"
     exon            1..130
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     exon            131..197
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1435
                     /gene="Hpn"
                     /EC_number="3.4.21.106"
                     /note="serine protease hepsin; hepsin (transmembrane
                     protease, serine 1)"
                     /codon_start=1
                     /product="serine protease hepsin precursor"
                     /protein_id="NP_058808.1"
                     /db_xref="GeneID:29135"
                     /db_xref="RGD:61982"
                     /translation="MAKEGGRTAPCCSRPKVAALTVGTLLFLTGIGAASWAIVTILLR
                     SDQEPLYQVQLSPGDSRLLVLDKTEGTWRLLCSSRSNARVAGLGCEEMGFLRALAHSE
                     LDVRTAGANGTSGFFCVDEGGLPLAQRLLDVISVCDCPRGRFLTATCQDCGRRKLPVD
                     RIVGGQDSSLGRWPWQVSLRYDGTHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFA
                     GAVARTSPHAVQLGVQAVIYHGGYLPFRDPTIDENSNDIALVHLSSSLPLTEYIQPVC
                     LPAAGQALVDGKVCTVTGWGNTQFYGQQAVVLQEARVPIISNEVCNSPDFYGNQIKPK
                     MFCAGYPEGGIDACQGDSGGHFVCEDRISGTSRWRLCGIVSWGTGCALARKPGVYTKV
                     IDFREWIFQAIKTHSEATGMVTQP"
     exon            198..299
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     exon            300..341
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     exon            342..471
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     exon            472..594
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     exon            595..635
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     exon            636..801
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     exon            802..992
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1088
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1231
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1396
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1739
                     /gene="Hpn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggcccca cgctgctggc tgctgctgcc acccttgcct cccgggctgc ccgctgctgt
       61 ggggacacca tgccccttcc caggcccgga gactaacccc aaacctgcac catctccggc
      121 gaaccccagg gttccgcccc agcccaacag gtcaacctgg gaatcattaa caagagtccc
      181 tgacatggcg aaggagggtg gccggactgc accatgctgt tccagaccca aggtggcagc
      241 tctcactgtg gggaccctgc tgttcctgac aggcattggg gctgcgtcct gggccattgt
      301 gaccatccta ctacggagtg accaggagcc actgtaccaa gtgcagctca gtcccgggga
      361 ctctcgactt ttggtgttgg acaagacaga gggaacgtgg aggctgctgt gctcctcacg
      421 ctccaacgcc agggtagcag ggctcggctg tgaggagatg ggctttctca gggctctggc
      481 gcactcagag ctggatgtgc gaaccgcggg cgccaacggc acatcgggct tcttctgcgt
      541 ggacgagggc ggtctgcctc tggctcagcg gttgctggat gtcatctctg tatgcgactg
      601 tcctagaggc cgattcctga ctgccacctg ccaagactgt ggccgcagga agctgccggt
      661 ggatcgcatt gtggggggcc aggacagcag cctgggaaga tggccatggc aggtcagcct
      721 gcgttatgat gggacccacc tctgtggggg atccctgctg tccggggact gggtactgac
      781 cgctgcacac tgctttccag agaggaaccg ggtcctgtct cggtggcgag tatttgctgg
      841 tgctgtagcc cggacctcac ctcatgccgt gcagctgggg gttcaggctg tgatctatca
      901 tgggggctac cttccctttc gagaccctac tatcgacgaa aacagcaatg acattgccct
      961 ggtccacctc tctagctccc tgcctctcac agaatacatc cagccggttt gtctccctgc
     1021 tgcgggacag gccctggtgg acggcaaggt ctgtacagtg accggctggg gtaacacaca
     1081 gttctatggc cagcaagctg tggtgctcca agaggcccgg gtccccatca taagcaacga
     1141 agtttgcaac agccccgact tctacgggaa tcagatcaaa cccaagatgt tctgtgctgg
     1201 ctatcctgag ggtggtattg atgcatgcca gggtgacagc ggaggccact ttgtatgtga
     1261 ggacagaatc tctggaacat caagatggcg gctctgcggc attgtaagct ggggtacggg
     1321 ctgtgctttg gcccggaagc cgggagtgta caccaaagtc attgacttcc gggagtggat
     1381 cttccaggcc ataaagactc actccgaagc taccggcatg gtaactcagc cctgaccccg
     1441 cctcatcgcc tgctccgcgc tgctccagca tccagagtca gagttggtct ggtggctcca
     1501 gccgcacgtg gcaggctcca cactgggcct cacatggaac ggttttctgc tcggatccag
     1561 tccatagatc caaggatgct gggtccaagg acctctcttc cacagtggcc ggcccactca
     1621 atcccagggc cattggcctc accctcccac cccatgtaaa tattactctg tcctctgggg
     1681 gctgctttcg aggcgcccct tgtgcggatg ctctttaaat aataaaggtg gttttgatt
//
