LOCUS       NM_031644               1199 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hematopoietic prostaglandin D synthase (Hpgds),
            mRNA.
ACCESSION   NM_031644
VERSION     NM_031644.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1199)
  AUTHORS   Moniot,B., Ujjan,S., Champagne,J., Hirai,H., Aritake,K., Nagata,K.,
            Dubois,E., Nidelet,S., Nakamura,M., Urade,Y., Poulat,F. and
            Boizet-Bonhoure,B.
  TITLE     Prostaglandin D2 acts through the Dp2 receptor to influence male
            germ cell differentiation in the foetal mouse testis
  JOURNAL   Development 141 (18), 3561-3571 (2014)
   PUBMED   25142465
REFERENCE   2  (bases 1 to 1199)
  AUTHORS   Majed,B.H. and Khalil,R.A.
  TITLE     Molecular mechanisms regulating the vascular prostacyclin pathways
            and their adaptation during pregnancy and in the newborn
  JOURNAL   Pharmacol Rev 64 (3), 540-582 (2012)
   PUBMED   22679221
  REMARK    Review article
REFERENCE   3  (bases 1 to 1199)
  AUTHORS   Hirata,T. and Narumiya,S.
  TITLE     Prostanoids as regulators of innate and adaptive immunity
  JOURNAL   Adv Immunol 116, 143-174 (2012)
   PUBMED   23063076
  REMARK    Review article
REFERENCE   4  (bases 1 to 1199)
  AUTHORS   Ragolia,L., Hall,C.E. and Palaia,T.
  TITLE     Post-translational modification regulates prostaglandin D2 synthase
            apoptotic activity: characterization by site-directed mutagenesis
  JOURNAL   Prostaglandins Other Lipid Mediat 83 (1-2), 25-32 (2007)
   PUBMED   17259069
  REMARK    GeneRIF: Post-translational modification of L-PGDS, by either
            glycosylation or phosphorylation, enhances its apoptotic activity
            and inhibits vascular smooth muscle cells hyperproliferation.
REFERENCE   5  (bases 1 to 1199)
  AUTHORS   Ragolia,L., Palaia,T., Paric,E. and Maesaka,J.K.
  TITLE     Prostaglandin D2 synthase inhibits the exaggerated growth phenotype
            of spontaneously hypertensive rat vascular smooth muscle cells
  JOURNAL   J Biol Chem 278 (24), 22175-22181 (2003)
   PUBMED   12684506
  REMARK    GeneRIF: L-PGDS is involved in the balance of VSMC proliferation
            and apoptosis
REFERENCE   6  (bases 1 to 1199)
  AUTHORS   Inoue,T., Irikura,D., Okazaki,N., Kinugasa,S., Matsumura,H.,
            Uodome,N., Yamamoto,M., Kumasaka,T., Miyano,M., Kai,Y. and Urade,Y.
  TITLE     Mechanism of metal activation of human hematopoietic prostaglandin
            D synthase
  JOURNAL   Nat Struct Biol 10 (4), 291-296 (2003)
   PUBMED   12627223
  REMARK    Erratum:[Nat Struct Biol. 2003 May;10(5):409]
REFERENCE   7  (bases 1 to 1199)
  AUTHORS   Kanaoka,Y., Fujimori,K., Kikuno,R., Sakaguchi,Y., Urade,Y. and
            Hayaishi,O.
  TITLE     Structure and chromosomal localization of human and mouse genes for
            hematopoietic prostaglandin D synthase. Conservation of the
            ancestral genomic structure of sigma-class glutathione
            S-transferase
  JOURNAL   Eur J Biochem 267 (11), 3315-3322 (2000)
   PUBMED   10824118
REFERENCE   8  (bases 1 to 1199)
  AUTHORS   Kanaoka,Y., Ago,H., Inagaki,E., Nanayama,T., Miyano,M., Kikuno,R.,
            Fujii,Y., Eguchi,N., Toh,H., Urade,Y. and Hayaishi,O.
  TITLE     Cloning and crystal structure of hematopoietic prostaglandin D
            synthase
  JOURNAL   Cell 90 (6), 1085-1095 (1997)
   PUBMED   9323136
  REMARK    Erratum:[Cell 1999 Feb 5;96(3):449]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087590.1.
            
            On Dec 26, 2004 this sequence version replaced NM_031644.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087590.1, D82071.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1199
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..1199
                     /gene="Hpgds"
                     /gene_synonym="Ptgds2"
                     /note="hematopoietic prostaglandin D synthase"
                     /db_xref="GeneID:58962"
                     /db_xref="RGD:69251"
     exon            1..352
                     /gene="Hpgds"
                     /gene_synonym="Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            353..494
                     /gene="Hpgds"
                     /gene_synonym="Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..961
                     /gene="Hpgds"
                     /gene_synonym="Ptgds2"
                     /EC_number="2.5.1.18"
                     /EC_number="5.3.99.2"
                     /note="glutathione-requiring prostaglandin D synthase;
                     H-PGDS; prostaglandin-H2 D-isomerase;
                     glutathione-dependent PGD synthetase; GST class-sigma;
                     glutathione S-transferase; glutathione-dependent PGD
                     synthase; prostaglandin D2 synthase 2, hematopoietic"
                     /codon_start=1
                     /product="hematopoietic prostaglandin D synthase"
                     /protein_id="NP_113832.1"
                     /db_xref="GeneID:58962"
                     /db_xref="RGD:69251"
                     /translation="MPNYKLLYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPKIKP
                     TLPFGKIPVLEVEGLTLHQSLAIARYLTKNTDLAGKTELEQCQVDAVVDTLDDFMSLF
                     PWAEENQDLKERTFNDLLTRQAPHLLKDLDTYLGDKEWFIGNYVTWADFYWDICSTTL
                     LVLKPDLLGIYPRLVSLRNKVQAIPAISAWILKRPQTKL"
     exon            495..587
                     /gene="Hpgds"
                     /gene_synonym="Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..697
                     /gene="Hpgds"
                     /gene_synonym="Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..796
                     /gene="Hpgds"
                     /gene_synonym="Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1175
                     /gene="Hpgds"
                     /gene_synonym="Ptgds2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaaacgtg acaggacttg ttcttattcc ccagaggcct gtggtgtaag actaagaaga
       61 aagaacatgt agcaatccgt acacacaagc acctgtgact gcgactttac tctttatgca
      121 aatttggtgg gtatatacag agagcttggg aaatggtggc aaaagctacc agagctcctt
      181 ccaggctgaa ctttggacgt gtgtatctcg tgtgagcaat gcaggaaggc ttttaggtgg
      241 aggaagtggg ctctggctgt cttgtgacta tcactcgctc atcacagaag ccacagtaca
      301 gataggaacg gagacacaga gacacagcac agcgaaggga ctctcggcat agaactgtac
      361 catgcccaac tacaaactgc tttattttaa tatgagggga agagcagaaa ttattcgtta
      421 tatatttgct tatttggaca tcaagtacga agatcacaga atagaacaag ctgactggcc
      481 taaaatcaaa ccaactcttc catttggcaa aatccctgtt ttggaggtgg aaggacttac
      541 acttcaccag agcctcgcaa tagcaagata tttgaccaaa aacacagatt tggctgggaa
      601 gacagagctg gagcagtgtc aagtggatgc agtggtggat accctggacg atttcatgtc
      661 actctttcca tgggcagagg aaaatcaaga tctaaaagag cggacgttca atgacttgct
      721 cacacgtcaa gcacctcatc ttctgaaaga tttggacaca tacttaggag acaaagagtg
      781 gtttattggc aattatgtaa cttgggcaga tttctattgg gatatctgca gcaccacact
      841 tttggtctta aagcccgacc tgttgggcat ctaccccaga ctggtgtcac tacggaacaa
      901 agtccaagct attcctgcta tttctgcctg gatcctaaag aggccacaga caaaactcta
      961 aatgattctg gacccatcat cagatgagaa gtccatcagc cggctacagc atttgcaaac
     1021 ttctcgccac cactaggcct tcctctcact ttgtagtatt gtgcttgctg tgtaggattc
     1081 ctttgttgtg actttgtctt tttctgtagg catttagttt ccaatatttt ttcaaaactt
     1141 cacacgtttt ataattacag ggaaatagtt cacaaaaaaa aaaaaaaaaa aaaaaaaaa
//
