LOCUS       NM_024390               1681 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus 15-hydroxyprostaglandin dehydrogenase (Hpgd),
            mRNA.
ACCESSION   NM_024390
VERSION     NM_024390.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1681)
  AUTHORS   Guo,J.Y., Bian,H. and Yao,Y.
  TITLE     Chronic unpredictable mild stress induces parallel reductions of
            15-PGDH in the hypothalamus and lungs in rats
  JOURNAL   Behav Brain Res 286, 278-284 (2015)
   PUBMED   25779923
  REMARK    GeneRIF: Results showed that 15-PGDH mRNA and protein expression
            was reduced in the hypothalamus and lungs in stressed animals
            compared with controls, which was correlated with a reduction of
            enzymatic activity
REFERENCE   2  (bases 1 to 1681)
  AUTHORS   Liu,Y., Jia,Z., Sun,Y., Zhou,L., Downton,M., Chen,R., Zhang,A. and
            Yang,T.
  TITLE     Postnatal regulation of 15-hydroxyprostaglandin dehydrogenase in
            the rat kidney
  JOURNAL   Am J Physiol Renal Physiol 307 (4), F388-F395 (2014)
   PUBMED   24647712
  REMARK    GeneRIF: results support a possibility that 15-PGDH may regulate
            postnatal kidney development through interaction with COX-2
REFERENCE   3  (bases 1 to 1681)
  AUTHORS   Wei,L., Yu,X., Shi,H., Zhang,B., Lian,M., Li,J., Shen,T., Xing,Y.
            and Zhu,D.
  TITLE     15-PGDH/15-KETE plays a role in hypoxia-induced pulmonary vascular
            remodeling through ERK1/2-dependent PAR-2 pathway
  JOURNAL   Cell Signal 26 (7), 1476-1488 (2014)
   PUBMED   24657469
REFERENCE   4  (bases 1 to 1681)
  AUTHORS   Moustafa,Y.M., El-Azab,M.F. and Fouda,A.
  TITLE     15-PGDH inhibitors: the antiulcer effects of carbenoxolone,
            pioglitazone and verapamil in indomethacin induced peptic ulcer
            rats
  JOURNAL   Eur Rev Med Pharmacol Sci 17 (15), 2000-2009 (2013)
   PUBMED   23884819
REFERENCE   5  (bases 1 to 1681)
  AUTHORS   Bai,J.W., Wang,Z., Gui,S.B. and Zhang,Y.Z.
  TITLE     Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor
            suppressor role in pituitary adenomas
  JOURNAL   Oncol Rep 28 (2), 714-720 (2012)
   PUBMED   22580984
REFERENCE   6  (bases 1 to 1681)
  AUTHORS   Ensor,C.M. and Tai,H.H.
  TITLE     Site-directed mutagenesis of the conserved tyrosine 151 of human
            placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase
            yields a catalytically inactive enzyme
  JOURNAL   Biochem Biophys Res Commun 176 (2), 840-845 (1991)
   PUBMED   2025296
REFERENCE   7  (bases 1 to 1681)
  AUTHORS   Chang,W.C., Wu,H.L., Hsu,S.Y. and Chen,F.S.
  TITLE     Isolation of rat renal NAD(+)-dependent 15-hydroxyprostaglandin
            dehydrogenase
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 41 (1), 19-25 (1990)
   PUBMED   2251293
REFERENCE   8  (bases 1 to 1681)
  AUTHORS   Tsuruta,K. and Mori,N.
  TITLE     Pulmonary and placental 15-hydroxyprostaglandin dehydrogenase in
            rat during pregnancy
  JOURNAL   Eur J Obstet Gynecol Reprod Biol 27 (1), 71-79 (1988)
   PUBMED   3338612
REFERENCE   9  (bases 1 to 1681)
  AUTHORS   Chang,W.C.
  TITLE     Effects of steroids on renal NAD+-dependent 15-hydroxyprostaglandin
            dehydrogenase activity in ovariectomized rats
  JOURNAL   Prostaglandins Leukot Med 29 (1), 25-32 (1987)
   PUBMED   3478736
REFERENCE   10 (bases 1 to 1681)
  AUTHORS   Pennington,S.N. and Taylor,W.A.
  TITLE     Kinetic changes in rat renal 15-hydroxy-prostaglandin dehydrogenase
            induced by chronic ethanol exposure
  JOURNAL   Prostaglandins 25 (2), 291-297 (1983)
   PUBMED   6574558
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_024390.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062399.1, U44750.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000016.1  39034720-39034831   c
            113-236             JAXUCZ010000016.1  39034369-39034492   c
            237-343             JAXUCZ010000016.1  39030365-39030471   c
            344-440             JAXUCZ010000016.1  39013453-39013549   c
            441-517             JAXUCZ010000016.1  39000180-39000256   c
            518-681             JAXUCZ010000016.1  38998860-38999023   c
            682-1681            JAXUCZ010000016.1  38996876-38997875   c
FEATURES             Location/Qualifiers
     source          1..1681
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..1681
                     /gene="Hpgd"
                     /note="15-hydroxyprostaglandin dehydrogenase"
                     /db_xref="GeneID:79242"
                     /db_xref="RGD:620087"
     exon            1..112
                     /gene="Hpgd"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..820
                     /gene="Hpgd"
                     /EC_number="1.1.1.141"
                     /EC_number="1.1.1.232"
                     /note="PGDH; 15-PGDH; prostaglandin dehydrogenase 1;
                     NAD-dependent 15-hydroxyprostaglandin dehydrogenase;
                     hydroxyprostaglandin dehydrogenase 15 (NAD);
                     eicosanoid/docosanoid dehydrogenase"
                     /codon_start=1
                     /product="15-hydroxyprostaglandin dehydrogenase [NAD(+)]"
                     /protein_id="NP_077366.2"
                     /db_xref="GeneID:79242"
                     /db_xref="RGD:620087"
                     /translation="MHVNGKVALVTGAAQGIGKAFTEALLLHGAKVALVDWNLETGVK
                     CKAALDEQFEPQKTLFIQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQ
                     TLQINLVSVISGTYLGLDYMSKQNGGEGGIIINISSIAGLMPVAQQPVYCASKHGIIG
                     FTRSAAMAANLMKSGVRLNVICPGFVKTPILESIEKEENMGQYIEYTDQIKAMMKFYG
                     ILDPSAIANGLINLIEDDALNGAIMKITASKGIHFQDYDLFPSFSKAP"
     exon            113..236
                     /gene="Hpgd"
                     /inference="alignment:Splign:2.1.0"
     exon            237..343
                     /gene="Hpgd"
                     /inference="alignment:Splign:2.1.0"
     exon            344..440
                     /gene="Hpgd"
                     /inference="alignment:Splign:2.1.0"
     exon            441..517
                     /gene="Hpgd"
                     /inference="alignment:Splign:2.1.0"
     exon            518..681
                     /gene="Hpgd"
                     /inference="alignment:Splign:2.1.0"
     exon            682..1681
                     /gene="Hpgd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagagaca cgacccgcca tgcacgtgaa cggcaaagtg gccctggtga ccggcgcggc
       61 tcaaggcata ggcaaagcct tcactgaggc tctgctgctc catggtgcca aggtagcatt
      121 ggtggattgg aatcttgaga caggtgtaaa atgtaaagcg gccctggatg agcagttcga
      181 acctcagaag acactgttca tccagtgtga tgtggctgac caaaaacaac tgagagatac
      241 ttttagaaaa gttgtagacc attttggaag attggatatt ttggtcaaca acgcaggagt
      301 gaacaatgag aaaaactggg aacagactct acaaattaac ttggtttctg ttatcagtgg
      361 gacctatctt ggtttggatt acatgagtaa gcaaaatgga ggtgaaggtg gcatcatcat
      421 caatatttct tcaatagcag ggctcatgcc tgttgcacag caacctgttt attgtgcctc
      481 aaagcatggc ataatcggat tcacacgctc agcagcgatg gctgctaacc ttatgaaaag
      541 cggtgtgaga ctgaatgtca tttgtccagg ctttgtgaaa acacccatcc ttgaatccat
      601 tgaaaaagaa gaaaatatgg ggcaatatat agaatatacg gaccagatca aggctatgat
      661 gaaattctat ggaattttgg acccatcagc cattgccaat ggattaataa atctcattga
      721 agatgatgct ctcaatggtg ccattatgaa gatcacggcc tcgaaaggaa ttcatttcca
      781 agattatgac ctctttccat ccttttcgaa agccccatga gcttcttcac catcagtcat
      841 aactgacaat cagcacaagt gactcactca gactgcagct ctactaatac agctttttca
      901 atggaatgac gcaggatgaa atctaccttc acatatctga tgttaatatt cttccaaatg
      961 attagttgaa tgtatagtta aagattatga taagctagca aaaagcgcag tgcaaaccaa
     1021 aactgggtta taacctatat gaagacaaaa caaaggagat tcaaaagaca ttctgccttt
     1081 cagaaaacat atttatgaca gttcctcata catattaatg gttttcagga agtcttctta
     1141 aaggagatac ttgaattgtt atttaagtca aagcagactt taaatgactc actttgtgtg
     1201 tttgcacttc aaaaggggga agctccttta caatggaaat atttagtaat gaaagtgtgc
     1261 actcgctctg caagctaaac atttcaactc tttgaagtag tgctgtattt gtgggccagt
     1321 gttagggaat gaattccagt gtagccatgt cccagtgaca agtctgttct atgggaatat
     1381 gatcctgtta ttaacactgg aaattcacag ttcagcctca aatcaaggaa gatgatttat
     1441 ttctgaattt aaaatttgta atggactcca aaacactcag gaatgaaact tttaacagtc
     1501 atagcaaaat aggggtggat gtaaatttat atatatatat atatatatat atatatatat
     1561 atatatatat aatatgcgta ttataaaatg atacaaatgt attttccaga ttatttctct
     1621 gttgatttat accaatttca aaagtgcctc tctttcaata aaactcttgt attcaaattc
     1681 a
//
