LOCUS       NM_001169105            1184 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus histone PARylation factor 1 (Hpf1), mRNA.
ACCESSION   NM_001169105 XM_001053568 XM_214341
VERSION     NM_001169105.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1184)
  AUTHORS   Han,W., Gu,D., Chen,H., Tao,X. and Chen,L.
  TITLE     HPF1 regulates tendon stem/progenitor cell senescence and tendon
            repair via PARP1-mediated poly-ADP ribosylation of HuR
  JOURNAL   Genes Genomics 46 (1), 27-36 (2024)
   PUBMED   37713069
  REMARK    GeneRIF: HPF1 regulates tendon stem/progenitor cell senescence and
            tendon repair via PARP1-mediated poly-ADP ribosylation of HuR.
REFERENCE   2  (bases 1 to 1184)
  AUTHORS   Palazzo,L., Leidecker,O., Prokhorova,E., Dauben,H., Matic,I. and
            Ahel,I.
  TITLE     Serine is the major residue for ADP-ribosylation upon DNA damage
  JOURNAL   Elife 7, e34334 (2018)
   PUBMED   29480802
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1184)
  AUTHORS   Bonfiglio,J.J., Fontana,P., Zhang,Q., Colby,T., Gibbs-Seymour,I.,
            Atanassov,I., Bartlett,E., Zaja,R., Ahel,I. and Matic,I.
  TITLE     Serine ADP-Ribosylation Depends on HPF1
  JOURNAL   Mol Cell 65 (5), 932-940 (2017)
   PUBMED   28190768
REFERENCE   4  (bases 1 to 1184)
  AUTHORS   Gibbs-Seymour,I., Fontana,P., Rack,J.G.M. and Ahel,I.
  TITLE     HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1
            ADP-Ribosylation Activity
  JOURNAL   Mol Cell 62 (3), 432-442 (2016)
   PUBMED   27067600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY557818.1 and BQ209040.1.
            
            On or before Dec 16, 2009 this sequence version replaced
            XM_214341.4, XM_001053568.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-723               DY557818.1         1-723
            724-1184            BQ209040.1         1-461               c
FEATURES             Location/Qualifiers
     source          1..1184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p12"
     gene            1..1184
                     /gene="Hpf1"
                     /gene_synonym="RGD1311747"
                     /note="histone PARylation factor 1"
                     /db_xref="GeneID:290706"
                     /db_xref="RGD:1311747"
     exon            1..92
                     /gene="Hpf1"
                     /gene_synonym="RGD1311747"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1100
                     /gene="Hpf1"
                     /gene_synonym="RGD1311747"
                     /codon_start=1
                     /product="UPF0609 protein C4orf27 homolog"
                     /protein_id="NP_001162576.1"
                     /db_xref="GeneID:290706"
                     /db_xref="RGD:1311747"
                     /translation="MVGGGGKRRPAGAGPQCEKTAEVKKSKSSEADISSDLRKEVEHL
                     YKLSLPEDFYHFWKFCEELDPEKPADALATSLGLRLVGPYDILAGKHKMKKNPTGLNC
                     NLHWRFYYDPPEFQTIIIGDNKTQYHMGYFRDSPDELPVYVGTNEAKKNCIIIQNGDN
                     VFAAIKLFLMKKLKEVTDRKKISILKNIDEKLTEAARKLGYSLEQRTVKMRQRDKKVV
                     TKTFHGAGLVVPVDKNDVGYRELPETDADLKKICKAIVDAASDEERLKAFAPIQEMMT
                     FVQFANDECDYGMGLELGMDLFCYGSHYFHKVAGQLLPLAYNLLKRDLFAKIIEDHLA
                     SRSEEDIDQLAGEPAVL"
     exon            93..252
                     /gene="Hpf1"
                     /gene_synonym="RGD1311747"
                     /inference="alignment:Splign:2.1.0"
     exon            253..442
                     /gene="Hpf1"
                     /gene_synonym="RGD1311747"
                     /inference="alignment:Splign:2.1.0"
     exon            443..541
                     /gene="Hpf1"
                     /gene_synonym="RGD1311747"
                     /inference="alignment:Splign:2.1.0"
     exon            542..692
                     /gene="Hpf1"
                     /gene_synonym="RGD1311747"
                     /inference="alignment:Splign:2.1.0"
     exon            693..780
                     /gene="Hpf1"
                     /gene_synonym="RGD1311747"
                     /inference="alignment:Splign:2.1.0"
     exon            781..953
                     /gene="Hpf1"
                     /gene_synonym="RGD1311747"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1167
                     /gene="Hpf1"
                     /gene_synonym="RGD1311747"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaagcggc gggaacgcgg gcctcggtgc gctgcggctg cgggatggtc ggcggtggcg
       61 ggaagcgccg acccgccggg gcgggaccgc agtgtgaaaa gacagctgag gtaaagaaga
      121 gtaagtcttc tgaagccgac atctccagtg acctccgcaa agaagtagaa catctttata
      181 agctctccct gcctgaagac ttctatcatt tctggaagtt ctgtgaagag cttgatcccg
      241 aaaagccagc tgatgcactt gccacaagcc tgggtcttcg gttagtgggt ccttatgata
      301 tccttgctgg gaaacataaa atgaagaaaa accccacagg cttgaactgt aatcttcact
      361 ggaggtttta ctatgatcct cctgagttcc agaccattat tattggagat aataaaactc
      421 agtaccacat ggggtatttc agagattctc ctgatgaact tcctgtatat gtgggtacaa
      481 atgaagcaaa gaaaaactgt ataattattc aaaatggaga caatgtgttt gctgccatca
      541 aattattttt gatgaaaaaa ctcaaagaag taacagatag aaagaaaatt agcattttga
      601 aaaacataga tgagaaactc acagaagcag ccagaaaact aggatactca ctggagcaga
      661 gaaccgtgaa gatgagacag agagataaga aggttgtgac aaagactttt catggtgcgg
      721 gcttggttgt tcctgtagat aaaaacgacg ttggctacag agagctccct gaaacagatg
      781 ctgacctgaa gaaaatctgc aaggcaattg ttgacgctgc aagtgatgag gagagactga
      841 aagcatttgc tcccattcag gagatgatga ctttcgtgca gtttgctaac gatgagtgtg
      901 attacggcat gggcctggaa ttaggaatgg acctcttctg ctatggctct cattattttc
      961 acaaagttgc tggccagctt ttacctcttg cgtataatct actgaagagg gatctgtttg
     1021 cgaaaatcat tgaagatcat ctggcaagca gaagtgagga ggacatagac cagctcgcag
     1081 gtgagcctgc agtgctttga agtgggccag cagtggcttt gtttttaagg aatggagaaa
     1141 taaatggaaa ctttatgaaa aactgtaaaa aaaaaaaaaa aaaa
//
