LOCUS       NM_017233               1360 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus 4-hydroxyphenylpyruvate dioxygenase (Hpd), mRNA.
ACCESSION   NM_017233
VERSION     NM_017233.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1360)
  AUTHORS   Bailey,W.J., Holder,D., Patel,H., Devlin,P., Gonzalez,R.J.,
            Hamilton,V., Muniappa,N., Hamlin,D.M., Thomas,C.E., Sistare,F.D.
            and Glaab,W.E.
  TITLE     A performance evaluation of three drug-induced liver injury
            biomarkers in the rat: alpha-glutathione S-transferase, arginase 1,
            and 4-hydroxyphenyl-pyruvate dioxygenase
  JOURNAL   Toxicol Sci 130 (2), 229-244 (2012)
   PUBMED   22872058
  REMARK    GeneRIF: Report utility of HPD for monitoring drug-induced liver
            injury in rat model.
REFERENCE   2  (bases 1 to 1360)
  AUTHORS   Brownlee,J.M., Heinz,B., Bates,J. and Moran,G.R.
  TITLE     Product analysis and inhibition studies of a causative Asn to Ser
            variant of 4-hydroxyphenylpyruvate dioxygenase suggest a simple
            route to the treatment of Hawkinsinuria
  JOURNAL   Biochemistry 49 (33), 7218-7226 (2010)
   PUBMED   20677779
  REMARK    GeneRIF: Mutation in the rat (N241S) 4-hydroxyphenylpyruvate
            dioxygenase genes shows that the variant enzyme forms quinolacetic
            acid in place of the native product 2,5-dihydroxyphenylacetic acid.
REFERENCE   3  (bases 1 to 1360)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1360)
  AUTHORS   Yang,C., Pflugrath,J.W., Camper,D.L., Foster,M.L., Pernich,D.J. and
            Walsh,T.A.
  TITLE     Structural basis for herbicidal inhibitor selectivity revealed by
            comparison of crystal structures of plant and mammalian
            4-hydroxyphenylpyruvate dioxygenases
  JOURNAL   Biochemistry 43 (32), 10414-10423 (2004)
   PUBMED   15301540
REFERENCE   5  (bases 1 to 1360)
  AUTHORS   Neve,S., Aarenstrup,L., Tornehave,D., Rahbek-Nielsen,H.,
            Corydon,T.J., Roepstorff,P. and Kristiansen,K.
  TITLE     Tissue distribution, intracellular localization and proteolytic
            processing of rat 4-hydroxyphenylpyruvate dioxygenase
  JOURNAL   Cell Biol Int 27 (8), 611-624 (2003)
   PUBMED   12867153
REFERENCE   6  (bases 1 to 1360)
  AUTHORS   Ruetschi,U., Cerone,R., Perez-Cerda,C., Schiaffino,M.C.,
            Standing,S., Ugarte,M. and Holme,E.
  TITLE     Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in
            patients with tyrosinemia type III
  JOURNAL   Hum Genet 106 (6), 654-662 (2000)
   PUBMED   10942115
REFERENCE   7  (bases 1 to 1360)
  AUTHORS   Lee,M.H., Zhang,Z.H., MacKinnon,C.H., Baldwin,J.E. and Crouch,N.P.
  TITLE     The C-terminal of rat 4-hydroxyphenylpyruvate dioxygenase is
            indispensable for enzyme activity
  JOURNAL   FEBS Lett 393 (2-3), 269-272 (1996)
   PUBMED   8814303
REFERENCE   8  (bases 1 to 1360)
  AUTHORS   Gershwin,M.E., Coppel,R.L., Bearer,E., Peterson,M.G., Sturgess,A.
            and Mackay,I.R.
  TITLE     Molecular cloning of the liver-specific rat F antigen
  JOURNAL   J Immunol 139 (11), 3828-3833 (1987)
   PUBMED   2445820
  REMARK    Erratum:[J Immunol 1988 Apr 1;140(7):2477]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017233.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF082834.1, BC081819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                JAXUCZ010000012.1  39042246-39042284
            40-66               JAXUCZ010000012.1  39042395-39042421
            67-129              JAXUCZ010000012.1  39043172-39043234
            130-234             JAXUCZ010000012.1  39043548-39043652
            235-277             JAXUCZ010000012.1  39044140-39044182
            278-360             JAXUCZ010000012.1  39044329-39044411
            361-450             JAXUCZ010000012.1  39045261-39045350
            451-554             JAXUCZ010000012.1  39047379-39047482
            555-632             JAXUCZ010000012.1  39048057-39048134
            633-795             JAXUCZ010000012.1  39049460-39049622
            796-867             JAXUCZ010000012.1  39049738-39049809
            868-990             JAXUCZ010000012.1  39051343-39051465
            991-1107            JAXUCZ010000012.1  39053152-39053268
            1108-1360           JAXUCZ010000012.1  39053344-39053596
FEATURES             Location/Qualifiers
     source          1..1360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1360
                     /gene="Hpd"
                     /note="4-hydroxyphenylpyruvate dioxygenase"
                     /db_xref="GeneID:29531"
                     /db_xref="RGD:61974"
     exon            1..39
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1218
                     /gene="Hpd"
                     /EC_number="1.13.11.27"
                     /note="4-hydroxyphenylpyruvic acid dioxygenase; 4HPPD;
                     HPPDase; f protein; f Alloantigen; 4-hydroxyphenylpyruvic
                     acid oxidase"
                     /codon_start=1
                     /product="4-hydroxyphenylpyruvate dioxygenase"
                     /protein_id="NP_058929.1"
                     /db_xref="GeneID:29531"
                     /db_xref="RGD:61974"
                     /translation="MTTYSNKGPKPERGRFLHFHSVTFWVGNAKQAASFYCNKMGFEP
                     LAYKGLETGSREVVSHVIKQGKIVFVLCSALNPWNKEMGDHLVKHGDGVKDIAFEVED
                     CEHIVQKARERGAKIVREPWVEEDKFGKVKFAVLQTYGDTTHTLVEKINYTGRFLPGF
                     EAPTYKDTLLPKLPSCNLEIIDHIVGNQPDQEMESASEWYLKNLQFHRFWSVDDTQVH
                     TEYSSLRSIVVANYEESIKMPINEPAPGRKKSQIQEYVDYNGGAGVQHIALRTEDIIT
                     TIRHLRERGMEFLAVPSSYYRLLRENLKTSKIQVKENMDVLEELKILVDYDEKGYLLQ
                     IFTKPMQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQALRGNLTDLETNGVRSG
                     M"
     exon            40..66
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            67..129
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            130..234
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            235..277
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            278..360
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            361..450
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            451..554
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            555..632
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            633..795
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            796..867
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            868..990
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1107
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1360
                     /gene="Hpd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagtactcc tggtagaggt ctgaccacca tcaaccatga caacctacag caacaaagga
       61 ccaaagcctg agagaggccg gttcctccat ttccactctg tgaccttctg ggttggcaac
      121 gccaagcagg ctgcctcctt ctattgcaac aagatgggct tcgaaccgct ggcctacaag
      181 ggcctggaga cgggctcccg ggaggtggtc agtcatgtca tcaagcaagg gaaaattgtg
      241 tttgttctct gctctgctct caatccctgg aacaaagaga tgggtgacca cctggtgaag
      301 catggtgatg gcgtaaagga catcgcattc gaggtggaag actgtgaaca cattgtgcag
      361 aaagcccgag aacggggcgc taaaattgta cgggagccat gggtggagga agacaaattc
      421 gggaaggtga agttcgctgt gctgcagacg tatggagata ccacgcacac cctggtggag
      481 aagatcaact acaccggtcg tttcttacct ggattcgagg ccccaacata caaggacacc
      541 ctacttccaa aactacccag ctgtaacctg gagatcatcg accatattgt aggcaaccag
      601 cccgaccagg aaatggagtc tgcctcagaa tggtacctga aaaacctgca gttccaccgg
      661 ttctggtctg tagacgacac acaggtgcac acggagtata gctctctgcg ctccatcgtg
      721 gtggccaact atgaggagtc catcaaaatg cccattaatg aaccggcccc gggcaggaag
      781 aagtctcaga tccaggaata tgtggactat aatgggggtg ctggggtcca gcacatcgct
      841 ctcaggaccg aagacatcat cacaacgatc cgccacttga gggaacgagg catggagttc
      901 ttggctgtcc cgtcttctta ctacagactg cttcgggaga atctcaagac ctccaagatc
      961 caagtgaagg agaacatgga tgtcttggag gagctaaaaa tcctggtaga ctacgatgag
     1021 aaaggctacc tcctacagat cttcaccaag cccatgcagg accggcccac gctcttcttg
     1081 gaagtcatcc aacgccacaa ccaccagggc tttggagcag gtaacttcaa ctctctgttc
     1141 aaagctttcg aagaggagca agccctacgg ggtaacctca ctgacctgga gaccaacggt
     1201 gtgaggtctg gaatgtaagc tccacccaca cccagaccgc gcaaggcgct ggacaagtca
     1261 atcagctcca actggctgaa aggctggacc tcagggctcc acccacacca tggccacgcc
     1321 ccctctacgg caaggcttct cctgatccgt ttcgagtaaa
//
