LOCUS       NM_017357                663 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hippocalcin-like 4 (Hpcal4), mRNA.
ACCESSION   NM_017357
VERSION     NM_017357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 663)
  AUTHORS   Few,A.P., Lautermilch,N.J., Westenbroek,R.E., Scheuer,T. and
            Catterall,W.A.
  TITLE     Differential regulation of CaV2.1 channels by calcium-binding
            protein 1 and visinin-like protein-2 requires N-terminal
            myristoylation
  JOURNAL   J Neurosci 25 (30), 7071-7080 (2005)
   PUBMED   16049184
  REMARK    GeneRIF: nonmyristoylated CaBP1 and VILIP-2 bind to CaV2.1 channels
            and regulate them like CaM, whereas myristoylation allows
            differential, Ca2+-independent regulation by the inactive EF-hands
            of CaBP1 and VILIP-2
REFERENCE   2  (bases 1 to 663)
  AUTHORS   Lautermilch,N.J., Few,A.P., Scheuer,T. and Catterall,W.A.
  TITLE     Modulation of CaV2.1 channels by the neuronal calcium-binding
            protein visinin-like protein-2
  JOURNAL   J Neurosci 25 (30), 7062-7070 (2005)
   PUBMED   16049183
  REMARK    GeneRIF: Differential regulation of CaV2.1 channels by CaM,
            VILIP-2, CaBP1, and other neurospecific Ca2+-binding proteins is a
            potentially important determinant of Ca2+ entry in
            neurotransmission.
REFERENCE   3  (bases 1 to 663)
  AUTHORS   Kajimoto,Y., Shirai,Y., Mukai,H., Kuno,T. and Tanaka,C.
  TITLE     Molecular cloning of two additional members of the neural
            visinin-like Ca(2+)-binding protein gene family
  JOURNAL   J Neurochem 61 (3), 1091-1096 (1993)
   PUBMED   8360675
REFERENCE   4  (bases 1 to 663)
  AUTHORS   Kobayashi,M., Takamatsu,K., Saitoh,S., Miura,M. and Noguchi,T.
  TITLE     Molecular cloning of hippocalcin, a novel calcium-binding protein
            of the recoverin family exclusively expressed in hippocampus
  JOURNAL   Biochem Biophys Res Commun 189 (1), 511-517 (1992)
   PUBMED   1280427
  REMARK    Erratum:[Biochem Biophys Res Commun. 1993 Oct 29;196(2):1017. PMID:
            8240319]
REFERENCE   5  (bases 1 to 663)
  AUTHORS   Okazaki,K., Watanabe,M., Ando,Y., Hagiwara,M., Terasawa,M. and
            Hidaka,H.
  TITLE     Full sequence of neurocalcin, a novel calcium-binding protein
            abundant in central nervous system
  JOURNAL   Biochem Biophys Res Commun 185 (1), 147-153 (1992)
   PUBMED   1599450
REFERENCE   6  (bases 1 to 663)
  AUTHORS   Kuno,T., Kajimoto,Y., Hashimoto,T., Mukai,H., Shirai,Y., Saheki,S.
            and Tanaka,C.
  TITLE     cDNA cloning of a neural visinin-like Ca(2+)-binding protein
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1219-1225 (1992)
   PUBMED   1375457
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D13125.1.
            
            [WARNING] On Apr 30, 2024 this sequence was replaced by
            NM_017357.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13125.1, FQ212482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..663
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W/Slc"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..663
                     /gene="Hpcal4"
                     /gene_synonym="Nvjp2; NVP-2"
                     /note="hippocalcin-like 4"
                     /db_xref="GeneID:50872"
                     /db_xref="RGD:708491"
     exon            1..65
                     /gene="Hpcal4"
                     /gene_synonym="Nvjp2; NVP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            66..234
                     /gene="Hpcal4"
                     /gene_synonym="Nvjp2; NVP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..648
                     /gene="Hpcal4"
                     /gene_synonym="Nvjp2; NVP-2"
                     /note="NVL-2; VILIP-2; visinin-like protein 2; neural
                     visinin-like protein 2; neural visinin-like Ca2+-binding
                     protein type 2"
                     /codon_start=1
                     /product="hippocalcin-like protein 4"
                     /protein_id="NP_059053.1"
                     /db_xref="GeneID:50872"
                     /db_xref="RGD:708491"
                     /translation="MGKNNSKLAPEELEDLVQNTEFSEQELKQWYKGFLKDCPSGILN
                     LEEFQQLYIKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSVTSRGSFEQKLN
                     WAFEMYDLDGDGRITRLEMLEIIEAIYKMVGTVIMMRMNQDGLTPQQRVDKIFKKMDQ
                     DKDDQITLEEFKEAAKSDPSIVLLLQCDMQK"
     exon            235..450
                     /gene="Hpcal4"
                     /gene_synonym="Nvjp2; NVP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            451..663
                     /gene="Hpcal4"
                     /gene_synonym="Nvjp2; NVP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttcacttca agccgagtcc ccagttcaag aaggaggtac ggccgcctcc ttacccccat
       61 ctcaggccca ccatggggaa gaacaatagc aagctggccc ctgaggagct ggaagatctg
      121 gtccagaaca cggagttcag cgagcaggag ctaaagcagt ggtataaggg tttcctgaag
      181 gactgcccca gcggcatcct caacctggag gagtttcagc aactctacat caagttcttt
      241 ccttacggag acgcctccaa gtttgcacag catgctttcc gcaccttcga caagaacggc
      301 gatggcacca tcgacttccg ggagttcatc tgcgcccttt ctgtcacctc ccgtggcagc
      361 tttgagcaga agctcaactg ggcctttgag atgtacgacc tggacggtga tggacgcatc
      421 acacggctgg agatgctgga gatcattgag gctatctata agatggtggg caccgtgatc
      481 atgatgcgca tgaaccagga tgggctcacg ccccagcagc gcgtagacaa gatcttcaag
      541 aagatggacc aggataagga tgaccagatt acgctggagg agttcaagga ggcggccaag
      601 agtgacccgt ccatcgtgtt gctgttgcaa tgtgacatgc agaagtaggg ctggtgaggg
      661 gca
//
