LOCUS       NM_017122               1569 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus hippocalcin (Hpca), mRNA.
ACCESSION   NM_017122 XM_346751
VERSION     NM_017122.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1569)
  AUTHORS   Osypenko,D.S., Dovgan,A.V., Kononenko,N.I., Dromaretsky,A.V.,
            Matvieienko,M., Rybachuk,O.A., Zhang,J., Korogod,S.M.,
            Venkataraman,V. and Belan,P.
  TITLE     Perturbed Ca2+-dependent signaling of DYT2 hippocalcin mutant as
            mechanism of autosomal recessive dystonia
  JOURNAL   Neurobiol Dis 132, 104529 (2019)
   PUBMED   31301343
  REMARK    GeneRIF: Slow after hyperpolarization was identified as a
            downstream cellular target perturbed by a hippocalin mutation in
            DYT2 dystonia.
REFERENCE   2  (bases 1 to 1569)
  AUTHORS   Park,D.J. and Koh,P.O.
  TITLE     Diabetes aggravates decreases in hippocalcin and parvalbumin
            expression in focal cerebral ischemia
  JOURNAL   Neurosci Lett 662, 189-194 (2018)
   PUBMED   29061397
  REMARK    GeneRIF: Study results suggest that significantly decreased levels
            of hippocalcin and parvalbumin exacerbate neuronal cell death in
            diabetic animals with ischemic brain injury.
REFERENCE   3  (bases 1 to 1569)
  AUTHORS   Helassa,N., Antonyuk,S.V., Lian,L.Y., Haynes,L.P. and Burgoyne,R.D.
  TITLE     Biophysical and functional characterization of hippocalcin mutants
            responsible for human dystonia
  JOURNAL   Hum Mol Genet 26 (13), 2426-2435 (2017)
   PUBMED   28398555
REFERENCE   4  (bases 1 to 1569)
  AUTHORS   Conesa-Zamora,P., Garcia-Solano,J., Garcia-Garcia,F., Turpin
            Mdel,C., Trujillo-Santos,J., Torres-Moreno,D., Oviedo-Ramirez,I.,
            Carbonell-Munoz,R., Munoz-Delgado,E., Rodriguez-Braun,E., Conesa,A.
            and Perez-Guillermo,M.
  TITLE     Expression profiling shows differential molecular pathways and
            provides potential new diagnostic biomarkers for colorectal
            serrated adenocarcinoma
  JOURNAL   Int J Cancer 132 (2), 297-307 (2013)
   PUBMED   22696308
REFERENCE   5  (bases 1 to 1569)
  AUTHORS   Kobayashi,M., Hamanoue,M., Masaki,T., Furuta,Y. and Takamatsu,K.
  TITLE     Hippocalcin mediates calcium-dependent translocation of brain-type
            creatine kinase (BB-CK) in hippocampal neurons
  JOURNAL   Biochem Biophys Res Commun 429 (3-4), 142-147 (2012)
   PUBMED   23142228
  REMARK    GeneRIF: These results indicate that Hpca associates with BB-CK and
            that together they translocate to membrane compartments in a
            Ca(2+)-dependent manner.
REFERENCE   6  (bases 1 to 1569)
  AUTHORS   Bastianelli,E., Takamatsu,K., Okazaki,K., Hidaka,H. and Pochet,R.
  TITLE     Hippocalcin in rat retina. Comparison with calbindin-D28k,
            calretinin and neurocalcin
  JOURNAL   Exp Eye Res 60 (3), 257-266 (1995)
   PUBMED   7789406
REFERENCE   7  (bases 1 to 1569)
  AUTHORS   Sugisaki,T., Yamada,T., Saitoh,S., Takamatsu,K., Kubota,C. and
            Noguchi,T.
  TITLE     Hippocalcin expression in the brain of the Snell dwarf mutant mouse
  JOURNAL   Brain Res 665 (1), 101-106 (1994)
   PUBMED   7882001
REFERENCE   8  (bases 1 to 1569)
  AUTHORS   Saitoh,S., Takamatsu,K., Kobayashi,M. and Noguchi,T.
  TITLE     Expression of hippocalcin in the developing rat brain
  JOURNAL   Brain Res Dev Brain Res 80 (1-2), 199-208 (1994)
   PUBMED   7955346
REFERENCE   9  (bases 1 to 1569)
  AUTHORS   Kobayashi,M., Takamatsu,K., Saitoh,S., Miura,M. and Noguchi,T.
  TITLE     Molecular cloning of hippocalcin, a novel calcium-binding protein
            of the recoverin family exclusively expressed in hippocampus
  JOURNAL   Biochem Biophys Res Commun 189 (1), 511-517 (1992)
   PUBMED   1280427
  REMARK    Erratum:[Biochem Biophys Res Commun. 1993 Oct 29;196(2):1017. doi:
            10.1006/bbrc.1993.2351.. PMID: 8240319]
REFERENCE   10 (bases 1 to 1569)
  AUTHORS   Takamatsu,K., Kitamura,K. and Noguchi,T.
  TITLE     Isolation and characterization of recoverin-like Ca(2+)-binding
            protein from rat brain
  JOURNAL   Biochem Biophys Res Commun 183 (1), 245-251 (1992)
   PUBMED   1543495
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017122.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D12573.1, CF976762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-552               JAXUCZ010000005.1  146747807-146748358 c
            553-658             JAXUCZ010000005.1  146741093-146741198 c
            659-1569            JAXUCZ010000005.1  146740033-146740943 c
FEATURES             Location/Qualifiers
     source          1..1569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1569
                     /gene="Hpca"
                     /note="hippocalcin"
                     /db_xref="GeneID:29177"
                     /db_xref="RGD:620060"
     exon            1..552
                     /gene="Hpca"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..756
                     /gene="Hpca"
                     /note="calcium-binding protein; P23K"
                     /codon_start=1
                     /product="neuron-specific calcium-binding protein
                     hippocalcin"
                     /protein_id="NP_058818.1"
                     /db_xref="GeneID:29177"
                     /db_xref="RGD:620060"
                     /translation="MGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILN
                     VDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLM
                     WAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNN
                     DGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF"
     exon            553..658
                     /gene="Hpca"
                     /inference="alignment:Splign:2.1.0"
     exon            659..1569
                     /gene="Hpca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgtgtgg tctggggcca cctctctctt tttgggtcaa atgagagttt ggggtatctt
       61 gtgtctgagg gcccttctgg agtagtgtca agggactaaa aggacgtaac cattgctctc
      121 tcctttcact tcctttggtt ggggggaacc caggtgggac ttggctcttc tgccatgggc
      181 aagcagaata gcaagctgcg gccagagatg ctgcaggacc tgcgagagaa caccgagttc
      241 tctgagctgg agcttcagga gtggtacaag ggcttcctga aggactgccc gactggcatc
      301 ctcaacgtgg atgagttcaa gaagatctac gccaacttct tcccctacgg cgatgcctcc
      361 aagttcgccg agcatgtctt ccgcactttt gacaccaaca gcgacggcac catcgacttc
      421 cgggagttca tcatcgctct gagcgtgacc tcgcgtggcc gcctggagca gaagctcatg
      481 tgggccttca gcatgtacga cctggacggc aatggctaca tcagccggga ggagatgcta
      541 gaaattgtgc aggccattta caagatggtt tcgtccgtga tgaagatgcc tgaggatgag
      601 tctaccccgg aaaagaggac tgagaaaatc ttccgccaaa tggacacaaa caatgacggc
      661 aagctgtcac tggaggagtt catccgcggg gccaaaagcg acccatcgat cgtgcgcctg
      721 ctgcaatgcg atcccagcag cgcttcccag ttctgagctg agaggagcca gctcgcctcc
      781 ctgccttcac cggccctccg gctctcagct tcctctccct cgtgtctatc caggctgggg
      841 aatccccttc tggggtctgc actgtggggg ggcctctgga gaagcgaacc ctgcaaggaa
      901 ggggctaagc aaggcagccg ttagtcccca cggcctaaga ggcagaatct cccttagtgg
      961 gaccgagatt acccccgggt caggttctgt attctttccc cagacagctg gatcaccttc
     1021 cacccaccca caacccggag gctcttccac aacacgggga agagggtcct tcttgggtgg
     1081 tcctcagcct ggagggaggt ggggatttgt gccaaggtga agagtctttt tgtttgtttg
     1141 gtggggagac ccggaggatt actgggctgt gggactttga agaagttccc tgatctactt
     1201 ccctgcagaa gaacacttcc tgtcccagct cttgctggct ggaggccatg gtaaaaagaa
     1261 gatctcccag gattccaact gggggtcccc aaacccagcc tgcctctttg cacttggata
     1321 accacagatt tacccgtctg tcctctgtat ttctctctcc ttcccccacc tcacacacgc
     1381 acgggcgcgc gcgcacatgc gcgcgcaaca cacacacaca cacacacacg cacgcatatg
     1441 cacgcacaca tgcacacgca cccgcgcaca cagaggccgg cagacagatg agcagagccc
     1501 ctccacagcg ttctgtgtgg gaaagaagtg caggcccctg gccaagcccc atgtccctct
     1561 gcatgcgcc
//
