LOCUS       NM_012582               1239 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus haptoglobin (Hp), mRNA.
ACCESSION   NM_012582
VERSION     NM_012582.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Ding,F., Sun,K., Sun,N., Jiang,Q., Cao,M. and Wu,Z.
  TITLE     iTRAQ-based proteomics reveals SOD2 as a potential salivary
            biomarker in liver cancer
  JOURNAL   Int J Biol Markers 34 (3), 221-231 (2019)
   PUBMED   31041878
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Yang,Y., Kimura-Ohba,S., Thompson,J.F., Salayandia,V.M., Cosse,M.,
            Raz,L., Jalal,F.Y. and Rosenberg,G.A.
  TITLE     Vascular tight junction disruption and angiogenesis in
            spontaneously hypertensive rat with neuroinflammatory white matter
            injury
  JOURNAL   Neurobiol Dis 114, 95-110 (2018)
   PUBMED   29486300
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Heawchaiyaphum,C., Pientong,C., Phusingha,P., Vatanasapt,P.,
            Promthet,S., Daduang,J., Teeramatwanich,W., Kongyingyoes,B.,
            Chuerduangphui,J. and Ekalaksananan,T.
  TITLE     Peroxiredoxin-2 and zinc-alpha-2-glycoprotein as potentially
            combined novel salivary biomarkers for early detection of oral
            squamous cell carcinoma using proteomic approaches
  JOURNAL   J Proteomics 173, 52-61 (2018)
   PUBMED   29199150
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Irwin,D.C., Baek,J.H., Hassell,K., Nuss,R., Eigenberger,P.,
            Lisk,C., Loomis,Z., Maltzahn,J., Stenmark,K.R., Nozik-Grayck,E. and
            Buehler,P.W.
  TITLE     Hemoglobin-induced lung vascular oxidation, inflammation, and
            remodeling contribute to the progression of hypoxic pulmonary
            hypertension and is attenuated in rats with repeated-dose
            haptoglobin administration
  JOURNAL   Free Radic Biol Med 82, 50-62 (2015)
   PUBMED   25656991
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Jubelirer,S.J.
  TITLE     Primary pulmonary hypertension. Its association with
            microangiopathic hemolytic anemia and thrombocytopenia
  JOURNAL   Arch Intern Med 151 (6), 1221-1223 (1991)
   PUBMED   2043024
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Marinkovic,S. and Baumann,H.
  TITLE     Structure, hormonal regulation, and identification of the
            interleukin-6- and dexamethasone-responsive element of the rat
            haptoglobin gene
  JOURNAL   Mol Cell Biol 10 (4), 1573-1583 (1990)
   PUBMED   2320005
REFERENCE   8  (bases 1 to 1239)
  AUTHORS   Frohlander,N. and Johnson,O.
  TITLE     Haptoglobin groups in acute myocardial infarction
  JOURNAL   Hum Hered 39 (6), 345-350 (1989)
   PUBMED   2613263
REFERENCE   9  (bases 1 to 1239)
  AUTHORS   Dash,S. and Das,K.C.
  TITLE     Serum haptoglobin concentrations in 'pure' iron-deficiency anemia
  JOURNAL   Clin Chem 24 (5), 839-840 (1978)
   PUBMED   647925
REFERENCE   10 (bases 1 to 1239)
  AUTHORS   Snyder,S., Coodley,E.L., Durham,B.C. and Pennock,R.S.
  TITLE     Serum glycoproteins in coronary artery disease
  JOURNAL   Circulation 56 (3), 359-362 (1977)
   PUBMED   884791
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089816.1.
            
            On Feb 20, 2005 this sequence version replaced NM_012582.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089816.1, AF476963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1239
                     /gene="Hp"
                     /gene_synonym="Ba1-647"
                     /note="haptoglobin"
                     /db_xref="GeneID:24464"
                     /db_xref="RGD:2825"
     exon            1..18
                     /gene="Hp"
                     /gene_synonym="Ba1-647"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1057
                     /gene="Hp"
                     /gene_synonym="Ba1-647"
                     /note="liver regeneration-related protein LRRG173;
                     zonulin"
                     /codon_start=1
                     /product="haptoglobin precursor"
                     /protein_id="NP_036714.2"
                     /db_xref="GeneID:24464"
                     /db_xref="RGD:2825"
                     /translation="MRALGAVVTLLLWGQLFAVELGNDATDIEDDSCPKPPEIANGYV
                     EHLVRYRCRQFYKLQTEGDGIYTLNSEKQWVNPAAGDKLPKCEAVCGKPKHPVDQVQR
                     IIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAQNLFLNHSENATAKDIAP
                     TLTLYVGKNQLVEIEKVVLHPERSVVDIGLIKLKQKVLVTEKVMPICLPSKDYVAPGR
                     MGYVSGWGRNVNFRFTERLKYVMLPVADQEKCELHYEKSTVPEKKGAVSPVGVQPILN
                     KHTFCAGLTKYEEDTCYGDAGSAFAVHDTEEDTWYAAGILSFDKSCAVAEYGVYVRAT
                     DLKDWVQETMAKN"
     exon            19..101
                     /gene="Hp"
                     /gene_synonym="Ba1-647"
                     /inference="alignment:Splign:2.1.0"
     exon            102..203
                     /gene="Hp"
                     /gene_synonym="Ba1-647"
                     /inference="alignment:Splign:2.1.0"
     exon            204..278
                     /gene="Hp"
                     /gene_synonym="Ba1-647"
                     /inference="alignment:Splign:2.1.0"
     exon            279..1197
                     /gene="Hp"
                     /gene_synonym="Ba1-647"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagaggccc acgatgagag ccctgggagc tgtcgtcact ctcctgctct ggggtcagct
       61 ttttgctgtg gaattgggca atgatgccac agacattgaa gatgacagct gcccaaagcc
      121 cccagagatt gcaaacggct atgtggaaca cttggttcgt tatcgctgcc gacagttcta
      181 caaactacag accgaaggag atggaatcta caccttaaac agtgagaagc aatgggtgaa
      241 cccagctgct ggcgataaac tccccaagtg tgaggcagtg tgtgggaagc ccaagcatcc
      301 tgtggaccag gtacagcgca tcatcggtgg ttccatggac gccaaaggca gctttccttg
      361 gcaggccaag atgatctcca gacatggact caccactggg gccacactga tcagtgacca
      421 gtggctgctg accactgccc aaaacctctt cctgaatcac agtgagaatg cgacagccaa
      481 ggacattgcc cctaccttaa cactctatgt ggggaaaaac cagctggtgg agattgagaa
      541 ggtagttctc caccccgagc gctctgtggt ggatatcggg ctgatcaagc tcaaacagaa
      601 agtgcttgtc actgagaaag tcatgcctat ctgcctgcct tccaaagact acgtagcgcc
      661 aggccgcatg ggctatgtgt ccggttgggg gcggaatgtc aactttagat ttactgaacg
      721 tctcaagtat gtcatgctgc ctgtggctga ccaggagaag tgtgagctgc actatgagaa
      781 aagcacagtg cctgagaaga aaggcgctgt aagtcctgtt ggggtacagc ccatcttgaa
      841 taagcatacc ttctgtgctg gccttaccaa gtatgaggaa gacacttgct atggtgacgc
      901 tggcagtgcc tttgccgtcc atgacacgga ggaggacacc tggtatgcag ctgggatcct
      961 gagctttgac aagagttgtg ccgtagctga gtatggtgtg tacgtgaggg caactgatct
     1021 gaaggactgg gtccaggaaa caatggccaa gaactagttc agggctgact agagggctgc
     1081 acacagtggg gcagggcaat tcaccctgga agaggaagta gaagggttgg ggacataatc
     1141 tgagggctgc tagccctgca ttgctcagtc aataataaaa aacgagcttt ggacccaaaa
     1201 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
