LOCUS       NM_001105885            2706 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus homeo box D4 (Hoxd4), mRNA.
ACCESSION   NM_001105885 XM_001064107 XM_221521
VERSION     NM_001105885.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2706)
  AUTHORS   Nishiyama,A., Xin,L., Sharov,A.A., Thomas,M., Mowrer,G., Meyers,E.,
            Piao,Y., Mehta,S., Yee,S., Nakatake,Y., Stagg,C., Sharova,L.,
            Correa-Cerro,L.S., Bassey,U., Hoang,H., Kim,E., Tapnio,R., Qian,Y.,
            Dudekula,D., Zalzman,M., Li,M., Falco,G., Yang,H.T., Lee,S.L.,
            Monti,M., Stanghellini,I., Islam,M.N., Nagaraja,R., Goldberg,I.,
            Wang,W., Longo,D.L., Schlessinger,D. and Ko,M.S.
  TITLE     Uncovering early response of gene regulatory networks in ESCs by
            systematic induction of transcription factors
  JOURNAL   Cell Stem Cell 5 (4), 420-433 (2009)
   PUBMED   19796622
REFERENCE   2  (bases 1 to 2706)
  AUTHORS   Horan,G.S., Ramirez-Solis,R., Featherstone,M.S., Wolgemuth,D.J.,
            Bradley,A. and Behringer,R.R.
  TITLE     Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4
            genes show more complete homeotic transformations and a
            dose-dependent increase in the number of vertebrae transformed
  JOURNAL   Genes Dev 9 (13), 1667-1677 (1995)
   PUBMED   7628700
REFERENCE   3  (bases 1 to 2706)
  AUTHORS   Horan,G.S., Kovacs,E.N., Behringer,R.R. and Featherstone,M.S.
  TITLE     Mutations in paralogous Hox genes result in overlapping homeotic
            transformations of the axial skeleton: evidence for unique and
            redundant function
  JOURNAL   Dev Biol 169 (1), 359-372 (1995)
   PUBMED   7750651
REFERENCE   4  (bases 1 to 2706)
  AUTHORS   Zappavigna,V., Renucci,A., Izpisua-Belmonte,J.C., Urier,G.,
            Peschle,C. and Duboule,D.
  TITLE     HOX4 genes encode transcription factors with potential auto- and
            cross-regulatory capacities
  JOURNAL   EMBO J 10 (13), 4177-4187 (1991)
   PUBMED   1756725
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001105885.1.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               JAXUCZ010000003.1  80021886-80022280
            396-473             JAXUCZ010000003.1  80032400-80032477
            474-509             JAXUCZ010000003.1  80033179-80033214
            510-1008            JAXUCZ010000003.1  80035301-80035799
            1009-1838           JAXUCZ010000003.1  80036696-80037525
            1839-2706           JAXUCZ010000003.1  80038081-80038948
FEATURES             Location/Qualifiers
     source          1..2706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..2706
                     /gene="Hoxd4"
                     /note="homeo box D4"
                     /db_xref="GeneID:288153"
                     /db_xref="RGD:1309690"
     exon            1..395
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            396..473
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            474..509
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            510..1008
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1838
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1412..2167
                     /gene="Hoxd4"
                     /codon_start=1
                     /product="homeobox protein Hox-D4"
                     /protein_id="NP_001099355.1"
                     /db_xref="GeneID:288153"
                     /db_xref="RGD:1309690"
                     /translation="MAMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGSGAQGS
                     DFQPPGLYPRPDFGEQPFGGGGPGPGSALPARGHGQEPSGPGSHYSAPGEPCPAPPPA
                     PLPGARACSQPTGPKQPPPGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYT
                     RQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKG
                     RSSSSSSSCSSSAAPSQHLQPMAKDHHTDLTTL"
     exon            1839..2706
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cattctgctt tcccagagcc tcaccccctc tttttctaac ctttgtctct gcagaggtgg
       61 gctctagtcg ccggctgcgg gatcgcgtgg tccgcagcgg cctgggctcc cgccgcgact
      121 ccacggcacc tcgccccggg tcgcgatcag ggccgcctcc ggagtcggcg gggagcccgg
      181 aaggagcccc gggcgccgag ccacccgcag ccgctcacac tcctgcggag agccgaccgc
      241 ctgcttccac aaggcgaccc gggccgcgca cttcccaccg gaccccttca gcaacatgag
      301 cccaaacctg cggccgacgg taagcgcagc cccgcagcgc cggatggatc ccagcggtgg
      361 cccgggccga ccgaccgcag ctccgcaccc tccgggggac taaaaacttg aagctggaca
      421 tgagcgcctg aggaaaccac cattctgtga tccgtctgta ggttctcctg caggtttcgg
      481 agcaccagga attatcaggg agaaccattc tcaacagtct cagcccgggg aggctccgtg
      541 gccgcaaaca gcgcctgccg cagggtctgc agcagcagta gcagcagaag cagcagcagc
      601 agcggatccg aaagtctggc ggggctgagg gcccaggaag gtaaatgctc gaattctagg
      661 aggactagtc ttggccacta acttggctca ggttttgttg aagagtatcc cttttgcctt
      721 tttcaaaact ccttttctgc tgctaaaggc ctttgcttct ttttgggaaa taccacttga
      781 taagggggcg ggagatttgt attctgagaa ggggcaataa agccgccatc tctggggtga
      841 aagaaattcc tcatcttttc ttttcctttt tttaaaaaag aaggtactgg ttgctcagct
      901 gcttggtggc ccccatcctg gcagtgggag gatgagggga ctcattacta caaattgtca
      961 ccgagcctac ctgcaccatc tctgaacacc aggcttgggg agttcctgta ggagaattca
     1021 ctcttctttg aactatgccc attctggggg ctgcttcagg cgatggtgag tgaggagggc
     1081 atgggaggtt agcaaagtca gtggaagaca aaagcgaaga ttatctgctg caaattgggg
     1141 tctcggggat agaatcaaaa ctatattaac atctgtcagg gactctcaaa tgtggcatgg
     1201 caagtcactt gattacacgt atgttattta gttaaatttg tgaaaattat gagatgctca
     1261 ccaacccggt gataaacatg ctctcttcct attggctggc ctggtcacat ggccgcccaa
     1321 ctttattcag ttgacagcaa gtaggagggc ccaatggaag gagaaaaaag acaacacgag
     1381 aaaaattagt attttctacc ttctgaaatt aatggccatg agttcgtata tggtgaactc
     1441 taagtacgtg gaccccaagt ttcctccgtg cgaggaatat ttgcagggtg gctacctagg
     1501 cgagcaggga gccgactact acggcagcgg tgcacagggc tccgacttcc agcccccggg
     1561 gctctaccca cggcccgact tcggtgagca acccttcgga ggcggcgggc ccgggcctgg
     1621 ctcagcgctg cccgcgcggg gtcacggaca ggagccgagc ggcccgggaa gtcactacag
     1681 tgccccggga gagccgtgcc cagcgccccc gcctgcgccc ctgcctggcg ctcgggcctg
     1741 cagccagccc accggcccca agcagccgcc ccccgggaca gcactcaagc agcccgctgt
     1801 ggtctaccct tggatgaaga aggtgcatgt gaattcggtg aaccccaact acaccggcgg
     1861 ggagcccaag cgttcccgga cggcctacac cagacagcaa gtcctagaac tggaaaagga
     1921 atttcatttt aacaggtatc tgaccaggcg ccgtcggatt gaaatcgctc acaccctgtg
     1981 tctttctgag cgccagatca agatctggtt ccagaaccgg aggatgaagt ggaaaaaaga
     2041 tcacaaactg cccaacacca agggcagatc ttcttcttcc tcatcttcct gctcctcttc
     2101 agctgccccc agccagcatt tgcagccaat ggccaaggac caccatacgg acctgacgac
     2161 cttatagaag tgggaaccct gggcccattc cttcttgcac tccaggttga ggcgaagctg
     2221 cgggtgcagg cggggcctgc tgtcacctca ctgggctcta aggtactgtg ggggtggacc
     2281 tgggacccgc aggttaccat cctgcctgag ggcagccccc tccctaaagt ggggaagggt
     2341 gggagggagg gcgggcttct ttaaatagat tatcaaacgg caggagctac tgagaacata
     2401 aacccttggt gagtcattaa actcctgaaa atctctgctg ttggattttg aatttgcaaa
     2461 tgaaggtcgg aggcttcacc ccagtgtgaa ccgggatgtt ctcctccgca ccacccctcc
     2521 agggagctgc gtggcatagt aactgtgggg gagttgaggc agaaggccag cacccagtgc
     2581 taggtgcttc cactgcaagc aggagagctg agtcagaagc tcagaacttt ctgaataatc
     2641 tatagaattt cttctgtgat aaaaagaaat gttttgctcc cagtggccca tgcccaaaga
     2701 aataaa
//
