LOCUS       NM_001109884            2068 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus homeo box C4 (Hoxc4), mRNA.
ACCESSION   NM_001109884 XM_235703
VERSION     NM_001109884.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2068)
  AUTHORS   Schmidt,J.A., Avarbock,M.R., Tobias,J.W. and Brinster,R.L.
  TITLE     Identification of glial cell line-derived neurotrophic
            factor-regulated genes important for spermatogonial stem cell
            self-renewal in the rat
  JOURNAL   Biol Reprod 81 (1), 56-66 (2009)
   PUBMED   19339709
REFERENCE   2  (bases 1 to 2068)
  AUTHORS   Calonge,W.M., Martinez,L., Lacadena,J., Fernandez-Dumont,V.,
            Matesanz,R. and Tovar,J.A.
  TITLE     Expression of homeotic genes Hoxa3, Hoxb3, Hoxd3 and Hoxc4 is
            decreased in the lungs but not in the hearts of adriamycin-exposed
            mice
  JOURNAL   Pediatr Surg Int 23 (5), 419-424 (2007)
   PUBMED   17211587
REFERENCE   3  (bases 1 to 2068)
  AUTHORS   Wissmuller,S., Kosian,T., Wolf,M., Finzsch,M. and Wegner,M.
  TITLE     The high-mobility-group domain of Sox proteins interacts with
            DNA-binding domains of many transcription factors
  JOURNAL   Nucleic Acids Res 34 (6), 1735-1744 (2006)
   PUBMED   16582099
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2068)
  AUTHORS   Kim,E.C., Edmonston,C.R., Wu,X., Schaffer,A. and Casali,P.
  TITLE     The HoxC4 homeodomain protein mediates activation of the
            immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells.
            Relevance to class switch DNA recombination
  JOURNAL   J Biol Chem 279 (40), 42258-42269 (2004)
   PUBMED   15252056
REFERENCE   5  (bases 1 to 2068)
  AUTHORS   Boulet,A.M. and Capecchi,M.R.
  TITLE     Targeted disruption of hoxc-4 causes esophageal defects and
            vertebral transformations
  JOURNAL   Dev Biol 177 (1), 232-249 (1996)
   PUBMED   8660891
REFERENCE   6  (bases 1 to 2068)
  AUTHORS   Saegusa,H., Takahashi,N., Noguchi,S. and Suemori,H.
  TITLE     Targeted disruption in the mouse Hoxc-4 locus results in axial
            skeleton homeosis and malformation of the xiphoid process
  JOURNAL   Dev Biol 174 (1), 55-64 (1996)
   PUBMED   8626021
REFERENCE   7  (bases 1 to 2068)
  AUTHORS   Chung,S.Y., Dai,P.H., Lei,J., Riviere,M., Levan,G., Szpirer,J. and
            Szpirer,C.
  TITLE     Chromosomal assignment of seven rat homeobox genes to rat
            chromosomes 3, 4, 7, and 10
  JOURNAL   Mamm Genome 4 (9), 537-540 (1993)
   PUBMED   7906969
REFERENCE   8  (bases 1 to 2068)
  AUTHORS   Falzon,M. and Chung,S.Y.
  TITLE     The expression of rat homeobox-containing genes is developmentally
            regulated and tissue specific
  JOURNAL   Development 103 (3), 601-610 (1988)
   PUBMED   2907739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 10, 2007 this sequence version replaced XM_235703.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.32650.1, FN802484.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-866               JAXUCZ010000007.1  136049059-136049924
            867-2068            JAXUCZ010000007.1  136050400-136051601
FEATURES             Location/Qualifiers
     source          1..2068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2068
                     /gene="Hoxc4"
                     /gene_synonym="Hox3r3"
                     /note="homeo box C4"
                     /db_xref="GeneID:24459"
                     /db_xref="RGD:1586210"
     exon            1..866
                     /gene="Hoxc4"
                     /gene_synonym="Hox3r3"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..1222
                     /gene="Hoxc4"
                     /gene_synonym="Hox3r3"
                     /note="homeobox protein R3; Homeobox gene C4"
                     /codon_start=1
                     /product="homeobox protein Hox-C4"
                     /protein_id="NP_001103354.1"
                     /db_xref="GeneID:24459"
                     /db_xref="RGD:1586210"
                     /translation="MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESG
                     FQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRAHGPAQAGHHHPEKSQPLCEPAP
                     LSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSR
                     TAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLP
                     NTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL"
     exon            867..2068
                     /gene="Hoxc4"
                     /gene_synonym="Hox3r3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggaaaggca ctggagccga ggcccaccgg gtccactgaa ggccggagag gagactctgg
       61 gtgggggctg aatcacagcc taccaacagc ccccaatgcc cagacattgg agtcgagctg
      121 ggagccaccc atcttctgca agggaggatt gtcagtctgg tggggtgtgc aatggtgagc
      181 accccagctt ctgccagcca tccccccacc ccaccccctc agcagcagca gcaccacaca
      241 cacaaaaaat tggatacatt ttgaataaag cgattcggtt ccttatccgg ggactgagtt
      301 gctcggtgtg attggccggc ggagtcacat ggtgaaagta actttacagg gtcgctagct
      361 agtaggaggg ctttatggag cagaaaaacg acaaagcgag aaaaattatt ttccactcca
      421 gaaattaatg atcatgagct cgtatttgat ggactctaac tacatcgatc cgaaatttcc
      481 tccatgcgaa gaatattcgc aaaatagcta catccctgaa cacagtccgg aatattacgg
      541 ccggaccagg gaatcgggat tccagcatca ccaccaggag ctgtacccac caccgcctcc
      601 gcgccctagc taccctgagc gtcagtatag ctgcaccagt ctccaggggc ccggcaattc
      661 gcgagcccac gggccggccc aggcgggcca ccaccaccct gagaaatcgc agccgctctg
      721 cgagccggcg cctctctcag gcgcctctgc ctccccgtcc ccagccccgc cagcctgcag
      781 ccagccagcc cctgaccatc cctccagcgc cgccagcaag cagcccatag tctacccttg
      841 gatgaaaaaa attcacgtta gcacggtgaa ccccaattat aacggagggg agcccaagcg
      901 ctcgaggaca gcctacaccc ggcagcaggt cctggaatta gagaaagagt ttcattacaa
      961 ccgctacctg acccgaagga gaaggatcga gatcgcccac tcgctgtgcc tctctgagag
     1021 gcagatcaaa atctggttcc aaaaccgtcg catgaaatgg aagaaggacc accgactccc
     1081 caacaccaaa gtgaggtcag cgcccccggc cggcgctgca cccagcaccc tctcggcagc
     1141 cacccccggc acttctgaag accactccca gagcgccacg ccgccggagc agcaacgggc
     1201 agaggacatc accaggttat aagacataac ttacacccct gcccccaccc tgtgctccgt
     1261 gccccctcac acacaaattg actcttattt atagaattta atatatatat atttttggtt
     1321 ctttttttct ctctcttcct cctgtctcct cccttgtcag ttccaaacag acaaaacaga
     1381 taaacaaaca agccccttgc ccttttccct ttgctgttaa ggaccccttt aagcatgtgg
     1441 tgttgtctta gcatggtacc tgctgggttt tattttttgt tgttttgttt tgttttgctt
     1501 tgctttgctt ttaaggccat tggggggtat ttatttttta aggaaaaaaa gctgcaaaaa
     1561 ttatatattg caaggtgtga tggtctggtt tgggtgaatt tcaggggaaa tgaggaacag
     1621 aaaaaggaaa gggagatttg taagtggatt ctcatcctct ctcctcctca ccccccctcc
     1681 ctttccttag gccttttgca ttgaaaatgc accaggggag gttagtgagg ggggggagtc
     1741 attttaagga gaacaaagct atgaagttct tttgtattct tgtggggggg tggtaggagg
     1801 ggggaggaca gcaaacaaag ctaaatgcat ctggagagcc tctgggagct gttcagtttg
     1861 aggagccaaa aaataaataa ataaataaaa atgaactttc agttcagaga ggcagtctat
     1921 aggtagatgc tcccctaccc ccatcgtggt tattgtgttt ttggactgaa tttacttgat
     1981 tattgtaaaa cttgcaataa agaattttag tgttgatgtg aaatgccccc gtgatcaata
     2041 ataaaccagt ggctgtgaat tagtttta
//
