LOCUS       NM_001100787            1791 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus homeo box B4 (Hoxb4), mRNA.
ACCESSION   NM_001100787 XM_001081292 XM_573184
VERSION     NM_001100787.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Taherkhani S, Moradi F, Hosseini M, Alipour M and Feizi H.
  TITLE     Homeobox B4 gene expression is upregulated by ghrelin through
            PI3-kinase signaling pathway in rat's bone marrow stromal cells
  JOURNAL   Endocr Regul 53 (2), 65-70 (2019)
   PUBMED   31517625
  REMARK    GeneRIF: Upregulating HOXB4 in Bone marrow stromal cells and its
            possible differentiation to Hematopoietic stem cells might in the
            future open the doors to new treatment for hematologic disorders.
REFERENCE   2  (bases 1 to 1791)
  AUTHORS   Karner E, Unger C, Cerny R, Ahrlund-Richter L, Ganss B, Dilber MS
            and Wendel M.
  TITLE     Differentiation of human embryonic stem cells into osteogenic or
            hematopoietic lineages: a dose-dependent effect of osterix
            over-expression
  JOURNAL   J Cell Physiol 218 (2), 323-333 (2009)
   PUBMED   18932205
REFERENCE   3  (bases 1 to 1791)
  AUTHORS   Magnusson M, Brun AC, Lawrence HJ and Karlsson S.
  TITLE     Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic
            defects
  JOURNAL   Exp Hematol 35 (9), 1421-1428 (2007)
   PUBMED   17761289
REFERENCE   4  (bases 1 to 1791)
  AUTHORS   Brun AC, Bjornsson JM, Magnusson M, Larsson N, Leveen P, Ehinger M,
            Nilsson E and Karlsson S.
  TITLE     Hoxb4-deficient mice undergo normal hematopoietic development but
            exhibit a mild proliferation defect in hematopoietic stem cells
  JOURNAL   Blood 103 (11), 4126-4133 (2004)
   PUBMED   14962901
REFERENCE   5  (bases 1 to 1791)
  AUTHORS   Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz
            L, Nusse R and Weissman IL.
  TITLE     A role for Wnt signalling in self-renewal of haematopoietic stem
            cells
  JOURNAL   Nature 423 (6938), 409-414 (2003)
   PUBMED   12717450
REFERENCE   6  (bases 1 to 1791)
  AUTHORS   Medina-Martinez O, Bradley A and Ramirez-Solis R.
  TITLE     A large targeted deletion of Hoxb1-Hoxb9 produces a series of
            single-segment anterior homeotic transformations
  JOURNAL   Dev Biol 222 (1), 71-83 (2000)
   PUBMED   10885747
REFERENCE   7  (bases 1 to 1791)
  AUTHORS   Barrow JR and Capecchi MR.
  TITLE     Targeted disruption of the Hoxb-2 locus in mice interferes with
            expression of Hoxb-1 and Hoxb-4
  JOURNAL   Development 122 (12), 3817-3828 (1996)
   PUBMED   9012503
REFERENCE   8  (bases 1 to 1791)
  AUTHORS   Schnabel CA and Abate-Shen C.
  TITLE     Repression by HoxA7 is mediated by the homeodomain and the
            modulatory action of its N-terminal-arm residues
  JOURNAL   Mol Cell Biol 16 (6), 2678-2688 (1996)
   PUBMED   8649375
REFERENCE   9  (bases 1 to 1791)
  AUTHORS   Horan GS, Ramirez-Solis R, Featherstone MS, Wolgemuth DJ, Bradley A
            and Behringer RR.
  TITLE     Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4
            genes show more complete homeotic transformations and a
            dose-dependent increase in the number of vertebrae transformed
  JOURNAL   Genes Dev 9 (13), 1667-1677 (1995)
   PUBMED   7628700
REFERENCE   10 (bases 1 to 1791)
  AUTHORS   Pellerin I, Schnabel C, Catron KM and Abate C.
  TITLE     Hox proteins have different affinities for a consensus DNA site
            that correlate with the positions of their genes on the hox cluster
  JOURNAL   Mol Cell Biol 14 (7), 4532-4545 (1994)
   PUBMED   7911971
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161863.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_001081292.1, XM_573184.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161863.1, CK365489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1791
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1791
                     /gene="Hoxb4"
                     /gene_synonym="RGD1560113"
                     /note="homeo box B4"
                     /db_xref="GeneID:497988"
                     /db_xref="RGD:1560113"
     exon            1..664
                     /gene="Hoxb4"
                     /gene_synonym="RGD1560113"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..963
                     /gene="Hoxb4"
                     /gene_synonym="RGD1560113"
                     /codon_start=1
                     /product="homeobox protein Hox-B4"
                     /protein_id="NP_001094257.1"
                     /db_xref="GeneID:497988"
                     /db_xref="RGD:1560113"
                     /translation="MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRR
                     ESGFQPEAAFGRRAPCTVQRYAACRDPGPPPPPPPPPPPPPPGLSPRAPVQSTAGALL
                     PEPGQRSEVVSSSPPPPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGE
                     PKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKK
                     DHKLPNTKIRSGGTAGAAGGPPGRPNGGPPAL"
     exon            665..1769
                     /gene="Hoxb4"
                     /gene_synonym="RGD1560113"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaaataaa cctctttggc tggagtaggg tccgggtgag cagatttcct tatccgggaa
       61 tcgcaggccg ggtggccatt ggctcggagg atcacgtggg cctctaactt tgttcacttg
      121 acagtaagta ggagggcttt cggaaacagg aaaacgagtc aggggtcgga ataaatttta
      181 gtatattttg tgggcaattc ccagaaatta atggctatga gttccttttt gatcaactca
      241 aactatgtcg accccaagtt ccctccgtgc gaggagtatt cacagagcga ttacctaccc
      301 agcgaccact cgccggggta ctacgccggc ggccagaggc gagagagcgg cttccagccg
      361 gaggcggcct ttgggcgccg ggcgccgtgc actgtgcagc gctacgcggc ctgccgagac
      421 cccgggcccc cgccacctcc gccgcccccg ccgcccccgc caccgcccgg gctgtcccct
      481 cgggctcccg tgcagtcaac agccggggcc ctcctcccgg agcccgggca gcgcagcgag
      541 gtggtcagca gcagtccccc gccgcctccc tgcgcccaga accccctgca tcccagcccg
      601 tcccactccg cgtgcaaaga gcccgtcgtc tacccctgga tgcgcaaagt tcacgtgagc
      661 acggtaaacc ccaattacgc cggcggggag cccaagcgct cccggaccgc ctacactcgc
      721 cagcaggtcc tggaactgga gaaggagttt cactacaatc gctacctgac gcgacgccgg
      781 agggtggaga ttgcccacgc gctctgcctg tccgagcgcc agatcaagat ctggttccaa
      841 aatcggcgca tgaagtggaa aaaagaccac aagttgccca acaccaagat ccgctcgggt
      901 ggtaccgcgg gcgcagccgg aggcccccct ggccggccca acggaggccc ccctgcgctc
      961 tagtgccccc caagcaggaa ctcgaacttg gggggcgggg ggggactgcg aacaccgaag
     1021 ggggtatgcg gggtatggga aggtccccag gcttgagccc agaaaaacct atctacccta
     1081 cccccacttt atctataagg aataaacgca gagaaggggg gtagggaagc cttatttata
     1141 gaaacgacaa tagggagccg ggtaaagtcc tccggaagca agattcgagt ctcttgcttt
     1201 cttccttaaa aaaagagaga gagagaaaga aaagaaaaaa gaagaaagaa aggaagaaag
     1261 aaagaaaagg aagaaaggaa aagacagaag agaaatggag aggcttttgc gcctggcttt
     1321 cagctttggt gaagatggat ccatgtttca tctttaatca tgccaggcct cggcccatct
     1381 gtcttgttta ctccgccgag gagaagacga gcttcggtgg cgaccattac ctcgacactt
     1441 ggctaacaaa tgaggccggc tcggccgctg ccgctgcctt tgctgctgcc gctgctggac
     1501 cacagcctgg attttctttc tttgtccctt attcctgaca cccagcgaat gcaccctcag
     1561 actgccagat agcacagtgt tttggccacg gtaacaaaca cacacacaca cataactttc
     1621 ctccctgtct gtgcccactt tggggtgggg gtgggaagac cgctcccctc ccttccacca
     1681 tagacttaga aggggaaaaa gaagggaagc gaggggtggt ctgcacaatg tgggttccca
     1741 aatctgaacc caagaaataa atgaagaaaa aaaaaaaaaa aaaaaaaaaa a
//
