LOCUS       NP_001094257             250 aa            linear   ROD 26-FEB-2024
DEFINITION  homeobox protein Hox-B4 [Rattus norvegicus].
ACCESSION   NP_001094257 XP_001081292 XP_573184
VERSION     NP_001094257.1
DBSOURCE    REFSEQ: accession NM_001100787.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 250)
  AUTHORS   Taherkhani S, Moradi F, Hosseini M, Alipour M and Feizi H.
  TITLE     Homeobox B4 gene expression is upregulated by ghrelin through
            PI3-kinase signaling pathway in rat's bone marrow stromal cells
  JOURNAL   Endocr Regul 53 (2), 65-70 (2019)
   PUBMED   31517625
  REMARK    GeneRIF: Upregulating HOXB4 in Bone marrow stromal cells and its
            possible differentiation to Hematopoietic stem cells might in the
            future open the doors to new treatment for hematologic disorders.
REFERENCE   2  (residues 1 to 250)
  AUTHORS   Karner E, Unger C, Cerny R, Ahrlund-Richter L, Ganss B, Dilber MS
            and Wendel M.
  TITLE     Differentiation of human embryonic stem cells into osteogenic or
            hematopoietic lineages: a dose-dependent effect of osterix
            over-expression
  JOURNAL   J Cell Physiol 218 (2), 323-333 (2009)
   PUBMED   18932205
REFERENCE   3  (residues 1 to 250)
  AUTHORS   Magnusson M, Brun AC, Lawrence HJ and Karlsson S.
  TITLE     Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic
            defects
  JOURNAL   Exp Hematol 35 (9), 1421-1428 (2007)
   PUBMED   17761289
REFERENCE   4  (residues 1 to 250)
  AUTHORS   Brun AC, Bjornsson JM, Magnusson M, Larsson N, Leveen P, Ehinger M,
            Nilsson E and Karlsson S.
  TITLE     Hoxb4-deficient mice undergo normal hematopoietic development but
            exhibit a mild proliferation defect in hematopoietic stem cells
  JOURNAL   Blood 103 (11), 4126-4133 (2004)
   PUBMED   14962901
REFERENCE   5  (residues 1 to 250)
  AUTHORS   Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz
            L, Nusse R and Weissman IL.
  TITLE     A role for Wnt signalling in self-renewal of haematopoietic stem
            cells
  JOURNAL   Nature 423 (6938), 409-414 (2003)
   PUBMED   12717450
REFERENCE   6  (residues 1 to 250)
  AUTHORS   Medina-Martinez O, Bradley A and Ramirez-Solis R.
  TITLE     A large targeted deletion of Hoxb1-Hoxb9 produces a series of
            single-segment anterior homeotic transformations
  JOURNAL   Dev Biol 222 (1), 71-83 (2000)
   PUBMED   10885747
REFERENCE   7  (residues 1 to 250)
  AUTHORS   Barrow JR and Capecchi MR.
  TITLE     Targeted disruption of the Hoxb-2 locus in mice interferes with
            expression of Hoxb-1 and Hoxb-4
  JOURNAL   Development 122 (12), 3817-3828 (1996)
   PUBMED   9012503
REFERENCE   8  (residues 1 to 250)
  AUTHORS   Schnabel CA and Abate-Shen C.
  TITLE     Repression by HoxA7 is mediated by the homeodomain and the
            modulatory action of its N-terminal-arm residues
  JOURNAL   Mol Cell Biol 16 (6), 2678-2688 (1996)
   PUBMED   8649375
REFERENCE   9  (residues 1 to 250)
  AUTHORS   Horan GS, Ramirez-Solis R, Featherstone MS, Wolgemuth DJ, Bradley A
            and Behringer RR.
  TITLE     Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4
            genes show more complete homeotic transformations and a
            dose-dependent increase in the number of vertebrae transformed
  JOURNAL   Genes Dev 9 (13), 1667-1677 (1995)
   PUBMED   7628700
REFERENCE   10 (residues 1 to 250)
  AUTHORS   Pellerin I, Schnabel C, Catron KM and Abate C.
  TITLE     Hox proteins have different affinities for a consensus DNA site
            that correlate with the positions of their genes on the hox cluster
  JOURNAL   Mol Cell Biol 14 (7), 4532-4545 (1994)
   PUBMED   7911971
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161863.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XP_001081292.1, XP_573184.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161863.1, CK365489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..250
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     Protein         1..250
                     /product="homeobox protein Hox-B4"
                     /calculated_mol_wt=27406
     Region          162..218
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..250
                     /gene="Hoxb4"
                     /gene_synonym="RGD1560113"
                     /coded_by="NM_001100787.1:211..963"
                     /db_xref="GeneID:497988"
                     /db_xref="RGD:1560113"
ORIGIN      
        1 mamssflins nyvdpkfppc eeysqsdylp sdhspgyyag gqrresgfqp eaafgrrapc
       61 tvqryaacrd pgpppppppp ppppppglsp rapvqstaga llpepgqrse vvsssppppp
      121 caqnplhpsp shsackepvv ypwmrkvhvs tvnpnyagge pkrsrtaytr qqvlelekef
      181 hynryltrrr rveiahalcl serqikiwfq nrrmkwkkdh klpntkirsg gtagaaggpp
      241 grpnggppal
//
