LOCUS       NM_001107042            1863 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus homeo box B3 (Hoxb3), mRNA.
ACCESSION   NM_001107042 XM_001081342 XM_220893
VERSION     NM_001107042.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1863)
  AUTHORS   Jia,X., Yang,S., Wang,X., Ruan,J. and Huang,W.
  TITLE     HOXB3 promotes trophoblast cell proliferation, invasion, and
            migration to alleviate preeclampsia via mediating the
            Notch/Wnt/beta-catenin pathway
  JOURNAL   Eur J Pharmacol 960, 176015 (2023)
   PUBMED   37652291
  REMARK    GeneRIF: HOXB3 promotes trophoblast cell proliferation, invasion,
            and migration to alleviate preeclampsia via mediating the
            Notch/Wnt/beta-catenin pathway.
REFERENCE   2  (bases 1 to 1863)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 1863)
  AUTHORS   Wong,E.Y., Wang,X.A., Mak,S.S., Sae-Pang,J.J., Ling,K.W.,
            Fritzsch,B. and Sham,M.H.
  TITLE     Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain
            patterning
  JOURNAL   Dev Biol 352 (2), 382-392 (2011)
   PUBMED   21320481
REFERENCE   4  (bases 1 to 1863)
  AUTHORS   Chung,N., Jee,B.K., Chae,S.W., Jeon,Y.W., Lee,K.H. and Rha,H.K.
  TITLE     HOX gene analysis of endothelial cell differentiation in human bone
            marrow-derived mesenchymal stem cells
  JOURNAL   Mol Biol Rep 36 (2), 227-235 (2009)
   PUBMED   17972163
REFERENCE   5  (bases 1 to 1863)
  AUTHORS   Magnusson,M., Brun,A.C., Lawrence,H.J. and Karlsson,S.
  TITLE     Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic
            defects
  JOURNAL   Exp Hematol 35 (9), 1421-1428 (2007)
   PUBMED   17761289
REFERENCE   6  (bases 1 to 1863)
  AUTHORS   Medina-Martinez,O., Bradley,A. and Ramirez-Solis,R.
  TITLE     A large targeted deletion of Hoxb1-Hoxb9 produces a series of
            single-segment anterior homeotic transformations
  JOURNAL   Dev Biol 222 (1), 71-83 (2000)
   PUBMED   10885747
REFERENCE   7  (bases 1 to 1863)
  AUTHORS   Guazzi,S., Pintonello,M.L., Vigano,A. and Boncinelli,E.
  TITLE     Regulatory interactions between the human HOXB1, HOXB2, and HOXB3
            proteins and the upstream sequence of the Otx2 gene in embryonal
            carcinoma cells
  JOURNAL   J Biol Chem 273 (18), 11092-11099 (1998)
   PUBMED   9556594
REFERENCE   8  (bases 1 to 1863)
  AUTHORS   Manley,N.R. and Capecchi,M.R.
  TITLE     Hox group 3 paralogs regulate the development and migration of the
            thymus, thyroid, and parathyroid glands
  JOURNAL   Dev Biol 195 (1), 1-15 (1998)
   PUBMED   9520319
REFERENCE   9  (bases 1 to 1863)
  AUTHORS   Manley,N.R. and Capecchi,M.R.
  TITLE     Hox group 3 paralogous genes act synergistically in the formation
            of somitic and neural crest-derived structures
  JOURNAL   Dev Biol 192 (2), 274-288 (1997)
   PUBMED   9441667
REFERENCE   10 (bases 1 to 1863)
  AUTHORS   Guazzi,S., Lonigro,R., Pintonello,L., Boncinelli,E., Di Lauro,R.
            and Mavilio,F.
  TITLE     The thyroid transcription factor-1 gene is a candidate target for
            regulation by Hox proteins
  JOURNAL   EMBO J 13 (14), 3339-3347 (1994)
   PUBMED   7913891
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081342.1, XM_220893.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132293,
                              SAMD00132300 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1863
                     /gene="Hoxb3"
                     /note="homeo box B3"
                     /db_xref="GeneID:303488"
                     /db_xref="RGD:1310780"
     exon            1..913
                     /gene="Hoxb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..1755
                     /gene="Hoxb3"
                     /codon_start=1
                     /product="homeobox protein Hox-B3"
                     /protein_id="NP_001100512.1"
                     /db_xref="GeneID:303488"
                     /db_xref="RGD:1310780"
                     /translation="MQKATYYDNTAAALFGGYSSYPGSNGFGYDGPPQPPFQAATHLE
                     GDYQRSACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPLPAPPGSPPPSAAPTSTTSN
                     SNNGGGPSKSGPPKCGASSNSTLTKQIFPWMKESRQTSKLKNSSPGTAEGCGGGGGGG
                     GGGGSSSGGGGSGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRV
                     EMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMN
                     ALHSMTPSYDSPSPPAFSKGHQNAYALPSNYQPPLKGCGAPQKYPPTPAPEYESHVLQ
                     ANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAAPMA
                     PGQHHGPCDPHPTYTDLSSHHAPPQGRIQEAPKLTHL"
     exon            914..1863
                     /gene="Hoxb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagtgcaggc gccagagaga ggcggtggtc cacgaggcag tggtatttta ttcctaagta
       61 ttcaccaaag gagtacagtc ttgattttgt agaaaatgga aatggaaatc ggtgttttct
      121 ttttcccttt aaaattaaag ttgaagcgag aagcatccat gtcaggttag atacttggtc
      181 tcagcgcctg ctgcagagat agtggcgagg ggagaagaaa aagaaaacct attgatgtca
      241 gttccctttt tagttcctaa gatggattcg aggcccagtc ctcttctccc cctctgtctc
      301 ttctctcgcc ccgcaggtca gccgcttgga acagacccgg gaggaggggg gcagaaaggg
      361 gaggggggtc cggcgtgtca cgtgaccccc aggggtgcca atgtccggtc gtgagggtat
      421 caggcccttg caagttgcca cccactgccc gggcctcgcc cagcgatgca gaaagccacc
      481 tactacgaca acaccgcagc tgcgctcttc ggaggctact cctcgtaccc tggcagcaat
      541 ggtttcggct acgacgggcc tccccagccc ccctttcagg ccgctacaca cctggagggt
      601 gactaccagc gctcagcgtg ttccctgcag tccctgggca atgccgcccc acatgccaag
      661 agcaaggagc tcaacggcag ctgcatgagg ccaggcctgg ccccagagcc cctgcccgca
      721 ccgccgggtt cacccccacc cagcgccgca cctaccagta ccactagcaa cagcaataac
      781 gggggtgggc ccagcaaaag cggccccccc aagtgcggtg ccagctccaa ctccaccctc
      841 accaaacaga tattcccctg gatgaaagag tcaaggcaaa cgtccaagct gaaaaacagc
      901 tccccgggca cagcagaagg ttgtggtggc ggcggcggcg gcggtggcgg cggcggtagt
      961 agcagcggcg ggggcggcag cggcggcggg ggaggggaca agagcccccc ggggtcggcg
     1021 gcgtccaagc gggcgcggac ggcatacaca agcgcgcagc tggttgagct ggagaaggag
     1081 ttccacttca accgttattt gtgccggccg cgccgcgtcg agatggccaa tctgctgaac
     1141 ctcagcgagc ggcagatcaa gatctggttc cagaaccgcc gcatgaagta caagaaagac
     1201 cagaaggcca aggggctggc ctcgtcctcc gggggtccct ctccggccgg aagccccccg
     1261 cagcccatgc agtccacggc cggcttcatg aacgccttac actccatgac ccccagctac
     1321 gacagcccgt ccccaccagc cttcagcaaa ggccaccaga atgcctacgc gctgccttcc
     1381 aactatcagc cccctctcaa gggttgcggc gccccacaga agtacccccc gaccccggcg
     1441 ccggagtatg agtcccacgt cctccaagcc aacgggggag cctacgggac gcccaccatg
     1501 cagggcagtc ctgtctatgt gggcgggggt ggctacgcgg atccgttgcc gccccctgcc
     1561 ggcccctccc tctacggcct caatcacctt tcccaccacc cctcggggaa cctggactac
     1621 aacggggcgg cccctatggc ccccggccag catcacggac cctgtgaccc tcaccccacg
     1681 tacacagacc tctcctctca ccacgcaccg cctcagggta gaatccaaga agcgcccaaa
     1741 ctgacacacc tgtgatggga ggggcgggct ggggaggggg gggtgaggtt aagggacagg
     1801 gagaccgtgg aactggggga tgggcgcggt ttggagtcct gaaaaaggta tgtgttgggg
     1861 ttg
//
