LOCUS       NM_001399735            1650 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus homeobox B2 (Hoxb2), mRNA.
ACCESSION   NM_001399735 XM_002727806
VERSION     NM_001399735.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Jolma,A., Yan,J., Whitington,T., Toivonen,J., Nitta,K.R.,
            Rastas,P., Morgunova,E., Enge,M., Taipale,M., Wei,G., Palin,K.,
            Vaquerizas,J.M., Vincentelli,R., Luscombe,N.M., Hughes,T.R.,
            Lemaire,P., Ukkonen,E., Kivioja,T. and Taipale,J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Prabagaran,E., Hegde,U.C., Moodbidri,S.B., Bandivdekar,A.H. and
            Raghavan,V.P.
  TITLE     Postnatal expression and androgen regulation of HOXBES2
            homeoprotein in rat epididymis
  JOURNAL   J Androl 28 (5), 755-771 (2007)
   PUBMED   17494099
  REMARK    GeneRIF: HOXBES2 expression could be regulated by androgens, and
            its expression level is closely associated with the postnatal
            development of the epididymis.
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Prabagaran,E., Bandivdekar,A.H., Dighe,V. and Raghavan,V.P.
  TITLE     HOXBES2: a novel epididymal HOXB2 homeoprotein and its
            domain-specific association with spermatozoa
  JOURNAL   Biol Reprod 76 (2), 314-326 (2007)
   PUBMED   17065603
  REMARK    GeneRIF: We have identified and characterized a novel epididymal
            homeoprotein different from HOXB2 protein and hereafter referred to
            as HOXBES2, (HOXB2 homeodomain containing epididymis-specific sperm
            protein) with a probable role in fertilization.
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   5  (bases 1 to 1650)
  AUTHORS   Samad,O.A., Geisen,M.J., Caronia,G., Varlet,I., Zappavigna,V.,
            Ericson,J., Goridis,C. and Rijli,F.M.
  TITLE     Integration of anteroposterior and dorsoventral regulation of
            Phox2b transcription in cranial motoneuron progenitors by
            homeodomain proteins
  JOURNAL   Development 131 (16), 4071-4083 (2004)
   PUBMED   15289435
REFERENCE   6  (bases 1 to 1650)
  AUTHORS   Manley,N.R., Barrow,J.R., Zhang,T. and Capecchi,M.R.
  TITLE     Hoxb2 and hoxb4 act together to specify ventral body wall formation
  JOURNAL   Dev Biol 237 (1), 130-144 (2001)
   PUBMED   11518511
REFERENCE   7  (bases 1 to 1650)
  AUTHORS   Medina-Martinez,O., Bradley,A. and Ramirez-Solis,R.
  TITLE     A large targeted deletion of Hoxb1-Hoxb9 produces a series of
            single-segment anterior homeotic transformations
  JOURNAL   Dev Biol 222 (1), 71-83 (2000)
   PUBMED   10885747
REFERENCE   8  (bases 1 to 1650)
  AUTHORS   Davenne,M., Maconochie,M.K., Neun,R., Pattyn,A., Chambon,P.,
            Krumlauf,R. and Rijli,F.M.
  TITLE     Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal
            development in the rostral hindbrain
  JOURNAL   Neuron 22 (4), 677-691 (1999)
   PUBMED   10230789
REFERENCE   9  (bases 1 to 1650)
  AUTHORS   Barrow,J.R. and Capecchi,M.R.
  TITLE     Targeted disruption of the Hoxb-2 locus in mice interferes with
            expression of Hoxb-1 and Hoxb-4
  JOURNAL   Development 122 (12), 3817-3828 (1996)
   PUBMED   9012503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 13, 2022 this sequence version replaced XM_002727806.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU671493.1, SRR26643297.35705.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-586               JAXUCZ010000010.1  81814340-81814925
            587-1650            JAXUCZ010000010.1  81815668-81816731
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1650
                     /gene="Hoxb2"
                     /gene_synonym="Hoxbes2"
                     /note="homeobox B2"
                     /db_xref="GeneID:100361765"
                     /db_xref="RGD:2319509"
     exon            1..586
                     /gene="Hoxb2"
                     /gene_synonym="Hoxbes2"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1266
                     /gene="Hoxb2"
                     /gene_synonym="Hoxbes2"
                     /note="Hoxb2-like epididymal protein; homeo box B2-like"
                     /codon_start=1
                     /product="homeobox protein Hox-B2"
                     /protein_id="NP_001386664.1"
                     /db_xref="GeneID:100361765"
                     /db_xref="RGD:2319509"
                     /translation="MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIP
                     PPPPPLEQTFPSLQLGASTLQRPGSQKPAGDGPALRPPPPLPVAPPAPEFPWMKEKKS
                     AKKPSQSAATPSPAASSVRASGVGSPSDGPGLPESGGSGSRRLRTAYTNTQLLELEKE
                     FHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQHREPPDGEPGGLSAQD
                     DAGEPAEEPTVSPGDVASHRLREACFLPAEAAQGPRGAPPPLPPATALESVGASSPGC
                     TMLRAGGLQSEPLPEDACPERQDSPFLPDLNFFAADSCLPMSGGLSPSLQGSLDSPVP
                     FSEEELDFFTSTLCAIDLQFP"
     exon            587..1650
                     /gene="Hoxb2"
                     /gene_synonym="Hoxbes2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagtccc catacgcttt tatttatcaa caatatacaa ttatacaggc ctaaatttaa
       61 aaaaagagag agagcaaatc cccctccccc gcgaaatcgc tccattgcat aaacctgggg
      121 ggggcgggag agggggtccc tctgatcctc ccttctgacg ccccccccag caggccccct
      181 cccccaccat tgaaagccat gaattttgaa tttgagaggg agattgggtt tataaacagc
      241 cagccatcgc tcgccgagtg tctgacttcc ttccccgctg tcttggagac atttcaaact
      301 tcatcaatca aggagtcgac attaattcct cctcctcctc ctcctctgga gcaaaccttc
      361 cccagcctcc agctcggcgc ctccaccctt cagagaccag ggagccaaaa gccagccgga
      421 gatgggcctg ctctgcggcc accgccgcca ctccccgtcg cccccccagc ccccgagttc
      481 ccctggatga aagagaagaa atccgccaag aaacccagcc aatccgccgc aaccccttct
      541 ccagccgcct cctcggtccg ggcctccggg gtcggatcac catcagatgg tcccggactg
      601 ccggagagcg gcggcagcgg ctcccgcaga ctgcgcacgg cctataccaa cacgcaactg
      661 ctggagctgg agaaggagtt ccacttcaac aagtacctgt gccggccgcg gcgggttgag
      721 atcgccgcct tgctggacct caccgaaagg caggtcaaag tctggttcca gaaccgacgc
      781 atgaaacaca agcgacagac tcagcatcga gaaccgcccg atggagaacc aggcgggctg
      841 agcgcccagg acgacgcggg agagccagcc gaggagccca cggtcagccc cggcgacgtg
      901 gcgtcacatc ggctgaggga agcctgcttt ctcccagccg aggccgcaca gggaccccgg
      961 ggcgcaccgc cgccgctgcc tcctgccact gccctggaga gtgtgggtgc atcgagcccc
     1021 ggctgcacaa tgctcagagc cggaggcctg cagagcgagc ccctgcccga agacgcctgc
     1081 cccgagcggc aggattcgcc tttcctgccg gacctcaact tcttcgctgc agattcctgt
     1141 ctcccgatgt ccggaggcct ttcgcccagc ctgcagggct cgctggacag ccccgtgccc
     1201 ttttctgagg aagagctgga cttcttcacc agcacgctct gtgccatcga cttgcagttt
     1261 ccctaactgt tttctatctt tgttcttttc catctggtcc tccttggctg ttgggggcaa
     1321 aaatagagcc ttctccactc ctagtcacat ttatgtgttt gttaaaatcc aggtattaac
     1381 gaattagtgt ttaatccagt ccttttcaat ttttaaaacc acacaaaaaa ttccacttga
     1441 taaaacttct tccaacgaaa tctcaggaat aattaaactc tagtgggaga gggttttctt
     1501 acaaagaaat agagggacct attttcctct ttttttttaa gttttagatt gtagattatt
     1561 tattaaaatt gtttaataat aggaaagggg gaaagtattt attgtacatt attttcatag
     1621 agtaaataaa tgtctttata atacgaaaaa
//
