LOCUS       NP_001386664             355 aa            linear   ROD 27-MAR-2024
DEFINITION  homeobox protein Hox-B2 [Rattus norvegicus].
ACCESSION   NP_001386664 XP_002727852
VERSION     NP_001386664.1
DBSOURCE    REFSEQ: accession NM_001399735.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 355)
  AUTHORS   Jolma,A., Yan,J., Whitington,T., Toivonen,J., Nitta,K.R.,
            Rastas,P., Morgunova,E., Enge,M., Taipale,M., Wei,G., Palin,K.,
            Vaquerizas,J.M., Vincentelli,R., Luscombe,N.M., Hughes,T.R.,
            Lemaire,P., Ukkonen,E., Kivioja,T. and Taipale,J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   2  (residues 1 to 355)
  AUTHORS   Prabagaran,E., Hegde,U.C., Moodbidri,S.B., Bandivdekar,A.H. and
            Raghavan,V.P.
  TITLE     Postnatal expression and androgen regulation of HOXBES2
            homeoprotein in rat epididymis
  JOURNAL   J Androl 28 (5), 755-771 (2007)
   PUBMED   17494099
  REMARK    GeneRIF: HOXBES2 expression could be regulated by androgens, and
            its expression level is closely associated with the postnatal
            development of the epididymis.
REFERENCE   3  (residues 1 to 355)
  AUTHORS   Prabagaran,E., Bandivdekar,A.H., Dighe,V. and Raghavan,V.P.
  TITLE     HOXBES2: a novel epididymal HOXB2 homeoprotein and its
            domain-specific association with spermatozoa
  JOURNAL   Biol Reprod 76 (2), 314-326 (2007)
   PUBMED   17065603
  REMARK    GeneRIF: We have identified and characterized a novel epididymal
            homeoprotein different from HOXB2 protein and hereafter referred to
            as HOXBES2, (HOXB2 homeodomain containing epididymis-specific sperm
            protein) with a probable role in fertilization.
REFERENCE   4  (residues 1 to 355)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   5  (residues 1 to 355)
  AUTHORS   Samad,O.A., Geisen,M.J., Caronia,G., Varlet,I., Zappavigna,V.,
            Ericson,J., Goridis,C. and Rijli,F.M.
  TITLE     Integration of anteroposterior and dorsoventral regulation of
            Phox2b transcription in cranial motoneuron progenitors by
            homeodomain proteins
  JOURNAL   Development 131 (16), 4071-4083 (2004)
   PUBMED   15289435
REFERENCE   6  (residues 1 to 355)
  AUTHORS   Manley,N.R., Barrow,J.R., Zhang,T. and Capecchi,M.R.
  TITLE     Hoxb2 and hoxb4 act together to specify ventral body wall formation
  JOURNAL   Dev Biol 237 (1), 130-144 (2001)
   PUBMED   11518511
REFERENCE   7  (residues 1 to 355)
  AUTHORS   Medina-Martinez,O., Bradley,A. and Ramirez-Solis,R.
  TITLE     A large targeted deletion of Hoxb1-Hoxb9 produces a series of
            single-segment anterior homeotic transformations
  JOURNAL   Dev Biol 222 (1), 71-83 (2000)
   PUBMED   10885747
REFERENCE   8  (residues 1 to 355)
  AUTHORS   Davenne,M., Maconochie,M.K., Neun,R., Pattyn,A., Chambon,P.,
            Krumlauf,R. and Rijli,F.M.
  TITLE     Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal
            development in the rostral hindbrain
  JOURNAL   Neuron 22 (4), 677-691 (1999)
   PUBMED   10230789
REFERENCE   9  (residues 1 to 355)
  AUTHORS   Barrow,J.R. and Capecchi,M.R.
  TITLE     Targeted disruption of the Hoxb-2 locus in mice interferes with
            expression of Hoxb-1 and Hoxb-4
  JOURNAL   Development 122 (12), 3817-3828 (1996)
   PUBMED   9012503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 13, 2022 this sequence version replaced XP_002727852.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU671493.1, SRR26643297.35705.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     Protein         1..355
                     /product="homeobox protein Hox-B2"
                     /note="Hoxb2-like epididymal protein; homeo box B2-like"
                     /calculated_mol_wt=37833
     Region          143..199
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..355
                     /gene="Hoxb2"
                     /gene_synonym="Hoxbes2"
                     /coded_by="NM_001399735.1:199..1266"
                     /db_xref="GeneID:100361765"
                     /db_xref="RGD:2319509"
ORIGIN      
        1 mnfefereig finsqpslae cltsfpavle tfqtssikes tlippppppl eqtfpslqlg
       61 astlqrpgsq kpagdgpalr pppplpvapp apefpwmkek ksakkpsqsa atpspaassv
      121 rasgvgspsd gpglpesggs gsrrlrtayt ntqlleleke fhfnkylcrp rrveiaalld
      181 lterqvkvwf qnrrmkhkrq tqhreppdge pgglsaqdda gepaeeptvs pgdvashrlr
      241 eacflpaeaa qgprgapppl ppatalesvg asspgctmlr agglqseplp edacperqds
      301 pflpdlnffa adsclpmsgg lspslqgsld spvpfseeel dfftstlcai dlqfp
//
