LOCUS       NM_001401868            2051 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus homeobox A9 (Hoxa9), mRNA.
ACCESSION   NM_001401868 XM_003752183
VERSION     NM_001401868.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Quan,X.Z., Ye,J.H., Yang,X.Z. and Xie,Y.
  TITLE     HOXA9-induced chemerin signals through CMKLR1/AMPK/TXNIP/NLRP3
            pathway to induce pyroptosis of trophoblasts and aggravate
            preeclampsia
  JOURNAL   Exp Cell Res 408 (2), 112802 (2021)
   PUBMED   34461109
  REMARK    GeneRIF: HOXA9-induced chemerin signals through
            CMKLR1/AMPK/TXNIP/NLRP3 pathway to induce pyroptosis of
            trophoblasts and aggravate preeclampsia.
REFERENCE   2  (bases 1 to 2051)
  AUTHORS   Lu,X., Liang,B., Li,S., Chen,Z. and Chang,W.
  TITLE     Modulation of HOXA9 after skeletal muscle denervation and
            reinnervation
  JOURNAL   Am J Physiol Cell Physiol 318 (6), C1154-C1165 (2020)
   PUBMED   32233950
  REMARK    GeneRIF: HOXA9 inhibited myogenic differentiation, affected the
            best known atrophic signaling pathways, and promoted apoptosis but
            did not eliminate the differentiation potential of primary
            satellite cells. HOXA9 may promote denervated muscle atrophy by
            regulating the activity of satellite cells.
REFERENCE   3  (bases 1 to 2051)
  AUTHORS   Raines,A.M., Adam,M., Magella,B., Meyer,S.E., Grimes,H.L., Dey,S.K.
            and Potter,S.S.
  TITLE     Recombineering-based dissection of flanking and paralogous Hox gene
            functions in mouse reproductive tracts
  JOURNAL   Development 140 (14), 2942-2952 (2013)
   PUBMED   23760953
REFERENCE   4  (bases 1 to 2051)
  AUTHORS   Bandyopadhyay,S., Harris,D.P., Adams,G.N., Lause,G.E., McHugh,A.,
            Tillmaand,E.G., Money,A., Willard,B., Fox,P.L. and Dicorleto,P.E.
  TITLE     HOXA9 methylation by PRMT5 is essential for endothelial cell
            expression of leukocyte adhesion molecules
  JOURNAL   Mol Cell Biol 32 (7), 1202-1213 (2012)
   PUBMED   22269951
REFERENCE   5  (bases 1 to 2051)
  AUTHORS   Magnusson,M., Brun,A.C., Lawrence,H.J. and Karlsson,S.
  TITLE     Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic
            defects
  JOURNAL   Exp Hematol 35 (9), 1421-1428 (2007)
   PUBMED   17761289
REFERENCE   6  (bases 1 to 2051)
  AUTHORS   Shen,W.F., Rozenfeld,S., Kwong,A., Kom ves,L.G., Lawrence,H.J. and
            Largman,C.
  TITLE     HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells
  JOURNAL   Mol Cell Biol 19 (4), 3051-3061 (1999)
   PUBMED   10082572
REFERENCE   7  (bases 1 to 2051)
  AUTHORS   Chen,F. and Capecchi,M.R.
  TITLE     Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function
            together to control development of the mammary gland in response to
            pregnancy
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 541-546 (1999)
   PUBMED   9892669
REFERENCE   8  (bases 1 to 2051)
  AUTHORS   Shen,W.F., Montgomery,J.C., Rozenfeld,S., Moskow,J.J.,
            Lawrence,H.J., Buchberg,A.M. and Largman,C.
  TITLE     AbdB-like Hox proteins stabilize DNA binding by the Meis1
            homeodomain proteins
  JOURNAL   Mol Cell Biol 17 (11), 6448-6458 (1997)
   PUBMED   9343407
REFERENCE   9  (bases 1 to 2051)
  AUTHORS   Chen,F. and Capecchi,M.R.
  TITLE     Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic
            interactions
  JOURNAL   Dev Biol 181 (2), 186-196 (1997)
   PUBMED   9013929
REFERENCE   10 (bases 1 to 2051)
  AUTHORS   Fromental-Ramain,C., Warot,X., Lakkaraju,S., Favier,B., Haack,H.,
            Birling,C., Dierich,A., Doll e,P. and Chambon,P.
  TITLE     Specific and redundant functions of the paralogous Hoxa-9 and
            Hoxd-9 genes in forelimb and axial skeleton patterning
  JOURNAL   Development 122 (2), 461-472 (1996)
   PUBMED   8625797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Feb 28, 2022 this sequence version replaced XM_003752183.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.16044.1,
                                           SRR26643292.17950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-653               JAXUCZ010000004.1  82656396-82657048   c
            654-2051            JAXUCZ010000004.1  82653847-82655244   c
FEATURES             Location/Qualifiers
     source          1..2051
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2051
                     /gene="Hoxa9"
                     /gene_synonym="Hoxa9l; RGD1310001"
                     /note="homeobox A9"
                     /db_xref="GeneID:297099"
                     /db_xref="RGD:1310001"
     exon            1..653
                     /gene="Hoxa9"
                     /gene_synonym="Hoxa9l; RGD1310001"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..892
                     /gene="Hoxa9"
                     /gene_synonym="Hoxa9l; RGD1310001"
                     /note="homeo box A9; homeobox protein Hox-A9-like"
                     /codon_start=1
                     /product="homeobox protein Hox-A9"
                     /protein_id="NP_001388797.1"
                     /db_xref="GeneID:297099"
                     /db_xref="RGD:1310001"
                     /translation="MATTGALGNYYVDSFLLGADAADELGAGRYAPGALGQPQRQAAA
                     LAEHPDFSPCSFQSKAAVFGASWNPVHAAGANAVPAAVYHHHHHPYVHPQAPVAAAAP
                     DGRYMRSWLEPTPGALSFAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGS
                     PPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTL
                     ELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE"
     exon            654..2051
                     /gene="Hoxa9"
                     /gene_synonym="Hoxa9l; RGD1310001"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaagttgtt acatgaaatc tgcagtttca taatttcggc gggtcgggct gggccggcca
       61 ggcgcgggct actgcgatgg ctaccaccgg ggccctgggc aactactatg tggactcctt
      121 cctgctaggc gctgacgctg cggacgagct gggtgcggga cgctacgctc caggggccct
      181 gggccaaccc caaaggcagg cggcagcgct ggccgaacac cccgacttca gcccttgcag
      241 cttccagtcc aaggcggcgg tgttcggtgc ctcgtggaac ccagtgcacg cggcaggcgc
      301 caatgcggtg cctgctgcgg tgtatcacca ccaccaccac ccctacgtgc acccccaggc
      361 gcccgtggcg gcggcggcgc cggacggcag gtacatgcgc tcctggctgg agcccacgcc
      421 gggtgcgctc tccttcgcgg gcttaccctc cagccggcct tatggcatta aacctgaacc
      481 gctgtcggcc agaaggggtg actgtcccac gcttgacact cacactttgt ccctgactga
      541 ctatgcttgt ggttctcctc cagttgatag agaaaaacaa cccagcgaag gcgccttctc
      601 cgaaaacaat gccgagaatg agagcggtgg agacaagccc cccatcgatc ccaataaccc
      661 ggccgccaac tggctacatg ctcgctccac tcggaagaag cggtgtccct acacaaaaca
      721 ccagacgctg gaactggaga aagaatttct gttcaacatg tacctcacac gggaccgcag
      781 gtacgaagtg gcccggctac tcaacctcac cgaaaggcag gtcaagatct ggttccagaa
      841 ccgcaggatg aaaatgaaga agatcaacaa ggaccgagca aaagacgagt gagcctttgg
      901 ggggctcgtt taaaaaaaaa gagagcaagc tagaaagaaa aagaaaggac tgtctgtctc
      961 cctttctctc ccctctccca aacccagcct ccaccacccg cacaaagggg ctctaaatcc
     1021 caggcctcat gtctccctgg cagtccctgc tcaggctggg tcctaggcct tcggctttaa
     1081 tggaggaggt attgtaagct ttccgttttc tagaaggcac acacacaagg gagggcatta
     1141 gcgctgttgt ctgtatgtgc tagcttgtat atatatatat ttaaaaaaaa tctacctgct
     1201 tccgacttta agcaaaagga aagaaaacta cctttttata taatgcacaa ctgttgatga
     1261 ctggctgtat agtttttagt ctctgtagct aatttaattt gctcttcgtg tggcagagca
     1321 ttctgccaaa atacttgaac actgtgtttt attgtggtaa ttatgttttg tgactcaaac
     1381 ttctgtgctg ggtgaagtgc ccattgtgat tgtggatgct agaattcaat ttgaactcag
     1441 gttgtttatg ggggaagaga agctgtcgca tagagtatag ctctgtagtg ggatacgtct
     1501 tctgtgtaac tagactgtta acctacaact gtaaactagc tgtaaggatt tcccagtgaa
     1561 atcaaacttg gaaagaaaag ggaggtagtt ctccaggatg catagattcc tgatttatct
     1621 gcttttgaaa tgtgggtttt tttttccatc tttacacgtt ctagattcca gttttgtcca
     1681 atgtatatag gatctccaca ttaaagaaat atccatgatc agaaagcttg aagattgttt
     1741 ttgcaccaga ggagaagtga ggaaattcgg agctatacac atgtgcagag ggttactacc
     1801 tatggtttat gcttaatttt aattagggga aagtgagtgc ttactgtaat ggagttaatt
     1861 ttattgataa taaattatac accatgaaaa cgctattggg ctactgtaga tttgtatcct
     1921 tggtgaattt ggggtttcca tcggactgaa catacactgt atattttgca atagttacct
     1981 caaggcctac tgaccaaatt gttgtgtcaa gatatttaac ttttgccaaa taaaatatat
     2041 tgattctttt a
//
