LOCUS       NM_024389               2938 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus homeo box A5 (Hoxa5), mRNA.
ACCESSION   NM_024389 XM_003752180
VERSION     NM_024389.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2938)
  AUTHORS   Kato,H., Ario,T., Kishida,T., Tadano,M., Osawa,S., Maeda,Y.,
            Takakura,H. and Izawa,T.
  TITLE     Homeobox A5 and C10 genes modulate adaptation of brown adipose
            tissue during exercise training in juvenile rats
  JOURNAL   Exp Physiol 106 (2), 463-474 (2021)
   PUBMED   33369800
  REMARK    GeneRIF: Homeobox A5 and C10 genes modulate adaptation of brown
            adipose tissue during exercise training in juvenile rats.
REFERENCE   2  (bases 1 to 2938)
  AUTHORS   Wang,Y., Wang,M.D., Xia,Y.P., Gao,Y., Zhu,Y.Y., Chen,S.C., Mao,L.,
            He,Q.W., Yue,Z.Y. and Hu,B.
  TITLE     MicroRNA-130a regulates cerebral ischemia-induced blood-brain
            barrier permeability by targeting Homeobox A5
  JOURNAL   FASEB J 32 (2), 935-944 (2018)
   PUBMED   29070584
  REMARK    GeneRIF: MiR-130a, by inhibiting Homeobox A5 expression, could
            down-regulate occludin, thereby increasing BBB permeability. Our
            results suggested that miR-130a might be implicated in
            ischemia-induced BBB dysfunction and serve as a target for the
            treatment of ischemic stroke
REFERENCE   3  (bases 1 to 2938)
  AUTHORS   Jakob,P., Doerries,C., Briand,S., Mocharla,P., Krankel,N.,
            Besler,C., Mueller,M., Manes,C., Templin,C., Baltes,C., Rudin,M.,
            Adams,H., Wolfrum,M., Noll,G., Ruschitzka,F., Luscher,T.F. and
            Landmesser,U.
  TITLE     Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells
            from patients with chronic heart failure: role for impaired in vivo
            neovascularization and cardiac repair capacity
  JOURNAL   Circulation 126 (25), 2962-2975 (2012)
   PUBMED   23136161
REFERENCE   4  (bases 1 to 2938)
  AUTHORS   Chen,Y. and Gorski,D.H.
  TITLE     Regulation of angiogenesis through a microRNA (miR-130a) that
            down-regulates antiangiogenic homeobox genes GAX and HOXA5
  JOURNAL   Blood 111 (3), 1217-1226 (2008)
   PUBMED   17957028
REFERENCE   5  (bases 1 to 2938)
  AUTHORS   McIntyre,D.C., Rakshit,S., Yallowitz,A.R., Loken,L., Jeannotte,L.,
            Capecchi,M.R. and Wellik,D.M.
  TITLE     Hox patterning of the vertebrate rib cage
  JOURNAL   Development 134 (16), 2981-2989 (2007)
   PUBMED   17626057
REFERENCE   6  (bases 1 to 2938)
  AUTHORS   Zhao,J.J., Lazzarini,R.A. and Pick,L.
  TITLE     Functional dissection of the mouse Hox-a5 gene
  JOURNAL   EMBO J 15 (6), 1313-1322 (1996)
   PUBMED   8635464
REFERENCE   7  (bases 1 to 2938)
  AUTHORS   Pellerin,I., Schnabel,C., Catron,K.M. and Abate,C.
  TITLE     Hox proteins have different affinities for a consensus DNA site
            that correlate with the positions of their genes on the hox cluster
  JOURNAL   Mol Cell Biol 14 (7), 4532-4545 (1994)
   PUBMED   7911971
REFERENCE   8  (bases 1 to 2938)
  AUTHORS   Gorski,D.H., LePage,D.F. and Walsh,K.
  TITLE     Cloning and sequence analysis of homeobox transcription factor
            cDNAs with an inosine-containing probe
  JOURNAL   Biotechniques 16 (5), 856-858 (1994)
   PUBMED   7915120
REFERENCE   9  (bases 1 to 2938)
  AUTHORS   Jeannotte,L., Lemieux,M., Charron,J., Poirier,F. and Robertson,E.J.
  TITLE     Specification of axial identity in the mouse: role of the Hoxa-5
            (Hox1.3) gene
  JOURNAL   Genes Dev 7 (11), 2085-2096 (1993)
   PUBMED   7901120
REFERENCE   10 (bases 1 to 2938)
  AUTHORS   Odenwald,W.F., Taylor,C.F., Palmer-Hill,F.J., Friedrich,V. Jr.,
            Tani,M. and Lazzarini,R.A.
  TITLE     Expression of a homeo domain protein in noncontact-inhibited
            cultured cells and postmitotic neurons
  JOURNAL   Genes Dev 1 (5), 482-496 (1987)
   PUBMED   2890554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 25, 2019 this sequence version replaced XM_003752180.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU758364.1, BQ782052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676788
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2386              JAXUCZ010000004.1  82634466-82636851   c
            2387-2938           JAXUCZ010000004.1  82632958-82633509   c
FEATURES             Location/Qualifiers
     source          1..2938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2938
                     /gene="Hoxa5"
                     /note="homeo box A5"
                     /db_xref="GeneID:79241"
                     /db_xref="RGD:620609"
     exon            1..2386
                     /gene="Hoxa5"
                     /inference="alignment:Splign:2.1.0"
     CDS             1492..2637
                     /gene="Hoxa5"
                     /note="hox-1.3; homeobox protein Hox-1.3; homeobox protein
                     Hox-A5-like"
                     /codon_start=1
                     /product="homeobox protein Hox-A5"
                     /protein_id="NP_077365.1"
                     /db_xref="GeneID:79241"
                     /db_xref="RGD:620609"
                     /translation="MRPVSSGWRSSPTERRRRVAGTRPGSARHPSRLHPTPPLLHEFT
                     SRGHQAGFTTGQQKHVIRSRTPYLGAYVGGNRVHVPVISIIHHKLCKGAIDAQTTASH
                     KSSTHIKKQMSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGY
                     NGMDLSVGRSGSGHFGSGERARSYAAGASAAPAEPRYSQPATSTHSPPPDPLPCSAVA
                     PSPGSDSHHGGKNSLGNSSGASANAGSTHISSREGVGTASAAEEDAPASSEQAGAQSE
                     PSPAPPAQPQIYPWMRKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRR
                     RRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSMAAAGGAFRP"
     exon            2387..2938
                     /gene="Hoxa5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacacacaca cacacacaca cacacacaca ggttttctcc ccaaggctgc ccgagccagc
       61 ttgggaatcc cggggtgcac ccagaattgg tcctgctgct gtgttagcgt ctctgcgccc
      121 tgtgagctac agacgcgggg ttgttggggg aagaaggagc cccaggcagt gccccgtttg
      181 gtgcctgggt ttttccgcct tggtccctcg ccatcaaatc ctaaagggca tcgccaaatc
      241 gactctggct actgaaaaga aagggtccac aagctgggcc ccagccctgt cccggcctct
      301 caggatgccc ctaaacaaga agcctgagga acaaagggga actcgcccct tccccgacag
      361 aaccaaatct ctctaccggc gcatacccgt cagtgggaga gtagcagcct caacggaggc
      421 aagccaacct gggcgcgaga ggaacgttac aacctcggga gcgactaggc tcctgcaggc
      481 tcccagctcc cgatttcact cccagcctca taagctgacc gccgccacct aaccgctttc
      541 aggacccaaa gagggggccc aggaccatga gagccgcaag agtcctggct tccaaacgtg
      601 ccagggactc ctgagatgcc aggcctctag tagagaaagt ctcttctcct ctcagctaca
      661 tttgtgattt actttcgtct atcggagccc aggaaaataa ctacggtgat actaggcact
      721 gccacgaaat gattccatta gttcccgcaa tttattccca gtggtctaag cgagatccca
      781 atagctctac ccacggatcc cagcttccaa gcagcctcgg aggccgttgg gtatcagggc
      841 ccactctctg ggttcaccaa gaaccctgct acctggggcc gggctagtca gaagaaacgg
      901 accagggacg aagatcttcc aggctggata aataaacaaa tgagatagca aactaatgac
      961 acgaaaaaca tattttcacg gaagaaaaaa atgattctgg ttatacgagt gtatggaatt
     1021 tgacctcgcc tcggagaaac actacacaaa agctgtcttt aatagacgcc tgtggtttaa
     1081 gagcggcagg gacactgtcc ttcatgcgct cacaaacaca gagccataat tgtggctgct
     1141 gctgtgggca ggatttattt cttcaattgg ctaaatcgtc ttcccttcct cgaaggtgat
     1201 atctgtgttt tcaaaattca cagctgctag ccgggcgggc aaaccgaccc caacctccac
     1261 acaaaaataa gaggggatac aaagctgggg aaataaagtt gttgtaaata attctaagtc
     1321 atcacctccc cctaatcctc tgtatcctcg ccgggtgtgc gatcggcagc tgacggcctc
     1381 acaattggta catcctaatg gaactgcgag ggaaatgcaa taattttgcc ataatgggct
     1441 gtaacctcaa ttcgaccccg gcccttgctg cccgaggtcg gaagcggagc gatgcgccca
     1501 gtctccagcg ggtggcgctc gagtccgact gaacggcggc ggcgggtggc gggcacgcgc
     1561 ccagggagcg cgcgccaccc ctctcgcctc cacccaactc ccccattact gcacgagttt
     1621 acctctagag gtcatcaggc aggatttacg actggacaac aaaagcacgt gattcgaagt
     1681 cgtaccccat atttgggtgc ctacgtagga gggaaccgag tacatgtccc agtcatttcc
     1741 ataattcatc ataaattgtg caagggtgct atagacgcac aaacgaccgc gagccacaaa
     1801 tcaagcacac atatcaaaaa acaaatgagc tcttattttg taaactcatt ttgcggtcgc
     1861 tatccaaatg gcccggacta ccagttgcat aattatggag atcatagttc cgtgagcgaa
     1921 caattcaggg actcggcgag catgcactcc ggcaggtacg gctacggcta caatggcatg
     1981 gatctcagcg tcggccgttc gggttccggc cactttggct ccggcgagcg cgcccgcagc
     2041 tacgcggctg gggccagtgc ggcgcccgcc gagcccaggt acagccagcc ggccacgtcc
     2101 acgcactcgc caccgcccga cccgctgccc tgctcagcgg tggccccctc gcccggcagc
     2161 gacagccacc acggcgggaa aaactccctg ggcaactcca gcggcgcctc ggccaacgcc
     2221 ggcagcaccc acatcagcag cagagagggg gttggcacgg cgtccgcagc ggaggaggac
     2281 gcccctgcca gcagcgagca ggcgggcgcc cagagcgagc cgagcccggc gccgcccgct
     2341 caaccccaga tctacccctg gatgcgcaag ctgcacatta gtcacgacaa cataggtggc
     2401 ccagaaggca aaagggcccg gacggcctac acgcgctacc agaccctgga gctggagaaa
     2461 gaattccact tcaaccgcta cctgacccgc cgaagaagga ttgaaatagc acatgccctt
     2521 tgcctctccg agagacaaat taaaatctgg ttccaaaaca ggaggatgaa gtggaaaaag
     2581 gataataagc tgaaaagtat gagtatggcc gcggcagggg gggccttccg cccctgaggt
     2641 tctgagcggc caaagtactg ggcagtagta gcgcgcggag caactctccg tagtgtcagt
     2701 actaaggtga ctttctgaaa ctccccttgt gttccttctg tgaagaagcc ctgttctcgt
     2761 tgccctaatt catcttttaa tcatgagcct gtttattgcc attatagcgc ctgtataagt
     2821 agatcagctt ctgttcatct ctttgtcctg aatggctttg tcttgaaaaa aaaaatagat
     2881 gttttaactt atttatatga agcaagctgt gttacttgaa gtaactaaaa caaaaaaa
//
