LOCUS       NM_024350               1518 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus homeo box A4 (Hoxa4), mRNA.
ACCESSION   NM_024350
VERSION     NM_024350.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1518)
  AUTHORS   Zhao,Y. and Potter,S.S.
  TITLE     Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11
            homeoboxes
  JOURNAL   Dev Biol 244 (1), 21-36 (2002)
   PUBMED   11900456
REFERENCE   2  (bases 1 to 1518)
  AUTHORS   Horan,G.S., Ramirez-Solis,R., Featherstone,M.S., Wolgemuth,D.J.,
            Bradley,A. and Behringer,R.R.
  TITLE     Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4
            genes show more complete homeotic transformations and a
            dose-dependent increase in the number of vertebrae transformed
  JOURNAL   Genes Dev 9 (13), 1667-1677 (1995)
   PUBMED   7628700
REFERENCE   3  (bases 1 to 1518)
  AUTHORS   Sakoyama,Y., Mizuta,I., Ogasawara,N. and Yoshikawa,H.
  TITLE     Cloning of rat homeobox genes
  JOURNAL   Biochem Genet 32 (9-10), 351-360 (1994)
   PUBMED   7702549
REFERENCE   4  (bases 1 to 1518)
  AUTHORS   Kostic,D. and Capecchi,M.R.
  TITLE     Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result
            in homeotic transformations of components of the vertebral column
  JOURNAL   Mech Dev 46 (3), 231-247 (1994)
   PUBMED   7918106
REFERENCE   5  (bases 1 to 1518)
  AUTHORS   Gorski,D.H., LePage,D.F. and Walsh,K.
  TITLE     Cloning and sequence analysis of homeobox transcription factor
            cDNAs with an inosine-containing probe
  JOURNAL   Biotechniques 16 (5), 856-858 (1994)
   PUBMED   7915120
REFERENCE   6  (bases 1 to 1518)
  AUTHORS   Chung,S.Y., Dai,P.H., Lei,J., Riviere,M., Levan,G., Szpirer,J. and
            Szpirer,C.
  TITLE     Chromosomal assignment of seven rat homeobox genes to rat
            chromosomes 3, 4, 7, and 10
  JOURNAL   Mamm Genome 4 (9), 537-540 (1993)
   PUBMED   7906969
REFERENCE   7  (bases 1 to 1518)
  AUTHORS   Falzon,M., Sanderson,N. and Chung,S.Y.
  TITLE     Cloning and expression of rat homeo-box-containing sequences
  JOURNAL   Gene 54 (1), 23-32 (1987)
   PUBMED   2886401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            Summary: The protein encoded by this gene is likely a homeobox
            transcription factor. [provided by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created genomic sequence data
            to make the sequence consistent with the reference genome assembly.
            The genomic coordinates used for the transcript record were based
            on transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK366967.1, SRR26360181.635342.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               JAXUCZ010000004.1  82621788-82622302   c
            516-1518            JAXUCZ010000004.1  82620294-82621296   c
FEATURES             Location/Qualifiers
     source          1..1518
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1518
                     /gene="Hoxa4"
                     /gene_synonym="hox1.4; Hox1r2"
                     /note="homeo box A4"
                     /db_xref="GeneID:100912525"
                     /db_xref="RGD:2814"
     exon            1..515
                     /gene="Hoxa4"
                     /gene_synonym="hox1.4; Hox1r2"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..862
                     /gene="Hoxa4"
                     /gene_synonym="hox1.4; Hox1r2"
                     /note="homeobox protein Hox-A4-like; Homeobox gene A4;
                     homeobox protein R2; homeobox A4-like"
                     /codon_start=1
                     /product="homeobox protein Hox-A4"
                     /protein_id="NP_077326.1"
                     /db_xref="GeneID:100912525"
                     /db_xref="RGD:2814"
                     /translation="MTMSSFLINSNYIEPKFPPFEEFAPHGGPGGGDGGVGGGPGYPR
                     PQSSPHLPAPNPHAARQTPAYYAPRAREPSYHGGLYPAPAAACPYACRGASPARPEQS
                     PAPGAHPSPAPQPPAPPRRCAPGPTTPAVATGGSAPACPLLLADQGPAGPKGKEPVVY
                     PWMKKIHVSAVNPSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLC
                     LSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNPASAPAGPPGKAQTHSPHPHPHPLPG
                     ASTPIPSSI"
     exon            516..1518
                     /gene="Hoxa4"
                     /gene_synonym="hox1.4; Hox1r2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attaatgacc atgagctcgt ttttgataaa ctccaactac atcgagccca agttccctcc
       61 cttcgaggag ttcgcaccgc acggtggccc gggcggtggg gacggcggcg tgggcggggg
      121 tcccggctac ccgcggcctc agagctcccc gcacctgccg gccccgaacc cgcacgcggc
      181 ccgacagacc cccgcatact acgcgccaag ggcgcgcgag cccagctacc acgggggcct
      241 gtaccccgcg cccgccgccg cctgtcccta cgcctgtcgc ggggccagcc ccgcgcgacc
      301 cgagcagtcc ccggcccccg gcgcgcatcc cagcccggcc ccgcagcccc ctgcgccccc
      361 tcggcgctgc gctccgggcc ccaccacccc ggctgtcgcg acggggggca gcgcccccgc
      421 gtgcccgctg ctgctggcgg accagggccc cgcgggcccg aagggcaagg agccggtggt
      481 gtacccctgg atgaagaaga tccacgtgag cgccgtcaac cccagttata acggaggtga
      541 gcccaagcgc tctcgaaccg cctatacccg gcagcaagtc ttggagctgg agaaggaatt
      601 ccactttaac cgatacctga cccggcgccg ccgcatcgag atcgctcaca cgctctgctt
      661 gtccgagcgc caggtcaaga tctggttcca gaaccggaga atgaagtgga agaaagacca
      721 caaacttccc aacaccaaga tgcgatcttc caaccctgcc tcggcccctg ccggcccgcc
      781 tgggaaagca caaactcaca gcccacaccc ccatccccac cctctccccg gtgcttccac
      841 acccattccc tcgtctatat aatctagaga cctagatcag tttctgtcac ttatgtgccc
      901 aactcatctc ctgctcctgt cctcgtctgc tccttcctaa gtaaacctga gacaccaaaa
      961 caaaatccaa cttgctggaa atcataacca aaaagaagat attattcctg gttggtgtct
     1021 gtgtgtgacc cccccaagag gacatctgtc ctggttactg cttagtggaa caacctgctg
     1081 acctggacaa ctttgccagg gttggacacc tgtaaggaag cactggtcat cgactacctt
     1141 tgagtccacc agacagcacg tgctgactgg ggacatgtat gtttgttgca agcagaagaa
     1201 gcaggcagtt ccccagcttc cttacctttc tcttctgcat taaggcagct cacatgagct
     1261 ttactgagta gacattgtgg acctcaccag attatttaat tctcaaagtg tgtagacctt
     1321 gatggtaggt gtggcatgta gtttcctctc cttgcattta tttaagatac tgttatagag
     1381 atattgttgt cttattctgg ggcacagtct tggggagagg gaaatgcatt tagacccact
     1441 tgcaactgta cagagcgata tggttgtata aagaggaatg tgctaagaat aaacttcaat
     1501 ttataagaca tttaaaaa
//
