LOCUS       NM_001313820            2555 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus homeobox A3 (Hoxa3), mRNA.
ACCESSION   NM_001313820
VERSION     NM_001313820.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2555)
  AUTHORS   Iacovino,M., Chong,D., Szatmari,I., Hartweck,L., Rux,D.,
            Caprioli,A., Cleaver,O. and Kyba,M.
  TITLE     HoxA3 is an apical regulator of haemogenic endothelium
  JOURNAL   Nat Cell Biol 13 (1), 72-78 (2011)
   PUBMED   21170035
REFERENCE   2  (bases 1 to 2555)
  AUTHORS   Simmonds,C.S., Karsenty,G., Karaplis,A.C. and Kovacs,C.S.
  TITLE     Parathyroid hormone regulates fetal-placental mineral homeostasis
  JOURNAL   J Bone Miner Res 25 (3), 594-605 (2010)
   PUBMED   19968565
REFERENCE   3  (bases 1 to 2555)
  AUTHORS   Chung,N., Jee,B.K., Chae,S.W., Jeon,Y.W., Lee,K.H. and Rha,H.K.
  TITLE     HOX gene analysis of endothelial cell differentiation in human bone
            marrow-derived mesenchymal stem cells
  JOURNAL   Mol Biol Rep 36 (2), 227-235 (2009)
   PUBMED   17972163
REFERENCE   4  (bases 1 to 2555)
  AUTHORS   Wissmuller,S., Kosian,T., Wolf,M., Finzsch,M. and Wegner,M.
  TITLE     The high-mobility-group domain of Sox proteins interacts with
            DNA-binding domains of many transcription factors
  JOURNAL   Nucleic Acids Res 34 (6), 1735-1744 (2006)
   PUBMED   16582099
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2555)
  AUTHORS   Chisaka,O. and Kameda,Y.
  TITLE     Hoxa3 regulates the proliferation and differentiation of the third
            pharyngeal arch mesenchyme in mice
  JOURNAL   Cell Tissue Res 320 (1), 77-89 (2005)
   PUBMED   15714286
REFERENCE   6  (bases 1 to 2555)
  AUTHORS   Yamagoe,S., Mizuno,S. and Suzuki,K.
  TITLE     Molecular cloning of human and bovine LECT2 having a neutrophil
            chemotactic activity and its specific expression in the liver
  JOURNAL   Biochim Biophys Acta 1396 (1), 105-113 (1998)
   PUBMED   9524238
REFERENCE   7  (bases 1 to 2555)
  AUTHORS   Manley,N.R. and Capecchi,M.R.
  TITLE     Hox group 3 paralogs regulate the development and migration of the
            thymus, thyroid, and parathyroid glands
  JOURNAL   Dev Biol 195 (1), 1-15 (1998)
   PUBMED   9520319
REFERENCE   8  (bases 1 to 2555)
  AUTHORS   Manley,N.R. and Capecchi,M.R.
  TITLE     Hox group 3 paralogous genes act synergistically in the formation
            of somitic and neural crest-derived structures
  JOURNAL   Dev Biol 192 (2), 274-288 (1997)
   PUBMED   9441667
REFERENCE   9  (bases 1 to 2555)
  AUTHORS   Manley,N.R. and Capecchi,M.R.
  TITLE     The role of Hoxa-3 in mouse thymus and thyroid development
  JOURNAL   Development 121 (7), 1989-2003 (1995)
   PUBMED   7635047
REFERENCE   10 (bases 1 to 2555)
  AUTHORS   Condie,B.G. and Capecchi,M.R.
  TITLE     Mice with targeted disruptions in the paralogous genes hoxa-3 and
            hoxd-3 reveal synergistic interactions
  JOURNAL   Nature 370 (6487), 304-307 (1994)
   PUBMED   7913519
  REMARK    Erratum:[Nature 1994 Oct 6;371(6497):537]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.19284.1,
                                           SRR26643285.16176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                JAXUCZ010000004.1  82643804-82643831   c
            29-135              JAXUCZ010000004.1  82631491-82631597   c
            136-219             JAXUCZ010000004.1  82614421-82614504   c
            220-868             JAXUCZ010000004.1  82602915-82603563   c
            869-2555            JAXUCZ010000004.1  82599860-82601546   c
FEATURES             Location/Qualifiers
     source          1..2555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2555
                     /gene="Hoxa3"
                     /gene_synonym="RGD1561431"
                     /note="homeobox A3"
                     /db_xref="GeneID:103690130"
                     /db_xref="RGD:1561431"
     exon            1..28
                     /gene="Hoxa3"
                     /gene_synonym="RGD1561431"
                     /inference="alignment:Splign:2.1.0"
     exon            29..135
                     /gene="Hoxa3"
                     /gene_synonym="RGD1561431"
                     /inference="alignment:Splign:2.1.0"
     exon            136..219
                     /gene="Hoxa3"
                     /gene_synonym="RGD1561431"
                     /inference="alignment:Splign:2.1.0"
     exon            220..868
                     /gene="Hoxa3"
                     /gene_synonym="RGD1561431"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1674
                     /gene="Hoxa3"
                     /gene_synonym="RGD1561431"
                     /note="homeobox protein Hox-A3-like"
                     /codon_start=1
                     /product="homeobox protein Hox-A3"
                     /protein_id="NP_001300749.1"
                     /db_xref="GeneID:103690130"
                     /db_xref="RGD:1561431"
                     /translation="MQKATYYDSSAIYGGYPYQAANGFAYNASQQPYAPSATLGTDGV
                     EYHRPACSLQSPASAGAHPKSHELSEACLRTLSGPPSQPPGLGDPPLPPPPPQAAPPA
                     PQPPQPPPQPPAPTPAAPPPPSSVSPPQSANSNPTPASTAKSPLLNSPTVGKQIFPWM
                     KESRQNTKQKTSGSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLC
                     RPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGG
                     YLNSMHSLVNSVPYEPQSPPPFSKPPQGAYGLPPASYPAPLPSCAPPPPPQKRYTAAG
                     SGAGGTPEYDPHAHGLQGNGSYGTPHLQGSPVFVGGSYVEPMGNSGPALFGLTHLPHT
                     TSAAVDYGGSGPLGSGHHHGPGPGEPHPTYTDLTAHHPSQGRIQEAPKLTHL"
     exon            869..2555
                     /gene="Hoxa3"
                     /gene_synonym="RGD1561431"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagcttct gggagctgcg gtctgaaggc tacgtgtgct gcctggtcat tcaaagtgtc
       61 aattttaggt ccagaagtgt ccaaaccaca agttctcaga actctctgaa aaaaaatggc
      121 tccctccatg ttaagagtgc ctggacaccg gagaaaaaga ttccctgagc acctggaacc
      181 ggagaccatt cctggtctcg gatttaaaca tctttggagg tctgcgcgcg gcggccattg
      241 gcggcggagt gtcacgtgac tgcgggggcg tgccaatgtg ctcccttacg ggtgtcaagc
      301 ccttgtcaga gagtgtgatc acgatcgtga aacatcgcga tgcaaaaagc gacctactac
      361 gacagctcgg cgatctacgg tggctacccc taccaagcag ccaatgggtt cgcttacaat
      421 gccagtcagc agccatacgc gccgtccgcc actctgggca cggatggtgt tgagtaccat
      481 cgacccgcct gctccctcca gtctcccgcc agcgctgggg cccaccccaa aagtcatgag
      541 ctgagcgaag cttgtctgcg caccctgagc gggcctccta gccagccccc aggcctgggt
      601 gatccacctt tgcctccacc tcctccccag gcagcgcccc cagcccccca gcctccacag
      661 cccccaccac agccccctgc acccacccct gcagctcctc cgcctccctc atctgtctct
      721 ccccctcaaa gtgccaacag caaccctacc cctgccagca cagccaagag ccccctgctc
      781 aactctccca ccgtgggcaa acaaatcttt ccctggatga aagagtcaag gcagaacact
      841 aagcagaaaa ccagcggctc cagctcaggg gagagctgcg ctggtgacaa gagcccgcct
      901 gggcaggctt cgtccaagcg cgcgcgcacg gcgtacacga gcgcgcagct ggtggagctg
      961 gagaaggagt tccacttcaa ccgctaccta tgccggccgc gccgagtgga gatggccaac
     1021 ctgctgaacc tcaccgagcg ccagatcaag atctggttcc agaaccgccg tatgaagtac
     1081 aagaaggacc agaagggcaa aggcatgctg acttcgtctg ggggccagtc cccaagtcgt
     1141 agccctgtgc ctcccggtgc aggaggttat ctgaattcta tgcattcgct ggtcaacagt
     1201 gtcccatatg agccccagtc accccctcct ttctccaagc ccccccaagg cgcctacggg
     1261 ttgcctccgg cctcctaccc tgctcccctg cccagttgcg ctcccccacc tcccccacag
     1321 aaacgctaca cagcggcggg gtcaggcgca gggggcaccc ctgagtacga cccacatgct
     1381 cacggcctgc agggcaacgg cagctatggg accccacact tacagggaag ccccgtcttc
     1441 gtagggggca gctatgtgga gcccatgggc aactctgggc cagcactctt tggcctaact
     1501 cacctccccc acaccacctc ggctgccgtg gactacgggg gctctgggcc gctgggcagc
     1561 ggtcaccacc atgggcctgg gcctggggag ccacacccca cctacacgga ccttactgcc
     1621 caccatcctt ctcagggaag aattcaggaa gcgcccaagc tcacccacct gtgatgatgg
     1681 gctggggctg caagccagga gagttgccca cccaaccttc tttggtttct ttttcctctg
     1741 ttttgttttg ttttatgttc ttctcgcctt tcccctttct cctctgcacc tctccctcat
     1801 tttccccctt cggtaatgcg tttttatagt ttatgtgacg tagcaatctt ggttgctgga
     1861 aaggctgtca gtatcagtag caacatttac taccacccct cctcgccctg gcctctggcc
     1921 ctgcaccctc taccctctct actcttcgat aagaaacagg gtatatgaac aaactttcta
     1981 gtcgagtttt caatgtgaat ttgttcatac tttatggctc ccgagaggaa gcaactgcgt
     2041 tttttttttt aagttttagt ttttaaaatt gcacttcttg taatgatcga gaaaaagaaa
     2101 tcaaaggcgc tttgaaacag ggactccctg tgcaaagttg actaagtgta cgtctttccg
     2161 tgtgtgtgtg ctggtgaaca gtcagattta tttatatttt tttgcaagca ttgaatagtc
     2221 taagttttaa atattattta tccccatccg ttcgtattta tattaaagaa attctgtacc
     2281 ctgattgttc agaaggtttc ttgagccttt tgttcaatgg tgtattggca tacatataaa
     2341 atttatttga aagggaaata aaattccttt ataaaaaccg tagcaatgca ataagaacag
     2401 agaggaccca gagtttgaaa atagtggttt aggtttgtaa catccggcaa aactgaacgc
     2461 taaaaatgcc agatttgttt tgagagtttt acattccttg ctgctcacat tctgagaaac
     2521 aaaacaaaaa aaaataaagt ttttattctg attaa
//
