LOCUS       NM_012581               1661 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus homeobox A2 (Hoxa2), mRNA.
ACCESSION   NM_012581
VERSION     NM_012581.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1661)
  AUTHORS   Wang,M., Doucette,J.R. and Nazarali,A.J.
  TITLE     Conditional Tet-regulated over-expression of Hoxa2 in CG4 cells
            increases their proliferation and delays their differentiation into
            oligodendrocyte-like cells expressing myelin basic protein
  JOURNAL   Cell Mol Neurobiol 31 (6), 875-886 (2011)
   PUBMED   21479584
  REMARK    GeneRIF: The impact of Hoxa2 over-expression on the proliferation
            and differentiation of CG4-SHoxa2 cells was investigated.
REFERENCE   2  (bases 1 to 1661)
  AUTHORS   Alasti,F., Sadeghi,A., Sanati,M.H., Farhadi,M., Stollar,E.,
            Somers,T. and Van Camp,G.
  TITLE     A mutation in HOXA2 is responsible for autosomal-recessive microtia
            in an Iranian family
  JOURNAL   Am J Hum Genet 82 (4), 982-991 (2008)
   PUBMED   18394579
  REMARK    Erratum:[Am J Hum Genet. 2008 Sep;83(3):424]
REFERENCE   3  (bases 1 to 1661)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   4  (bases 1 to 1661)
  AUTHORS   Gorski,D.H., LePage,D.F. and Walsh,K.
  TITLE     Cloning and sequence analysis of homeobox transcription factor
            cDNAs with an inosine-containing probe
  JOURNAL   Biotechniques 16 (5), 856-858 (1994)
   PUBMED   7915120
REFERENCE   5  (bases 1 to 1661)
  AUTHORS   Patel,C.V., Gorski,D.H., LePage,D.F., Lincecum,J. and Walsh,K.
  TITLE     Molecular cloning of a homeobox transcription factor from adult
            aortic smooth muscle
  JOURNAL   J Biol Chem 267 (36), 26085-26090 (1992)
   PUBMED   1361191
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 27, 2023 this sequence version replaced NM_012581.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M91802.1, AW251417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676806
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-563               JAXUCZ010000004.1  82595130-82595692   c
            564-1661            JAXUCZ010000004.1  82593389-82594486   c
FEATURES             Location/Qualifiers
     source          1..1661
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1661
                     /gene="Hoxa2"
                     /gene_synonym="hox-1.11; Hoxa-2; Hoxa11; Hoxa2l;
                     RATHOX111A"
                     /note="homeobox A2"
                     /db_xref="GeneID:103690123"
                     /db_xref="RGD:11468112"
     exon            1..563
                     /gene="Hoxa2"
                     /gene_synonym="hox-1.11; Hoxa-2; Hoxa11; Hoxa2l;
                     RATHOX111A"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1303
                     /gene="Hoxa2"
                     /gene_synonym="hox-1.11; Hoxa-2; Hoxa11; Hoxa2l;
                     RATHOX111A"
                     /note="Homeobox gene A11; Homeobox gene A2; homeobox
                     protein Hox-1.11; homeo box A2"
                     /codon_start=1
                     /product="homeobox protein Hox-A2"
                     /protein_id="NP_036713.2"
                     /db_xref="GeneID:103690123"
                     /db_xref="RGD:11468112"
                     /translation="MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSH
                     STLIPPPFEQTIPSLNPGSHPRQSAGAGGRPKSSPAGSRGSPVPARALQPPEYPWMKE
                     KKAAKKTALPPAAASTGPACLGHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHF
                     NKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKFKNLEDSDK
                     VEEDEEEKSLFEQALSVSGALLEREGYTFQQNALSQQQAPNGHNGDSQTFPVSPLTSN
                     EKNLKHFQHQSPTVPNCLSTMGQNCGAGLNNDSPEALEVPSLQDFNVFSTDSCLQLSD
                     ALSPSLPGSLDSPVDISADSFDFFTDTLTTIDLQHLNY"
     exon            564..1661
                     /gene="Hoxa2"
                     /gene_synonym="hox-1.11; Hoxa-2; Hoxa11; Hoxa2l;
                     RATHOX111A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttaatag tagcgcggtc cccatacggc tgtaatcagt gaattagaaa aaaaacaccc
       61 cagcagcgat cttctatgat agattttttt ttccttcgct ctcgcctttt tcctgggcct
      121 tgccccccca aagcccctcc aaaagaggga acttttcctc cgagggggct ccaaggagaa
      181 ggccatgaat tacgaatttg agcgagagat tggttttatc aatagccagc cgtcgctcgc
      241 tgagtgcctg acatcttttc cccctgtcgc tgatacattt caaagttcat caatcaagac
      301 ctcgacgctt tcacactcga cactgattcc tcctcctttt gagcagacca ttcccagcct
      361 gaacccgggc agtcaccctc gccaaagcgc tggcgctggc ggccgcccca agtcgagccc
      421 cgcgggcagt cgcggcagcc cggtgcccgc ccgcgccctg cagccgcctg agtacccctg
      481 gatgaaggag aagaaggcgg ccaagaaaac cgcgctgccg cccgccgccg cctccacggg
      541 ccctgcctgc ctcggccaca aagaatccct ggaaatagcc gatggcagcg gtgggggatc
      601 caggcgtctg agaactgctt acaccaacac tcagcttttg gaactggaaa aggaatttca
      661 tttcaacaag tacctctgca gaccccggag ggtggaaatc gccgcgctgc tggatttgac
      721 cgagagacaa gtgaaagtgt ggtttcagaa ccggaggatg aagcataaga ggcaaaccca
      781 gtgcaaggag aaccaaaaca gcgaagggaa atttaaaaac ctggaggatt cggacaaagt
      841 ggaggaagac gaggaagaga agtcactctt tgagcaagcc ctcagtgtct ccggggccct
      901 tctggagagg gaaggttaca cttttcagca aaacgcgctc tctcaacagc aggctcccaa
      961 tggacacaat ggcgactccc aaactttccc agtttcgcct ttaaccagca atgagaaaaa
     1021 tttgaaacat tttcagcacc agtcacccac tgttcctaac tgcttgtcaa caatgggcca
     1081 gaactgtgga gctggcctaa acaatgacag tcccgaggcc ctcgaggtcc cctctttgca
     1141 ggactttaat gttttctcca cagattcctg cctgcagctt tcagacgcac tgtcgcccag
     1201 tttgccaggc tccctggaca gtcctgtaga tatttcagct gacagctttg acttttttac
     1261 agacacactc accacaatcg acctacagca tctgaattac taagaacatt aaagcaaaag
     1321 aaagcttcac aaaacaaaac gcctttggcc aggtggcttt gccttctttt attccgggag
     1381 ttgattttcg ttctattctc ttctcgatct acccctgttc tcttaaatgt tcaggacttt
     1441 ctgttttaca cccagtttga aagccatctc ttccaaatga tgttggcgtt ctaagtgttt
     1501 tacaccgaac ccaacaagct tctatgtgat tttcctgaaa acaaaacacg aggcctgcaa
     1561 gaaagtgacc ataagttgtc ttgtcacttt ctttttattt ttgtaccaca ttaggatgca
     1621 ttgtcatgcg tatttttggt agaataaact ctcctctgct a
//
