LOCUS       NM_001271355            1412 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus homeo box A13 (Hoxa13), mRNA.
ACCESSION   NM_001271355 XM_003749759 XM_003749760 XM_575481
VERSION     NM_001271355.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1412)
  AUTHORS   Kherdjemil,Y., Lalonde,R.L., Sheth,R., Dumouchel,A., de Martino,G.,
            Pineault,K.M., Wellik,D.M., Stadler,H.S., Akimenko,M.A. and
            Kmita,M.
  TITLE     Evolution of Hoxa11 regulation in vertebrates is linked to the
            pentadactyl state
  JOURNAL   Nature 539 (7627), 89-92 (2016)
   PUBMED   27706137
REFERENCE   2  (bases 1 to 1412)
  AUTHORS   Zhu,Y.P., Li,E.H., Sun,W.L., Xu,D.L., Liu,Z.H., Zhao,W., Wood,K.,
            Xia,S.J. and Jiang,J.T.
  TITLE     Maternal exposure to di-n-butyl phthalate (DBP) induces combined
            anorectal and urogenital malformations in male rat offspring
  JOURNAL   Reprod Toxicol 61, 169-176 (2016)
   PUBMED   27079746
REFERENCE   3  (bases 1 to 1412)
  AUTHORS   Jolma,A., Yan,J., Whitington,T., Toivonen,J., Nitta,K.R.,
            Rastas,P., Morgunova,E., Enge,M., Taipale,M., Wei,G., Palin,K.,
            Vaquerizas,J.M., Vincentelli,R., Luscombe,N.M., Hughes,T.R.,
            Lemaire,P., Ukkonen,E., Kivioja,T. and Taipale,J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   4  (bases 1 to 1412)
  AUTHORS   Zhang,Y., Larsen,C.A., Stadler,H.S. and Ames,J.B.
  TITLE     Structural basis for sequence specific DNA binding and protein
            dimerization of HOXA13
  JOURNAL   PLoS One 6 (8), e23069 (2011)
   PUBMED   21829694
REFERENCE   5  (bases 1 to 1412)
  AUTHORS   Kawakami,Y., Uchiyama,Y., Rodriguez Esteban,C., Inenaga,T.,
            Koyano-Nakagawa,N., Kawakami,H., Marti,M., Kmita,M.,
            Monaghan-Nichols,P., Nishinakamura,R. and Izpisua Belmonte,J.C.
  TITLE     Sall genes regulate region-specific morphogenesis in the mouse limb
            by modulating Hox activities
  JOURNAL   Development 136 (4), 585-594 (2009)
   PUBMED   19168674
REFERENCE   6  (bases 1 to 1412)
  AUTHORS   Williams,T.M., Williams,M.E. and Innis,J.W.
  TITLE     Range of HOX/TALE superclass associations and protein domain
            requirements for HOXA13:MEIS interaction
  JOURNAL   Dev Biol 277 (2), 457-471 (2005)
   PUBMED   15617687
REFERENCE   7  (bases 1 to 1412)
  AUTHORS   Knosp,W.M., Scott,V., Bachinger,H.P. and Stadler,H.S.
  TITLE     HOXA13 regulates the expression of bone morphogenetic proteins 2
            and 7 to control distal limb morphogenesis
  JOURNAL   Development 131 (18), 4581-4592 (2004)
   PUBMED   15342482
REFERENCE   8  (bases 1 to 1412)
  AUTHORS   Morgan,E.A., Nguyen,S.B., Scott,V. and Stadler,H.S.
  TITLE     Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes
            hypospadia
  JOURNAL   Development 130 (14), 3095-3109 (2003)
   PUBMED   12783783
REFERENCE   9  (bases 1 to 1412)
  AUTHORS   Podlasek,C.A., Clemens,J.Q. and Bushman,W.
  TITLE     Hoxa-13 gene mutation results in abnormal seminal vesicle and
            prostate development
  JOURNAL   J Urol 161 (5), 1655-1661 (1999)
   PUBMED   10210434
REFERENCE   10 (bases 1 to 1412)
  AUTHORS   Mortlock,D.P. and Innis,J.W.
  TITLE     Mutation of HOXA13 in hand-foot-genital syndrome
  JOURNAL   Nat Genet 15 (2), 179-180 (1997)
   PUBMED   9020844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Sep 19, 2012 this sequence version replaced
            XM_003749759.1, XM_003749760.1, XM_575481.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ195316.1, SRR26643297.16083.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-939               JAXUCZ010000004.1  82690763-82691701   c
            940-1412            JAXUCZ010000004.1  82689566-82690038   c
FEATURES             Location/Qualifiers
     source          1..1412
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1412
                     /gene="Hoxa13"
                     /gene_synonym="RGD1562483"
                     /note="homeo box A13"
                     /db_xref="GeneID:500129"
                     /db_xref="RGD:1562483"
     exon            1..939
                     /gene="Hoxa13"
                     /gene_synonym="RGD1562483"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1184
                     /gene="Hoxa13"
                     /gene_synonym="RGD1562483"
                     /note="homeobox A13; homeobox protein Hox-A13-like"
                     /codon_start=1
                     /product="homeobox protein Hox-A13"
                     /protein_id="NP_001258284.1"
                     /db_xref="GeneID:500129"
                     /db_xref="RGD:1562483"
                     /translation="MTASVLLHPRWIEPTVMFLYDNGGGLVADELNKNMEGAAAAAAA
                     AAAAAAAGAGGGGFPHPAAAAAGGNFSVAAAAAAAAAAAANQCRNLMAHPAPLAPGAA
                     AAYSSAPGEAPPTAAAAAAAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQCSPCSAAA
                     QSSSGPAALPYGYFGSGYYPCARMGPHPNAIKSCAQPASAAAAFADKYMDTAGPAAEE
                     FSSRAKEFAFYHQGYAAGPYHHHQPVPGYLDMPVVPGLGGPGESRHEPLGLPMESYQP
                     WALPNGWNGQMYCPKEQTQPPHLWKSTLPDVVSHPSDASSYRRGRKKRVPYTKVQLKE
                     LEREYATNKFITKDKRRRISATTNLSERQVTIWFQNRRVKEKKVINKLKTTS"
     exon            940..1412
                     /gene="Hoxa13"
                     /gene_synonym="RGD1562483"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttctcca tgcggctcgg gctatgacag cctccgtgct cctccacccc cgctggatcg
       61 agcccaccgt catgtttctc tacgacaacg gcggcggcct ggtggccgac gagctcaaca
      121 agaacatgga aggggcggcg gcggcggcag cggcggcggc agcggcagcg gcggcgggag
      181 ctgggggcgg gggcttcccc cacccggctg cggcggccgc ggggggcaac ttctcggtgg
      241 ccgcagcggc tgccgccgcc gccgccgccg cggccaacca gtgccgcaac ctgatggcgc
      301 atcccgcacc actggcgccg ggcgccgcgg ccgcgtacag cagcgccccg ggggaggcgc
      361 ccccgaccgc cgccgccgcc gccgctgccg ctgctgccgc cgccgccgcc gcggctgccg
      421 cgtcgtcgtc gggagggccc ggaccggcgg ggcccgcggg tgccgaggcc gccaagcagt
      481 gtagtccctg ctcggcggcg gcacaaagct cgtcgggtcc cgcggcgctg ccctatggct
      541 acttcggcag cggctactac ccgtgcgccc gcatgggccc gcaccccaac gccatcaagt
      601 cctgcgcgca gcctgcctcg gctgcggccg ccttcgccga caagtacatg gacaccgccg
      661 gccccgcggc cgaggagttc agctcccgcg ccaaggagtt tgccttctac caccagggct
      721 acgcagccgg gccttaccac caccaccagc ccgtgcccgg ctatctggat atgccagtgg
      781 ttccggggct cgggggtcct ggcgagtcgc gccacgagcc tctggggctt cctatggaaa
      841 gctatcagcc ctgggctctg cccaacggct ggaacggcca aatgtactgc cccaaagagc
      901 agacgcagcc tccccacctc tggaagtcca ctctgcccga cgtcgtctcc catccttcag
      961 acgccagctc ctataggagg gggagaaaga agcgggtgcc ttacactaag gtgcagttga
     1021 aagaactcga acgggaatac gctacgaaca aattcattac caaggacaaa cggaggagga
     1081 tatcagccac aacgaacctc tctgagaggc aggtcacaat ctggttccag aacaggaggg
     1141 tcaaagagaa aaaagtcatc aataaactca agaccacgag ttaatggatt aaaatgcgga
     1201 gtagagggca gcttgaagaa acgcgtaagg acttgtttct ttgcccagat cataagaatg
     1261 cgtaataata actgaagaat gggatagaga gacactgacg ttttgctctc ctaaggggac
     1321 tcctcttcaa tggaatctac aattaaaaaa aaaaaactta agaaatggta aagattgcca
     1381 gttctcccga caaacccacc agaccgttaa gt
//
