LOCUS       NM_001401619            1949 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus HORMA domain containing 2 (Hormad2), transcript
            variant 1, mRNA.
ACCESSION   NM_001401619 XM_017599331
VERSION     NM_001401619.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1949)
  AUTHORS   Jordan,P.W., Karppinen,J. and Handel,M.A.
  TITLE     Polo-like kinase is required for synaptonemal complex disassembly
            and phosphorylation in mouse spermatocytes
  JOURNAL   J Cell Sci 125 (Pt 21), 5061-5072 (2012)
   PUBMED   22854038
REFERENCE   2  (bases 1 to 1949)
  AUTHORS   Kogo,H., Tsutsumi,M., Inagaki,H., Ohye,T., Kiyonari,H. and
            Kurahashi,H.
  TITLE     HORMAD2 is essential for synapsis surveillance during meiotic
            prophase via the recruitment of ATR activity
  JOURNAL   Genes Cells 17 (11), 897-912 (2012)
   PUBMED   23039116
REFERENCE   3  (bases 1 to 1949)
  AUTHORS   Wojtasz,L., Cloutier,J.M., Baumann,M., Daniel,K., Varga,J., Fu,J.,
            Anastassiadis,K., Stewart,A.F., Remenyi,A., Turner,J.M. and Toth,A.
  TITLE     Meiotic DNA double-strand breaks and chromosome asynapsis in mice
            are monitored by distinct HORMAD2-independent and -dependent
            mechanisms
  JOURNAL   Genes Dev 26 (9), 958-973 (2012)
   PUBMED   22549958
REFERENCE   4  (bases 1 to 1949)
  AUTHORS   Wojtasz,L., Daniel,K., Roig,I., Bolcun-Filas,E., Xu,H.,
            Boonsanay,V., Eckmann,C.R., Cooke,H.J., Jasin,M., Keeney,S.,
            McKay,M.J. and Toth,A.
  TITLE     Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal
            proteins, are depleted from synapsed chromosome axes with the help
            of TRIP13 AAA-ATPase
  JOURNAL   PLoS Genet 5 (10), e1000702 (2009)
   PUBMED   19851446
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Feb 16, 2022 this sequence version replaced XM_017599331.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.57755.1,
                                           SRR26360181.1259543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000014.1  83523243-83523450   c
            209-296             JAXUCZ010000014.1  83517798-83517885   c
            297-438             JAXUCZ010000014.1  83511564-83511705   c
            439-502             JAXUCZ010000014.1  83509148-83509211   c
            503-539             JAXUCZ010000014.1  83508646-83508682   c
            540-560             JAXUCZ010000014.1  83505772-83505792   c
            561-587             JAXUCZ010000014.1  83505075-83505101   c
            588-655             JAXUCZ010000014.1  83497716-83497783   c
            656-807             JAXUCZ010000014.1  83494695-83494846   c
            808-1112            JAXUCZ010000014.1  83494224-83494528   c
            1113-1949           JAXUCZ010000014.1  83438563-83439399   c
FEATURES             Location/Qualifiers
     source          1..1949
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1949
                     /gene="Hormad2"
                     /note="HORMA domain containing 2"
                     /db_xref="GeneID:498400"
                     /db_xref="RGD:1565447"
     exon            1..208
                     /gene="Hormad2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..296
                     /gene="Hormad2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1217
                     /gene="Hormad2"
                     /note="isoform 1 is encoded by transcript variant 1; HORMA
                     domain-containing protein 2"
                     /codon_start=1
                     /product="HORMA domain-containing protein 2 isoform 1"
                     /protein_id="NP_001388548.1"
                     /db_xref="GeneID:498400"
                     /db_xref="RGD:1565447"
                     /translation="MATAQLSHNPRTLKASKKTIFPSQITNERESLVMVKKLFATSIS
                     CITYLRGLFPESSYRDRYLDDLSLKILREDKKCPGSLHIIKWIQGCFDALEKRYLHMA
                     VLTLYTNPKEPEKVTEIYQFKFKYTKKGTSMDFDSSSTSFESGAHSKDVKKACSLLIR
                     QLYVLMQNLGPLPNDVILTMKLHYYNSVTPHDYQPPGFKEGVNSHFLLFEGEPVSLQM
                     GSVSSDFHSMKLKVTTEATRMLDGENSVGQDDSTTGIAPQGIDCVSQDNGTTEIAHQG
                     LDWDEEEEASSSQVQRMNFVHIEPSFESTRKKRKVSEPVTIFIPNRK"
     exon            297..438
                     /gene="Hormad2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..502
                     /gene="Hormad2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..539
                     /gene="Hormad2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..560
                     /gene="Hormad2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..587
                     /gene="Hormad2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..655
                     /gene="Hormad2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..807
                     /gene="Hormad2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1112
                     /gene="Hormad2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1949
                     /gene="Hormad2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggctgaggt gaaggcctca ccgcgtgtcc atacgctggg ggtctccaga gacaggcgtt
       61 cgggtgggtt ctgtggtctt cgagttcaga cttctttgtt ctttttaatt gagaggtttg
      121 atttggaagt atttcgtgga actcgaaagc cctcagagta gaagtataat cgtgttgggg
      181 ggatgccaag taggaccgga agctgcaggt tggagttgtt gaacgaatcc tgattcattc
      241 tcacgatggc tactgctcag ctctctcaca accccagaac actgaaggca tctaagaaaa
      301 caattttccc atcccaaatc acaaatgagc gtgagtcact ggtgatggtg aagaaactct
      361 ttgccacctc tatctcgtgt ataacgtatc tgaggggcct gtttccagag agctcttaca
      421 gagatcgcta tttggatgac ctcagtttaa aaattctccg ggaagacaaa aagtgtcctg
      481 ggtcattaca tattattaaa tggattcaag gttgttttga tgctttggaa aagagatacc
      541 tgcacatggc ggtgttaaca ctttacacaa atcccaagga accggagaaa gtgactgaga
      601 tataccaatt caaattcaaa tacacaaaaa agggaaccag tatggacttt gacagcagca
      661 gcacgagctt tgaaagtggg gcacacagta aagatgttaa gaaagcctgc tccctactca
      721 tccgccagtt gtatgtcctg atgcagaacc ttggacccct tcctaatgat gtcatactca
      781 ctatgaaact ccactattat aactcagtga ccccacatga ttaccaaccc cctggtttta
      841 aagaaggggt gaattcacac ttcctattgt ttgagggtga gcccgtgagc cttcaaatgg
      901 gttcagtctc ctctgacttt cacagcatga aattaaaagt cacaactgag gccaccagaa
      961 tgctggatgg ggagaacagt gtcggtcagg acgacagcac tactgggata gcccctcagg
     1021 gtatagactg tgtcagtcag gacaacggca ctactgagat agcccatcag ggtctagact
     1081 gggatgagga agaggaggcc tccagcagcc aagttcaaag aatgaatttt gtgcacattg
     1141 agccaagttt tgaaagcacc aggaagaaga ggaaggtcag cgaaccagtg acaatcttca
     1201 ttccaaacag aaaatgaaac aggtgccttt gctacgcctg tttgcaaaaa catgaaatgt
     1261 cgtaacagga gtcaccaaaa ctttttccta aagcttttgc tcaatttttg actcagtttg
     1321 tgaaggggct aagctattga gcaggtcctg ggttcgcttc tccagaagga aacaagatca
     1381 ccagagctgc cttggcctgg cattatctca cggccgagtt agagatgaga catgctttgt
     1441 gcttgcacga aaacccagca gttattttgg gaagaaatag ctgctgttct taaagaaaag
     1501 gcttttcttt acataattca gttctccagg tatctcgact gctgtgaact actctgactt
     1561 gttataacct gtgtgtggga atccttctgt agctttagta aagctcacac acacagagcc
     1621 gcataggacg tctgaaggtg cttagcccag tgtgagttat atgttgactt cagtctcaag
     1681 gttgatgagg agcgtgcagg tcctgatgcc ctccctgtaa acctcctcag ctctgcctca
     1741 ggcccttttg ttggccaatc ccaaaagctg acatgcagtt caggggcctg gttcccttgt
     1801 aagacctatg ttgagtgttt tccccaaaat acctgccttt atcagtctgt aacttgcagg
     1861 tgatgctatt tgtcctctcc atattctgga agaattttga taggcttaat gattaatgta
     1921 aaatgaataa taaatgactt aaagaattg
//
