LOCUS       NM_001108949            1640 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus HORMA domain containing 1 (Hormad1), mRNA.
ACCESSION   NM_001108949 XM_001060782 XM_345248
VERSION     NM_001108949.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1640)
  AUTHORS   Jordan,P.W., Karppinen,J. and Handel,M.A.
  TITLE     Polo-like kinase is required for synaptonemal complex disassembly
            and phosphorylation in mouse spermatocytes
  JOURNAL   J Cell Sci 125 (Pt 21), 5061-5072 (2012)
   PUBMED   22854038
REFERENCE   2  (bases 1 to 1640)
  AUTHORS   Kogo,H., Tsutsumi,M., Ohye,T., Inagaki,H., Abe,T. and Kurahashi,H.
  TITLE     HORMAD1-dependent checkpoint/surveillance mechanism eliminates
            asynaptic oocytes
  JOURNAL   Genes Cells 17 (6), 439-454 (2012)
   PUBMED   22530760
REFERENCE   3  (bases 1 to 1640)
  AUTHORS   Wojtasz,L., Cloutier,J.M., Baumann,M., Daniel,K., Varga,J., Fu,J.,
            Anastassiadis,K., Stewart,A.F., Remenyi,A., Turner,J.M. and Toth,A.
  TITLE     Meiotic DNA double-strand breaks and chromosome asynapsis in mice
            are monitored by distinct HORMAD2-independent and -dependent
            mechanisms
  JOURNAL   Genes Dev 26 (9), 958-973 (2012)
   PUBMED   22549958
REFERENCE   4  (bases 1 to 1640)
  AUTHORS   Daniel,K., Lange,J., Hached,K., Fu,J., Anastassiadis,K., Roig,I.,
            Cooke,H.J., Stewart,A.F., Wassmann,K., Jasin,M., Keeney,S. and
            Toth,A.
  TITLE     Meiotic homologue alignment and its quality surveillance are
            controlled by mouse HORMAD1
  JOURNAL   Nat Cell Biol 13 (5), 599-610 (2011)
   PUBMED   21478856
REFERENCE   5  (bases 1 to 1640)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   6  (bases 1 to 1640)
  AUTHORS   Shin,Y.H., Choi,Y., Erdin,S.U., Yatsenko,S.A., Kloc,M., Yang,F.,
            Wang,P.J., Meistrich,M.L. and Rajkovic,A.
  TITLE     Hormad1 mutation disrupts synaptonemal complex formation,
            recombination, and chromosome segregation in mammalian meiosis
  JOURNAL   PLoS Genet 6 (11), e1001190 (2010)
   PUBMED   21079677
  REMARK    Erratum:[PLoS Genet. 2011;7(2). doi:
            10.1371/annotation/8aa656b6-55f7-4795-a441-cf243ea62175]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1640)
  AUTHORS   Fukuda,T., Daniel,K., Wojtasz,L., Toth,A. and Hoog,C.
  TITLE     A novel mammalian HORMA domain-containing protein, HORMAD1,
            preferentially associates with unsynapsed meiotic chromosomes
  JOURNAL   Exp Cell Res 316 (2), 158-171 (2010)
   PUBMED   19686734
REFERENCE   8  (bases 1 to 1640)
  AUTHORS   Wojtasz,L., Daniel,K., Roig,I., Bolcun-Filas,E., Xu,H.,
            Boonsanay,V., Eckmann,C.R., Cooke,H.J., Jasin,M., Keeney,S.,
            McKay,M.J. and Toth,A.
  TITLE     Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal
            proteins, are depleted from synapsed chromosome axes with the help
            of TRIP13 AAA-ATPase
  JOURNAL   PLoS Genet 5 (10), e1000702 (2009)
   PUBMED   19851446
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474015.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_345248.3, XM_001060782.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1640
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /note="HORMA domain containing 1"
                     /db_xref="GeneID:365868"
                     /db_xref="RGD:1564960"
     exon            1..59
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            60..112
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1255
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /codon_start=1
                     /product="HORMA domain-containing protein 1"
                     /protein_id="NP_001102419.1"
                     /db_xref="GeneID:365868"
                     /db_xref="RGD:1564960"
                     /translation="MATMQLRRTASMSALVFPNKISTEQQSLMFVKRLLAVSVSCITY
                     LRGIFPERAYGTRYLDDLCVKILKEDKNCPGSSQLVKWMLGCYDALQKKYLRMIILAV
                     YTNPEDPQTISECYQFKFKYTKNGPIMDFISKNQNNKSSTTSADTKKASILLIRKIYV
                     LMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFDGDPTYLNVGEVPT
                     PFHTFRLKVTTEKERMENIDSAILTPKDSKIPFQKILMDKDDVEDENHNNFDIKTKMN
                     EQNENSGTSEIKEPNLDCKEEEIMQFKKNQSSSISQCQVEQLISKTSELDVSESKTRS
                     GKIFQCKMVNGNQQGQISKENRKRSLRQSGKTVLHILESSSQESVLKRRRVSEPNEHT
                     "
     exon            113..257
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            258..321
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            322..358
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            359..379
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            380..406
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            407..474
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            475..626
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            627..874
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            875..941
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1018
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1102
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1174
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1640
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcacttc gagcctcttc cctgtcgctg ctggacgctt ctctcaggcg ttgtgtaaaa
       61 aaatatttct tggaagatgg ccactatgca gttgcggagg acagcttcta tgagtgcatt
      121 ggtatttcct aataagatat caaccgagca gcagtctttg atgtttgtga agaggctcct
      181 ggctgtttca gtatcctgca ttacctattt gagaggaata tttccagaac gtgcttatgg
      241 gacaagatat ctggatgatc tctgtgtcaa aattctgaaa gaagataaaa attgtccagg
      301 ttcttcacag ctagttaagt ggatgctagg atgctatgat gctctacaga agaaatatct
      361 aaggatgatc attctagccg tatataccaa tccagaagat cctcagacaa tttcagaatg
      421 ttaccagttt aaattcaagt acaccaaaaa tggaccaatc atggacttta taagcaaaaa
      481 tcaaaacaat aaatctagta caacatctgc tgacaccaag aaagcaagta ttctcctcat
      541 tcggaagatt tatgtcctaa tgcaaaatct agggccatta cctaatgatg tttgtctgac
      601 catgaaactt ttttactacg atgaagttac acccccagat taccagccac caggttttaa
      661 ggatggtgat tgtgaaggag taatatttga tggggaccct acatacttaa atgtgggaga
      721 agtcccaaca ccttttcaca ccttcagatt aaaagtgacc actgagaagg aacgaatgga
      781 aaatattgat tcagccatac taacaccaaa agattcaaaa ataccatttc aaaaaattct
      841 aatggacaaa gatgatgtag aagatgaaaa tcataataat tttgatatta aaactaaaat
      901 gaacgaacag aatgaaaact ctggaacttc tgaaatcaaa gaaccaaatt tagattgtaa
      961 ggaagaagaa attatgcaat tcaaaaagaa ccaaagttct tcaatttctc agtgtcaggt
     1021 tgaacagtta atcagtaaaa catctgaact tgatgtgtct gaaagcaaaa caagaagtgg
     1081 aaaaatcttt cagtgtaaaa tggtaaatgg aaatcaacaa ggacaaattt ctaaagaaaa
     1141 tcggaagaga agtcttcgtc aatctgggaa aacagtcctt catatcttgg aatcttctag
     1201 tcaagagtcg gtgctgaaga gaaggagagt tagtgaacca aatgaacata cctaaaaatt
     1261 atttttctta tgcagattac agttctcaac atttaaacta acatgctgta ttatttgaag
     1321 gtgtgccttc tgtactgctg aaaattactt tgtagttcac agttattaat ctaatgaaag
     1381 ttttagctat tatattgtgt ctacctgtga taaatccaag ggaacttttg actaaacaaa
     1441 aatacaaatg tcatcaattc tgctcatatc cactgaatac aacctgcctt ccattttaaa
     1501 gaaaactttt tataaaatgt gttaagtttt aagaccctct aaaaccattg tttattctgg
     1561 cattgaaatt ttgtaaggat tcacttttta cttatgttaa aactgtacca tttaattggt
     1621 gctattaaaa taatgtttgc
//
