LOCUS       NP_001102419             392 aa            linear   ROD 30-JUL-2024
DEFINITION  HORMA domain-containing protein 1 [Rattus norvegicus].
ACCESSION   NP_001102419 XP_001060782 XP_345249
VERSION     NP_001102419.1
DBSOURCE    REFSEQ: accession NM_001108949.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 392)
  AUTHORS   Jordan,P.W., Karppinen,J. and Handel,M.A.
  TITLE     Polo-like kinase is required for synaptonemal complex disassembly
            and phosphorylation in mouse spermatocytes
  JOURNAL   J Cell Sci 125 (Pt 21), 5061-5072 (2012)
   PUBMED   22854038
REFERENCE   2  (residues 1 to 392)
  AUTHORS   Kogo,H., Tsutsumi,M., Ohye,T., Inagaki,H., Abe,T. and Kurahashi,H.
  TITLE     HORMAD1-dependent checkpoint/surveillance mechanism eliminates
            asynaptic oocytes
  JOURNAL   Genes Cells 17 (6), 439-454 (2012)
   PUBMED   22530760
REFERENCE   3  (residues 1 to 392)
  AUTHORS   Wojtasz,L., Cloutier,J.M., Baumann,M., Daniel,K., Varga,J., Fu,J.,
            Anastassiadis,K., Stewart,A.F., Remenyi,A., Turner,J.M. and Toth,A.
  TITLE     Meiotic DNA double-strand breaks and chromosome asynapsis in mice
            are monitored by distinct HORMAD2-independent and -dependent
            mechanisms
  JOURNAL   Genes Dev 26 (9), 958-973 (2012)
   PUBMED   22549958
REFERENCE   4  (residues 1 to 392)
  AUTHORS   Daniel,K., Lange,J., Hached,K., Fu,J., Anastassiadis,K., Roig,I.,
            Cooke,H.J., Stewart,A.F., Wassmann,K., Jasin,M., Keeney,S. and
            Toth,A.
  TITLE     Meiotic homologue alignment and its quality surveillance are
            controlled by mouse HORMAD1
  JOURNAL   Nat Cell Biol 13 (5), 599-610 (2011)
   PUBMED   21478856
REFERENCE   5  (residues 1 to 392)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   6  (residues 1 to 392)
  AUTHORS   Shin,Y.H., Choi,Y., Erdin,S.U., Yatsenko,S.A., Kloc,M., Yang,F.,
            Wang,P.J., Meistrich,M.L. and Rajkovic,A.
  TITLE     Hormad1 mutation disrupts synaptonemal complex formation,
            recombination, and chromosome segregation in mammalian meiosis
  JOURNAL   PLoS Genet 6 (11), e1001190 (2010)
   PUBMED   21079677
  REMARK    Erratum:[PLoS Genet. 2011;7(2). doi:
            10.1371/annotation/8aa656b6-55f7-4795-a441-cf243ea62175]
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 392)
  AUTHORS   Fukuda,T., Daniel,K., Wojtasz,L., Toth,A. and Hoog,C.
  TITLE     A novel mammalian HORMA domain-containing protein, HORMAD1,
            preferentially associates with unsynapsed meiotic chromosomes
  JOURNAL   Exp Cell Res 316 (2), 158-171 (2010)
   PUBMED   19686734
REFERENCE   8  (residues 1 to 392)
  AUTHORS   Wojtasz,L., Daniel,K., Roig,I., Bolcun-Filas,E., Xu,H.,
            Boonsanay,V., Eckmann,C.R., Cooke,H.J., Jasin,M., Keeney,S.,
            McKay,M.J. and Toth,A.
  TITLE     Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal
            proteins, are depleted from synapsed chromosome axes with the help
            of TRIP13 AAA-ATPase
  JOURNAL   PLoS Genet 5 (10), e1000702 (2009)
   PUBMED   19851446
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474015.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_345249.3, XP_001060782.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     Protein         1..392
                     /product="HORMA domain-containing protein 1"
                     /calculated_mol_wt=44754
     Region          27..221
                     /region_name="HORMA"
                     /note="HORMA domain; pfam02301"
                     /db_xref="CDD:460526"
     Region          271..292
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZWE7.1)"
     Region          371..392
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZWE7.1)"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9D5T7; propagated from
                     UniProtKB/Swiss-Prot (D3ZWE7.1)"
     Region          381..384
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZWE7.1)"
     CDS             1..392
                     /gene="Hormad1"
                     /gene_synonym="RGD1564960"
                     /coded_by="NM_001108949.1:77..1255"
                     /db_xref="GeneID:365868"
                     /db_xref="RGD:1564960"
ORIGIN      
        1 matmqlrrta smsalvfpnk isteqqslmf vkrllavsvs citylrgifp eraygtryld
       61 dlcvkilked kncpgssqlv kwmlgcydal qkkylrmiil avytnpedpq tisecyqfkf
      121 kytkngpimd fisknqnnks sttsadtkka sillirkiyv lmqnlgplpn dvcltmklfy
      181 ydevtppdyq ppgfkdgdce gvifdgdpty lnvgevptpf htfrlkvtte kermenidsa
      241 iltpkdskip fqkilmdkdd vedenhnnfd iktkmneqne nsgtseikep nldckeeeim
      301 qfkknqsssi sqcqveqlis ktseldvses ktrsgkifqc kmvngnqqgq iskenrkrsl
      361 rqsgktvlhi lesssqesvl krrrvsepne ht
//
