LOCUS       NM_001136098            2893 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hook microtubule-tethering protein 3 (Hook3),
            mRNA.
ACCESSION   NM_001136098 XM_001062163 XM_224952
VERSION     NM_001136098.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2893)
  AUTHORS   Schroeder,C.M. and Vale,R.D.
  TITLE     Assembly and activation of dynein-dynactin by the cargo adaptor
            protein Hook3
  JOURNAL   J Cell Biol 214 (3), 309-318 (2016)
   PUBMED   27482052
REFERENCE   2  (bases 1 to 2893)
  AUTHORS   Ge,X., Frank,C.L., Calderon de Anda,F. and Tsai,L.H.
  TITLE     Hook3 interacts with PCM1 to regulate pericentriolar material
            assembly and the timing of neurogenesis
  JOURNAL   Neuron 65 (2), 191-203 (2010)
   PUBMED   20152126
REFERENCE   3  (bases 1 to 2893)
  AUTHORS   Xu,L., Sowa,M.E., Chen,J., Li,X., Gygi,S.P. and Harper,J.W.
  TITLE     An FTS/Hook/p107(FHIP) complex interacts with and promotes
            endosomal clustering by the homotypic vacuolar protein sorting
            complex
  JOURNAL   Mol Biol Cell 19 (12), 5059-5071 (2008)
   PUBMED   18799622
REFERENCE   4  (bases 1 to 2893)
  AUTHORS   Sano,H., Ishino,M., Kramer,H., Shimizu,T., Mitsuzawa,H.,
            Nishitani,C. and Kuroki,Y.
  TITLE     The microtubule-binding protein Hook3 interacts with a cytoplasmic
            domain of scavenger receptor A
  JOURNAL   J Biol Chem 282 (11), 7973-7981 (2007)
   PUBMED   17237231
  REMARK    GeneRIF: Hook3 interacts with a cytoplasmic domain of scavenger
            receptor A
REFERENCE   5  (bases 1 to 2893)
  AUTHORS   Walenta,J.H., Didier,A.J., Liu,X. and Kramer,H.
  TITLE     The Golgi-associated hook3 protein is a member of a novel family of
            microtubule-binding proteins
  JOURNAL   J Cell Biol 152 (5), 923-934 (2001)
   PUBMED   11238449
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473970.2.
            
            On or before Oct 23, 2008 this sequence version replaced
            XM_224952.4, XM_001062163.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2893
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2893
                     /gene="Hook3"
                     /note="hook microtubule-tethering protein 3"
                     /db_xref="GeneID:306548"
                     /db_xref="RGD:1560960"
     exon            1..187
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2287
                     /gene="Hook3"
                     /codon_start=1
                     /product="protein Hook homolog 3"
                     /protein_id="NP_001129570.1"
                     /db_xref="GeneID:306548"
                     /db_xref="RGD:1560960"
                     /translation="MFNVESVERVELCESLLTWIQTFNVDTPCQTVEDLTNGVVMSQV
                     LQKIDPAYFDDNWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPD
                     VNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSK
                     ESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLA
                     ENQILMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELE
                     KEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLR
                     RQVKLLEEKNTMYMQNTVSLEEELRKANAARGQLETYKRQVVELQNRLSDESKKADKL
                     DFEYKRLKEKVDGLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQES
                     SDSLAAEIVTPEIREKLIRLQHENKMLKINQEGSDNEKIALLQSLLDDANLRKNELET
                     ENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKR
                     AIIEDLEPRFNNSSLRIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQ
                     GAAPEIQALKNQLQERDRLFHSLEKEYEKTKTQRDMEEKYIVSAWYNMGMTLHKKAAE
                     DRLASTGSGQSFLARQRQATSTRRSYPGHVQPATAR"
     exon            188..273
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            274..346
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            347..397
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            398..530
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            531..598
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            599..661
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            662..745
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            746..909
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1050
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1252
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1363
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1451
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1521
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1662
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1750
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1785
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1868
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1969
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2074
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2146
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2893
                     /gene="Hook3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggagcggc cggacggaag agaaggttcg ccagacgccg gtcggctgcc tgacccttcg
       61 gactcaaccc cgagccgagc ggccgcggct tctggttggt tgaggagacg cctgcggcca
      121 cctcaggaag atgtttaacg tggagtctgt ggagcgggtg gagctgtgcg agagcctgct
      181 cacttggatc cagaccttta atgtggatac accatgccag acggtggaag acttaacaaa
      241 tggggttgtg atgtcccagg ttcttcagaa gatagatcct gcatatttcg atgataattg
      301 gctgaacaga atcaagactg aagtaggaga caactggagg ttaaagatta gcaacttaaa
      361 gaaaatttta aaaggcatct tggattataa tcatgagatt ttagggcagc agattaatga
      421 ttttaccctt cctgatgtga accttattgg ggagcattcg gatgcagcag agctcgggag
      481 gatgctccag ctcattctag gctgtgctgt gaactgtgaa cagaagcaag agtacattca
      541 agccattatg atgatggagg agtctgttca gcatgtcgtc atgacagcca tccaagagct
      601 aatgagtaaa gagtctcccg tctctgctgg aaatgatgcc tatgttgatc tcgatcgcca
      661 gttgaagaaa actacagaag aactaaatga agctttgtca gcgaaggaag aaattgctca
      721 aaggtgccat gaattggata tgcaggttgc agcactgcaa gaggagaaga gtagtttatt
      781 ggcagaaaat cagatattaa tggaacgact caatcaatct gattctatag aagatcccaa
      841 tagtccagca ggaagaagac atttgcaact tcagacccag ttagaacagc tgcaagaaga
      901 aacattcaga ctagaagcag ccaaagacga ttatcgaata cgctgtgagg agttagaaaa
      961 ggaaatctct gagcttcggc aacagaacga tgaactaacc actttggccg atgaggctca
     1021 gtctctaaag gatgaaatag atgttctcag acactcttct gataaagtat ctaaactaga
     1081 aggtcaggtc gaatcttata aaaagaagct ggaagacctt ggagatttga gacggcaggt
     1141 taaactccta gaagagaaga atacgatgta catgcagaac actgtcagcc tggaggagga
     1201 actgaggaaa gctaatgccg cccgtggtca gctcgagacg tacaagagac aggttgtaga
     1261 actgcaaaat agattatctg acgaatcaaa gaaagcagat aagttagatt ttgaatataa
     1321 gcggctaaag gaaaaagttg atggtcttca gaaagaaaag gataggttac gaacggaaag
     1381 ggattctctg aaggaaacca ttgaagagct gcgttgtgtg caggctcagg aggggcagct
     1441 caccactcaa gggttaatgc ctctgggaag ccaggagtct tcagacagcc ttgcagcaga
     1501 gattgtcaca ccggaaatca gggagaaact tattcgtctt cagcatgaga ataagatgtt
     1561 aaaaatcaac caagagggtt cagacaatga gaaaattgcc ttattgcaga gccttctaga
     1621 tgatgcaaat cttcgcaaga atgagctgga gacagagaac aggcttgtga atcagagact
     1681 tctggaagta cagtcacaag tagaagaact gcaaaaatct ttgcaggatc aaggctcaaa
     1741 agcagaagat tcagttcttc taaaaaagaa gcttgaagaa catctagaga agctgcatga
     1801 agccaacaat gaattacaga aaaagagagc cattattgaa gatctcgagc caagatttaa
     1861 caacagctcc ttaagaattg aagaattgca agaagcttta cggaagaaag aagaagaaat
     1921 gaagcaaatg gaagaacgct ataaaaaata cctggaaaaa gccaaaagtg ttatccgtac
     1981 attagaccct aaacagaatc aaggagcagc accagaaata caggcactta aaaaccaact
     2041 gcaggagcgc gatcggctct tccactcatt agagaaagaa tatgagaaaa cgaagactca
     2101 aagagacatg gaggagaaat acattgttag tgcctggtac aatatgggga tgacactaca
     2161 taaaaaggcg gctgaagaca gactagctag cacaggttca gggcagtcgt ttctggctag
     2221 gcaaagacaa gcaaccagca caagaagatc ctacccaggc catgtccagc cagccacagc
     2281 caggtagaaa ggtcttgtcc ggggagtttt taaaaagcat acttctgtta cacatgacaa
     2341 catttcagga aattcagcca gcttgtttaa tttctcacct gtgttaatac ttagtgtttc
     2401 tcacgtgaag atttctctct ctcgtatctt ttagttactt tgtcctttac tttatggtct
     2461 tttcagttcc ttttaatgtg ccaaaaattt gtaaatgtac aattaaaagt gttgtataat
     2521 agtgtaatac tttttctttg tatgaaaatg tcttcttccc catttgtgtg ggctttgtaa
     2581 agaattggat tttctgccaa taattgatac acaatttata ttctttatcg tgcctactgt
     2641 gttaccatac tttataagaa tgtctttgtt taaagggaat taatcttttt atggtgtatt
     2701 aatctgtgtt ttcgattgtt ttccaatgca cttcagataa cttaaatatt tactgtacta
     2761 tacgaagtga tgtcagatgc acgttttgca aagacaaata cattggcaga ggtgctagtc
     2821 agcctggggc acctggcaag gtcactcaga ggggaggaat taaacttatt ctaagttcaa
     2881 ttatattgga gtt
//
