LOCUS       NM_001100562            2613 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus hook microtubule-tethering protein 2 (Hook2),
            transcript variant 2, mRNA.
ACCESSION   NM_001100562
VERSION     NM_001100562.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2613)
  AUTHORS   Xu L, Sowa ME, Chen J, Li X, Gygi SP and Harper JW.
  TITLE     An FTS/Hook/p107(FHIP) complex interacts with and promotes
            endosomal clustering by the homotypic vacuolar protein sorting
            complex
  JOURNAL   Mol Biol Cell 19 (12), 5059-5071 (2008)
   PUBMED   18799622
REFERENCE   2  (bases 1 to 2613)
  AUTHORS   Szebenyi G, Hall B, Yu R, Hashim AI and Kramer H.
  TITLE     Hook2 localizes to the centrosome, binds directly to
            centriolin/CEP110 and contributes to centrosomal function
  JOURNAL   Traffic 8 (1), 32-46 (2007)
   PUBMED   17140400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB696289.1, CB785578.1, CB548211.1, BC099235.1 and BQ203898.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CB696289.1         3-19
            18-392              CB785578.1         58-432
            393-424             CB696289.1         394-425
            425-462             CB548211.1         37-74
            463-2505            BC099235.1         1-2043
            2506-2613           BQ203898.1         1-108               c
FEATURES             Location/Qualifiers
     source          1..2613
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2613
                     /gene="Hook2"
                     /note="hook microtubule-tethering protein 2"
                     /db_xref="GeneID:304669"
                     /db_xref="RGD:1310171"
     exon            1..128
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2243
                     /gene="Hook2"
                     /note="isoform 2 is encoded by transcript variant 2; hook
                     homolog 2"
                     /codon_start=1
                     /product="protein Hook homolog 2 isoform 2"
                     /protein_id="NP_001094032.1"
                     /db_xref="GeneID:304669"
                     /db_xref="RGD:1310171"
                     /translation="MSMDKAELCGSLLTWLQTFQVSPPCASPQDLSSGLAIAHVLNQI
                     DPSWFNDAWLQGISEDPSPSWRLKVRKLERILQSLVEYSKDVLGHPVSHQHLPDVSLI
                     GEFSNPAELGKLLQLVLACAISCEKKQEYIQRIMMLEESVQHVVMEAIQELMTKDTPD
                     SLSPENYGNFDTQSRRYYFLSEEVEEGGDLQQHYLDLERQLVLLSEEKQSLAQENAAL
                     RERVGRSEVESASGLTAKKLLLLQSQLEQLQEENFRLESSREDERLRCVELEREVAEL
                     QQRNQALASLSQEAQALKDEMDELRQSSERARQLEATLNSCRRRLGELQELRRQVRQL
                     EERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVRQMQELQGQWQEEAMKAEKWLFE
                     CQNLEEKCDLLTKEKERLLTERDSLRETNEELRCAQLQPRGLNQAGLSLDPTPSGLEN
                     LAAEILPAELRETLVRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLEAQQRL
                     NQQQLSELRAQVEELQKALQEQGGKTDDPTLLKRKLEDHLQKLHEADLELQRKREYIE
                     ELEPPTDSNTRRIEELQDSLQKKDADLRAMEERYRRYVDKARTVIQTLEPKQRPPSVV
                     SPEFHTLRSQLWERNMRIRQLEMDYEKSRSRQEQEEKLLISAWYSMGMALEHRAGEEH
                     APAHAQSFLAQQRLATNARRGPLGRQASLSLRPTDKH"
     exon            129..214
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            215..287
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..338
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            339..471
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..539
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..602
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..683
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..844
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..985
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1196
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1307
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1395
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1465
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1603
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1691
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1726
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1809
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1910
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2021
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2093
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2596
                     /gene="Hook2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcggccgct cgctggtggc ggacccggag gctgctgctg cgtgccgggg ctccttggcc
       61 cggatcgaat tcgatccgga gccatgagta tggacaaggc cgagctatgc gggtctctgc
      121 tcacctggtt gcagacgttt caagtttcgc ccccctgtgc cagtccccag gacctgagca
      181 gcggactcgc catagcccat gtgctgaatc agatagaccc ttcctggttc aacgacgcat
      241 ggctccaagg catctcagag gacccgagtc ccagctggag gttgaaggtc aggaagctgg
      301 agaggatcct acagagcttg gtggaatact caaaggatgt tctggggcac cctgtgtcac
      361 atcagcatct tccagatgtg agcctcatcg gcgagttctc aaaccccgca gaactcggca
      421 aactgcttca gttggtactg gcctgtgcta tcagttgtga gaaaaagcag gagtatatcc
      481 aaagaattat gatgctggag gaatctgttc aacatgttgt gatggaagcc atccaggagc
      541 tcatgaccaa agacacacct gattccctgt caccagagaa ttacgggaac tttgatacac
      601 agtcccgcag gtactatttc ctgagcgagg aggtggaaga gggtggcgat cttcagcaac
      661 actacctgga tctggagcgg cagcttgtgc tcctttcaga ggagaagcag agtctggcac
      721 aagagaatgc tgccctacgg gagagggtgg gccggtcgga agtggagagt gcctcaggcc
      781 tcaccgccaa gaagctgttg cttctgcagt cacagctaga acagctccag gaggagaatt
      841 tcaggctgga gagtagccgg gaagatgagc ggctacgctg cgtggaactg gagcgtgagg
      901 tcgctgagct gcagcaacgg aaccaagccc tggccagctt atcccaggag gcgcaagcgc
      961 tgaaggatga gatggatgag ctccgacagt cctccgaacg tgcaaggcag ctggaggcca
     1021 ctctgaacag ctgccgtcgt cgcctgggtg agctccagga gctccggcgg caggtgcggc
     1081 agctggagga gcgaaatgca gggcacgcgg agcgcacgcg gcagctggag gatgagctgc
     1141 gccgggccgg atccctgcgt gcccagctcg aggctcagcg caggcaggta aggcagatgc
     1201 aagagttgca gggccagtgg caggaggagg ccatgaaggc tgagaagtgg ctgttcgaat
     1261 gccaaaacct agaggaaaag tgtgacctgt tgacaaaaga gaaggagcgg ctgttgactg
     1321 agagggactc cctgagggag accaatgagg agctccgatg tgcccagttg cagcccaggg
     1381 gattgaatca ggctggcctc tccctggatc ctaccccttc tggcctggag aacttagcag
     1441 cagagatcct gcctgcagag ctcagagaga cactcgtgcg gcttcagctg gagaacaaga
     1501 gactgtgcca gcaagaggct gcggaccggg agcgacagga ggaactgcag cgccacctgg
     1561 aggaggccaa ccgtgcacgc catgggctgg aagcgcagca acggctgaac cagcagcagc
     1621 tttctgagct gagggcccag gtggaagagc tacagaaggc cttgcaggag caggggggca
     1681 agacagacga ccccaccctg ctgaagcgga agctggagga tcatctgcag aagctgcatg
     1741 aggctgatct ggagcttcag aggaaacggg aatacattga ggagttggag cctcccacgg
     1801 acagcaacac taggcggatc gaggagctgc aggacagtct gcagaagaag gatgcagacc
     1861 tgcgggccat ggaggaacga taccgccgct acgtggacaa ggcacgcacg gtcattcaga
     1921 ccctggaacc caagcagagg ccacccagtg tggtgtcccc agaattccat actctaaggt
     1981 cacagctctg ggagcggaac atgcgaatac ggcagctgga gatggactat gagaagagtc
     2041 ggagtcggca ggagcaggag gaaaagctgc tcatcagtgc ctggtacagc atgggcatgg
     2101 ccttggagca tcgggctggg gaagagcatg cccctgccca tgcccagtcc ttcctggcac
     2161 agcaaagact ggccaccaat gctcgccgag gacccctggg gcgccaggca tctctgagcc
     2221 ttcgccccac tgacaagcac tgacagacct cgacttcctg ctgcctgctg aagtcttcca
     2281 gtttacattt acccaggctg gggctttgac ctcgatggag actgacttct gccctctgct
     2341 tccttagatg ggagagaagg ggaaggcagg tggcaggtgt aggactattc cttttagcaa
     2401 tgtgattctt cttgattctt ctcctgggcc tcatgtacta cctgggaaga gcctgatttt
     2461 atatttgaaa aaaaaaataa agactttaaa tctgtcttga atgtactcta gacacaatgg
     2521 tgaggaataa aaattgcact agggacacag acggttactt ttaaaataaa tgtatgagca
     2581 tttttgccca tctgtaaaaa aaaaaaaaaa aaa
//
