LOCUS       NM_001107946            5475 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus hook microtubule-tethering protein 1 (Hook1),
            mRNA.
ACCESSION   NM_001107946 XM_001054663 XM_233196
VERSION     NM_001107946.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5475)
  AUTHORS   Olenick MA, Dominguez R and Holzbaur ELF.
  TITLE     Dynein activator Hook1 is required for trafficking of
            BDNF-signaling endosomes in neurons
  JOURNAL   J Cell Biol 218 (1), 220-233 (2019)
   PUBMED   30373907
  REMARK    GeneRIF: It has been found that the dynein effector Hook1 mediates
            transport of TrkB-BDNF-signaling endosomes in primary hippocampal
            neurons.
REFERENCE   2  (bases 1 to 5475)
  AUTHORS   Xu L, Sowa ME, Chen J, Li X, Gygi SP and Harper JW.
  TITLE     An FTS/Hook/p107(FHIP) complex interacts with and promotes
            endosomal clustering by the homotypic vacuolar protein sorting
            complex
  JOURNAL   Mol Biol Cell 19 (12), 5059-5071 (2008)
   PUBMED   18799622
REFERENCE   3  (bases 1 to 5475)
  AUTHORS   Moreno RD, Palomino J and Schatten G.
  TITLE     Assembly of spermatid acrosome depends on microtubule organization
            during mammalian spermiogenesis
  JOURNAL   Dev Biol 293 (1), 218-227 (2006)
   PUBMED   16540102
REFERENCE   4  (bases 1 to 5475)
  AUTHORS   Luiro K, Yliannala K, Ahtiainen L, Maunu H, Jarvela I, Kyttala A
            and Jalanko A.
  TITLE     Interconnections of CLN3, Hook1 and Rab proteins link Batten
            disease to defects in the endocytic pathway
  JOURNAL   Hum Mol Genet 13 (23), 3017-3027 (2004)
   PUBMED   15471887
REFERENCE   5  (bases 1 to 5475)
  AUTHORS   Richardson SC, Winistorfer SC, Poupon V, Luzio JP and Piper RC.
  TITLE     Mammalian late vacuole protein sorting orthologues participate in
            early endosomal fusion and interact with the cytoskeleton
  JOURNAL   Mol Biol Cell 15 (3), 1197-1210 (2004)
   PUBMED   14668490
REFERENCE   6  (bases 1 to 5475)
  AUTHORS   Mendoza-Lujambio I, Burfeind P, Dixkens C, Meinhardt A,
            Hoyer-Fender S, Engel W and Neesen J.
  TITLE     The Hook1 gene is non-functional in the abnormal spermatozoon head
            shape (azh) mutant mouse
  JOURNAL   Hum Mol Genet 11 (14), 1647-1658 (2002)
   PUBMED   12075009
REFERENCE   7  (bases 1 to 5475)
  AUTHORS   Schumacher JM, Artzt K and Braun RE.
  TITLE     Spermatid perinuclear ribonucleic acid-binding protein binds
            microtubules in vitro and associates with abnormal manchettes in
            vivo in mice
  JOURNAL   Biol Reprod 59 (1), 69-76 (1998)
   PUBMED   9674995
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473998.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_233196.4, XM_001054663.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132293 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..5475
                     /gene="Hook1"
                     /note="hook microtubule-tethering protein 1"
                     /db_xref="GeneID:313370"
                     /db_xref="RGD:1309987"
     exon            1..316
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..2440
                     /gene="Hook1"
                     /note="hook homolog 1"
                     /codon_start=1
                     /product="protein Hook homolog 1"
                     /protein_id="NP_001101416.1"
                     /db_xref="GeneID:313370"
                     /db_xref="RGD:1309987"
                     /translation="MEDPQPLPQPELPLCDSLIIWLQTFKTASPCQDVKQLTNGVTMA
                     QVLHQIDVAWFSESWLSRIKDDVGDNWRIKASNLKKVLHGITSYYHEFLGQQISEELI
                     PDLNQITESSDPVELGRLLQLILGCAVNCEKKQEHIKNIMTLEESVQHVVMTAIQELM
                     SKEIVSSPASDAVGELEQQLKRALEELQEALAEKEELKQRCQELDMQVTALQDEKNSL
                     VSENEMMNEKLDQLDGSFDDPNTMVAKKYFHVQLQLEQLQEENYRLEAAKDDYRVHCE
                     ELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEVYRQKLQDLN
                     DLRKQVKSLQETNMMYMHNTVSLEEELKKANAARAQLETYKRQVQDLHTKLSSESKRA
                     DTLAFEMKRLEEKHETLLKEKERLIEQRDTLKETNEELRCSKAQQDHLNQADSSATKS
                     YENLAAEIMPVEYREVFIRLQHENKMLRLQQEGTENERIEQLQEQLEQKHRKMNELET
                     EQRLSKERIGELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQK
                     KQELIEDLQPDISQNAQKISELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKL
                     NPASAEIMLLRKQLAEKDRRIEILESECKVAKFRDYEEKLIVSAWYNKSLAFQKLGME
                     SRLVSGASACKDSVAAAPARSFLAQQRHITSTRRNLSVKVPAAASD"
     exon            317..402
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..475
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..526
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..659
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..727
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..790
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..874
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1041
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1182
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1384
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1495
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1583
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1644
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1785
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1879
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1914
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..1997
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2098
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2200
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2269
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..5475
                     /gene="Hook1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgctcgcag aggtcactca gcttgcggtg tgcgatcggc gggcggggct ggctcaggtg
       61 ccgcggcgcg ggacggacgc ggtgggccag ggggcggtcg cgccgcgacg tttgcggcgt
      121 gaggcttcgc gcgtgaacgg cgcgggcgcc gggcctggcc gccgagctcc agtggcgggc
      181 gcggaggtcg ttgacgcggg ctcgggtgga ggcgcgtccg tcgctgtgag cgcggcgtcg
      241 aggttctcgg accatggagg acccgcagcc gctgccacag cctgagctgc cgctgtgtga
      301 cagcctcatc atctggctgc agacatttaa gactgcctca ccctgtcaag atgtcaaaca
      361 gctgactaat ggagtgacca tggcacaagt tcttcatcaa attgacgtag cttggttcag
      421 cgaatcttgg ttaagccgaa ttaaagatga tgttggagac aactggagaa taaaggctag
      481 taacctaaag aaggtcctcc atggaattac aagttactat catgagtttt tggggcagca
      541 gatttctgaa gaacttattc ctgatttaaa tcaaataact gagagctcag atcctgtgga
      601 gcttgggaga ttgcttcagc taattctagg atgcgcagtc aactgtgaga agaaacaaga
      661 acatattaaa aatataatga ccctggaaga atctgttcaa catgtggtca tgactgcaat
      721 tcaggagttg atgagtaaag aaatagtgag ctctcctgca agtgacgctg taggagaatt
      781 agagcagcag ctaaaaaggg ctttagaaga gcttcaggag gccctagcag aaaaggaaga
      841 gctgaagcag aggtgccagg aactggatat gcaggtaact gcacttcagg atgagaagaa
      901 ttccctggtc tctgagaatg agatgatgaa tgaaaagctt gaccagttgg atggctcttt
      961 tgatgaccca aatacaatgg ttgcaaagaa gtattttcac gtacagctgc aactagaaca
     1021 attacaagaa gaaaactata gacttgaagc tgcaaaagat gattaccgtg ttcactgtga
     1081 ggaactggaa aagcagctga ttgaatttca gcacaggaac gatgagctga cgagccttgc
     1141 tgaggagacc agagccctaa aagacgagat agatgttctt agggctacct cagacaaagc
     1201 aaataagctg gagtcaacag tggaggtgta tcgtcagaag ctccaggacc taaatgacct
     1261 ccgcaagcag gtgaaatcct tacaggagac aaatatgatg tatatgcaca acactgtgag
     1321 cttggaagaa gagctgaaga aggccaatgc agctcgtgca cagctagaga cctataagcg
     1381 ccaggttcag gaccttcaca ctaagctttc ctctgaatcc aaaagggcag atacactagc
     1441 attcgaaatg aagaggcttg aagagaaaca cgaaacttta ctcaaggaaa aagagcgatt
     1501 gatagaacag cgtgacactc tgaaagagac gaatgaggag ctgcggtgct caaaagcaca
     1561 acaagatcac ctaaatcaag ctgattcatc tgctacaaaa agttatgaaa atcttgctgc
     1621 tgagatcatg ccagtggagt acagagaggt gttcattcga ctccagcatg aaaacaaaat
     1681 gcttcgcctg cagcaagaag ggacggagaa tgagcgcatc gagcagctgc aggagcagtt
     1741 ggaacagaaa caccgcaaga tgaacgagct ggaaactgag caaaggttga gcaaagagcg
     1801 cattggagaa ctacagcagc aaattgagga cctccagaag tcgttacaag aacagggctc
     1861 taagtctgaa ggtgaaagtt ccagcaaatt aaagcagaag ttggaagctc atatggaaaa
     1921 actaacagaa gtccatgaag aattacagaa gaaacaggag ctcattgaag accttcagcc
     1981 agatataagt cagaatgccc aaaagatcag tgaacttgaa gcggctcttc agaagaaaga
     2041 tgaagacatg aaagcgatgg aggagagata caaaatgtac ttagagaaag ccaggaatgt
     2101 cattaaaact ttagatccca aattaaatcc agcatcagca gaaataatgt tactgagaaa
     2161 gcagctggcg gagaaggaca gaagaattga aattctagag agtgaatgta aagtggcaaa
     2221 attcagggat tatgaggaaa aactcattgt ttctgcctgg tataacaaga gcctggcctt
     2281 tcagaaactg ggcatggaat ctcggctggt gagcggtgct agtgcttgca aagacagcgt
     2341 cgcggctgct cccgcgcgct ccttcttagc acagcagcgg cacatcacca gcacccgaag
     2401 aaacctctct gtgaaagtcc cagctgcggc gtctgactag tctgcaaagc aaacacaaca
     2461 gaagtgcctc agaatgtctg taccccaagg aactaccaga tagaaaacaa aggttaagat
     2521 gcttggtagc agctagtttt attttggttt cgctttgaga cagggtctca taaccccaaa
     2581 atggcataga attcacaata tattcaagga tgatcttgaa catctgatca atccttccta
     2641 ccgttcctgt gcactgggat taatagacaa cacttgtaga ctaccgtatc aagtttatat
     2701 agttctaggg atcaaaatca attgctctac taattgagct accttcccaa cctcagaatc
     2761 aactgtattt aagtcaaaat atatcaaatc aacatttcca gcttacttag aaagcaaagt
     2821 acagactcag ctctgtctct gggcagcaca ttggagtagt tggaagtgtg atgaagtaaa
     2881 tacttgtctt gaaatggcat catcatcatc atcatgtgtg ggaaagcaaa tgcagattcc
     2941 aactttgttt ttagttgtga cagcaagtca gttaatttgc aagaagtaat cagtagtttg
     3001 tcatttacta tctagattaa ccttatggaa aagtttccag ttaggcatgt ggtgaaaaac
     3061 tgttgcaggt gaattcctta gactgttgtg tagttgcctc tgtagttaat tctgccctct
     3121 agaggatgct tcgggtgctg tggaaacgac agagctggga aactgctgtt gtagtgactt
     3181 tgtccttaaa agtgacaaac gcgcagcttc tctgagttgg atgccccttt gaacatggat
     3241 tgctgtgaat gagtgtggac caaagggtta agatgggaaa taaactgaca tttatatttc
     3301 tgatgaaaag caaactacac tttgaaatgt ccacatgcct ttaagtatgc actgttgtgg
     3361 gctttgcttt ctaagaagaa attttgcctc tttattgaaa agaaacagtg atgaaacagc
     3421 ttatagccag attggtttct gctttcctct aaggagtgtc tggagctgta tttgtggcat
     3481 tcagttcatg tctgcccaag gatgtctgtt ccagaggtgt tactttccaa tttggggtca
     3541 ctttttaaag tcacagcttt ggaatattag ttgttaaatc agtattgctt aatgtagcca
     3601 caaatggttc attcttgtgt tggtcacact tccaacactt actagccaca tttttctctc
     3661 attgttgaga gttcttgtgc agtgagtcac agtaagtctt ggtttttgat gacttcctta
     3721 gactacaaat gtaggaagtg tacatccatt tcccatgtac agaggaatca gatggtgaca
     3781 agagcgtagc aaacacaagt gagacaacgt tgtgtctacc ccaaacattc ccaatcataa
     3841 tgtgaaggag caaacttgtg agctgcttga tccttgtgaa tcagctcctc acctctgtcc
     3901 tcgtagcata aaagaaggga gttgtcatat gtaagcaaaa tggggtggtg gtagctgagt
     3961 aaggcagatt gagctggcag gctgtggggc tgtggtctac atctaattct tagtcctttg
     4021 cagatatgag tattgttcta tttgcagtat taactcattt agataactgc ctataaatcc
     4081 ttgcacagta acttttaacc tcttaaaata taagaatttc acagtgattt ggggtctttg
     4141 agattagtgg catctgccag gatattttgt tttatcaggg ttccttctgt tgactacctc
     4201 ttagattttg atgattcttg tctgtatttt acactgttgg tttgtatttt gtatgttctt
     4261 acagtgtctg cttgcctatg tcttttagtg aaataagact ttgaaattat tagcatgcta
     4321 tttaacattt ttctaaaaat tatgacattt gggtatattt ttgtcaatga agacattgat
     4381 ggtagtgttt gtatttgctt ataattgaga ttttataagt acccttttaa tggagctgac
     4441 tgtaaaacat caacttcaat aaatttgttt ctagtacaat tgctcataaa tttctaagta
     4501 agtaatatag cacaaataag gacataagga tgatttcttt tttcttaatt aaaaaaaagc
     4561 aaattttctg atttttctag ttttaagtag aattttgaat gtttgataca tgtttataca
     4621 aaactagtgt aaagttctat atcatctaga ttaatcacag aaatccaggc tgtgatcagg
     4681 gtgagattct ttccttgtat agtttatgca gtgagactgg tgccctacca ggtagaagtc
     4741 agatctggaa ccatgctttt ccaagaggat tgaagggaag attgaatgca taagcagggg
     4801 tttgtcccag tgactataaa gttagaaaca accttgaatt tcaagtggtt gtccttggag
     4861 tgatactcct ttctcttttt ggatataatt atgacactga tgtttatctt gggattaact
     4921 taatgtattg agacatattt gaagtttatt ctattttttt aatgatttga ctaatgattt
     4981 aatgtaagta aaaaatgtct tgcctagcaa cctttagctg agtatacttt aataataaat
     5041 atctggtctt tgatgactgg atgttaaaaa cttcacaacc acatgtactt ctgtataatg
     5101 gtgtatctgg cattttgggg atgatggtgg tttgggccag agtactgaca ttttgtgtaa
     5161 aaatgaatgt atatggcttg ttatacattc agtcttactg tgatcctgtt tgttgcacag
     5221 aaatagtttg gacatttata aagcacaagt catcagagga aatagtgtgt agttattaaa
     5281 cttgaggaag tttcagtgta gcgtttagtt tattcaaaag gtcccttcta ttttctatgg
     5341 caaatgctgt cacacttgaa aactagaagc aatacttgat ttatttttgt aagtatttag
     5401 aatattattt taaataaata attgtcaata taattgtgaa atgttttaag taaataaacg
     5461 tctgcttctg agtca
//
