LOCUS       NP_690062                553 aa            linear   ROD 27-APR-2025
DEFINITION  homeobox and leucine zipper protein Homez [Rattus norvegicus].
ACCESSION   NP_690062
VERSION     NP_690062.3
DBSOURCE    REFSEQ: accession NM_152849.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 553)
  AUTHORS   Bayarsaihan,D., Enkhmandakh,B., Makeyev,A., Greally,J.M.,
            Leckman,J.F. and Ruddle,F.H.
  TITLE     Homez, a homeobox leucine zipper gene specific to the vertebrate
            lineage
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10358-10363 (2003)
   PUBMED   12925734
  REMARK    GeneRIF: Homez is a homeobox leucine zipper gene specific to the
            vertebrate lineage.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC084701.1.
            
            On Sep 13, 2012 this sequence version replaced NP_690062.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC084701.1, BC085694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     Protein         1..553
                     /product="homeobox and leucine zipper protein Homez"
                     /note="homeodomain leucine zipper-containing factor;
                     homeodomain leucine zipper-encoding; homeodomain-leucine
                     zipper protein HOMEZ"
                     /calculated_mol_wt=61757
     Region          62..109
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Region          346..403
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Site            order(346..349,351,368,374,387,389..390,393..394,396..398,
                     400..401)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(347,350,390,393..394,397)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Region          448..495
                     /region_name="Homez"
                     /note="Homeodomain leucine-zipper encoding, Homez;
                     pfam11569"
                     /db_xref="CDD:463297"
     CDS             1..553
                     /gene="Homez"
                     /coded_by="NM_152849.2:26..1687"
                     /db_xref="GeneID:260325"
                     /db_xref="RGD:628904"
ORIGIN      
        1 mrtrhperav segykseqvm spnkdsssln ssgaglvclp pvseelqlvw tqavqtseld
       61 gnehllqafs yfpypsladi allclrhglq mekvktwfma qrlrcgisws seeieetrar
      121 vvyhrdqllf ksllsfthha vrppqemppv tppeqvalgl rplalseptq mkglkvepee
      181 pfqvsqlpln hqkvkeplmm gsrtlnhqsd cqdlqisgls keqagggpdq scgggtaswn
      241 hsiavhqpdk splislldns ckeesepsgt ppsssasspf qvlangttat pkplqplgyi
      301 pqsfspseqa lspqveplws qrlrnnsvps rvgpteylsp dmqhqrktkr ktkeqlailk
      361 sfflqcqwar redyhkleqi tglprpeiiq wfgdtryalk hgqlkwfrdn avlgtpsfqd
      421 paistsstrs lkewaktppl papppppdir plerywaahq qlqeadilkl sqasrlstqq
      481 vldwfdsrlp kpaevvvcld eeeeeedeel pedgeeeeee eeeedddgls cgqkdhgllt
      541 ngavergsll tvg
//
