LOCUS       NM_053309               2269 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus homer scaffold protein 2 (Homer2), mRNA.
ACCESSION   NM_053309 XM_579550
VERSION     NM_053309.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Haider,A., Woodward,N.C., Lominac,K.D., Sacramento,A.D.,
            Klugmann,M., Bell,R.L. and Szumlinski,K.K.
  TITLE     Homer2 within the nucleus accumbens core bidirectionally regulates
            alcohol intake by both P and Wistar rats
  JOURNAL   Alcohol 49 (6), 533-542 (2015)
   PUBMED   26254965
  REMARK    GeneRIF: In alcohol-preferring rats, Homer2b expression in the
            nucleus accumbens regulates alcohol consumption.
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Azaiez,H., Decker,A.R., Booth,K.T., Simpson,A.C., Shearer,A.E.,
            Huygen,P.L., Bu,F., Hildebrand,M.S., Ranum,P.T., Shibata,S.B.,
            Turner,A., Zhang,Y., Kimberling,W.J., Cornell,R.A. and Smith,R.J.
  TITLE     HOMER2, a stereociliary scaffolding protein, is essential for
            normal hearing in humans and mice
  JOURNAL   PLoS Genet 11 (3), e1005137 (2015)
   PUBMED   25816005
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Tao-Cheng,J.H., Thein,S., Yang,Y., Reese,T.S. and Gallant,P.E.
  TITLE     Homer is concentrated at the postsynaptic density and does not
            redistribute after acute synaptic stimulation
  JOURNAL   Neuroscience 266, 80-90 (2014)
   PUBMED   24530450
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Bortoloso,E., Megighian,A., Furlan,S., Gorza,L. and Volpe,P.
  TITLE     Homer 2 antagonizes protein degradation in slow-twitch skeletal
            muscles
  JOURNAL   Am J Physiol Cell Physiol 304 (1), C68-C77 (2013)
   PUBMED   23076792
  REMARK    GeneRIF: Homer 2 is required for trophic homeostasis of slow-twitch
            skeletal muscles; Homer isoform 1b/c is identical irrespective of
            the muscle, while Homer 2a/b is characteristic of the slow-twitch
            phenotype.
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Hong,Q., Zhang,M., Pan,X.Q., Guo,M., Li,F., Tong,M.L., Chen,R.H.,
            Guo,X.R. and Chi,X.
  TITLE     Prefrontal cortex Homer expression in an animal model of
            attention-deficit/hyperactivity disorder
  JOURNAL   J Neurol Sci 287 (1-2), 205-211 (2009)
   PUBMED   19709672
  REMARK    GeneRIF: It is plausible that Homer 1a and Homer 2a/b may be
            involved in the etiology and pathogenesis of ADHD. Future work will
            focus on elucidating the specific mechanisms of Homer 1a and Homer
            2a/b in ADHD.
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Shin,D.M., Dehoff,M., Luo,X., Kang,S.H., Tu,J., Nayak,S.K.,
            Ross,E.M., Worley,P.F. and Muallem,S.
  TITLE     Homer 2 tunes G protein-coupled receptors stimulus intensity by
            regulating RGS proteins and PLCbeta GAP activities
  JOURNAL   J Cell Biol 162 (2), 293-303 (2003)
   PUBMED   12860966
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   Shiraishi,Y., Mizutani,A., Bito,H., Fujisawa,K., Narumiya,S.,
            Mikoshiba,K. and Furuichi,T.
  TITLE     Cupidin, an isoform of Homer/Vesl, interacts with the actin
            cytoskeleton and activated rho family small GTPases and is
            expressed in developing mouse cerebellar granule cells
  JOURNAL   J Neurosci 19 (19), 8389-8400 (1999)
   PUBMED   10493740
REFERENCE   8  (bases 1 to 2269)
  AUTHORS   Tu,J.C., Xiao,B., Yuan,J.P., Lanahan,A.A., Leoffert,K., Li,M.,
            Linden,D.J. and Worley,P.F.
  TITLE     Homer binds a novel proline-rich motif and links group 1
            metabotropic glutamate receptors with IP3 receptors
  JOURNAL   Neuron 21 (4), 717-726 (1998)
   PUBMED   9808459
REFERENCE   9  (bases 1 to 2269)
  AUTHORS   Xiao,B., Tu,J.C., Petralia,R.S., Yuan,J.P., Doan,A., Breder,C.D.,
            Ruggiero,A., Lanahan,A.A., Wenthold,R.J. and Worley,P.F.
  TITLE     Homer regulates the association of group 1 metabotropic glutamate
            receptors with multivalent complexes of homer-related, synaptic
            proteins
  JOURNAL   Neuron 21 (4), 707-716 (1998)
   PUBMED   9808458
REFERENCE   10 (bases 1 to 2269)
  AUTHORS   Kato,A., Ozawa,F., Saitoh,Y., Fukazawa,Y., Sugiyama,H. and
            Inokuchi,K.
  TITLE     Novel members of the Vesl/Homer family of PDZ proteins that bind
            metabotropic glutamate receptors
  JOURNAL   J Biol Chem 273 (37), 23969-23975 (1998)
   PUBMED   9727012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 24, 2020 this sequence version replaced NM_053309.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007689.1, SRR26643297.2479.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000001.1  145068728-145068997 c
            271-427             JAXUCZ010000001.1  145009337-145009493 c
            428-559             JAXUCZ010000001.1  144997119-144997250 c
            560-652             JAXUCZ010000001.1  144988029-144988121 c
            653-792             JAXUCZ010000001.1  144985079-144985218 c
            793-949             JAXUCZ010000001.1  144981480-144981636 c
            950-1060            JAXUCZ010000001.1  144979494-144979604 c
            1061-1141           JAXUCZ010000001.1  144978562-144978642 c
            1142-2269           JAXUCZ010000001.1  144976642-144977769 c
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2269
                     /gene="Homer2"
                     /gene_synonym="Vesl-2"
                     /note="homer scaffold protein 2"
                     /db_xref="GeneID:29547"
                     /db_xref="RGD:620705"
     exon            1..270
                     /gene="Homer2"
                     /gene_synonym="Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..1330
                     /gene="Homer2"
                     /gene_synonym="Vesl-2"
                     /function="bind to mGluR1/5"
                     /note="cupidin; homer-2; VASP/Ena-related gene
                     up-regulated during seizure and LTP 2; homer, neuronal
                     immediate early gene, 2; homer homolog 2; homer
                     scaffolding protein 2"
                     /codon_start=1
                     /product="homer protein homolog 2"
                     /protein_id="NP_445761.1"
                     /db_xref="GeneID:29547"
                     /db_xref="RGD:620705"
                     /translation="MGEQPIFTTRAHVFQIDPSTKKNWVPASKQAVTVSYFYDVTRNS
                     YRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEK
                     FQEVREAARLARDKSQEKIETSSNHSQESGCETPSSTQASSVNGTDDEKASHASPADT
                     HLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC
                     RDENDRLRSKIEELEEQCGEINREKEKNTQLKRRIEELESEVREKEMELKDLRKQSEI
                     IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKGELKSFLEVLD
                     GKIDDLHDFRRGLSKLGTDN"
     exon            271..427
                     /gene="Homer2"
                     /gene_synonym="Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..559
                     /gene="Homer2"
                     /gene_synonym="Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..652
                     /gene="Homer2"
                     /gene_synonym="Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..792
                     /gene="Homer2"
                     /gene_synonym="Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..949
                     /gene="Homer2"
                     /gene_synonym="Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1060
                     /gene="Homer2"
                     /gene_synonym="Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1141
                     /gene="Homer2"
                     /gene_synonym="Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..2269
                     /gene="Homer2"
                     /gene_synonym="Vesl-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggaggga ccggcggctc cgcccgagcg cggccgccca gccccgggcc gcccagccgc
       61 ccagcccccg ccctcccgcc ggcccgcgcc tggcggcggc cccgacaccg acagagcagc
      121 cgcgctgccg gcggaatgga gcggcgccgg ggctgagccg ggcgcactcg ggccgccgca
      181 tgtgccgcgc ggggagcagc tgccgagcgg gcggagagcg aacgccaggg gccccgtcgg
      241 agcggccaca ggagcagcgc cggagatggg agagcagccc atcttcacca cgcgagcgca
      301 cgtcttccag attgacccca gcaccaagaa gaactgggtg ccggcaagca agcaggccgt
      361 cactgtttcc tacttctacg atgtcaccag gaacagctat cggatcatca gtgtggatgg
      421 agccaaggta atcataaaca gcaccatcac cccgaacatg acgttcacca aaacttcaca
      481 gaagttcggg cagtgggctg acagcagggc caacaccgtg ttcggtctgg gattctcctc
      541 agagcagcag ctcacaaagt ttgcagagaa attccaggag gtaagagaag ctgccaggtt
      601 agccagagac aagtcccagg agaaaatcga gacgtcaagt aatcattccc aagaatctgg
      661 gtgtgaaacc ccgtcttcca ctcaggcatc cagcgtcaat gggacagatg acgagaaagc
      721 ctcccatgcg agtccggccg acacacacct caagtctgag aatgacaagc tgaagatcgc
      781 tttgacacag agtgctgcca atgtgaagaa gtgggagatc gagctgcaga ccctgcggga
      841 gagcaatgcc cggctgacca ccgcgctgca ggagtcggcg gccagtgtag aacagtggaa
      901 gcggcaattc tccatctgca gagatgagaa tgacaggctc cgcagcaaga ttgaggagct
      961 ggaagaacag tgcggtgaga tcaacaggga gaaggaaaag aacacccagc tgaagaggag
     1021 gattgaggag ctggagtcag aggtccgaga aaaggaaatg gagttgaagg atctccgcaa
     1081 acaaagtgaa atcatacctc agctcatgtc cgagtgtgaa tatgtctctg agaagttaga
     1141 ggctgcagaa agagacaatc aaaacttgga agacaaagtg cggtctctaa agacagacat
     1201 cgaggagagt aaataccggc agcgccacct gaagggggag ctcaagagct tccttgaggt
     1261 gctggacgga aagatcgatg acctccacga cttccgccga gggctctcca agctaggcac
     1321 ggataactag ggtggggcgg agcctagatg gagagtggaa agcgtgtgtg agagatgaag
     1381 tggacatagg gcattctccg tttgcttctg taatgcgggt gcgttctgtc tgtctccagg
     1441 ccagtcgtgc cgtccactcg ctcctccaga atagaaaatc tcttgcttct ctggctttgt
     1501 gaggtcgtgg acacctggaa gcttctgact caggaatcca gaacggtcta ccttagccgt
     1561 ttacgcagtc agggcaggga cattcagatc ttcccttaag ggctgttgca accctatgaa
     1621 ctggggatgg gggaagtatt ttctaatcca agtatcatta acctttacaa caggcctttg
     1681 ggcgccttcc gctgcgtggc actcagtgtg taagactcta gattccagac cgggagcacg
     1741 tggagggaac atcttttccc aggatgcatt ctgttccttt agcagaggta gctaaccttt
     1801 cgaagttatg acagatttca cactcaaaaa ctgcacaatt gatctaccca aaaagaaata
     1861 attattaaaa aaaaaaaaac cctaacatat tttaagtaaa tacactgttt tgggttggag
     1921 cgcattcata gttaccctca gctgcatgtg gcctttggac tgtaggccac acaaacctac
     1981 ttgaaaggaa ccatttaatg gagacttgtc cagtgggaag acaaaccaga agttttggcg
     2041 tgcgcttact gacaaggaat tacttgtacc tactctgacc catcctcccc tgatttgtca
     2101 cggttgcaac aatgtttttt tgtttgtttg ttttgttttt gttttgtttg ctttcctttt
     2161 taaatttcag aacagatgct tgagctgttg gaacagaatg cagggagggt gtctagcaca
     2221 gtctgggcac ataataggtg cttaataaac attcgttcac ttaaacata
//
