LOCUS       NM_031707               4051 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus homer scaffold protein 1 (Homer1), mRNA.
ACCESSION   NM_031707 XM_001068911
VERSION     NM_031707.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4051)
  AUTHORS   Iasevoli,F., Buonaguro,E.F., Avagliano,C., Barone,A., Eramo,A.,
            Vellucci,L. and de Bartolomeis,A.
  TITLE     The Effects of Antipsychotics on the Synaptic Plasticity Gene
            Homer1a Depend on a Combination of Their Receptor Profile, Dose,
            Duration of Treatment, and Brain Regions Targeted
  JOURNAL   Int J Mol Sci 21 (15), 5555 (2020)
   PUBMED   32756473
  REMARK    GeneRIF: The Effects of Antipsychotics on the Synaptic Plasticity
            Gene Homer1a Depend on a Combination of Their Receptor Profile,
            Dose, Duration of Treatment, and Brain Regions Targeted.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4051)
  AUTHORS   Wang,Y., Zhao,M., Shang,L., Zhang,Y., Huang,C., He,Z., Luo,M.,
            Wu,B., Song,P., Wang,M. and Duan,F.
  TITLE     Homer1a protects against neuronal injury via PI3K/AKT/mTOR
            signaling pathway
  JOURNAL   Int J Neurosci 130 (6), 621-630 (2020)
   PUBMED   32013638
  REMARK    GeneRIF: Homer1a protects against neuronal injury via PI3K/AKT/mTOR
            signaling pathway.
REFERENCE   3  (bases 1 to 4051)
  AUTHORS   Crans,R.A.J., Daelemans,S., Raedt,R., Ciruela,F. and Stove,C.P.
  TITLE     Kainic acid-induced status epilepticus decreases mGlu5 receptor and
            phase-specifically downregulates Homer1b/c expression
  JOURNAL   Brain Res 1730, 146640 (2020)
   PUBMED   31891692
  REMARK    GeneRIF: Kainic acid-induced status epilepticus decreases mGlu5
            receptor and phase-specifically downregulates Homer1b/c expression.
REFERENCE   4  (bases 1 to 4051)
  AUTHORS   Buonaguro,E.F., Morley-Fletcher,S., Avagliano,C., Vellucci,L.,
            Iasevoli,F., Bouwalerh,H., Van Camp,G., Nicoletti,F., Maccari,S.
            and de Bartolomeis,A.
  TITLE     Glutamatergic postsynaptic density in early life stress
            programming: Topographic gene expression of mGlu5 receptors and
            Homer proteins
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 96, 109725 (2020)
   PUBMED   31404590
  REMARK    GeneRIF: Glutamatergic postsynaptic density in early life stress
            programming: Topographic gene expression of mGlu5 receptors and
            Homer proteins.
REFERENCE   5  (bases 1 to 4051)
  AUTHORS   Zhu,L., Zhu,J. and Guo,S.W.
  TITLE     Homer1/mGluR1-mediated ER stress contributes to lysophosphatidic
            acid-induced neurotoxicity in cortical neurons
  JOURNAL   Neurochem Int 129, 104515 (2019)
   PUBMED   31369778
  REMARK    GeneRIF: Lysophosphatidic acid treatment did not alter the
            expression and distribution of Homer1 in cortical neurons.
            Knockdown of Homer1 using specific siRNA partially prevented the
            LPA-induced neurotoxicity and ER stress. LPA induced intracellular
            Ca(2+) release could be partly prevented by downregulation of
            Homer1.
REFERENCE   6  (bases 1 to 4051)
  AUTHORS   Kato,A., Ozawa,F., Saitoh,Y., Fukazawa,Y., Sugiyama,H. and
            Inokuchi,K.
  TITLE     Novel members of the Vesl/Homer family of PDZ proteins that bind
            metabotropic glutamate receptors
  JOURNAL   J Biol Chem 273 (37), 23969-23975 (1998)
   PUBMED   9727012
REFERENCE   7  (bases 1 to 4051)
  AUTHORS   Berke,J.D., Paletzki,R.F., Aronson,G.J., Hyman,S.E. and Gerfen,C.R.
  TITLE     A complex program of striatal gene expression induced by
            dopaminergic stimulation
  JOURNAL   J Neurosci 18 (14), 5301-5310 (1998)
   PUBMED   9651213
REFERENCE   8  (bases 1 to 4051)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   9  (bases 1 to 4051)
  AUTHORS   Kato,A., Ozawa,F., Saitoh,Y., Hirai,K. and Inokuchi,K.
  TITLE     vesl, a gene encoding VASP/Ena family related protein, is
            upregulated during seizure, long-term potentiation and
            synaptogenesis
  JOURNAL   FEBS Lett 412 (1), 183-189 (1997)
   PUBMED   9257717
REFERENCE   10 (bases 1 to 4051)
  AUTHORS   Brakeman,P.R., Lanahan,A.A., O'Brien,R., Roche,K., Barnes,C.A.,
            Huganir,R.L. and Worley,P.F.
  TITLE     Homer: a protein that selectively binds metabotropic glutamate
            receptors
  JOURNAL   Nature 386 (6622), 284-288 (1997)
   PUBMED   9069287
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031707.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017140.1, AB007688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               JAXUCZ010000002.1  26279012-26279310
            300-456             JAXUCZ010000002.1  26318900-26319056
            457-588             JAXUCZ010000002.1  26323602-26323733
            589-681             JAXUCZ010000002.1  26326234-26326326
            682-821             JAXUCZ010000002.1  26333472-26333611
            822-857             JAXUCZ010000002.1  26364664-26364699
            858-1014            JAXUCZ010000002.1  26365746-26365902
            1015-1125           JAXUCZ010000002.1  26368303-26368413
            1126-1206           JAXUCZ010000002.1  26369157-26369237
            1207-4051           JAXUCZ010000002.1  26377711-26380555
FEATURES             Location/Qualifiers
     source          1..4051
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..4051
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /note="homer scaffold protein 1"
                     /db_xref="GeneID:29546"
                     /db_xref="RGD:628725"
     exon            1..299
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1395
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /note="scaffold protein; homer scaffolding protein 1;
                     VASP/Ena-related gene up-regulated during seizure and LTP
                     1; PSD-Zip45; homer, neuronal immediate early gene, 1;
                     homer homolog 1"
                     /codon_start=1
                     /product="homer protein homolog 1"
                     /protein_id="NP_113895.1"
                     /db_xref="GeneID:29546"
                     /db_xref="RGD:628725"
                     /translation="MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNV
                     YRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEK
                     FQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNS
                     EPRAEPAQNALPFSHSAGDRTQGLSHASSAISKHWEAELATLKGNNAKLTAALLESTA
                     NVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHSHKTELSQTVQELEETLKVKE
                     EEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSELEQRLEKSQSEQDAF
                     RSNLKTLLEILDGKIFELTELRDNLAKLLECS"
     exon            300..456
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..588
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..681
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..821
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..857
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1014
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1125
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1206
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..4051
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaagctgg cttttgcgtt tttctacacg tacactaatt ttatggaata gttaaagtgc
       61 tatattctcc gcgcaacctt ttcaaattcc aaatgtttga acgttttggt gtcagcgcga
      121 gtgaaatcat tttaccgaca agaactaact gaattgtctg cctcgttgag ttgcctccgg
      181 aaaagatctc gggggtggaa aagcaactgc aaaataacag acggagaaaa ttccttggaa
      241 gttatttctg tagcataaga gcagaaactt cagagcaagt tttcattggg caaaatgggg
      301 gaacaaccta tcttcagcac tcgagctcat gtcttccaga tcgacccaaa cacaaagaag
      361 aactgggtac ccaccagcaa gcatgcagtt actgtgtctt atttctatga cagcacaagg
      421 aatgtgtata ggataatcag tctagacggc tcaaaggcaa taataaatag caccatcact
      481 ccaaacatga catttactaa aacatctcaa aagtttggcc aatgggctga tagccgggca
      541 aacactgttt atggactggg attctcctct gagcatcatc tctcaaaatt tgcagaaaag
      601 tttcaggaat ttaaagaagc tgctcggctg gcaaaggaga agtcgcagga gaagatggaa
      661 ctgaccagta ccccttcaca ggaatcagca ggaggagatc ttcagtctcc tttaacacca
      721 gaaagtatca atgggacaga tgatgagaga acacccgatg tgacacagaa ctcagagcca
      781 agggctgagc cagctcagaa tgcattgcca ttttcacata gtgccgggga tcgaacccag
      841 ggcctctctc atgctagttc agccatcagc aaacactggg aggctgaact agccacgctc
      901 aaggggaaca atgccaagct caccgcagcg ctgctggagt ccactgccaa cgtgaagcag
      961 tggaagcaac agctggctgc ctaccaggag gaggcagagc ggctgcacaa gcgggtcacg
     1021 gagctggaat gtgttagtag tcaagcaaac gcggtgcaca gccacaagac agagctgagt
     1081 cagacagtgc aggagctgga agagacccta aaagtaaagg aagaggaaat agaaagatta
     1141 aaacaagaaa ttgataacgc cagagaactt caagaacaga gggactcttt gactcagaaa
     1201 ctacaggaag ttgagattcg aaataaagac ctggaggggc agctgtcgga gctggagcag
     1261 cgcctggaga agagccagag cgagcaggac gctttccgca gtaacctgaa gactctccta
     1321 gagattctgg acgggaaaat atttgaacta acagaattgc gggataattt ggccaagcta
     1381 ctagaatgca gctaaagaaa gtgaaatttc agtgccaata gatgaagaga tactgtctgt
     1441 cttcgtagga ctgtttgggc tctgtaccaa gattgcacaa aattttttga atatcattcc
     1501 tccagaagga gggtgttttg aaaattggaa ttgtatattt cagtataaat tttagaattt
     1561 agcttatagc tagttggggg aaaaaaagac atgaaaaact tgaaccacaa attacctcca
     1621 tgtacattgg ccatagttaa ccagaaagtt ataagtagac acttaatgca atcttttccc
     1681 ctgatagtag ccaatgggag aattaacaat gtctgggtcc cttctccttt ttctgttcaa
     1741 cacagtgaag attatctgct ttttaaattt atttacgata tctacagctg tgttttgtgt
     1801 aaaaacttag taatggaagc cctgtctttg ttgttatctg aataatttct caggatattt
     1861 ttttgctgct gagaaagggc cattaccaat taatccttgc caggagttgg ggagctatgt
     1921 ctctaattgg aatcactata actgggtgtc tggagttctt cccttttcgt actgagagtg
     1981 ttctcactct agtgactact ctggtacact ccgtgttctc caatcttgtc tgttgtactt
     2041 tacttttcca tattgactcc atgtatttat gagaagatat tatctcccat tttattatac
     2101 attttgaagc caactaaaca aaggcagctg agtccttcag atatttttct ttttaaattt
     2161 atagtaaatt tgacacagaa ctgaaattca gcagtccgtc tttgacggtt tagtctagca
     2221 atgttaagga tatttagaga aaatatgcag ttacgtttat ttatatattt ggcaagaaat
     2281 tttttctgga tgatcaatgc ttttcaattt atgataaata atggttaggg gcgctgttta
     2341 ttatagataa ttttaaggtg tatagctgtt ttcaaggagg tccactcccg tctagcagcc
     2401 aagcagagga ctgtatctaa atcgtgatcg tggcagatgg gtcttcatag aaaccatgtc
     2461 tttattcaaa cttcataggg caatattttg aactgttacc taggcatttc aaaacaggaa
     2521 ataccgtcaa cagactcttc tccaagagca ggttttactg ttgttttgat gtaattttaa
     2581 gacatttagc aaacatgcat ttctttatat gatacatttc tttcacaaaa caatttaaaa
     2641 gtaagccacg tgctgtctgc tctgcccggg taggaattgc atcagaatac atatatcttg
     2701 ctgtacaatg cctgtgatat tgaagagggt tcttttcatg tatgcttgag tatctaactc
     2761 tggagtcaat gaatgcactg actttttttt ttgttcgtac cccaaatgat tgaattgtta
     2821 agtacaaatt aagcagatta actcattttt tcactcataa acagattctt agtactagtt
     2881 ttgttttata tttatgtgta tgtatgtaaa tacatacata ttaatttata ttagagtgaa
     2941 aaataaattg tttgtttcta acattagttt ctacagtaag gtgtctctga aacatgtgtg
     3001 tcagacactt agccaccatg cattctatgt gctaccccat catgccagtc acctccatcg
     3061 acgttagggt attttcctta cctgtctatt ataaagagaa taacttaggt acacatgctc
     3121 agagccgaga tatttctctg ataaatcagg taataaaatc tatttgatgg gtagaatttt
     3181 gaaaacagac atgattttat ctatgagttt ctgaatatca aagaacacca ggttttcatt
     3241 taaatagagg tctaacacta gggatcaggg aatttagtta tgaagagttt aaaaaaaaaa
     3301 tctaaaaaag taaaaaaaaa acagtataag ctgttgataa ggtaagcaaa ttattttaat
     3361 gatgtaataa aatattttta aattttggca tagtgatcat ttaatgggaa aatactcacc
     3421 aaaatgtctc cacttgaatt gtactgataa tgtgaggcat atgtgtaact caatatatac
     3481 atatacctat atgtatatac agaaattatt tttaatattt tcctactgct gtgaaattta
     3541 aaattggaaa attttgtgag tgttttccat gtccaataga gcctaactgt ttctttttta
     3601 gtaacttaac aatctcttga gggctgcacc tataaagtcc cagcttgtca gtagacatgt
     3661 acagtgtttg ggataaggtg gacacagtgc acatatgagt aagaccttcc tgactatttt
     3721 aaacatcact cacatgagga gagcctctat gctataggtt gtgtgcctac tgtagctttt
     3781 ccatcgctgt attatataga catttgcata ttaaaatttg atttttccca gagataaata
     3841 ttatatagtg tatctatatt tagatcaaac tgtggtaaca tgttgatgag atcatagcgt
     3901 tggggaatgt agcctgaacg tgtggactcg cagagacccc gagggagagc aggggtcaat
     3961 cccatctgtg tataagttat tataactatg aaatcttgta caaaagcaaa aactggaaaa
     4021 aaaaacaaaa atacagtttt tattttgaaa t
//
