LOCUS       NP_113895                366 aa            linear   ROD 01-APR-2024
DEFINITION  homer protein homolog 1 [Rattus norvegicus].
ACCESSION   NP_113895 XP_001068911
VERSION     NP_113895.1
DBSOURCE    REFSEQ: accession NM_031707.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 366)
  AUTHORS   Iasevoli,F., Buonaguro,E.F., Avagliano,C., Barone,A., Eramo,A.,
            Vellucci,L. and de Bartolomeis,A.
  TITLE     The Effects of Antipsychotics on the Synaptic Plasticity Gene
            Homer1a Depend on a Combination of Their Receptor Profile, Dose,
            Duration of Treatment, and Brain Regions Targeted
  JOURNAL   Int J Mol Sci 21 (15), 5555 (2020)
   PUBMED   32756473
  REMARK    GeneRIF: The Effects of Antipsychotics on the Synaptic Plasticity
            Gene Homer1a Depend on a Combination of Their Receptor Profile,
            Dose, Duration of Treatment, and Brain Regions Targeted.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 366)
  AUTHORS   Wang,Y., Zhao,M., Shang,L., Zhang,Y., Huang,C., He,Z., Luo,M.,
            Wu,B., Song,P., Wang,M. and Duan,F.
  TITLE     Homer1a protects against neuronal injury via PI3K/AKT/mTOR
            signaling pathway
  JOURNAL   Int J Neurosci 130 (6), 621-630 (2020)
   PUBMED   32013638
  REMARK    GeneRIF: Homer1a protects against neuronal injury via PI3K/AKT/mTOR
            signaling pathway.
REFERENCE   3  (residues 1 to 366)
  AUTHORS   Crans,R.A.J., Daelemans,S., Raedt,R., Ciruela,F. and Stove,C.P.
  TITLE     Kainic acid-induced status epilepticus decreases mGlu5 receptor and
            phase-specifically downregulates Homer1b/c expression
  JOURNAL   Brain Res 1730, 146640 (2020)
   PUBMED   31891692
  REMARK    GeneRIF: Kainic acid-induced status epilepticus decreases mGlu5
            receptor and phase-specifically downregulates Homer1b/c expression.
REFERENCE   4  (residues 1 to 366)
  AUTHORS   Buonaguro,E.F., Morley-Fletcher,S., Avagliano,C., Vellucci,L.,
            Iasevoli,F., Bouwalerh,H., Van Camp,G., Nicoletti,F., Maccari,S.
            and de Bartolomeis,A.
  TITLE     Glutamatergic postsynaptic density in early life stress
            programming: Topographic gene expression of mGlu5 receptors and
            Homer proteins
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 96, 109725 (2020)
   PUBMED   31404590
  REMARK    GeneRIF: Glutamatergic postsynaptic density in early life stress
            programming: Topographic gene expression of mGlu5 receptors and
            Homer proteins.
REFERENCE   5  (residues 1 to 366)
  AUTHORS   Zhu,L., Zhu,J. and Guo,S.W.
  TITLE     Homer1/mGluR1-mediated ER stress contributes to lysophosphatidic
            acid-induced neurotoxicity in cortical neurons
  JOURNAL   Neurochem Int 129, 104515 (2019)
   PUBMED   31369778
  REMARK    GeneRIF: Lysophosphatidic acid treatment did not alter the
            expression and distribution of Homer1 in cortical neurons.
            Knockdown of Homer1 using specific siRNA partially prevented the
            LPA-induced neurotoxicity and ER stress. LPA induced intracellular
            Ca(2+) release could be partly prevented by downregulation of
            Homer1.
REFERENCE   6  (residues 1 to 366)
  AUTHORS   Kato,A., Ozawa,F., Saitoh,Y., Fukazawa,Y., Sugiyama,H. and
            Inokuchi,K.
  TITLE     Novel members of the Vesl/Homer family of PDZ proteins that bind
            metabotropic glutamate receptors
  JOURNAL   J Biol Chem 273 (37), 23969-23975 (1998)
   PUBMED   9727012
REFERENCE   7  (residues 1 to 366)
  AUTHORS   Berke,J.D., Paletzki,R.F., Aronson,G.J., Hyman,S.E. and Gerfen,C.R.
  TITLE     A complex program of striatal gene expression induced by
            dopaminergic stimulation
  JOURNAL   J Neurosci 18 (14), 5301-5310 (1998)
   PUBMED   9651213
REFERENCE   8  (residues 1 to 366)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   9  (residues 1 to 366)
  AUTHORS   Kato,A., Ozawa,F., Saitoh,Y., Hirai,K. and Inokuchi,K.
  TITLE     vesl, a gene encoding VASP/Ena family related protein, is
            upregulated during seizure, long-term potentiation and
            synaptogenesis
  JOURNAL   FEBS Lett 412 (1), 183-189 (1997)
   PUBMED   9257717
REFERENCE   10 (residues 1 to 366)
  AUTHORS   Brakeman,P.R., Lanahan,A.A., O'Brien,R., Roche,K., Barnes,C.A.,
            Huganir,R.L. and Worley,P.F.
  TITLE     Homer: a protein that selectively binds metabotropic glutamate
            receptors
  JOURNAL   Nature 386 (6622), 284-288 (1997)
   PUBMED   9069287
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jun 25, 2006 this sequence version replaced XP_001068911.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017140.1, AB007688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     Protein         1..366
                     /product="homer protein homolog 1"
                     /note="scaffold protein; homer scaffolding protein 1;
                     VASP/Ena-related gene up-regulated during seizure and LTP
                     1; PSD-Zip45; homer, neuronal immediate early gene, 1;
                     homer homolog 1"
                     /calculated_mol_wt=41174
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylglycine.
                     /evidence=ECO:0000250|UniProtKB:Q86YM7; propagated from
                     UniProtKB/Swiss-Prot (Q9Z214.2)"
     Region          3..111
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Site            order(24,70,74,89)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269917"
     Region          114..189
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z214.2)"
     Region          <197..>364
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          302..366
                     /region_name="Required for tetramerization.
                     /evidence=ECO:0000269|PubMed:19345194"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z214.2)"
     Site            318
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z2Y3; propagated from
                     UniProtKB/Swiss-Prot (Q9Z214.2)"
     CDS             1..366
                     /gene="Homer1"
                     /gene_synonym="HOMER1F; Vesl-1"
                     /coded_by="NM_031707.2:295..1395"
                     /db_xref="GeneID:29546"
                     /db_xref="RGD:628725"
ORIGIN      
        1 mgeqpifstr ahvfqidpnt kknwvptskh avtvsyfyds trnvyriisl dgskaiinst
       61 itpnmtftkt sqkfgqwads rantvyglgf ssehhlskfa ekfqefkeaa rlakeksqek
      121 meltstpsqe saggdlqspl tpesingtdd ertpdvtqns epraepaqna lpfshsagdr
      181 tqglshassa iskhweaela tlkgnnaklt aallestanv kqwkqqlaay qeeaerlhkr
      241 vtelecvssq anavhshkte lsqtvqelee tlkvkeeeie rlkqeidnar elqeqrdslt
      301 qklqeveirn kdlegqlsel eqrleksqse qdafrsnlkt lleildgkif eltelrdnla
      361 kllecs
//
