LOCUS       NM_001106355            1771 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus 4-hydroxy-2-oxoglutarate aldolase 1 (Hoga1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106355 XM_001058220 XM_215248
VERSION     NM_001106355.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1771)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1771)
  AUTHORS   Monico,C.G., Rossetti,S., Belostotsky,R., Cogal,A.G., Herges,R.M.,
            Seide,B.M., Olson,J.B., Bergstrahl,E.J., Williams,H.J., Haley,W.E.,
            Frishberg,Y. and Milliner,D.S.
  TITLE     Primary hyperoxaluria type III gene HOGA1 (formerly DHDPSL) as a
            possible risk factor for idiopathic calcium oxalate urolithiasis
  JOURNAL   Clin J Am Soc Nephrol 6 (9), 2289-2295 (2011)
   PUBMED   21896830
REFERENCE   3  (bases 1 to 1771)
  AUTHORS   Riedel,T.J., Johnson,L.C., Knight,J., Hantgan,R.R., Holmes,R.P. and
            Lowther,W.T.
  TITLE     Structural and biochemical studies of human
            4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline
            metabolism in primary hyperoxaluria
  JOURNAL   PLoS One 6 (10), e26021 (2011)
   PUBMED   21998747
REFERENCE   4  (bases 1 to 1771)
  AUTHORS   Belostotsky,R., Seboun,E., Idelson,G.H., Milliner,D.S.,
            Becker-Cohen,R., Rinat,C., Monico,C.G., Feinstein,S.,
            Ben-Shalom,E., Magen,D., Weissman,I., Charon,C. and Frishberg,Y.
  TITLE     Mutations in DHDPSL are responsible for primary hyperoxaluria type
            III
  JOURNAL   Am J Hum Genet 87 (3), 392-399 (2010)
   PUBMED   20797690
REFERENCE   5  (bases 1 to 1771)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 1771)
  AUTHORS   MAITRA,U. and DEKKER,E.E.
  TITLE     PURIFICATION AND PROPERTIES OF RAT LIVER 2-KETO-4-HYDROXYGLUTARATE
            ALDOLASE
  JOURNAL   J Biol Chem 239, 1485-1491 (1964)
   PUBMED   14193832
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001058220.1, XM_215248.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210513.1, FQ218423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132284, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1771
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1771
                     /gene="Hoga1"
                     /gene_synonym="Dhdpsl; Npl2; RGD1310475"
                     /note="4-hydroxy-2-oxoglutarate aldolase 1"
                     /db_xref="GeneID:293949"
                     /db_xref="RGD:1310475"
     exon            1..413
                     /gene="Hoga1"
                     /gene_synonym="Dhdpsl; Npl2; RGD1310475"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1186
                     /gene="Hoga1"
                     /gene_synonym="Dhdpsl; Npl2; RGD1310475"
                     /EC_number="4.1.3.16"
                     /note="N-acetylneuraminate pyruvate lyase 2 (putative);
                     probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial;
                     dihydrodipicolinate synthase-like, mitochondrial"
                     /codon_start=1
                     /product="4-hydroxy-2-oxoglutarate aldolase,
                     mitochondrial"
                     /protein_id="NP_001099825.1"
                     /db_xref="GeneID:293949"
                     /db_xref="RGD:1310475"
                     /translation="MLGPQIWASMRQGLSRGLSRNVKGKKIDIAGIYPPVTTPFTATA
                     EVDYGKLEENLNKLAAFPFRGFVVQGSTGEFPFLTSLERLEVVSRVRQAIPKDKLLIA
                     GSGCESTQATVEMTVSMAQVGADAAMVVTPCYYRGRMNSAALIHHYTKVADLSPIPVV
                     LYSVPGNTGLELPVDAVVTLSQHPNIIGLKDSGGDVTRTGLIVHKTSKQDFQVLAGSV
                     GFLLASYAVGAVGGICGLANVLGAQVCQLERLCLTGQGEAAQRLQHRLIEPNTAVTRR
                     FGIPGLKKTMDWFGYYGGPCRAPLQELSPSEEEALRLDFSNNGWL"
     exon            414..542
                     /gene="Hoga1"
                     /gene_synonym="Dhdpsl; Npl2; RGD1310475"
                     /inference="alignment:Splign:2.1.0"
     exon            543..670
                     /gene="Hoga1"
                     /gene_synonym="Dhdpsl; Npl2; RGD1310475"
                     /inference="alignment:Splign:2.1.0"
     exon            671..805
                     /gene="Hoga1"
                     /gene_synonym="Dhdpsl; Npl2; RGD1310475"
                     /inference="alignment:Splign:2.1.0"
     exon            806..902
                     /gene="Hoga1"
                     /gene_synonym="Dhdpsl; Npl2; RGD1310475"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1036
                     /gene="Hoga1"
                     /gene_synonym="Dhdpsl; Npl2; RGD1310475"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1771
                     /gene="Hoga1"
                     /gene_synonym="Dhdpsl; Npl2; RGD1310475"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcggcttc acagcaggga agaaagccta tctggagatt ctaggccggg agactctagg
       61 cccgcccctg accctgggac acgcagtgca aagctgcacc ttgtggtggg aacacaaaat
      121 tttaactggg tatgtagatc attaacagtg gggggagaaa aaagtccaaa ttcagttctc
      181 ctgtggccac agacgactgg gcctcagacc tcctgcagaa atgctgggcc cccaaatctg
      241 ggcctccatg aggcaggggc tgagcagggg cttgtctagg aacgtgaagg ggaagaagat
      301 agacattgcc ggcatctacc cacccgtgac caccccattc accgccaccg cagaagtaga
      361 ctatgggaaa ctggaagaga acctgaacaa actggccgcc ttcccctttc gaggcttcgt
      421 ggtccagggc tctactggag agtttccatt cctgaccagc cttgagcgcc tagaggtggt
      481 gagccgagtg cgccaggcca tacccaagga caagctcctg atagccggct ctggctgcga
      541 gtccacgcaa gccacagtag agatgactgt cagcatggct caggtgggtg ctgatgccgc
      601 catggtggtg accccttgtt actatcgcgg ccgcatgaac agcgctgccc tcattcacca
      661 ctacaccaag gttgctgatc tttctccaat cccggtggtg ctgtacagtg tcccaggcaa
      721 cacgggtcta gagctgcctg tggatgccgt ggtcacattg tctcagcacc caaatatcat
      781 tggcttgaag gacagtggtg gagatgtgac caggactggg ctgattgttc acaagaccag
      841 caagcaggat ttccaggtgt tggctgggtc agttggcttc ctcctggcca gctatgctgt
      901 gggagctgtt gggggcatat gtggcctggc caatgtcttg ggggcccagg tgtgccagct
      961 ggagagactc tgcctcacag ggcaggggga agctgcccag agactgcagc accgcctcat
     1021 cgagcccaac actgcggtga cccggcgctt cggaatacca gggctgaaga aaaccatgga
     1081 ctggtttggc tactatggag gtccctgccg tgcccccttg caggagttga gcccctcaga
     1141 ggaagaggcg cttcgcttgg atttcagcaa caatggctgg ctttaatgac aagcggggga
     1201 cacctggtct gagctgtctc agactctcgt tcccacagtc tgaggaggag cagggcattg
     1261 gaattagggc ttatttttgt ctgtgttcta ttgctgtgaa gagacaccat gaccatgaca
     1321 taaaagagag tgtttaatgg tggctggctc acagtttcag acgttcagtc cattgtcatc
     1381 atggcaggga gcatggcagc ctgcaggcag acagtgctgg agaagtaaca gagaggtcta
     1441 catctagatc cacaggaagc aggaacagaa agctactggg ccttgcttgg acttttgaaa
     1501 aaccaggaag cccacctcca gcaacattga ctccagtaag ctacacttcc taatactttc
     1561 aaatagtatc actccctaag catttatata tgttgggggg gcattcctat tcaaaccacc
     1621 acattctgcc ccctggcctc ataggctggt agccatatca taatgcaaaa tgcatttagt
     1681 ccaacttcaa aattttccat agtctctcac aggctcaaga ctgcttaaaa gtccaaaatt
     1741 caaagtctct tctgaggctc actgtaaaat c
//
