LOCUS       NP_001099825             321 aa            linear   ROD 19-SEP-2024
DEFINITION  4-hydroxy-2-oxoglutarate aldolase, mitochondrial [Rattus
            norvegicus].
ACCESSION   NP_001099825 XP_001058220 XP_215248
VERSION     NP_001099825.1
DBSOURCE    REFSEQ: accession NM_001106355.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 321)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 321)
  AUTHORS   Monico,C.G., Rossetti,S., Belostotsky,R., Cogal,A.G., Herges,R.M.,
            Seide,B.M., Olson,J.B., Bergstrahl,E.J., Williams,H.J., Haley,W.E.,
            Frishberg,Y. and Milliner,D.S.
  TITLE     Primary hyperoxaluria type III gene HOGA1 (formerly DHDPSL) as a
            possible risk factor for idiopathic calcium oxalate urolithiasis
  JOURNAL   Clin J Am Soc Nephrol 6 (9), 2289-2295 (2011)
   PUBMED   21896830
REFERENCE   3  (residues 1 to 321)
  AUTHORS   Riedel,T.J., Johnson,L.C., Knight,J., Hantgan,R.R., Holmes,R.P. and
            Lowther,W.T.
  TITLE     Structural and biochemical studies of human
            4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline
            metabolism in primary hyperoxaluria
  JOURNAL   PLoS One 6 (10), e26021 (2011)
   PUBMED   21998747
REFERENCE   4  (residues 1 to 321)
  AUTHORS   Belostotsky,R., Seboun,E., Idelson,G.H., Milliner,D.S.,
            Becker-Cohen,R., Rinat,C., Monico,C.G., Feinstein,S.,
            Ben-Shalom,E., Magen,D., Weissman,I., Charon,C. and Frishberg,Y.
  TITLE     Mutations in DHDPSL are responsible for primary hyperoxaluria type
            III
  JOURNAL   Am J Hum Genet 87 (3), 392-399 (2010)
   PUBMED   20797690
REFERENCE   5  (residues 1 to 321)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (residues 1 to 321)
  AUTHORS   MAITRA,U. and DEKKER,E.E.
  TITLE     PURIFICATION AND PROPERTIES OF RAT LIVER 2-KETO-4-HYDROXYGLUTARATE
            ALDOLASE
  JOURNAL   J Biol Chem 239, 1485-1491 (1964)
   PUBMED   14193832
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001058220.1, XP_215248.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210513.1, FQ218423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132284, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     Protein         1..321
                     /product="4-hydroxy-2-oxoglutarate aldolase,
                     mitochondrial"
                     /EC_number="4.1.3.16"
                     /note="N-acetylneuraminate pyruvate lyase 2 (putative);
                     probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial;
                     dihydrodipicolinate synthase-like, mitochondrial"
                     /calculated_mol_wt=34334
     Region          32..312
                     /region_name="DHDPS-like"
                     /note="Dihydrodipicolinate synthase family; cd00408"
                     /db_xref="CDD:188630"
     Site            order(35,67,70..72,162,190)
                     /site_type="inhibition"
                     /note="inhibitor site"
                     /db_xref="CDD:188630"
     Site            order(67,70..72,162,190,233)
                     /site_type="active"
                     /db_xref="CDD:188630"
     Site            order(71,76..77,108..109,133..134,143,147,298..299)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:188630"
     Site            190
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:188630"
     CDS             1..321
                     /gene="Hoga1"
                     /gene_synonym="Dhdpsl; Npl2; RGD1310475"
                     /coded_by="NM_001106355.1:221..1186"
                     /db_xref="GeneID:293949"
                     /db_xref="RGD:1310475"
ORIGIN      
        1 mlgpqiwasm rqglsrglsr nvkgkkidia giyppvttpf tataevdygk leenlnklaa
       61 fpfrgfvvqg stgefpflts lerlevvsrv rqaipkdkll iagsgcestq atvemtvsma
      121 qvgadaamvv tpcyyrgrmn saalihhytk vadlspipvv lysvpgntgl elpvdavvtl
      181 sqhpniiglk dsggdvtrtg livhktskqd fqvlagsvgf llasyavgav ggicglanvl
      241 gaqvcqlerl cltgqgeaaq rlqhrliepn tavtrrfgip glkktmdwfg yyggpcrapl
      301 qelspseeea lrldfsnngw l
//
