LOCUS       NM_057139               3380 bp    mRNA    linear   ROD 13-NOV-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein U
            (Hnrnpu), mRNA.
ACCESSION   NM_057139 XM_346451
VERSION     NM_057139.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3380)
  AUTHORS   Liu,J., Ma,X., Guo,W., Lu,B., Yue,Y., Yang,X., Wang,R., Wu,C.,
            Zhang,B., Li,X. and Luo,X.
  TITLE     Deacetylation of HnRNP U mediated by sirtuin1 ameliorates aged rat
            with liver fibrosis via inhibiting p53-related senescence and
            NLRP3-related inflammation
  JOURNAL   Int Immunopharmacol 141, 113026 (2024)
   PUBMED   39216234
  REMARK    GeneRIF: Deacetylation of HnRNP U mediated by sirtuin1 ameliorates
            aged rat with liver fibrosis via inhibiting p53-related senescence
            and NLRP3-related inflammation.
REFERENCE   2  (bases 1 to 3380)
  AUTHORS   Miyaji,M., Kawano,S., Furuta,R., Murakami,E., Ikeda,S.,
            Tsutsui,K.M. and Tsutsui,K.
  TITLE     Selective DNA-binding of SP120 (rat ortholog of human hnRNP U) is
            mediated by arginine-glycine rich domain and modulated by RNA
  JOURNAL   PLoS One 18 (8), e0289599 (2023)
   PUBMED   37540655
  REMARK    GeneRIF: Selective DNA-binding of SP120 (rat ortholog of human
            hnRNP U) is mediated by arginine-glycine rich domain and modulated
            by RNA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3380)
  AUTHORS   Qu,J., Xiong,X., Hujie,G., Ren,J., Yan,L. and Ma,L.
  TITLE     MicroRNA-132-3p alleviates neuron apoptosis and impairments of
            learning and memory abilities in Alzheimer's disease by
            downregulation of HNRNPU stabilized BACE1
  JOURNAL   Cell Cycle 20 (21), 2309-2320 (2021)
   PUBMED   34585626
  REMARK    GeneRIF: MicroRNA-132-3p alleviates neuron apoptosis and
            impairments of learning and memory abilities in Alzheimer's disease
            by downregulation of HNRNPU stabilized BACE1.
REFERENCE   4  (bases 1 to 3380)
  AUTHORS   Majewski,L., Nowak,J., Sobczak,M., Karatsai,O., Havrylov,S.,
            Lenartowski,R., Suszek,M., Lenartowska,M. and Redowicz,M.J.
  TITLE     Myosin VI in the nucleus of neurosecretory PC12 cells:
            Stimulation-dependent nuclear translocation and interaction with
            nuclear proteins
  JOURNAL   Nucleus 9 (1), 125-141 (2018)
   PUBMED   29293066
REFERENCE   5  (bases 1 to 3380)
  AUTHORS   Li,S., Mi,L., Yu,L., Yu,Q., Liu,T., Wang,G.X., Zhao,X.Y., Wu,J. and
            Lin,J.D.
  TITLE     Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and
            beige fat development and thermogenesis
  JOURNAL   Proc Natl Acad Sci U S A 114 (34), E7111-E7120 (2017)
   PUBMED   28784777
REFERENCE   6  (bases 1 to 3380)
  AUTHORS   Malik,K.F., Jaffe,H., Brady,J. and Young,W.S. 3rd.
  TITLE     The class III POU factor Brn-4 interacts with other class III POU
            factors and the heterogeneous nuclear ribonucleoprotein U
  JOURNAL   Brain Res Mol Brain Res 45 (1), 99-107 (1997)
   PUBMED   9105675
REFERENCE   7  (bases 1 to 3380)
  AUTHORS   Jordan,P., Heid,H., Kinzel,V. and Kubler,D.
  TITLE     Major cell surface-located protein substrates of an ecto-protein
            kinase are homologs of known nuclear proteins
  JOURNAL   Biochemistry 33 (49), 14696-14706 (1994)
   PUBMED   7993898
REFERENCE   8  (bases 1 to 3380)
  AUTHORS   Fackelmayer,F.O. and Richter,A.
  TITLE     Purification of two isoforms of hnRNP-U and characterization of
            their nucleic acid binding activity
  JOURNAL   Biochemistry 33 (34), 10416-10422 (1994)
   PUBMED   8068679
REFERENCE   9  (bases 1 to 3380)
  AUTHORS   Fackelmayer,F.O., Dahm,K., Renz,A., Ramsperger,U. and Richter,A.
  TITLE     Nucleic-acid-binding properties of hnRNP-U/SAF-A, a nuclear-matrix
            protein which binds DNA and RNA in vivo and in vitro
  JOURNAL   Eur J Biochem 221 (2), 749-757 (1994)
   PUBMED   8174554
REFERENCE   10 (bases 1 to 3380)
  AUTHORS   Kiledjian,M. and Dreyfuss,G.
  TITLE     Primary structure and binding activity of the hnRNP U protein:
            binding RNA through RGG box
  JOURNAL   EMBO J 11 (7), 2655-2664 (1992)
   PUBMED   1628625
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072529.1.
            
            On Jun 10, 2007 this sequence version replaced NM_057139.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072529.1, D14048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3380
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q25"
     gene            1..3380
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /note="heterogeneous nuclear ribonucleoprotein U"
                     /db_xref="GeneID:117280"
                     /db_xref="RGD:620372"
     exon            1..780
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2564
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /note="system N1 Na+ and H+-coupled glutamine transporter;
                     transporter protein; transporter protein; system N1 Na+
                     and H+-coupled glutamine transporter; scaffold-attachment
                     factor A"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein U"
                     /protein_id="NP_476480.2"
                     /db_xref="GeneID:117280"
                     /db_xref="RGD:620372"
                     /translation="MSSSPVNVKKLKVSELKEELKKRRLSDKGLKADLMDRLQAALDN
                     EAGGRPAMEPGNGSLDLGGDAAGRSGAGLEQEAAAGAEDDEEEEGIAALDGDQMELGE
                     ENGAAGAADAGAMEEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGEQQSQPP
                     AAAQQASQQRGPGKEAAGKSSGPTSLFAVTVAPPGARQGQQQAGGDGKTEQKAGDKKR
                     GVKRPREDHGRGYFEYIEENKYSRAKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFKIS
                     RDRLSASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVR
                     IGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFETDEVE
                     LSYAKNGQDLGVAFKISKEVLADRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEDCTFI
                     QNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIM
                     DKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRK
                     MCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFD
                     EITYVELQKEEAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRG
                     RGGFNMRGGNFRGGAPGNRGGYNRRGNMPQRGGGGGSGGIGYPYPRGPVFPGRGGYSN
                     RGNYNRGGMPNRGNYNQNFRGRGNNRGYKNQSQGYNQWQQGQFWGQKPWSQHYHQGYY
                     "
     exon            781..892
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            893..966
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1106
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1206
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1319
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1583
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1703
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1832
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..2001
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2256
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2438
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2510
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..3347
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAF-A; SN1; SP120"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgcctcgc gaactcggtg aaaggaattg gcgccgttcg acaccaggcg ggtccgttct
       61 gcagcagcac tcagctatct ccagcagcag ccgccgcccg ggccgaccag cagccgccgc
      121 cacaggccga gggagccagc agtcagcggt gaacccgggc cctcaccatg agttcttcgc
      181 ctgttaatgt caagaagctg aaggtgtcgg agctgaagga ggagctcaag aagcggcgcc
      241 tctcagacaa gggcctcaag gccgatctca tggatcgact ccaggccgcg ctggacaacg
      301 aggcaggagg ccgccccgcc atggagcccg ggaacggcag cctcgacctg ggtggcgatg
      361 cggccgggcg ctcgggagca ggcctagagc aggaggccgc ggccggcgcc gaagacgatg
      421 aggaggagga gggcattgcc gctctggacg gcgaccagat ggagctgggc gaggagaacg
      481 gggcggcggg ggcggctgac gcgggcgcga tggaggagga ggaggcggcg tcggaagacg
      541 agaacggcga cgaccagggc ttccaggagg gggaggacga gctcggcgac gaagaggagg
      601 gcgcgggcga cgagaacggc cacggggagc agcagtccca accgccggcg gcggcgcagc
      661 aggcttctca gcagcgcggg cctggcaagg aggccgcggg gaaaagcagc ggccccacct
      721 cgctcttcgc ggtgacggtg gcgccgccag gggcgaggca gggccaacag caggcgggag
      781 gagacggcaa aacagaacag aaagctggag ataaaaagag aggtgttaaa agaccccggg
      841 aagatcatgg ccgaggatat tttgagtaca ttgaagaaaa caagtacagc agagccaagt
      901 ctcctcagcc acctgttgaa gaagaagacg aacacttcga tgacacagtg gtttgtcttg
      961 atacttataa ttgtgatctg cattttaaaa tatcaagaga ccgtctcagt gcttcttccc
     1021 ttactatgga gagtttcgct tttctttggg ctggaggaag agcttcttat ggtgtgtcaa
     1081 aaggcaaagt ctgctttgag atgaaggtaa cagagaagat tccagtaaga catttatata
     1141 caaaagatat tgatatacat gaagttcgga ttggctggtc actaaccaca agtggaatgt
     1201 tgcttggtga agaagaattt tcttatgggt attctctgaa aggaataaaa acctgcaact
     1261 gtgagacaga agattatgga gagaagtttg atgaaaatga tgtgattacg tgctttgcta
     1321 actttgagac tgatgaagtt gaactctctt acgcaaagaa tggacaagat cttggtgttg
     1381 cctttaagat tagtaaggaa gttcttgctg accggccatt attcccccat gttctctgcc
     1441 ataactgtgc agttgagttt aattttggtc aaaaggaaaa gccatacttt ccaatacctg
     1501 aagactgtac ttttatccaa aatgtcccat tagaggaccg agtcagagga ccaaaaggac
     1561 ctgaagagaa gaaggattgt gaagttgtga tgatgattgg cttgccagga gctggaaaaa
     1621 ctacctgggt tactaaacat gcagctgaaa accctgggaa atataacatt cttggaacaa
     1681 acactattat ggacaaaatg atggtggcag gctttaagaa gcaaatggca gatactggaa
     1741 aactgaacac actgttgcag agagccccac agtgtcttgg caagtttatt gagattgctg
     1801 cccgaaagaa gcgaaatttt attctggatc agacaaatgt gtctgctgct gcccagagga
     1861 gaaaaatgtg cctgtttgca ggcttccaac gaaaagccgt ggtcgtttgc ccaaaagacg
     1921 aagactataa gcagaggaca cagaagaaag cggaagtaga ggggaaagac ctaccagagc
     1981 atgctgtcct caagatgaaa ggaaacttca cccttccaga ggttgcagag tgttttgatg
     2041 aaataaccta tgttgaactt cagaaggagg aagcccagaa gcttttggag caatataaag
     2101 aagaaagcaa aaaggcactg ccaccagaaa aaaagcaaaa cactggctca aagaaaagca
     2161 ataaaaataa gagtggcaag aaccagttca acagaggtgg tggccataga ggacgtggag
     2221 gattcaatat gcgtggtggc aatttcagag ggggagctcc tgggaatcgt ggtggatata
     2281 ataggagagg caacatgccc cagagaggtg gtggcggcgg aagtggtgga attggctatc
     2341 catacccgcg tggccctgtc tttcctggcc gaggtggtta ctcaaacaga ggaaattaca
     2401 acagaggtgg aatgcccaac agagggaact ataaccagaa cttcagagga cgaggaaata
     2461 atcgtggcta caaaaatcaa tctcagggct acaaccagtg gcagcagggt caattctggg
     2521 gtcagaagcc atggagtcag cattatcacc aaggatatta ttgaataccc aaataaaacg
     2581 aactgataca tatttctcca aaaccttcac aagaagtcga ctgttttctt tagtaggcta
     2641 actttttaaa cattccacaa gaggaagtgc ctgcgggttc cttttttaga agctttgtgg
     2701 gttgattttt ttttcttttc ttttttgtac atttttaatt gcagttttaa agtgaatcgt
     2761 aagagaacct cagcattgtg cacgataaga gaatgtgtca gtatttcagg gttctacatt
     2821 ttatctgtaa aatgtgactt ttttttttta tcacaacaaa agtaaaatgt tgctttgtac
     2881 ctggtgtctt ttattaagca tttactcccc catttctcac agagaataac agtcgggagt
     2941 cattgtcaca atgaaatagc aatgtcagca accagattca tggaaggact gagggtcctc
     3001 atgaatggca ttaagattct gtactgctca taatacactc catcctctct agatggccgg
     3061 gcaatagtgg aggggtaatc tctgacaaaa aaaaaaggga aggctatttt ttttctgctt
     3121 aacaatggaa ttggcataat tgggattgaa gataaaattt ggaaccaaga ctgagaagat
     3181 ggagtgtatg tagaagggct gtttaaaaat gtaaacttgg ttgcattata tgtggaggct
     3241 caaacttgtg aaggttaaat accacaaaat tttccatttg ttctgcattt tgattctgaa
     3301 aagaaagctg gctttgccca ttttcttatt aaaaaacttg ttgtaaaaaa aaaaaaaaaa
     3361 aaaaaaaaaa aaaaaaaaaa
//
