LOCUS       NM_175603               2694 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein R
            (Hnrnpr), mRNA.
ACCESSION   NM_175603 XM_001069226
VERSION     NM_175603.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2694)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2694)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 2694)
  AUTHORS   Peng,Z.Y., Huang,J., Lee,S.C., Shi,Y.L., Chen,X.H. and Xu,P.
  TITLE     The expression pattern of heterogeneous nuclear ribonucleoprotein R
            in rat retina
  JOURNAL   Neurochem Res 34 (6), 1083-1088 (2009)
   PUBMED   19015982
  REMARK    GeneRIF: The expression of hnRNP-R1 and hnRNP-R2 is developmentally
            regulated in rat retina. hnRNP-R may play roles in retinal
            development and light-elicited cellular activities.
REFERENCE   4  (bases 1 to 2694)
  AUTHORS   Huang,J., Li,S.J., Chen,X.H., Han,Y. and Xu,P.
  TITLE     hnRNP-R regulates the PMA-induced c-fos expression in retinal cells
  JOURNAL   Cell Mol Biol Lett 13 (2), 303-311 (2008)
   PUBMED   18197392
  REMARK    GeneRIF: These findings indicate that hnRNP-R regulates the c-fos
            expression in retinal cells, and that the AU-rich element of c-fos
            mRNAs contributes to this regulation.
REFERENCE   5  (bases 1 to 2694)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   6  (bases 1 to 2694)
  AUTHORS   Rossoll,W., Jablonka,S., Andreassi,C., Kroning,A.K., Karle,K.,
            Monani,U.R. and Sendtner,M.
  TITLE     Smn, the spinal muscular atrophy-determining gene product,
            modulates axon growth and localization of beta-actin mRNA in growth
            cones of motoneurons
  JOURNAL   J Cell Biol 163 (4), 801-812 (2003)
   PUBMED   14623865
REFERENCE   7  (bases 1 to 2694)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   8  (bases 1 to 2694)
  AUTHORS   Rossoll,W., Kroning,A.K., Ohndorf,U.M., Steegborn,C., Jablonka,S.
            and Sendtner,M.
  TITLE     Specific interaction of Smn, the spinal muscular atrophy
            determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role
            for Smn in RNA processing in motor axons?
  JOURNAL   Hum Mol Genet 11 (1), 93-105 (2002)
   PUBMED   11773003
REFERENCE   9  (bases 1 to 2694)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
REFERENCE   10 (bases 1 to 2694)
  AUTHORS   Hassfeld,W., Chan,E.K., Mathison,D.A., Portman,D., Dreyfuss,G.,
            Steiner,G. and Tan,E.M.
  TITLE     Molecular definition of heterogeneous nuclear ribonucleoprotein R
            (hnRNP R) using autoimmune antibody: immunological relationship
            with hnRNP P
  JOURNAL   Nucleic Acids Res 26 (2), 439-445 (1998)
   PUBMED   9421497
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 2, 2020 this sequence version replaced NM_175603.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093598.1, SRR26643286.18292.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000005.1  153826519-153826639
            122-287             JAXUCZ010000005.1  153829700-153829865
            288-406             JAXUCZ010000005.1  153832046-153832164
            407-514             JAXUCZ010000005.1  153832746-153832853
            515-628             JAXUCZ010000005.1  153835050-153835163
            629-805             JAXUCZ010000005.1  153843609-153843785
            806-941             JAXUCZ010000005.1  153845427-153845562
            942-1147            JAXUCZ010000005.1  153848923-153849128
            1148-1297           JAXUCZ010000005.1  153853686-153853835
            1298-1419           JAXUCZ010000005.1  153856852-153856973
            1420-2694           JAXUCZ010000005.1  153857095-153858369
FEATURES             Location/Qualifiers
     source          1..2694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2694
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /note="heterogeneous nuclear ribonucleoprotein R"
                     /db_xref="GeneID:319110"
                     /db_xref="RGD:631348"
     exon            1..121
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            122..287
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2029
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein R"
                     /protein_id="NP_783193.2"
                     /db_xref="GeneID:319110"
                     /db_xref="RGD:631348"
                     /translation="MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLVEAGLPQKVAE
                     RLDEIFQTGLVAYVDLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVM
                     KTYRQREKQGSKVQESTKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQ
                     PGIGTEVFVGKIPRDLYEDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEA
                     AQEAVKLCDSYEIRPGKHLGVCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDV
                     ILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDP
                     EVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMD
                     EMNGKEIEGEEIEIVLAKPPDKKRKERQAARQASRSTAYEDYYYHPPPRMPPPMRGRG
                     RGGRGGYGYPPDYYGYEDYYDDYYGYDYHDYRGGYEDPYYGYDDGYAVRGRGGGRGGR
                     GAPPPPRGRGAPPPRGRAGYSQRGAPLGPPRGSRGGRGGPAQQQRGRGSRGARGNRGG
                     NVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIAQQPLQQGGDYSGNYGYNNDNQEFYQ
                     DTYGQQWK"
     exon            288..406
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            407..514
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            515..628
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            629..805
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            806..941
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1147
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1297
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1419
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..2694
                     /gene="Hnrnpr"
                     /gene_synonym="Hnrpr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatcgcgt ctctgtccat gcaggggggg agggggtggc gcgcgcgcca tttctagtcg
       61 ttttcaaagc gcctcgcgct gattctcacg ggccaggctg ccggcccccc gctctgccct
      121 gcataataaa atggctaatc aggtgaatgg taatgcggta cagttaaaag aagaggagga
      181 gccaatggac acttccagtg ttactcacac agagcactac aagacactgg tagaggcagg
      241 cctcccacag aaggtggcag agagacttga tgaaatattt cagacagggt tggtagctta
      301 tgtcgatctt gatgaaagag caatcgatgc tctcagggaa tttaatgaag aaggagctct
      361 gtctgtgctg cagcagttca aagagagcga cttatcccat gttcagaaca aaagtgcatt
      421 tttatgtgga gttatgaaga cctacaggca aagagagaaa caaggcagca aggtacaaga
      481 gtccacgaaa gggcctgatg aagcaaagat caaggccttg ctcgagagga ctggttatac
      541 tttggatgta accacaggac agaggaagta tggtgggcct ccaccagaca gtgtgtactc
      601 aggtgtgcaa ccaggaattg gaacagaggt ctttgtaggt aaaattccaa gagacttgta
      661 tgaggatgag ttggtgcccc tttttgagaa ggctggtcct atctgggatc tacgcctcat
      721 gatggatcca ctttctggtc agaacagagg ctatgcgttt atcaccttct gtggaaagga
      781 agccgcccag gaagcagtta aactgtgtga cagctatgag attcgccctg gtaaacacct
      841 gggagtgtgc atttctgtgg caaacaacag actttttgtt ggatccattc caaagaataa
      901 aactaaagag aatattctgg aagagttcag taaagtcaca gagggtttgg tggacgttat
      961 tctctatcat caacccgatg acaaaaagaa gaatcggggg ttctgcttcc ttgaatatga
     1021 ggatcacaag tcagcagcac aagccagacg ccggctgatg agtggaaaag tcaaagtgtg
     1081 gggaaatgta gttacagttg agtgggctga ccccgtggaa gaaccggatc cggaagtcat
     1141 ggcaaaggta aaagttttat ttgtgagaaa cctggctact acagtgacag aagaaatact
     1201 agaaaagtca ttctctgaat ttggaaaact ggagagagtg aagaagttga aagattatgc
     1261 atttgttcat tttgaagaca gaggagctgc tgttaaggct atggatgaaa tgaatggaaa
     1321 agaaatagaa ggggaagaaa ttgaaattgt cttagctaag ccaccagaca agaaaaggaa
     1381 agagcgccaa gctgctagac aggcctccag aagcactgcg tatgaagatt attattatca
     1441 ccctcctccc cgaatgccgc ctccaatgag aggtcgaggt cgcggaggga gaggtggata
     1501 tggctaccct ccagattact atggttatga agactactat gatgattact atggttatga
     1561 ttatcacgac taccgtggag gctatgaaga tccctactac ggctatgatg atggctatgc
     1621 agtaagagga agaggaggag gaaggggggg gcgaggtgct ccaccaccac caagggggcg
     1681 gggagcacca cctccaagag gtagagctgg ctattcacag aggggggcac ctttgggacc
     1741 accaagaggc tcaaggggtg gcagaggggg tcctgcacaa cagcagagag gccgtggttc
     1801 tcgtggagct cggggcaatc gagggggcaa tgtaggaggc aagagaaagg cagatgggta
     1861 caaccagcct gattccaaac gtcgtcagac caacaaccaa cagaactggg gttcccaacc
     1921 catcgctcag cagccgcttc agcaaggtgg tgactattct ggtaactatg gttacaataa
     1981 tgacaaccaa gaattttatc aggatactta tgggcaacag tggaaataga caagtgaggg
     2041 cttgtaaacg attctgtcaa gatccgattg gctctagatc tacattcttc aaacaaaatt
     2101 ggcgtaactg tttcatcttt aagtagcagt ttgctgccat ttgtattcag ctgaggaagt
     2161 cactcttgtg tatattctca aggcttctta tttttcttct tttctaaatg ctctcggaca
     2221 ttactgggct tgcagaggtc ccttattctg gggtcacaat gcttttaccg ttccaagctt
     2281 catcctagct tcagaacaaa ctgtaaatca tgattttgca gagcctttgg tttggacagt
     2341 tctgtgtttt ggatgtggaa tagattacat aggagtatga cgtatgctgt aaataaaagt
     2401 acaacagtac tttgtctcag tacttttaag gaattaaagc aaacagactt aagtttcctt
     2461 gtattgaaaa taacctatga ctgtatgttt tgcattccta gaagcaggtt aactgtgttt
     2521 ttaaattgtt ataaccacac ctttttgaaa tctgccctac aaaatttgtt tggcttaaac
     2581 gtcaaagccg tgacaatttg ttctttgatg tgattgtatt tccaatttct tgttcatgta
     2641 agatttcaat aaaactcaaa aatctattca aaacatcacc tatttcaaat tcaa
//
