LOCUS       NM_001109911            2492 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein M
            (Hnrnpm), transcript variant 1, mRNA.
ACCESSION   NM_001109911
VERSION     NM_001109911.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2492)
  AUTHORS   Chen,S., Zhang,J., Duan,L., Zhang,Y., Li,C., Liu,D., Ouyang,C.,
            Lu,F. and Liu,X.
  TITLE     Identification of HnRNP M as a novel biomarker for colorectal
            carcinoma by quantitative proteomics
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 306 (5), G394-G403 (2014)
   PUBMED   24381081
REFERENCE   2  (bases 1 to 2492)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   3  (bases 1 to 2492)
  AUTHORS   Soteriou,D., Iskender,B., Byron,A., Humphries,J.D.,
            Borg-Bartolo,S., Haddock,M.C., Baxter,M.A., Knight,D.,
            Humphries,M.J. and Kimber,S.J.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   4  (bases 1 to 2492)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2492)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2492)
  AUTHORS   Tchernev,V.T., Mansfield,T.A., Giot,L., Kumar,A.M., Nandabalan,K.,
            Li,Y., Mishra,V.S., Detter,J.C., Rothberg,J.M., Wallace,M.R.,
            Southwick,F.S. and Kingsmore,S.F.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
REFERENCE   7  (bases 1 to 2492)
  AUTHORS   Bajenova,O.V., Zimmer,R., Stolper,E., Salisbury-Rowswell,J.,
            Nanji,A. and Thomas,P.
  TITLE     Heterogeneous RNA-binding protein M4 is a receptor for
            carcinoembryonic antigen in Kupffer cells
  JOURNAL   J Biol Chem 276 (33), 31067-31073 (2001)
   PUBMED   11406629
REFERENCE   8  (bases 1 to 2492)
  AUTHORS   Kafasla,P., Patrinou-Georgoula,M. and Guialis,A.
  TITLE     The 72/74-kDa polypeptides of the 70-110 S large heterogeneous
            nuclear ribonucleoprotein complex (LH-nRNP) represent a discrete
            subset of the hnRNP M protein family
  JOURNAL   Biochem J 350 Pt 2 (Pt 2), 495-503 (2000)
   PUBMED   10947964
REFERENCE   9  (bases 1 to 2492)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   10 (bases 1 to 2492)
  AUTHORS   Cuervo,A.M., Dice,J.F. and Knecht,E.
  TITLE     A population of rat liver lysosomes responsible for the selective
            uptake and degradation of cytosolic proteins
  JOURNAL   J Biol Chem 272 (9), 5606-5615 (1997)
   PUBMED   9038169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EV774465.1, AY724543.1 and BC088317.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY724543.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                EV774465.1         39-51
            14-1309             AY724543.1         1-1296
            1310-2492           BC088317.1         821-2003
FEATURES             Location/Qualifiers
     source          1..2492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2492
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /note="heterogeneous nuclear ribonucleoprotein M"
                     /db_xref="GeneID:116655"
                     /db_xref="RGD:620369"
     exon            1..134
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2211
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /note="isoform a is encoded by transcript variant 1; hnRNP
                     M; M4 protein"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein M
                     isoform a"
                     /protein_id="NP_001103381.1"
                     /db_xref="GeneID:116655"
                     /db_xref="RGD:620369"
                     /translation="MAAGVEAAAEVAATEPKMEEESGAPCVPSGNGAPVPKGEERPTQ
                     NEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVEL
                     LMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVM
                     ATTGGMGMGPGGPGMINIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKK
                     LKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVK
                     MDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNLGPAGMG
                     MEGIGFGINKIGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGG
                     AGGSVPGIERMGPGIDRISGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMG
                     SGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIE
                     RMGSGVERMGPAIERMGLSMDRMVPTGMGAGLERMGPVMDRMATGLERMGANNLERMG
                     LERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGAGGASFDRAIEM
                     ERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYAD
                     IKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA"
     exon            135..301
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            302..354
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            355..362
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            363..456
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            457..648
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            649..802
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            803..852
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            853..913
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1015
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1060
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1138
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1192
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1995
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2047
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2470
                     /gene="Hnrnpm"
                     /gene_synonym="Hnrpm; Hnrpm4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaagcccag acgcggagaa aatggcggca ggggtcgaag cggcggccga agtggcagcg
       61 acagagccca aaatggagga agagagcggc gcgccctgcg tgccgagcgg caacggagct
      121 ccggtcccga agggtgaaga acgacctact cagaatgaga agaggaagga gaaaaacata
      181 aaaagaggag gcaatcgctt tgagccatat gcaaacccaa ctaaaagata cagagccttc
      241 attacaaata taccttttga tgtgaaatgg cagtcactta aagacctggt taaagaaaaa
      301 gttggtgagg taacatacgt ggagctctta atggacgctg aaggaaagtc aaggggatgt
      361 gctgttgttg agttcaagat ggaggagagc atgaaaaaag ctgccgaagt tctaaacaag
      421 catagtctga gtggaaggcc actgaaagtc aaagaagatc ctgatggtga acatgcaagg
      481 agagcaatgc aaaaggtgat ggctacgact ggtgggatgg gtatgggacc aggtggccca
      541 ggaatgatta atatcccacc cagtatccta aataatccta acatcccaaa tgagattatc
      601 catgcattac aggctggaag acttggaagc acagtatttg tagcaaatct ggattataaa
      661 gttggctgga agaaactgaa agaagtattt agtatggctg gtgtggtggt ccgagcagac
      721 attctggaag ataaagatgg gaaaagtcgt ggaataggca ctgtgacttt tgaacagtcc
      781 attgaagctg tgcaagctat atctatgttt aatggccagt tgctgtttga tagaccgatg
      841 cacgtcaaga tggatgagag ggctttacca aagggagact tttttcctcc tgaacgccca
      901 cagcaacttc ctcatggact tggtggtatc ggtatggggt taggacctgg agggcagcct
      961 attgatgcca accacctgaa caaaggcatt ggaatgggaa acctaggacc tgcaggaatg
     1021 ggaatggaag gcataggatt tggaataaat aaaatcggag gcatggaagg accctttggt
     1081 ggtggtatgg aaaacatggg gcgatttgga tccgggatga acatgggccg gataaatgaa
     1141 atcctaagta atgcactgaa gaggggagag atcattgcaa agcaaggagg aggtggagct
     1201 ggaggcagtg tccctgggat cgaaaggatg ggccctggca ttgaccgcat tagcggtgct
     1261 ggcatggagc gcatgggcgc aggcttaggc catggcatgg atcgagtggg ctctgagatt
     1321 gagcgtatgg gcctggtcat ggaccgcatg ggctcagttg agcgcatggg ctccggcatc
     1381 gagcgcatgg gcccactagg ccttgaccac atggcctcca gtattgagcg catgggccag
     1441 accatggaac gcattggttc tggtgtggag cgcatgggtg ccggtatggg cttcggcctg
     1501 gagcgcatgg ccgcacccat tgaccgtgtg ggccaaacca ttgagcgcat gggctctggt
     1561 gtagagcgca tgggtcctgc cattgagcga atgggcctaa gcatggatcg aatggtgccc
     1621 acaggcatgg gggccggcct ggagcgcatg ggtcctgtga tggatcgtat ggccaccggc
     1681 ctggagcgca tgggcgccaa caacctggag cgcatgggcc ttgagcgcat gggagccaac
     1741 agtcttgagc gcatgggcct ggaacgaatg ggcgccaaca gcctggaacg gatgggccct
     1801 gccatgggcc cagcattggg cgctggtatt gagcgaatgg gcctggccat gggtggcgcc
     1861 ggcggtgcta gttttgaccg agccattgag atggagcggg gcaactttgg aggaagcttc
     1921 gcaggttcct ttggcggagc tggaggccat gcacctggag tagccaggaa ggcctgccag
     1981 atatttgtga gaaatctccc atttgatttt acatggaaga tgctaaagga caaattcaat
     2041 gaatgtggcc acgtgctgta cgccgacatc aagatggaga acggaaagtc caaggggtgc
     2101 ggtgtggtta agtttgagtc tccagaggtg gctgagagag cctgccggat gatgaatggc
     2161 atgaagctga gtggccgaga gattgatgtt cgaattgata gaaacgctta agcagttgcc
     2221 ttttttaaac atcagtacca gacctctgaa tttgtatttt ttcttgttaa ccattttaat
     2281 ttgttggctg gatgtataaa gatgtttaaa aaattcagtt gctttttggg gtaatttgaa
     2341 ttaatttttt aatgattggg gttccatttg actgtttgca ttgagattgc aatgtgcgca
     2401 attttttttg tagttgtggc atcttgttga catcgaatat gactttgata ataaatacca
     2461 gttcctgaaa aaaaaaaaaa aaaaaaaaaa aa
//
