LOCUS       NM_032619               2074 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein L
            (Hnrnpl), transcript variant 2, mRNA.
ACCESSION   NM_032619 XM_214878
VERSION     NM_032619.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2074)
  AUTHORS   Atianand,M.K., Hu,W., Satpathy,A.T., Shen,Y., Ricci,E.P.,
            Alvarez-Dominguez,J.R., Bhatta,A., Schattgen,S.A., McGowan,J.D.,
            Blin,J., Braun,J.E., Gandhi,P., Moore,M.J., Chang,H.Y.,
            Lodish,H.F., Caffrey,D.R. and Fitzgerald,K.A.
  TITLE     A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to
            Restrain Inflammation
  JOURNAL   Cell 165 (7), 1672-1685 (2016)
   PUBMED   27315481
REFERENCE   2  (bases 1 to 2074)
  AUTHORS   Loh,T.J., Cho,S., Moon,H., Jang,H.N., Williams,D.R., Jung,D.W.,
            Kim,I.C., Ghigna,C., Biamonti,G., Zheng,X. and Shen,H.
  TITLE     hnRNP L inhibits CD44 V10 exon splicing through interacting with
            its upstream intron
  JOURNAL   Biochim Biophys Acta 1849 (6), 743-750 (2015)
   PUBMED   25623890
REFERENCE   3  (bases 1 to 2074)
  AUTHORS   Yau,W.Y., Shih,H.C., Tsai,M.H., Sheu,J.C., Chen,C.H. and Chow,L.P.
  TITLE     Autoantibody recognition of an N-terminal epitope of hnRNP L marks
            the risk for developing HBV-related hepatocellular carcinoma
  JOURNAL   J Proteomics 94, 346-358 (2013)
   PUBMED   24125732
REFERENCE   4  (bases 1 to 2074)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2074)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2074)
  AUTHORS   Costain,W.J. and Mishra,R.K.
  TITLE     PLG regulates hnRNP-L expression in the rat striatum and
            pre-frontal cortex: identification by ddPCR
  JOURNAL   Peptides 24 (1), 137-146 (2003)
   PUBMED   12576095
REFERENCE   7  (bases 1 to 2074)
  AUTHORS   Kuninger,D.T., Izumi,T., Papaconstantinou,J. and Mitra,S.
  TITLE     Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like
            repressor element in the AP-endonuclease 1 promoter
  JOURNAL   Nucleic Acids Res 30 (3), 823-829 (2002)
   PUBMED   11809897
REFERENCE   8  (bases 1 to 2074)
  AUTHORS   Hamilton,B.J., Nichols,R.C., Tsukamoto,H., Boado,R.J.,
            Pardridge,W.M. and Rigby,W.F.
  TITLE     hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA
            and exist as a complex in vivo
  JOURNAL   Biochem Biophys Res Commun 261 (3), 646-651 (1999)
   PUBMED   10441480
REFERENCE   9  (bases 1 to 2074)
  AUTHORS   Ferreira,J. and Carmo-Fonseca,M.
  TITLE     The biogenesis of the coiled body during early mouse development
  JOURNAL   Development 121 (2), 601-612 (1995)
   PUBMED   7768196
REFERENCE   10 (bases 1 to 2074)
  AUTHORS   Pinol-Roma,S., Swanson,M.S., Gall,J.G. and Dreyfuss,G.
  TITLE     A novel heterogeneous nuclear RNP protein with a unique
            distribution on nascent transcripts
  JOURNAL   J Cell Biol 109 (6 Pt 1), 2575-2587 (1989)
   PUBMED   2687284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 4, 2008 this sequence version replaced NM_032619.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169048.1, SRR26643429.1451.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               JAXUCZ010000001.1  93228401-93228658
            259-377             JAXUCZ010000001.1  93230495-93230613
            378-615             JAXUCZ010000001.1  93231085-93231322
            616-701             JAXUCZ010000001.1  93231436-93231521
            702-798             JAXUCZ010000001.1  93232173-93232269
            799-871             JAXUCZ010000001.1  93232354-93232426
            872-943             JAXUCZ010000001.1  93235546-93235617
            944-1224            JAXUCZ010000001.1  93235729-93236009
            1225-1346           JAXUCZ010000001.1  93236945-93237066
            1347-1548           JAXUCZ010000001.1  93237349-93237550
            1549-1606           JAXUCZ010000001.1  93238087-93238144
            1607-1702           JAXUCZ010000001.1  93238259-93238354
            1703-2074           JAXUCZ010000001.1  93238713-93239084
FEATURES             Location/Qualifiers
     source          1..2074
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2074
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /note="heterogeneous nuclear ribonucleoprotein L"
                     /db_xref="GeneID:80846"
                     /db_xref="RGD:71059"
     CDS             1..1761
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /note="isoform b is encoded by transcript variant 2;
                     heterogenous nuclear ribonucleoprotein L"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein L
                     isoform b"
                     /protein_id="NP_116008.2"
                     /db_xref="GeneID:80846"
                     /db_xref="RGD:71059"
                     /translation="MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGG
                     GRYYGGGNEGGRAPKRLKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVH
                     IRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIY
                     IAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPV
                     QRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKND
                     QDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPP
                     PHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPDYGPHADSPVLMVYGLDQSKMN
                     CDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKMNVCV
                     SKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLE
                     VTEENFFEICDELGVKRPTSVKVFSGKSERSSSGLLEWDSKSDALETLGFLNHYQMKN
                     PNGPYPYTLKLCFSTAQHAS"
     exon            1..258
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            259..377
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            378..615
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            616..701
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            702..798
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            799..871
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            872..943
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1224
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1346
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1548
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1606
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1702
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..2074
                     /gene="Hnrnpl"
                     /gene_synonym="hnrnp-L; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcgcgga ggctgctgcc ccgggcggag aagcggcgtc ggcggctcga gcagaggcag
       61 cagccggacg agcagctgag gcgggcggga gcgatggtga agatggcggc ggcgggcggc
      121 ggaggcggcg gtggtcgcta ttacggcggc ggcaacgagg gaggccgagc ccctaaacgg
      181 ctgaagactg aaaacgccgg cgaccaacac ggaggaggcg gcggtggagg atccggggcg
      241 gcgggcggcg gcggcgggga gaactacgat gacccccaca aaacccctgc ctccccagtt
      301 gttcacatca ggggcctgat tgacggggtg gtggaagccg accttgtgga agccctgcaa
      361 gaatttggac ccatcagcta tgttgtggtg atgccaaaga agaggcaggc actggtagag
      421 tttgaagatg tgctgggggc ttgtaatgca gtaaactacg ctgcagacaa ccagatctac
      481 attgctggtc accctgcttt tgtcaattat tctaccagcc agaagatctc tcgccccggt
      541 gactctgatg actcccggag cgtcaacagt gtgcttctgt ttaccatcct gaaccccatc
      601 tactccataa ccacggatgt tctttacact atctgtaatc cttgtggccc tgtccagaga
      661 attgtcattt tccggaagaa tggagtccag gctatggtgg agtttgattc tgtgcaaagt
      721 gcccagcgcg ctaaggcctc actgaatggg gctgacatct attctggctg ttgcactctg
      781 aagattgagt acgcaaagcc tacacgttta aatgtgttca agaacgatca agatacttgg
      841 gactacacaa accccaatct cagtggacaa ggtgaccctg gcagtaaccc caacaaacgc
      901 cagcggcagc cccctctcct gggagatcat cccgcagaat atggagggcc ccatggtggg
      961 taccacagcc attaccatga tgagggctac gggccccccc cacctcacta cgaagggaga
     1021 aggatgggcc cacctgtggg gggtcaccgc cggggcccaa gtcgctatgg cccccagtat
     1081 ggtcatcccc caccccctcc cccaccaccc gactatggcc cccacgctga cagccctgtg
     1141 ctcatggtct atggcttgga tcaatctaag atgaactgtg atcgagtctt caatgtcttc
     1201 tgcttgtatg gcaatgtgga gaaggtgaaa tttatgaaaa gcaagccggg ggccgccatg
     1261 gtggagatgg ctgatggcta tgctgtggac cgagccatta ctcacctcaa caacaacttc
     1321 atgttcgggc agaagatgaa tgtctgtgtc tccaagcaac cagccattat gcccggtcag
     1381 tcatatgggc tagaagacgg atcttgcagt tacaaagact tcagcgagtc aaggaacaat
     1441 cggttctcta ctccagagca ggcagctaag aaccgcatcc agcaccctag caatgttctg
     1501 cacttcttca atgctcccct ggaggtgact gaggagaact tctttgagat ctgcgatgaa
     1561 ctgggagtga agcggccaac ctctgtgaaa gtattttcag gcaaaagcga gcgtagctcc
     1621 tctgggctgc tggagtggga ctccaagagt gacgccctgg agaccttggg cttcctgaac
     1681 cattaccaga tgaaaaaccc aaatggcccg tatccataca ctctgaagtt gtgcttctcc
     1741 accgcacagc acgcctccta attagatgct gggaaggaag actccatccg agcaggaaga
     1801 tgtttctttc ctttatgctg ttggtttctt tgttttgtct ttatttttgc agttcttttt
     1861 ttccatttaa atgctaggtc agtagaggct taaccacaac aaatgctgga actctggagg
     1921 gggggagggg aactggtatc tcccaagatt aaccttcact ttttaaaata actgtatgtg
     1981 tgattctttt tttcctgttc atacatttgt gctgcccatg tatcttggca catttcaata
     2041 aaattgtttg gaaaataaaa ctattcgctg gggc
//
