LOCUS       NM_057141               2563 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein K
            (Hnrnpk), mRNA.
ACCESSION   NM_057141
VERSION     NM_057141.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2563)
  AUTHORS   Cardozo,V., Vaamonde,L., Parodi-Talice,A., Zuluaga,M.J., Agrati,D.,
            Portela,M., Lima,A., Blasina,F., Dajas,F. and Bedo,G.
  TITLE     Multitarget neuroprotection by quercetin: Changes in gene
            expression in two perinatal asphyxia models
  JOURNAL   Neurochem Int 147, 105064 (2021)
   PUBMED   33951501
REFERENCE   2  (bases 1 to 2563)
  AUTHORS   Zhu,G., Zhu,Q., Zhang,W., Hui,C., Li,Y., Yang,M., Pang,S., Li,Y.,
            Xue,G. and Chen,H.
  TITLE     Mitochondrial uncoupling protein 2 is regulated through
            heterogeneous nuclear ribonucleoprotein K in lead exposure models
  JOURNAL   J Environ Sci Health C Toxicol Carcinog 39 (1), 1-16 (2021)
   PUBMED   33576715
  REMARK    GeneRIF: Mitochondrial uncoupling protein 2 is regulated through
            heterogeneous nuclear ribonucleoprotein K in lead exposure models.
REFERENCE   3  (bases 1 to 2563)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 2563)
  AUTHORS   Xu,H., Zhang,P., Li,R., Wu,W., Wang,S. and Xu,Y.
  TITLE     Expression analysis of multifunctional RNA-binding protein hnRNP K
            during development of mammalian testis
  JOURNAL   Pol J Vet Sci 21 (2), 343-351 (2018)
   PUBMED   30450874
  REMARK    GeneRIF: results showed that hnRNP K was widely distributed in
            gonocytes, spermatogonia, sertoli cells and Leydig cells. The
            dynamic expression profile of hnRNP K may imply its crucial and
            potential roles in the development of the testis.
REFERENCE   5  (bases 1 to 2563)
  AUTHORS   Leal,G., Comprido,D., de Luca,P., Morais,E., Rodrigues,L., Mele,M.,
            Santos,A.R., Costa,R.O., Pinto,M.J., Patil,S., Berentsen,B.,
            Afonso,P., Carreto,L., Li,K.W., Pinheiro,P., Almeida,R.D.,
            Santos,M.A.S., Bramham,C.R. and Duarte,C.B.
  TITLE     The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on
            Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in
            Hippocampal Neurons
  JOURNAL   eNeuro 4 (6) (2017)
   PUBMED   29255796
  REMARK    GeneRIF: Results show that synaptic activity and BDNF regulate
            hnRNP K and hnRNP K-bound mRNAs in vitro and in vivo. The large
            number of transcripts showing a decreased coimmunoprecipitation
            with hnRNP K on stimulation with BDNF suggests a role for this RNP
            in the regulation of neuronal function in general and, in
            particular, in the BDNF-mediated plasticity events.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2563)
  AUTHORS   Chang,C.J., Luh,H.W., Wang,S.H., Lin,H.J., Lee,S.C. and Hu,S.T.
  TITLE     The heterogeneous nuclear ribonucleoprotein K (hnRNP K) interacts
            with dengue virus core protein
  JOURNAL   DNA Cell Biol 20 (9), 569-577 (2001)
   PUBMED   11747608
REFERENCE   7  (bases 1 to 2563)
  AUTHORS   Venables,J.P., Elliott,D.J., Makarova,O.V., Makarov,E.M.,
            Cooke,H.J. and Eperon,I.C.
  TITLE     RBMY, a probable human spermatogenesis factor, and other hnRNP G
            proteins interact with Tra2beta and affect splicing
  JOURNAL   Hum Mol Genet 9 (5), 685-694 (2000)
   PUBMED   10749975
REFERENCE   8  (bases 1 to 2563)
  AUTHORS   Miau,L.H., Chang,C.J., Shen,B.J., Tsai,W.H. and Lee,S.C.
  TITLE     Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP
            K) as a repressor of C/EBPbeta-mediated gene activation
  JOURNAL   J Biol Chem 273 (17), 10784-10791 (1998)
   PUBMED   9553145
REFERENCE   9  (bases 1 to 2563)
  AUTHORS   Weng,Z., Thomas,S.M., Rickles,R.J., Taylor,J.A., Brauer,A.W.,
            Seidel-Dugan,C., Michael,W.M., Dreyfuss,G. and Brugge,J.S.
  TITLE     Identification of Src, Fyn, and Lyn SH3-binding proteins:
            implications for a function of SH3 domains
  JOURNAL   Mol Cell Biol 14 (7), 4509-4521 (1994)
   PUBMED   7516469
REFERENCE   10 (bases 1 to 2563)
  AUTHORS   Ito,K., Sato,K. and Endo,H.
  TITLE     Cloning and characterization of a single-stranded DNA binding
            protein that specifically recognizes deoxycytidine stretch
  JOURNAL   Nucleic Acids Res 22 (1), 53-58 (1994)
   PUBMED   8127654
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D17711.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2563
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="DONRYU"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2563
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /note="heterogeneous nuclear ribonucleoprotein K"
                     /db_xref="GeneID:117282"
                     /db_xref="RGD:71058"
     exon            1..85
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1419
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /function="binding to single-stranded dC-stretch DNA"
                     /note="hnRNP K; dC stretch-binding protein"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein K"
                     /protein_id="NP_476482.1"
                     /db_xref="GeneID:117282"
                     /db_xref="RGD:71058"
                     /translation="METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKRSRNTDEMVE
                     LRILLQSKNAGAVIGKGGKNIKALRTDYNASVSVPDSSGPERILSISADIETIGEILK
                     KIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYKGSDFDCELRLLIHQSLAGGII
                     GVKGAKIKELRENTQTTIKLFQECCPHSTDRVVLIGGKPDRVVECIKIILDLISESPI
                     KGRAQPYDPNFYDETYDYGGFTMMFDDRRGRPVGFPMRGRGGFDRMPPGRGGRPMPPS
                     RRDYDDMSPRRGPPPPPPGRGGRGGSRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYD
                     GMVGFSADETWDSAIDTWSPSEWQMAYEPQGGSGYDYSYAGGRGSYGDLGGPIITTQV
                     TIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQYL
                     LQNSVKQYSGKFF"
     exon            86..183
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            184..240
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            241..284
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            285..357
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            358..429
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            430..543
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            544..672
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            673..980
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1035
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1119
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1135
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1218
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1388
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..2563
                     /gene="Hnrnpk"
                     /gene_synonym="Csbp; Hnrpk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attggtggat ccatttagtt caagaaaatg gagaccgaac agccagaaga aaccttccct
       61 aacaccgaaa ccaatggtga atttggtaaa cgccctgcag aagatatgga agaggaacaa
      121 gcctttaaaa gatctagaaa tactgatgag atggttgaat tgcgcatttt gcttcagagc
      181 aagaatgctg gggcagtgat tggaaaagga ggcaagaata ttaaggctct ccgtacagac
      241 tacaatgcca gtgtttcagt cccagacagc agtggccccg agcgcatact gagtatcagt
      301 gctgatattg agacgattgg agaaattctg aagaaaatca tccctacttt ggaagagggc
      361 ctgcagttgc catcacccac tgcaaccagc cagctcccgc tcgaatctga tgctgtggaa
      421 tgcttaaatt accagcatta taaagggagt gacttcgact gcgagctgag actgttgatt
      481 catcaaagtc tggccggagg aattattggt gttaaaggtg ctaaaatcaa agaacttcga
      541 gaaaacactc agacaacaat caagcttttc caggaatgct gccctcattc tactgacaga
      601 gttgttctta ttggaggaaa gcccgatagg gttgtagaat gcatcaagat catccttgac
      661 cttatatctg agtctcccat caaaggacgt gcacaacctt atgatcccaa cttctatgat
      721 gaaacctatg attatggtgg ttttacaatg atgtttgatg accgccgagg acgacctgtg
      781 ggattcccca tgcggggaag aggtggtttt gacagaatgc ctcctggtcg gggtgggcgt
      841 cccatgcctc cttctagaag agattatgat gatatgagcc ctcgtcgagg accaccacca
      901 ccaccacctg gtcgaggtgg acggggtggc agcagagctc ggaatcttcc tcttcctcca
      961 ccaccaccac ccagaggggg agatctcatg gcttacgaca gaagaggacg gcctggagac
     1021 cgctatgatg gcatggttgg gttcagtgct gatgaaactt gggactctgc aattgacaca
     1081 tggagcccat cagaatggca aatggcttat gaaccacagg gtggttctgg atatgattat
     1141 tcttatgcag ggggccgtgg ctcgtatggt gatcttggcg gacctattat cactacacaa
     1201 gtaactattc ccaaagattt ggctggatct attattggca aaggtggtca gcggattaaa
     1261 caaattcgtc atgagtctgg agcatctatc aaaattgatg aacctttaga aggatctgaa
     1321 gatcggatca ttaccattac gggaacacag gaccagatac agaacgcaca gtatttgctg
     1381 cagaacagtg tgaagcagta ttctggaaag tttttctaag actagtgaag aactgaagga
     1441 gtcctgcatc tttttttttt tatctgcttc tgtttaaaaa gccaacattc ctctgcttcc
     1501 taggtgttct gcatttgagg tgtagtgaaa tctttgctgt tcaccagatg taatgtttta
     1561 gttccttaca aacagggttg gggggagggc atgcaaaaaa actaacattg aaattttgaa
     1621 acagcagcag agtgagtgac ttttattttt tgttcattgt tggtggtttt aaaaattccc
     1681 cccgtgtaat tattgtgaac accttgcttt gtggtcactg taacattggg gggtgggaca
     1741 gggaggaaag taatagtcca catgtccctg gcatttgttc agagcagtgt gcagaatgta
     1801 atgctctttt gtaagaaacg ttttatgatt tttaaaataa atttagtgaa tctatttttg
     1861 gtggtctttt tttttttttt taaagacaat ttcaaatggt ggttgaattt tccagcccac
     1921 ccctaaacta aacactaagt ttgattttca gcagctcctc tgttggatat aagtgcacct
     1981 cttggatata gacaaacaca ttggcaaatt tcagtttggg tgatttctta atggttggaa
     2041 agacttggct tgataaattt ccatcacata ttcatgctta taataagctt gggattttgt
     2101 ttgtttttgc aaatgtttgc cactactttt caacagtttt ctgttagtcg tggggaactg
     2161 cggtggggag caatactaca agagtaagca tctgagtatg tgccagaagc ctggtgggca
     2221 atgagcttta ttaaccagag taacacttgg ttatggaagt ggctgatgct gaataaatcc
     2281 tggttatttt tgttagataa tttctcacct atagacttaa gctgtcaact gctagcgtct
     2341 tgttagttga actttgtaaa aatatatata tacttgtttt tccattgtat gcacaatgaa
     2401 agaaaaaaga tgtaccattt ctctgttgtg tgttgaatta tgtaggaaat gtttgtgaac
     2461 gattcaaaaa aaatggaaaa gttcctgtgg atgttttgtg tagtaacttg gcatctgtat
     2521 tgatagttcc aaatccacat ctaaataaaa cttcatgatg tta
//
