LOCUS       NM_001014019            1725 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein H2
            (Hnrnph2), mRNA.
ACCESSION   NM_001014019 XM_218703
VERSION     NM_001014019.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1725)
  AUTHORS   Grammatikakis,I., Zhang,P., Panda,A.C., Kim,J., Maudsley,S.,
            Abdelmohsen,K., Yang,X., Martindale,J.L., Motino,O.,
            Hutchison,E.R., Mattson,M.P. and Gorospe,M.
  TITLE     Alternative Splicing of Neuronal Differentiation Factor TRF2
            Regulated by HNRNPH1/H2
  JOURNAL   Cell Rep 15 (5), 926-934 (2016)
   PUBMED   27117401
  REMARK    GeneRIF: HNRNPH is a splicing regulator of Trf2 pre-mRNA that
            prevents the expression of TRF2-S, a factor implicated in neuronal
            differentiation.
REFERENCE   2  (bases 1 to 1725)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1725)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1725)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1725)
  AUTHORS   Maggi,L.B. Jr., Kuchenruether,M., Dadey,D.Y., Schwope,R.M.,
            Grisendi,S., Townsend,R.R., Pandolfi,P.P. and Weber,J.D.
  TITLE     Nucleophosmin serves as a rate-limiting nuclear export chaperone
            for the Mammalian ribosome
  JOURNAL   Mol Cell Biol 28 (23), 7050-7065 (2008)
   PUBMED   18809582
REFERENCE   6  (bases 1 to 1725)
  AUTHORS   Mauger,D.M., Lin,C. and Garcia-Blanco,M.A.
  TITLE     hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth
            factor receptor 2 exon IIIc
  JOURNAL   Mol Cell Biol 28 (17), 5403-5419 (2008)
   PUBMED   18573884
  REMARK    GeneRIF: These results establish hnRNP H and hnRNP F as being
            repressors of exon inclusion and suggest that Fox proteins enhance
            their ability to antagonize ASF/SF2.
REFERENCE   7  (bases 1 to 1725)
  AUTHORS   Hoffert,J.D., Pisitkun,T., Wang,G., Shen,R.F. and Knepper,M.A.
  TITLE     Quantitative phosphoproteomics of vasopressin-sensitive renal
            cells: regulation of aquaporin-2 phosphorylation at two sites
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 7159-7164 (2006)
   PUBMED   16641100
REFERENCE   8  (bases 1 to 1725)
  AUTHORS   Li,K.W., Hornshaw,M.P., Van Der Schors,R.C., Watson,R., Tate,S.,
            Casetta,B., Jimenez,C.R., Gouwenberg,Y., Gundelfinger,E.D.,
            Smalla,K.H. and Smit,A.B.
  TITLE     Proteomics analysis of rat brain postsynaptic density. Implications
            of the diverse protein functional groups for the integration of
            synaptic physiology
  JOURNAL   J Biol Chem 279 (2), 987-1002 (2004)
   PUBMED   14532281
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079240.1.
            
            On Apr 20, 2005 this sequence version replaced XM_218703.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079240.1, EV769547.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1725
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..1725
                     /gene="Hnrnph2"
                     /gene_synonym="Hnrph2"
                     /note="heterogeneous nuclear ribonucleoprotein H2"
                     /db_xref="GeneID:308650"
                     /db_xref="RGD:1549784"
     exon            1..63
                     /gene="Hnrnph2"
                     /gene_synonym="Hnrph2"
                     /inference="alignment:Splign:2.1.0"
     exon            64..126
                     /gene="Hnrnph2"
                     /gene_synonym="Hnrph2"
                     /inference="alignment:Splign:2.1.0"
     exon            127..171
                     /gene="Hnrnph2"
                     /gene_synonym="Hnrph2"
                     /inference="alignment:Splign:2.1.0"
     exon            172..1701
                     /gene="Hnrnph2"
                     /gene_synonym="Hnrph2"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1574
                     /gene="Hnrnph2"
                     /gene_synonym="Hnrph2"
                     /note="hnRNP H'; hnRNP H2; heterogeneous nuclear
                     ribonucleoprotein H'; heterogeneous nuclear
                     ribonucleoprotein H2 (H')"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein H2"
                     /protein_id="NP_001014041.1"
                     /db_xref="GeneID:308650"
                     /db_xref="RGD:1549784"
                     /translation="MMLSTEGREGFVVKVRGLPWSCSAEEVMRFFSDCKIQNGTSGVR
                     FIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNSVEMDWVLKHTGP
                     NSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGMTLPVDFQGRSTGEAFVQFA
                     SQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMTMQRPGPYDRPGAGRG
                     YNSIGRGAGFERMRRGAYGGGYGGYDDYGGYNDGYGFGSDRFGRDLNYCFSGMSDHRY
                     GDGGSSFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPMRVHIEIGPDGRVTGEADVE
                     FATHEDAVAAMAKDKANMQHRYVELFLNSTAGTSGGAYDHSYVELFLNSTAGASGGAY
                     GSQMMGGMGLSNQSSYGGPASQQLSAGYGGGYGGQSSMSGYDQVLQENSSDYQSNLA"
ORIGIN      
        1 gtctatcgtc tcgctatagc cgtttgaggg aagaaggagg aaaatccccc ggtatcgttg
       61 gagcaaacat tttaaaagta tttctgtcgg ccagattcct ggaagaaact ctaacagggt
      121 caaaggataa ttccttaagg cacatacctg aagtggattt tctgtcagaa gccacattga
      181 aattgcattg agccaagctt gccaccaaga gtccatcagt caccatgatg ctgagcacag
      241 agggcaggga ggggttcgtg gtgaaggtca ggggcctacc ctggtcctgc tcagccgagg
      301 aagtgatgcg cttcttttct gattgcaaaa tccaaaatgg cacatcaggt gttcgtttca
      361 tctacaccag agaaggcaga ccgagtggtg aagcatttgt cgaactcgaa tctgaagatg
      421 aagtgaaatt ggctttaaag aaagacagag aaaccatggg acacagatat gttgaagtat
      481 tcaaatccaa cagtgttgaa atggattggg tgttaaagca tacaggtcca aatagtcctg
      541 atactgccaa tgatgggttt gtacggctca gaggactccc atttggctgt agcaaggaag
      601 aaattgttca gttcttttca gggttggaaa ttgtgccaaa tgggatgaca ctgccagtgg
      661 actttcaggg gcggagcaca ggggaagctt ttgtgcagtt tgcttcacag gagatagctg
      721 aaaaggcctt aaagaaacac aaggaaagaa tagggcatag gtacatcgag atcttcaaga
      781 gtagcagagc tgaagtccga acccactatg atccccctcg aaagctcatg actatgcagc
      841 gcccgggtcc ttatgatagg ccaggggctg ggagagggta taatagcatt ggcagaggag
      901 ctgggtttga aagaatgagg cggggtgcct atggtggagg gtacggaggc tatgatgact
      961 acggaggtta taatgacggg tatggttttg ggtctgatag atttggaaga gacctaaact
     1021 actgtttctc aggaatgtct gatcatcgat atggagatgg tgggtccagt ttccagagca
     1081 ccacagggca ctgtgtacac atgagggggt taccatacag agccactgag aatgatattt
     1141 acaatttttt ctcacctctt aatcccatga gagtacacat tgaaatcgga cctgatggca
     1201 gagtcacggg tgaggcagac gttgagtttg ctactcatga agacgctgtg gcagctatgg
     1261 caaaagataa agcaaatatg cagcacagat atgtggagct cttcctgaat tctaccgcag
     1321 ggacgagtgg aggagcttat gatcatagct atgtagagct ctttttgaat tctacagcag
     1381 gggcaagcgg tggtgcttat ggcagccaga tgatgggagg gatgggttta tccaaccagt
     1441 ctagttatgg aggtccagcc agccagcagc tgagtgctgg ctacggaggt ggttatggtg
     1501 gtcagagcag tatgagcgga tatgaccaag ttcttcagga aaactcaagt gactatcagt
     1561 caaaccttgc ttaggaagag aggaagcatc aaagagcatc tacaggaata aaaagtacat
     1621 tataggaact ggatagagta gggaggatgt ccagcatatc cagtatgatt ggtaaatggg
     1681 aaatacaatt gcttctgatc aaaaaaaaaa aaaaaaaaaa aaaaa
//
