LOCUS       NM_080896               2211 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein H1
            (Hnrnph1), mRNA.
ACCESSION   NM_080896
VERSION     NM_080896.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2211)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   2  (bases 1 to 2211)
  AUTHORS   Grammatikakis,I., Zhang,P., Panda,A.C., Kim,J., Maudsley,S.,
            Abdelmohsen,K., Yang,X., Martindale,J.L., Motino,O.,
            Hutchison,E.R., Mattson,M.P. and Gorospe,M.
  TITLE     Alternative Splicing of Neuronal Differentiation Factor TRF2
            Regulated by HNRNPH1/H2
  JOURNAL   Cell Rep 15 (5), 926-934 (2016)
   PUBMED   27117401
  REMARK    GeneRIF: HNRNPH is a splicing regulator of Trf2 pre-mRNA that
            prevents the expression of TRF2-S, a factor implicated in neuronal
            differentiation.
REFERENCE   3  (bases 1 to 2211)
  AUTHORS   Dardenne,E., Polay Espinoza,M., Fattet,L., Germann,S.,
            Lambert,M.P., Neil,H., Zonta,E., Mortada,H., Gratadou,L.,
            Deygas,M., Chakrama,F.Z., Samaan,S., Desmet,F.O., Tranchevent,L.C.,
            Dutertre,M., Rimokh,R., Bourgeois,C.F. and Auboeuf,D.
  TITLE     RNA helicases DDX5 and DDX17 dynamically orchestrate transcription,
            miRNA, and splicing programs in cell differentiation
  JOURNAL   Cell Rep 7 (6), 1900-1913 (2014)
   PUBMED   24910439
REFERENCE   4  (bases 1 to 2211)
  AUTHORS   Chettouh,H., Fartoux,L., Aoudjehane,L., Wendum,D., Claperon,A.,
            Chretien,Y., Rey,C., Scatton,O., Soubrane,O., Conti,F., Praz,F.,
            Housset,C., Rosmorduc,O. and Desbois-Mouthon,C.
  TITLE     Mitogenic insulin receptor-A is overexpressed in human
            hepatocellular carcinoma due to EGFR-mediated dysregulation of RNA
            splicing factors
  JOURNAL   Cancer Res 73 (13), 3974-3986 (2013)
   PUBMED   23633480
REFERENCE   5  (bases 1 to 2211)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 2211)
  AUTHORS   Shakib,K., Norman,J.T., Fine,L.G., Brown,L.R. and
            Godovac-Zimmermann,J.
  TITLE     Proteomics profiling of nuclear proteins for kidney fibroblasts
            suggests hypoxia, meiosis, and cancer may meet in the nucleus
  JOURNAL   Proteomics 5 (11), 2819-2838 (2005)
   PUBMED   15942958
REFERENCE   7  (bases 1 to 2211)
  AUTHORS   Li,K.W., Hornshaw,M.P., Van Der Schors,R.C., Watson,R., Tate,S.,
            Casetta,B., Jimenez,C.R., Gouwenberg,Y., Gundelfinger,E.D.,
            Smalla,K.H. and Smit,A.B.
  TITLE     Proteomics analysis of rat brain postsynaptic density. Implications
            of the diverse protein functional groups for the integration of
            synaptic physiology
  JOURNAL   J Biol Chem 279 (2), 987-1002 (2004)
   PUBMED   14532281
REFERENCE   8  (bases 1 to 2211)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 2211)
  AUTHORS   Matunis,M.J., Xing,J. and Dreyfuss,G.
  TITLE     The hnRNP F protein: unique primary structure, nucleic acid-binding
            properties, and subcellular localization
  JOURNAL   Nucleic Acids Res 22 (6), 1059-1067 (1994)
   PUBMED   7512260
REFERENCE   10 (bases 1 to 2211)
  AUTHORS   Hardin,C.D., Wiseman,R.W. and Kushmerick,M.J.
  TITLE     Tension responses of sheep aorta to simultaneous decreases in
            phosphocreatine, inorganic phosphate and ATP
  JOURNAL   J Physiol 458, 139-150 (1992)
   PUBMED   1302261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 24, 2020 this sequence version replaced NM_080896.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.62404.1,
                                           SRR26643298.60195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000010.1  35194633-35194695
            64-200              JAXUCZ010000010.1  35195196-35195332
            201-356             JAXUCZ010000010.1  35196538-35196693
            357-500             JAXUCZ010000010.1  35196890-35197033
            501-639             JAXUCZ010000010.1  35198523-35198661
            640-818             JAXUCZ010000010.1  35199611-35199789
            819-890             JAXUCZ010000010.1  35199881-35199952
            891-1024            JAXUCZ010000010.1  35200009-35200142
            1025-1160           JAXUCZ010000010.1  35200258-35200393
            1161-1220           JAXUCZ010000010.1  35201072-35201131
            1221-1310           JAXUCZ010000010.1  35201223-35201312
            1311-1403           JAXUCZ010000010.1  35202025-35202117
            1404-1453           JAXUCZ010000010.1  35202524-35202573
            1454-2211           JAXUCZ010000010.1  35203152-35203909
FEATURES             Location/Qualifiers
     source          1..2211
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2211
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /note="heterogeneous nuclear ribonucleoprotein H1"
                     /db_xref="GeneID:140931"
                     /db_xref="RGD:620840"
     exon            1..63
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            64..200
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1453
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein H"
                     /protein_id="NP_543172.2"
                     /db_xref="GeneID:140931"
                     /db_xref="RGD:620840"
                     /translation="MMLGAEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIR
                     FIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGP
                     NSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFA
                     SQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRG
                     YNSIGRGAGFERMRRGAYGGGYGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRY
                     GDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVE
                     FATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAY
                     GSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDFQSNIA"
     exon            201..356
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..500
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..639
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..818
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..890
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1024
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1160
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1220
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1310
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1403
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1453
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2211
                     /gene="Hnrnph1"
                     /gene_synonym="hnRNP H; Hnrph; Hnrph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttaggctg cgcaggcgct ctcctatcat ttttcctcag ccacgccgag gctttgtgtg
       61 gagccctgca gtctgtttcg acgccaggac cagcgaagag acgatgatgc tgggagcaga
      121 aggcggagag ggcttcgtgg tgaaggtccg gggcttgccc tggtcctgct ccgcggatga
      181 agtgcagcgg tttttttctg actgcaaaat tcaaaatggg gctcaaggta ttcgtttcat
      241 ctacaccaga gaaggcagac cgagtggcga ggcttttgtt gaacttgaat cagaagatga
      301 agtcaaattg gccttgaaaa aagacagaga aactatggga cacagatatg ttgaagtatt
      361 caagtcaaac aacgttgaaa tggattgggt gttgaagcat actggtccca atagtcctga
      421 cacggccaat gatggctttg tacggcttag aggactccct tttggatgta gcaaggaaga
      481 aattgttcag ttcttctcag ggttggaaat cgtgccaaat gggataacat tgccggtgga
      541 cttccagggg aggagtacgg gggaggcctt cgtgcagttt gcttcacagg aaatagctga
      601 aaaggctcta aagaaacaca aggaaagaat agggcacagg tatattgaaa tatttaagag
      661 cagtcgagct gaagttagaa ctcattatga tccaccacga aaacttatgg ccatgcagcg
      721 gccaggtccc tatgacagac ctggggctgg cagagggtat aacagcattg gcagaggagc
      781 tggctttgag aggatgaggc gtggtgctta tggtggaggc tatggaggct atgatgatta
      841 taatggctat aatgatggct atggatttgg ttcggataga tttggaagag acctcaatta
      901 ttgtttttca ggaatgtctg accacagata tggggatggt ggctccactt tccagagtac
      961 aacaggacac tgtgtacaca tgcggggatt accatacaga gctactgaga atgacattta
     1021 taattttttt tcaccactca accctgtgag agtacatatt gagattggac ctgatggcag
     1081 agtaactggt gaagcagatg ttgagtttgc aacccatgaa gatgctgttg cagctatgtc
     1141 aaaagataaa gcaaatatgc aacacagata tgtagaactc ttcttgaatt ctacagcagg
     1201 agcaagcggt ggtgcttacg aacacagata tgtagaactc ttcttgaatt ctacagcagg
     1261 agcaagcggt ggtgcttatg gtagccaaat gatgggaggc atgggcttgt caaaccagtc
     1321 cagttacggt ggcccagcca gccagcagct gagtggtggt tatggaggtg gctatggtgg
     1381 ccagagcagc atgagcggat atgaccaagt tttacaggaa aactccagtg attttcaatc
     1441 aaacattgca taggtagcca aggagcagtg aacagcagct actacagtag cggaagccgt
     1501 gcatctatgg gcgtgaatgg aatgggaggg atgtctagca tgtctagtat gagtggtgga
     1561 tggggaatgt aattgatttt gatcactgac tcttggtcaa aaagaaattt ttttaaaacc
     1621 cttcagttta acagtttttg caatccagcc ttgtggtttt aatgcctgct ctcttaagtg
     1681 aactttggca tcgatcgctc aaagaaggtt caatgttgaa catagcagtc acctaggatg
     1741 atagggcaaa gttgagtaac tttaactgtt aaacttaatt cctagctttt ctctagttat
     1801 gtaggatgta cgtaagcagt aagtgtattt aggttaaagc agttgaatta tgttaaatgt
     1861 tgctcttata catacataca ttgaacactg ttgatgcatg ttgaaaagac atgctttttt
     1921 tgtaaaacta taggagctgc gtctacaatt aaaagtgaaa catttggcat gtttgttaat
     1981 tctaaattca tttgataacc tgtaaggcac gtgagtttaa agctcttttc tttttttaag
     2041 ttaatggaga aattctgaga cgcaatacca ttacttttta ggatttttgg tcttggtgtt
     2101 tgtacgaaat tctgaggcct tgatttaagt ctttcattgt attgtgattt acttttaggt
     2161 gtattgcgct aagtgaacct tgtcaaataa atcttccttt taaaagctac a
//
