LOCUS       NM_001037286            2253 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein F
            (Hnrnpf), transcript variant 1, mRNA.
ACCESSION   NM_001037286
VERSION     NM_001037286.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2253)
  AUTHORS   Lo,C.S., Shi,Y., Chenier,I., Ghosh,A., Wu,C.H., Cailhier,J.F.,
            Ethier,J., Lattouf,J.B., Filep,J.G., Ingelfinger,J.R., Zhang,S.L.
            and Chan,J.S.D.
  TITLE     Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene
            Expression and Attenuates Nephropathy Progression in Diabetic Mice
  JOURNAL   Diabetes 66 (7), 1964-1978 (2017)
   PUBMED   28424160
  REMARK    GeneRIF: hnRNP F protects kidneys against oxidative stress and
            nephropathy via stimulation of Sirtuin-1 expression and signaling
            in diabetes.
REFERENCE   2  (bases 1 to 2253)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2253)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2253)
  AUTHORS   Dominguez,C., Fisette,J.F., Chabot,B. and Allain,F.H.
  TITLE     Structural basis of G-tract recognition and encaging by hnRNP F
            quasi-RRMs
  JOURNAL   Nat Struct Mol Biol 17 (7), 853-861 (2010)
   PUBMED   20526337
REFERENCE   5  (bases 1 to 2253)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2253)
  AUTHORS   Wei,C.C., Zhang,S.L., Chen,Y.W., Guo,D.F., Ingelfinger,J.R.,
            Bomsztyk,K. and Chan,J.S.
  TITLE     Heterogeneous nuclear ribonucleoprotein K modulates angiotensinogen
            gene expression in kidney cells
  JOURNAL   J Biol Chem 281 (35), 25344-25355 (2006)
   PUBMED   16837467
REFERENCE   7  (bases 1 to 2253)
  AUTHORS   Wei,C.C., Guo,D.F., Zhang,S.L., Ingelfinger,J.R. and Chan,J.S.
  TITLE     Heterogenous nuclear ribonucleoprotein F modulates angiotensinogen
            gene expression in rat kidney proximal tubular cells
  JOURNAL   J Am Soc Nephrol 16 (3), 616-628 (2005)
   PUBMED   15659559
  REMARK    GeneRIF: hnRNP F binds to rANG-IRE and modulates renal ANG gene
            expression, implicating that dysregulation of hnRNP F might affect
            renin-angiotensin system activation and, subsequently, kidney
            injury in diabetes
REFERENCE   8  (bases 1 to 2253)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 2253)
  AUTHORS   Yoshida,T., Makino,Y. and Tamura,T.
  TITLE     Association of the rat heterogeneous nuclear RNA-ribonucleoprotein
            F with TATA-binding protein
  JOURNAL   FEBS Lett 457 (2), 251-254 (1999)
   PUBMED   10471789
REFERENCE   10 (bases 1 to 2253)
  AUTHORS   Gamberi,C., Izaurralde,E., Beisel,C. and Mattaj,I.W.
  TITLE     Interaction between the human nuclear cap-binding protein complex
            and hnRNP F
  JOURNAL   Mol Cell Biol 17 (5), 2587-2597 (1997)
   PUBMED   9111328
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK359545.1 and BC103634.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK359545.1, EV769167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-729               CK359545.1         1-729
            730-2253            BC103634.1         647-2170
FEATURES             Location/Qualifiers
     source          1..2253
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2253
                     /gene="Hnrnpf"
                     /gene_synonym="Hnrpf"
                     /note="heterogeneous nuclear ribonucleoprotein F"
                     /db_xref="GeneID:64200"
                     /db_xref="RGD:620366"
     exon            1..254
                     /gene="Hnrnpf"
                     /gene_synonym="Hnrpf"
                     /inference="alignment:Splign:2.1.0"
     exon            255..315
                     /gene="Hnrnpf"
                     /gene_synonym="Hnrpf"
                     /inference="alignment:Splign:2.1.0"
     exon            316..2230
                     /gene="Hnrnpf"
                     /gene_synonym="Hnrpf"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..1612
                     /gene="Hnrnpf"
                     /gene_synonym="Hnrpf"
                     /note="hnRNP F; ribonucleoprotein F"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein F"
                     /protein_id="NP_001032363.1"
                     /db_xref="GeneID:64200"
                     /db_xref="RGD:620366"
                     /translation="MMLGPEGGEGYVVKLRGLPWSCSIEDVQNFLSDCTIHDGVAGVH
                     FIYTREGRQSGEAFVELESEDDVKLALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGP
                     NSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFA
                     SQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARR
                     YIGIVKQAGLDRMRSGAYSAGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRY
                     GDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVE
                     FATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGL
                     ESQSVSGCYGAGYSGQNSMGGYD"
ORIGIN      
        1 cgggcgaagg ccgcggagca gcgtcacctt gccctccgcc ctgcttcccg ccaaaacgct
       61 cgtctcaagg ggctccgctt ccgcaaaagc gtttcccctg gtcatttgaa cttccatttc
      121 aggttgagaa caaaaagaag atgcacctgg actttccccg gagccctctg cgtttttaag
      181 gcgtcgggtg gagttggggt tcgtaagccg cgttcgttat tgaaaataga agtcacttct
      241 accttcctcc cgtggaaaac ttgttatctt ccattctgtg tttcctacag aaggcatctg
      301 tggtggttct ttaagctaca aaaaattgcc caagcttgtg tgacatcaac cctgtcaagt
      361 gtccatgatg ctgggccctg agggaggtga aggctatgtg gtcaaactcc gtggcctacc
      421 ctggtcctgc tcaattgagg acgtacaaaa cttcctctcc gactgcacaa ttcatgatgg
      481 ggtcgcaggt gttcatttca tttatactag agaaggcagg cagagtggtg aggcttttgt
      541 tgaacttgag tcagaagatg atgtaaaatt ggctctgaaa aaagacaggg aaagcatggg
      601 acaccggtat attgaggtgt tcaagtcaca cagaaccgag atggattggg tgttgaagca
      661 cagtggtcca aacagcgccg acagtgccaa tgatggcttt gtgaggcttc ggggactccc
      721 gtttggatgc acaaaggaag aaatcgttca gttcttctca gggttggaaa ttgtgccaaa
      781 cgggatcaca ctacctgtgg acccggaagg caagattaca ggggaggcct tcgttcagtt
      841 tgcctcacaa gagttagccg agaaagcttt agggaagcac aaggagagaa tagggcacag
      901 gtatattgaa gtgttcaaga gcagtcagga ggaagttagg tcatactcag atccacctct
      961 gaagtttatg tctgtgcaga ggcctgggcc ttatgacagg cctggcacag cccggaggta
     1021 cattggcatt gtgaaacagg caggcctgga taggatgagg tctggtgcct atagtgcagg
     1081 ctatgggggc tatgaagaat acagtggcct cagtgatggc tatggcttca ccactgacct
     1141 gtttgggaga gacctcagct attgtctctc aggaatgtat gatcacagat acggagacag
     1201 cgagttcaca gtgcagagca ccaccggcca ctgcgtccac atgagagggc tgccctacaa
     1261 agcaacggag aacgacattt acaacttctt ctctccactc aaccctgtga gagttcatat
     1321 tgagattggt cctgatggaa gagtgaccgg agaagctgat gttgagtttg ctactcatga
     1381 agaagcagtg gcagctatgt ccaaggacag ggccaacatg cagcacagat acatagaact
     1441 cttcctgaat tcaacaacag gagctagcaa tggggcttat agcagccagg tgatgcaggg
     1501 catgggtgtg tcagctgccc aggcaactta cagtggcctg gagagccagt cagtgagtgg
     1561 ctgttacggg gccggctaca gcggtcagaa cagcatgggt ggatatgatt agtattgtag
     1621 gaacatttgg gttatttcaa tcagaaaatt tcacaggcag ccaataaaca gtcaagagca
     1681 gtttataact ctagaggaag ctgggggacc cactttgcac catgagtttg tgaaatctgg
     1741 attaaaaaat tacctcttca gtgtttctca tgcaaacttt tcttctagca tgtaatattg
     1801 agtaaactaa aaactatttt cttccgcttt tctcaattaa catttttggt agtatactta
     1861 agagtgatgt tatctgagtt aagtagttta agtatgttga gtggatcttt cagcacacca
     1921 cagtgaacac actgggggca tgtacttttc tggagaactc aaggtgctag atccctgatg
     1981 caaagagaag catttctcat gttcattcta gtttatattt tcatttaaaa tctttaggtt
     2041 aagtttaagc tttttaaaag ttagttttga gaattgagac acaatactaa tactgtagga
     2101 attggtgagg ccttgactta aagctttctt tgtactgtga tttccttttg ggtgtatttt
     2161 gctaagtgaa acttgttaaa ttttttgtta actaaatttt tttcttaaaa taaagacttt
     2221 ttcacaatga aaaaaaaaaa aaaaaaaaaa aaa
//
