LOCUS       NM_024404               1718 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein D
            (Hnrnpd), transcript variant 1, mRNA.
ACCESSION   NM_024404
VERSION     NM_024404.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Yan,J., Du,F., Li,S.D., Yuan,Y., Jiang,J.Y., Li,S., Li,X.Y. and
            Du,Z.X.
  TITLE     AUF1 modulates TGF-beta signal in renal tubular epithelial cells
            via post-transcriptional regulation of Nedd4L expression
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1865 (1), 48-56 (2018)
   PUBMED   28986222
  REMARK    GeneRIF: AUF1 might be a potential player in renal
            tubulointerstitial fibrosis through modulation of TGF-beta signal
            transduction via posttranscriptional regulation of Nedd4L.
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Castellanos-Rubio,A., Fernandez-Jimenez,N., Kratchmarov,R., Luo,X.,
            Bhagat,G., Green,P.H., Schneider,R., Kiledjian,M., Bilbao,J.R. and
            Ghosh,S.
  TITLE     A long noncoding RNA associated with susceptibility to celiac
            disease
  JOURNAL   Science 352 (6281), 91-95 (2016)
   PUBMED   27034373
REFERENCE   3  (bases 1 to 1718)
  AUTHORS   Lee,K.H., Kim,S.H., Kim,H.J., Kim,W., Lee,H.R., Jung,Y., Choi,J.H.,
            Hong,K.Y., Jang,S.K. and Kim,K.T.
  TITLE     AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic
            translation
  JOURNAL   Nucleic Acids Res 42 (6), 3590-3606 (2014)
   PUBMED   24423872
REFERENCE   4  (bases 1 to 1718)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1718)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1718)
  AUTHORS   Raineri,I., Wegmueller,D., Gross,B., Certa,U. and Moroni,C.
  TITLE     Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover
            studied by RNA interference
  JOURNAL   Nucleic Acids Res 32 (4), 1279-1288 (2004)
   PUBMED   14976220
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1718)
  AUTHORS   Arao,Y., Kikuchi,A., Ikeda,K., Nomoto,S., Horiguchi,H. and
            Kayama,F.
  TITLE     A+U-rich-element RNA-binding factor 1/heterogeneous nuclear
            ribonucleoprotein D gene expression is regulated by oestrogen in
            the rat uterus
  JOURNAL   Biochem J 361 (Pt 1), 125-132 (2002)
   PUBMED   11742537
REFERENCE   8  (bases 1 to 1718)
  AUTHORS   Faura,M., Renau-Piqueras,J., Bachs,O. and Bosser,R.
  TITLE     Differential distribution of heterogeneous nuclear
            ribonucleoproteins in rat tissues
  JOURNAL   Biochem Biophys Res Commun 217 (2), 554-560 (1995)
   PUBMED   7503735
REFERENCE   9  (bases 1 to 1718)
  AUTHORS   Ehrenman,K., Long,L., Wagner,B.J. and Brewer,G.
  TITLE     Characterization of cDNAs encoding the murine A+U-rich RNA-binding
            protein AUF1
  JOURNAL   Gene 149 (2), 315-319 (1994)
   PUBMED   7959009
REFERENCE   10 (bases 1 to 1718)
  AUTHORS   Ishikawa,F., Matunis,M.J., Dreyfuss,G. and Cech,T.R.
  TITLE     Nuclear proteins that bind the pre-mRNA 3' splice site sequence
            r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n
  JOURNAL   Mol Cell Biol 13 (7), 4301-4310 (1993)
   PUBMED   8321232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO567918.1, AB046615.1 and CB798484.1.
            
            On Mar 9, 2007 this sequence version replaced NM_024404.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046615.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-436               CO567918.1         1-436
            437-1476            AB046615.1         201-1240
            1477-1718           CB798484.1         152-393
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1718
                     /gene="Hnrnpd"
                     /gene_synonym="Auf1; Hnrpd"
                     /note="heterogeneous nuclear ribonucleoprotein D"
                     /db_xref="GeneID:79256"
                     /db_xref="RGD:620365"
     exon            1..512
                     /gene="Hnrnpd"
                     /gene_synonym="Auf1; Hnrpd"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..1347
                     /gene="Hnrnpd"
                     /gene_synonym="Auf1; Hnrpd"
                     /note="isoform a is encoded by transcript variant 1;
                     heterogeneous nuclear ribonucleoprotein D0; hnRNP D0;
                     AU-rich element RNA-binding protein 1; AU-rich element
                     RNA-binding factor 1; RNA binding protein p45AUF1"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein D0
                     isoform a"
                     /protein_id="NP_077380.2"
                     /db_xref="GeneID:79256"
                     /db_xref="RGD:620365"
                     /translation="MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAAAQGAAAAAGSG
                     SGGGSAPGGTEGGSTEAEGAKIDASKNEEDEGHSNSSPRHTEAATAQREEWKMFIGGL
                     SWDTTKKDLKDYFSKFGDVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKL
                     NGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTN
                     KRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGR
                     ARGRGGGPSQNWNQGYSNYWNQGYGSYGYNSQGYGGYGGYDYTGYNSYYGYGDYSNQQ
                     SGYGKVSRRGGHQNSYKPY"
     exon            513..569
                     /gene="Hnrnpd"
                     /gene_synonym="Auf1; Hnrpd"
                     /inference="alignment:Splign:2.1.0"
     exon            570..738
                     /gene="Hnrnpd"
                     /gene_synonym="Auf1; Hnrpd"
                     /inference="alignment:Splign:2.1.0"
     exon            739..900
                     /gene="Hnrnpd"
                     /gene_synonym="Auf1; Hnrpd"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1032
                     /gene="Hnrnpd"
                     /gene_synonym="Auf1; Hnrpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1132
                     /gene="Hnrnpd"
                     /gene_synonym="Auf1; Hnrpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1279
                     /gene="Hnrnpd"
                     /gene_synonym="Auf1; Hnrpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1377
                     /gene="Hnrnpd"
                     /gene_synonym="Auf1; Hnrpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1705
                     /gene="Hnrnpd"
                     /gene_synonym="Auf1; Hnrpd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcggcgc cattaaagcg aggaggaggc gagagtggcc gccgctgcta cttattcttt
       61 tttagtgcag ccggggagag tgagagtgcg cgctgcgcga gagtgggagg cgaggggggc
      121 aggccgggga gaggcgcagg agcctttgca gccacgcgcg cgccttgtct tgtgtgcctc
      181 gcgaggtaga gcgggcgcgc ggcggcggcg gggattactt tgctgctagt ttcggttcgc
      241 ggcggcggcg ggtgtcgtct cggcggcggc ggaggcagta gcactatgtc ggaggagcag
      301 ttcggagggg acggggcggc ggcggcggca acggcggcgg taggcggctc ggcgggcgag
      361 caggagggag ccatggtggc ggcggcgcag ggggcagcgg cggcggcggg aagcgggagc
      421 ggcggcggct ctgcgcccgg aggcaccgaa ggaggcagca ccgaggcaga gggagcgaag
      481 atcgacgcca gtaagaatga ggaggatgaa ggccattcaa actcctcccc acgacacact
      541 gaagcagcga cggcacagcg ggaagaatgg aaaatgttta taggaggcct tagctgggac
      601 accacaaaga aagacctgaa ggactacttt tccaaatttg gggacgttgt agactgcact
      661 ctgaagttag atcctatcac agggcgatca aggggttttg gctttgtgct atttaaagag
      721 tcggagagtg tagataaggt catggatcag aaagaacata aattgaatgg gaaagtcatt
      781 gatcctaaaa gggccaaagc catgaaaaca aaagagcccg tcaaaaaaat ttttgttggt
      841 ggcctttctc cagacacacc tgaagaaaaa ataagagagt actttggtgg ttttggtgag
      901 gttgaatcca tagagctgcc tatggacaac aagaccaata agaggcgtgg gttctgtttc
      961 attaccttta aggaagagga accagtgaag aagataatgg agaagaaata ccacaatgtt
     1021 ggtcttagta aatgtgaaat aaaagtagcc atgtcgaagg agcagtatca gcagcagcag
     1081 cagtggggat ctagaggagg gtttgcagga agagctcgcg gaagaggcgg tggccccagt
     1141 caaaactgga accagggata tagtaactat tggaaccaag gctatggcag ctatggatat
     1201 aacagccaag ggtacggtgg ttatggagga tatgactaca ctggttacaa cagctactat
     1261 ggatatggtg actatagcaa tcagcagagt ggttatggga aagtatccag acgaggtggt
     1321 catcaaaata gctacaaacc atactaaatt attccatttg caacttatcc ccaacaggtg
     1381 gtgaagcagt attttccaat ttgaagattc atttgaaggt ggctcctgcc acctgctaat
     1441 agcagttcaa actaaatttt ttctatcaag ttcccgaatg gaagtatgac gttgggtccc
     1501 tctgaagttt aattctgagt tctcattaaa agaatttgct ttcattgttt tatttcttaa
     1561 ttgctatgct tcagtatcaa tttgtgtttt atgcccccct cccccccagt attgtagagc
     1621 aagtcttgtg ttacaagccc agtgtgacag tgtcatgatg tagtagtgtc ttactggttt
     1681 tttaataaat ccttttgtat aaaaaaaaaa aaaaaaaa
//
