LOCUS       NM_001277601            1763 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein C
            (Hnrnpc), transcript variant 2, mRNA.
ACCESSION   NM_001277601
VERSION     NM_001277601.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1763)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (bases 1 to 1763)
  AUTHORS   Liu,N., Dai,Q., Zheng,G., He,C., Parisien,M. and Pan,T.
  TITLE     N(6)-methyladenosine-dependent RNA structural switches regulate
            RNA-protein interactions
  JOURNAL   Nature 518 (7540), 560-564 (2015)
   PUBMED   25719671
REFERENCE   3  (bases 1 to 1763)
  AUTHORS   Todd,M.A. and Picketts,D.J.
  TITLE     PHF6 interacts with the nucleosome remodeling and deacetylation
            (NuRD) complex
  JOURNAL   J Proteome Res 11 (8), 4326-4337 (2012)
   PUBMED   22720776
REFERENCE   4  (bases 1 to 1763)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1763)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1763)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   7  (bases 1 to 1763)
  AUTHORS   Raffalli-Mathieu,F., Geneste,O. and Lang,M.A.
  TITLE     Characterization of two nuclear proteins that interact with
            cytochrome P-450 1A2 mRNA. Regulation of RNA binding and possible
            role in the expression of the Cyp1a2 gene
  JOURNAL   Eur J Biochem 245 (1), 17-24 (1997)
   PUBMED   9128719
REFERENCE   8  (bases 1 to 1763)
  AUTHORS   Faura,M., Renau-Piqueras,J., Bachs,O. and Bosser,R.
  TITLE     Differential distribution of heterogeneous nuclear
            ribonucleoproteins in rat tissues
  JOURNAL   Biochem Biophys Res Commun 217 (2), 554-560 (1995)
   PUBMED   7503735
REFERENCE   9  (bases 1 to 1763)
  AUTHORS   Ferreira,J. and Carmo-Fonseca,M.
  TITLE     The biogenesis of the coiled body during early mouse development
  JOURNAL   Development 121 (2), 601-612 (1995)
   PUBMED   7768196
REFERENCE   10 (bases 1 to 1763)
  AUTHORS   Sharp,Z.D., Smith,K.P., Cao,Z.D. and Helsel,S.
  TITLE     Cloning of the nucleic acid-binding domain of the rat HnRNP C-type
            protein
  JOURNAL   Biochim Biophys Acta 1048 (2-3), 306-309 (1990)
   PUBMED   2088340
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region compared to variant 1. It encodes
            isoform 2 which is shorter compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF110512.1, SRR22399489.1099025.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840108, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000015.1  27282562-27282715   c
            155-180             JAXUCZ010000015.1  27276998-27277023   c
            181-457             JAXUCZ010000015.1  27263804-27264080   c
            458-533             JAXUCZ010000015.1  27261832-27261907   c
            534-581             JAXUCZ010000015.1  27261262-27261309   c
            582-742             JAXUCZ010000015.1  27255767-27255927   c
            743-856             JAXUCZ010000015.1  27254298-27254411   c
            857-1038            JAXUCZ010000015.1  27253928-27254109   c
            1039-1763           JAXUCZ010000015.1  27253098-27253822   c
FEATURES             Location/Qualifiers
     source          1..1763
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1763
                     /gene="Hnrnpc"
                     /gene_synonym="hnRNP C; Hnrpc"
                     /note="heterogeneous nuclear ribonucleoprotein C"
                     /db_xref="GeneID:290046"
                     /db_xref="RGD:1309982"
     exon            1..154
                     /gene="Hnrnpc"
                     /gene_synonym="hnRNP C; Hnrpc"
                     /inference="alignment:Splign:2.1.0"
     exon            155..180
                     /gene="Hnrnpc"
                     /gene_synonym="hnRNP C; Hnrpc"
                     /inference="alignment:Splign:2.1.0"
     exon            181..457
                     /gene="Hnrnpc"
                     /gene_synonym="hnRNP C; Hnrpc"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1119
                     /gene="Hnrnpc"
                     /gene_synonym="hnRNP C; Hnrpc"
                     /note="isoform 2 is encoded by transcript variant 2; hnRNP
                     C protein C-terminal fragment (158 AA); hnRNP core protein
                     C; heterogeneous nuclear ribonucleoprotein C (C1/C2);
                     heterogeneous nuclear ribonucleoproteins C1/C2"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein C
                     isoform 2"
                     /protein_id="NP_001264530.1"
                     /db_xref="GeneID:290046"
                     /db_xref="RGD:1309982"
                     /translation="MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIV
                     GCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAA
                     EMYGSSFDLDYDFQRDYYDRMYSYPARVPPPPPIARAVVPSKRQRVSGNTSRRGKSGF
                     NSKSGQRGSSSKSGKLKGDDLQAIKKELTQIKQKVDSLLESLEKIEKEQSKQADLSFS
                     SPVEMKNEKSEEEQSSASVKKDETNVKMESEAGADDSAEEGDLLDDDDNEDRGDDQLE
                     LKDDEKEPEEGEDDRDSANGEDDS"
     exon            458..533
                     /gene="Hnrnpc"
                     /gene_synonym="hnRNP C; Hnrpc"
                     /inference="alignment:Splign:2.1.0"
     exon            534..581
                     /gene="Hnrnpc"
                     /gene_synonym="hnRNP C; Hnrpc"
                     /inference="alignment:Splign:2.1.0"
     exon            582..742
                     /gene="Hnrnpc"
                     /gene_synonym="hnRNP C; Hnrpc"
                     /inference="alignment:Splign:2.1.0"
     exon            743..856
                     /gene="Hnrnpc"
                     /gene_synonym="hnRNP C; Hnrpc"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1038
                     /gene="Hnrnpc"
                     /gene_synonym="hnRNP C; Hnrpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1763
                     /gene="Hnrnpc"
                     /gene_synonym="hnRNP C; Hnrpc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacttttgc ctcggcggca gaggagctcg ggggccattt tgtgaagaga cggagagcga
       61 acggtcgtgt ggttccttgc tgttgtagct ccggcttctc ggcgtagacc cgcagtagga
      121 gaggcaggct cttctctctc tctccttcct cttgtgagat ttttttgatc ttcagctaca
      181 ttttcagctt tgtgagaaac cttactatca gaggagatgg ctagcaatgt taccaacaag
      241 acagatcctc gatccatgaa ttcccgtgta ttcattggga atctcaacac tctggtggtc
      301 aagaagtctg atgtggaggc catcttttca aagtatggca aaattgtggg ttgctctgtg
      361 cataagggct ttgcctttgt ccagtatgtt aatgaaagaa atgcccgagc tgctgtagct
      421 ggagaggatg gcagaatgat tgctggccag gttttagata ttaacctggc tgcagagcca
      481 aaagtgaacc gaggaaaagc gggtgtgaaa cgatctgcag cggagatgta cggttcctca
      541 tttgacttgg actatgactt tcaacgcgat tattatgaca ggatgtacag ttacccagca
      601 cgtgttcctc ctcctcctcc cattgctcga gctgtggtgc cttccaaacg ccagcgtgtg
      661 tcggggaaca cctcacgaag gggcaaaagt ggattcaatt caaagagtgg acaacgggga
      721 tcttcttcca aatctggaaa gttgaaaggt gatgaccttc aggccattaa aaaggagctg
      781 actcagataa aacaaaaagt ggattctctg ctggaaagcc tggaaaaaat tgaaaaagaa
      841 caaagcaaac aagcagactt gtccttctcg tccccagtag aaatgaagaa tgaaaagtct
      901 gaagaggagc agagcagtgc ctctgtgaag aaagatgaga ctaatgtgaa aatggagtct
      961 gaggcaggtg cagatgactc tgctgaggag ggcgacctgc tggatgatga cgataatgaa
     1021 gatcgggggg atgaccagct ggagttgaag gatgatgaaa aagagcctga ggaaggagaa
     1081 gatgacagag atagcgccaa tggggaggat gactcttaag cacatagtgg agcttagaaa
     1141 tcttaaccca ttattcactt acctaggcgc ttgtgagaga tcaaagtaac accagatcct
     1201 ctcccctaga atcttctgca cattctcact gttctccctc cttatccttc ctgtgttcat
     1261 taattcataa ttgccctgcg cctagttcca ttttcacttc ctgtgatgct ccttagtagt
     1321 tttgttaagt cttaccctgt aagttttgct ttaattttga tacctctttg acttaacaat
     1381 aaaaagttgt atggttttta tcaactgtct ccaaaataat ctctcgttat gcagggagta
     1441 cagttattcc cgttcacgat tgcagtagtc gcttccctaa ctgcagaggc atctccttta
     1501 cttgtaaccc tgagagcagc tttgcattag aggcgtgtgt tttccctcac acgagtggga
     1561 ctgttactac acaatggaac catgtatttt tgtgaatggg gttggcatgt caaatgcatc
     1621 ttacaggaaa atagtgttat agtcttaata tttgttttct aaagttatac catgggttat
     1681 ttttgtgaac agcctgatgt ttgggatctt tttctcaaaa ataaacaatt ccttattaaa
     1741 ccaggaattt gaaagaaaga aaa
//
