LOCUS       NM_031330               1592 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein A/B
            (Hnrnpab), mRNA.
ACCESSION   NM_031330
VERSION     NM_031330.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1592)
  AUTHORS   Zhou,Z.J., Dai,Z., Zhou,S.L., Hu,Z.Q., Chen,Q., Zhao,Y.M.,
            Shi,Y.H., Gao,Q., Wu,W.Z., Qiu,S.J., Zhou,J. and Fan,J.
  TITLE     HNRNPAB induces epithelial-mesenchymal transition and promotes
            metastasis of hepatocellular carcinoma by transcriptionally
            activating SNAIL
  JOURNAL   Cancer Res 74 (10), 2750-2762 (2014)
   PUBMED   24638979
REFERENCE   2  (bases 1 to 1592)
  AUTHORS   Carpenter,S., Aiello,D., Atianand,M.K., Ricci,E.P., Gandhi,P.,
            Hall,L.L., Byron,M., Monks,B., Henry-Bezy,M., Lawrence,J.B.,
            O'Neill,L.A., Moore,M.J., Caffrey,D.R. and Fitzgerald,K.A.
  TITLE     A long noncoding RNA mediates both activation and repression of
            immune response genes
  JOURNAL   Science 341 (6147), 789-792 (2013)
   PUBMED   23907535
REFERENCE   3  (bases 1 to 1592)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1592)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1592)
  AUTHORS   Nagel,S., Papadakis,M., Pfleger,K., Grond-Ginsbach,C., Buchan,A.M.
            and Wagner,S.
  TITLE     Microarray analysis of the global gene expression profile following
            hypothermia and transient focal cerebral ischemia
  JOURNAL   Neuroscience 208, 109-122 (2012)
   PUBMED   22366221
REFERENCE   6  (bases 1 to 1592)
  AUTHORS   Saitoh,Y., Miyagi,S., Ariga,H. and Tsutsumi,K.
  TITLE     Functional domains involved in the interaction between Orc1 and
            transcriptional repressor AlF-C that bind to an origin/promoter of
            the rat aldolase B gene
  JOURNAL   Nucleic Acids Res 30 (23), 5205-5212 (2002)
   PUBMED   12466545
REFERENCE   7  (bases 1 to 1592)
  AUTHORS   Percipalle,P., Jonsson,A., Nashchekin,D., Karlsson,C., Bergman,T.,
            Guialis,A. and Daneholt,B.
  TITLE     Nuclear actin is associated with a specific subset of hnRNP
            A/B-type proteins
  JOURNAL   Nucleic Acids Res 30 (8), 1725-1734 (2002)
   PUBMED   11937625
REFERENCE   8  (bases 1 to 1592)
  AUTHORS   Yabuki,T., Miyagi,S., Ueda,H., Saitoh,Y. and Tsutsumi,K.
  TITLE     A novel growth-related nuclear protein binds and inhibits rat
            aldolase B gene promoter
  JOURNAL   Gene 264 (1), 123-129 (2001)
   PUBMED   11245986
REFERENCE   9  (bases 1 to 1592)
  AUTHORS   Leverrier,S., Cinato,E., Paul,C., Derancourt,J., Bemark,M.,
            Leanderson,T. and Legraverend,C.
  TITLE     Purification and cloning of type A/B hnRNP proteins involved in
            transcriptional activation from the Rat spi 2 gene GAGA box
  JOURNAL   Biol Chem 381 (11), 1031-1040 (2000)
   PUBMED   11154060
REFERENCE   10 (bases 1 to 1592)
  AUTHORS   Mikheev,A.M., Mikheev,S.A., Zhang,Y., Aebersold,R. and Zarbl,H.
  TITLE     CArG binding factor A (CBF-A) is involved in transcriptional
            regulation of the rat Ha-ras promoter
  JOURNAL   Nucleic Acids Res 28 (19), 3762-3770 (2000)
   PUBMED   11000268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB780765.1, BC066664.1 and CK473681.1.
            
            On Apr 5, 2007 this sequence version replaced NM_031330.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066664.1, AJ238855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CB780765.1         1-5
            6-1588              BC066664.1         1-1583
            1589-1592           CK473681.1         570-573
FEATURES             Location/Qualifiers
     source          1..1592
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1592
                     /gene="Hnrnpab"
                     /gene_synonym="A1F-C1; CBF-A; Cgbf; Cgbfa; DBP40; Hnrpab"
                     /note="heterogeneous nuclear ribonucleoprotein A/B"
                     /db_xref="GeneID:83498"
                     /db_xref="RGD:69255"
     exon            1..176
                     /gene="Hnrnpab"
                     /gene_synonym="A1F-C1; CBF-A; Cgbf; Cgbfa; DBP40; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     exon            177..423
                     /gene="Hnrnpab"
                     /gene_synonym="A1F-C1; CBF-A; Cgbf; Cgbfa; DBP40; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1057
                     /gene="Hnrnpab"
                     /gene_synonym="A1F-C1; CBF-A; Cgbf; Cgbfa; DBP40; Hnrpab"
                     /note="CArG-binding factor-A"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein A/B"
                     /protein_id="NP_112620.2"
                     /db_xref="GeneID:83498"
                     /db_xref="RGD:69255"
                     /translation="MSDAAEEQPMETTGATENGHEAAPEGEAPVEPSPGAAAPATPAG
                     SGGGTTAAPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVV
                     DCTIKMDPNTGRSRGFGFILFKDSSSVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKK
                     IFVGGLNPEATEEKIREYFGQFGEIEAIELPIDPKLNKRRGFVFITFKEEDPVKKVLE
                     KKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGQGSTNYGKSQRRG
                     GHQNNYKPY"
     exon            424..592
                     /gene="Hnrnpab"
                     /gene_synonym="A1F-C1; CBF-A; Cgbf; Cgbfa; DBP40; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     exon            593..751
                     /gene="Hnrnpab"
                     /gene_synonym="A1F-C1; CBF-A; Cgbf; Cgbfa; DBP40; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     exon            752..883
                     /gene="Hnrnpab"
                     /gene_synonym="A1F-C1; CBF-A; Cgbf; Cgbfa; DBP40; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     exon            884..986
                     /gene="Hnrnpab"
                     /gene_synonym="A1F-C1; CBF-A; Cgbf; Cgbfa; DBP40; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1592
                     /gene="Hnrnpab"
                     /gene_synonym="A1F-C1; CBF-A; Cgbf; Cgbfa; DBP40; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcaccgcg cgggacggag ctgaggtctt ccttctcgat agcgtacggc ggctgccgag
       61 tagagcgata gggtctgtgg acccggacaa gccctagggg ggtccgagtg tgaccgcggc
      121 caagcccgcg tcgccttctg cggcgagtag ggcctcgcgg cgtcatcggc ggcgaggagc
      181 cgctgcggcc tggccgacca tgtcggacgc ggctgaggag cagcccatgg agacgacggg
      241 cgccaccgag aacggacacg aggccgcccc cgaaggcgag gccccggtcg agcctagccc
      301 tggggcagcg gcccccgcga ctccggcggg gtctgggggc gggaccacgg ccgccccgag
      361 cgggaaccag aacggcgccg aaggcgacca gatcaacgcc agcaagaacg aggaggacgc
      421 gggaaaaatg ttcgttggtg gtctgagctg ggataccagc aaaaaagatc taaaggatta
      481 ttttactaag tttggagagg tcgttgactg tacaataaaa atggatccga acactggtcg
      541 atcaagaggg tttgggttta ttctcttcaa agattcttct agtgtggaga aggtcttaga
      601 tcagaaggag cacagactgg atggtcgtgt cattgaccct aaaaaggcta tggctatgaa
      661 gaaggaccct gtgaagaaaa tctttgtggg aggtctaaac cctgaagcca cagaggaaaa
      721 gatcagagaa tactttggcc agtttgggga gattgaggcc attgaacttc caatagatcc
      781 caagttgaac aaaagacggg gttttgtttt tattacattt aaagaggaag accctgtgaa
      841 gaaagttctg gagaaaaaat tccatactgt cagtggtagc aagtgtgaaa tcaaggttgc
      901 ccagcccaaa gaggtgtacc agcaacagca gtatggctct gggggccgag gaaatcgcaa
      961 tcgagggaac cgaggcagtg gtggaggtca gggtagtaca aattacggga agagccagcg
     1021 acgtggtggt catcagaata actacaagcc atactgagag gcagcaggag cggccgagtg
     1081 acgaccgcac acgctttgtt tggacgcgga gtgaacacaa ttatgtacca aatttaactt
     1141 ggcaaacttt tatggcctgt cccatgtgca tcttatttaa aatttccccc ggaaatcact
     1201 ctcctgttta ctattccaga gctctagttg ttgtaggcag cgtgtggcgt ctcagaggtc
     1261 agagcggcat tagggggctg attttattac caggttaccc tgttctagat tggagggtct
     1321 gcttcctgct gccgctctgc agcctggacc tgtggaccct ggttgtaaag agtaaactgt
     1381 atcttaggaa accagtgtca cctttttcac cttttaattt tatattattt gtgtcataca
     1441 tttccagtaa tggaagtgtt aattttactg tactttttgg taccttttgg gaatctaatg
     1501 tattgtaagg tattttacac gtgtcctgat tttgccacga cctggatatt gaagctatcc
     1561 aagcttttga aataaaaatt aaacaaaacc cc
//
