LOCUS       NM_001111294            5280 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein A3
            (Hnrnpa3), transcript variant 1, mRNA.
ACCESSION   NM_001111294
VERSION     NM_001111294.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5280)
  AUTHORS   Mori,K., Nihei,Y., Arzberger,T., Zhou,Q., Mackenzie,I.R.,
            Hermann,A., Hanisch,F., Kamp,F., Nuscher,B., Orozco,D., Edbauer,D.
            and Haass,C.
  CONSRTM   German Consortium for Frontotemporal Lobar Degeneration; Bavarian
            Brain Banking Alliance
  TITLE     Reduced hnRNPA3 increases C9orf72 repeat RNA levels and
            dipeptide-repeat protein deposition
  JOURNAL   EMBO Rep 17 (9), 1314-1325 (2016)
   PUBMED   27461252
  REMARK    GeneRIF: Neurons in the hippocampus of C9orf72 patients are
            frequently devoid of hnRNPA3. Reduced nuclear hnRNPA3 in the
            hippocampus of patients with extended C9orf72 repeats correlates
            with increased DPR deposition.
REFERENCE   2  (bases 1 to 5280)
  AUTHORS   Todd,M.A. and Picketts,D.J.
  TITLE     PHF6 interacts with the nucleosome remodeling and deacetylation
            (NuRD) complex
  JOURNAL   J Proteome Res 11 (8), 4326-4337 (2012)
   PUBMED   22720776
REFERENCE   3  (bases 1 to 5280)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 5280)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 5280)
  AUTHORS   Chen,J.J., Jiang,H.Y., Liu,P., Liu,W., Wei,M.T., Wang,S.X. and
            Weng,Y.G.
  TITLE     [Differential analysis of two-dimensional gel electrophoresis
            profiles in lung tissue of rats exposed to silica early]
  JOURNAL   Zhonghua Yu Fang Yi Xue Za Zhi 43 (5), 418-422 (2009)
   PUBMED   19534998
REFERENCE   6  (bases 1 to 5280)
  AUTHORS   Shultz,M.A., Zhang,L., Gu,Y.Z., Baker,G.L., Fannuchi,M.V.,
            Padua,A.M., Gurske,W.A., Morin,D., Penn,S.G., Jovanovich,S.B.,
            Plopper,C.G. and Buckpitt,A.R.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
REFERENCE   7  (bases 1 to 5280)
  AUTHORS   Ma,A.S., Moran-Jones,K., Shan,J., Munro,T.P., Snee,M.J., Hoek,K.S.
            and Smith,R.
  TITLE     Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking
            response element-binding protein
  JOURNAL   J Biol Chem 277 (20), 18010-18020 (2002)
   PUBMED   11886857
  REMARK    GeneRIF: has a role in cytoplasmic trafficking of RNA (heterogenous
            nuclear ribonucleoprotein A3)
REFERENCE   8  (bases 1 to 5280)
  AUTHORS   Percipalle,P., Jonsson,A., Nashchekin,D., Karlsson,C., Bergman,T.,
            Guialis,A. and Daneholt,B.
  TITLE     Nuclear actin is associated with a specific subset of hnRNP
            A/B-type proteins
  JOURNAL   Nucleic Acids Res 30 (8), 1725-1734 (2002)
   PUBMED   11937625
REFERENCE   9  (bases 1 to 5280)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 5280)
  AUTHORS   Plomaritoglou,A., Choli-Papadopoulou,T. and Guialis,A.
  TITLE     Molecular characterization of a murine, major A/B type hnRNP
            protein: mBx
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 54-62 (2000)
   PUBMED   10786617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB585714.1, BC081878.1, CF110891.1, BI292197.1, AT006305.1,
            AW534817.1, BP488086.1, CV109437.1, CV107265.1 and CF110612.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               CB585714.1         13-318
            307-913             BC081878.1         247-853
            914-1927            CF110891.1         80-1093
            1928-2345           BI292197.1         18-435              c
            2346-2472           AT006305.1         130-256
            2473-2644           AW534817.1         186-357             c
            2645-3130           BP488086.1         2-487               c
            3131-3472           CV109437.1         344-685
            3473-4023           CV107265.1         100-650
            4024-4478           CF110612.1         537-991
            4479-5280           BC081878.1         1807-2608
FEATURES             Location/Qualifiers
     source          1..5280
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..5280
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="heterogeneous nuclear ribonucleoprotein A3"
                     /db_xref="GeneID:362152"
                     /db_xref="RGD:727807"
     exon            1..152
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1220
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="isoform a is encoded by transcript variant 1; hnRNP
                     A3"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein A3
                     isoform a"
                     /protein_id="NP_001104764.1"
                     /db_xref="GeneID:362152"
                     /db_xref="RGD:727807"
                     /translation="MEVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLRKLFIGGLSF
                     ETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDG
                     RVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMED
                     RQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGG
                     GSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGGN
                     YGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGGYDGYNEGGNFGGGNYGGGGNYNDFG
                     NYSGQQQSNYGPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGSRRF"
     exon            153..275
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            276..422
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            423..633
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            634..723
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            724..819
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            820..900
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1044
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1167
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1233
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..5256
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catcacgtgg ttactagccc cgcctcttcc tctcggtccc atattgaact cgagttggaa
       61 gaggcgagtc cggtctcaaa atggaggtaa aaccgccgcc cggtcgcccc cagcctgact
      121 ccggccgtcg ccgccgccgc cggggggagg agggccacga tccaaaggaa ccagagcagc
      181 tgaggaagct gtttattggt ggtctgagct ttgaaaccac agatgatagc ttaagagaac
      241 attttgagaa atggggcaca cttacagatt gtgtggtaat gagagatcct caaacaaaac
      301 gttccagagg ctttggtttt gtgacctact cttgtgtcga agaggtggat gctgcaatgt
      361 gtgctcggcc acacaaggtt gatggacgtg tggtggaacc aaagagagct gtttctagag
      421 aggattctgt aaagcctggt gcccatttaa cagtgaagaa gatttttgtt ggtggtatta
      481 aagaggatac agaagaatat aatctgagag actactttga aaagtatggc aagattgaaa
      541 ccatagaagt tatggaagat aggcagagtg ggaaaaagag aggatttgct tttgtaactt
      601 ttgatgatca tgacacagtt gataaaattg ttgttcagaa ataccacact attaatgggc
      661 ataattgtga agtgaaaaag gccctttcta aacaagagat gcagtctgct ggatcacaga
      721 gaggtcgtgg aggtggatct ggcaacttta tgggacgtgg aggaaacttt ggtggcggcg
      781 gaggaaactt tgggcgtgga ggaaactttg gtggaagagg aggctatggt ggtggaggtg
      841 gtggcagcag aggcagttat ggaggtggtg atggtggata taatggattt ggaggtgatg
      901 gtggcaacta tggtggtggt cctggttaca gtagtagagg aggttatgga ggtggtggac
      961 caggatatgg aaaccaaggt ggtggatatg gtggtggagg aggaggatat gatggttaca
     1021 atgaaggagg aaattttggt ggaggtaact atggtggtgg tgggaactat aatgactttg
     1081 gaaattatag tggacagcaa caatctaatt atggacccat gaaggggggc agttttggtg
     1141 gaagaagctc aggcagtccc tatggtggtg gctatggatc tggaggtgga agtggtggat
     1201 atggtagcag aaggttttaa aataaaacaa acggctacag ttcttagcag gagagagagc
     1261 gaggagttgt caggaaagct gcaggttact ttgagacagt cgtcctaaat gcattagagg
     1321 aactgtaaaa atctgccaca gaaggaacga tgatccatag tcagaaaagt tactgcagct
     1381 taaacaggaa gcccttcttg ttcaggactg tcatagccac agtttgcaaa agtgcagcta
     1441 tcgattaatg caatgtagtg tcaattagat gtacattcct gaggtctttt atctgttgta
     1501 gctttgtctt tttctttttc ttttcattac atcaggtata ttgccctgta aattgtggta
     1561 gtggtaccag gaataaaaaa ttaaggaatt tttaactttt caatatttgt gtagttcagt
     1621 ttttctacat tttagtacag aaactttaac aaaatgcagt tttgaaggtg tttccttgtg
     1681 agttaacaag taaagaagat cattgttaat cactattttg tatgaatttt gctaaagtta
     1741 actgtaaaga aacacctact gacttgcagt ttaaggggaa tctattctcc catttccaaa
     1801 accatgatga ctgggcgctg acatgtggag agaatagata cttgtatgtt tgcaaatgtg
     1861 tgttttagat aattaggatt gggtaataaa aaatagcata tttgtgaatt taatagcatt
     1921 aagattacat tcaaatgaaa aagatctcaa aatttgctgt ttggttttgt gcattttctt
     1981 tcaaaatgta atcatgattt tagtgtggta gacttaagtc ctaaccatgt ttaagaacat
     2041 ctccattcca catttacctt gataacattg aaactgctgc caatagtttg gggtatgaag
     2101 tgtttatact gccctctact tcccaagggc ggtagatgaa tgccatctcc ctatttaaca
     2161 gccttttaat atagaaccac caagtctgct gtgtctgagc agactgtggt gggtacctgg
     2221 tttgtttctg cttttaagat ttaaggtctc aaagccccat tggtctagtc aactttcctt
     2281 ggttacgttc cccacacaca gcttttcaga gcaaaggaat aaaaatcact ggtttgaacc
     2341 cctgactggc tggcatgctt tcctgttcat attctagcca ttttgctgga tggtgaagca
     2401 aagtatagta aggtgtcgtc taaaccaagc agcagaagat gtagcacaca cagttgctca
     2461 gtgcaagcac ctcacttccc aaatatctca attcaaattc agaacgtctt gagtccttaa
     2521 atccccaaag aacacatggt tattcttgta tatatatcat tctaaaacat gttgggtgtg
     2581 acaatttgga gaacctgttt gaggagcttt agatactaag gtggtcatat acatgaaaaa
     2641 aaaatgtctg ctgttgcgcc agctagtgct taacaatttc attcaagtcc taagtatgtg
     2701 ccctgctgtt actttctttg gcagttgacc gttgaattca gatttttact tggtttttaa
     2761 agtataagct aaacaagcaa taaaaagggg aatggggtgt gctagtattt caatatgctc
     2821 tcttgttgct ctactgtgcc tctgtgcatt aatatttgga tgcatgcaat gctagcatgg
     2881 aactttggtc ttcacaaata ctgcagtttt tccagaaaac actcacaaac caataaatgt
     2941 aacagacaac attccatttg ttaatgggca tatgtgcata agcagtgtag aaaataggct
     3001 catgttagaa actggttaca tccttcataa ctaaaagtgt ggttatttga atggacactg
     3061 tcaatgttca tagcttaaac ctgggtacct ggtcaaaatg cttaggaaac attaaaattg
     3121 agctaaattg tctcaagtcc ttttattcat ataataaaga tggaagaaat gggatggggg
     3181 aggctggcag ttcctgcttt gtttgtgaaa ttgttgggca caaccttgac agtatcctta
     3241 aatgtaatga ggtcaattgt attaaccaac tttttatgtt ctggaactag tatcatagtg
     3301 aaaccttttt cagtaagttg atgtttacaa cctataatca ggtgaaacct gtatgtggcc
     3361 tgtttataag ttgtactaag ttagtttttg tgaacagtgt ggaagagtaa gccatgagag
     3421 cgatttaacc agctttaaag gacctaagtt gtgcttttta agcactggat caaaggaaaa
     3481 cccactaaga caggacttca gcagccaatt gagtatggac aagtcagcat aaataaagaa
     3541 tgagaaggca gcagcaagag cttcaacaac agagaagtgg aggcataaga tactatggtg
     3601 atagtgagca acttcccaaa agctagttaa agctgcttat tacaactgaa tgtcgaagaa
     3661 agtagcagga aggagctccg ccatttggaa catcaatgag ctagttgcca caggcactag
     3721 gtctagcgtt tagacctgca aggaagggca ataagcatta ggtaaggctt gaatttgatt
     3781 tttttttcac taattaaaga atactttttg taaagcaagg taagagtaat ctttttgatt
     3841 tgcaggtgaa tgagaaccct acctgcctaa ctgaggaatg tctttcccac caccttaaat
     3901 acgaaggttt ctggctgggt aaggtttgta gctcacagta aaaaccgatg accgttggtt
     3961 tccctacaaa ttaatgggac agtttgagac attacccctc aagctcagtt ttatttggta
     4021 ccccatagaa caagttctaa gccttaggca gttataccat gccaagggta tttgtcatga
     4081 gccagatgtg ttctcttcat atgtacaact tgctgttcca agggaaaggc agctttccat
     4141 aacggaaagt catgttggct tttcagaaag taatttttgg tgtatgactt tataatgagc
     4201 tgctagtttc cctagttcca ccctaggaaa gcaaggaact ttcacaattg tcaaaatgtc
     4261 ttcctcaaag ttctctagct taaaagttta ctattgcatg gaccagcagg gacagtcagt
     4321 ttagttatgt gtttttagtc ttccccaaaa cccatcacac caacagtctg gtctcactgt
     4381 tgtcctagct tggaactcag tccaccagcc ttctgtcacc caagtgctgg gattaaaggg
     4441 tggtgcctat atgacaactc attcctttaa aaaaaaaaat ccaaagaacg gctgggttac
     4501 tattaaaatg tgttgctgat tgtccaaaag ggctatttct gctgccctga aagggcttct
     4561 ttgaaaattg cttaattcag gttacttttt aatagaatat tttcagggga caaatctgca
     4621 aaatgtttcc ttcacaggga taccctgcat tgcatcaaca agtttgtgtg gcatttaagt
     4681 caggatgaat tcacagaaat aggtagcaat ctttcagtgg tggttactta atagatttag
     4741 aaaaataaat acgttatctt aaaaggcatt tacagttcat ttcctttctg aaataaaatt
     4801 attttactta atatggttcc actgtcattt ctgcaaaaat cgttggtagc aacggtgaac
     4861 aagaaaacaa acgaaggctg actttggttt tgttggactt gtgggatact gcttccagtt
     4921 tatgtctgaa agctgtgttc acattcatgt tgaaattagg gaacacatgg agaaaaagtt
     4981 ctggtagggg actacagcga gttcaacttg gtttttatga gttctgtcac gatttaaaac
     5041 gcctgacaac ggtacggtga ttggcatggt agcaagcatg cagatatgca aggtgctgtg
     5101 aggatcggta gcctgtccaa gtattcagtt ttgaagctaa catgttttca gatctttatg
     5161 acagcagagg tggtctgtaa ttcaattgtt tcatttgtag cataatgaaa tgttacagaa
     5221 agatgacctt ttcattaaaa tatttttaga aatgtgaaaa aaaaaaaaaa aaaaaaaaaa
//
