LOCUS       NM_001104613            1777 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein A2/B1
            (Hnrnpa2b1), mRNA.
ACCESSION   NM_001104613 XM_001055961 XM_342684
VERSION     NM_001104613.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1777)
  AUTHORS   Xu,H. and Xu,B.
  TITLE     UBE2I regulates the nuclear translocation of hnRNPA2B1 by
            contributing to SUMO modification in osteoarthritis
  JOURNAL   Gene 927, 148740 (2024)
   PUBMED   38955308
  REMARK    GeneRIF: UBE2I regulates the nuclear translocation of hnRNPA2B1 by
            contributing to SUMO modification in osteoarthritis.
REFERENCE   2  (bases 1 to 1777)
  AUTHORS   Lan,X., Yan,J., Ren,J., Zhong,B., Li,J., Li,Y., Liu,L., Yi,J.,
            Sun,Q., Yang,X., Sun,J., Meng,L., Zhu,W., Holmdahl,R., Li,D. and
            Lu,S.
  TITLE     A novel long noncoding RNA Lnc-HC binds hnRNPA2B1 to regulate
            expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol
            metabolism
  JOURNAL   Hepatology 64 (1), 58-72 (2016)
   PUBMED   26663205
  REMARK    GeneRIF: lnc-HC negatively regulates cholesterol metabolism within
            hepatocytes through physical interaction with hnRNPA2B1. By further
            binding to the target messenger RNA of Cyp7a1 or Abca1, the
            lnc-HC-hnRNPA2B1 complex decreases expressions of the two genes
            that are implicated in cellular cholesterol excretion.
REFERENCE   3  (bases 1 to 1777)
  AUTHORS   Alarcon,C.R., Goodarzi,H., Lee,H., Liu,X., Tavazoie,S. and
            Tavazoie,S.F.
  TITLE     HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing
            Events
  JOURNAL   Cell 162 (6), 1299-1308 (2015)
   PUBMED   26321680
REFERENCE   4  (bases 1 to 1777)
  AUTHORS   Leal,G., Afonso,P.M. and Duarte,C.B.
  TITLE     Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a
            BDNF-dependent mechanism in cultured hippocampal neurons
  JOURNAL   PLoS One 9 (10), e108175 (2014)
   PUBMED   25286195
  REMARK    GeneRIF: These results show that the distribution of hnRNP A2/B1 is
            regulated by BDNF.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1777)
  AUTHORS   Kasim,M., Benko,E., Winkelmann,A., Mrowka,R., Staudacher,J.J.,
            Persson,P.B., Scholz,H., Meier,J.C. and Fahling,M.
  TITLE     Shutdown of achaete-scute homolog-1 expression by heterogeneous
            nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia
  JOURNAL   J Biol Chem 289 (39), 26973-26988 (2014)
   PUBMED   25124043
  REMARK    GeneRIF: data suggest that a prominent down-regulation of
            hnRNP-A2/B1 during hypoxia is associated with the
            post-transcriptional suppression of hASH1 synthesis.
REFERENCE   6  (bases 1 to 1777)
  AUTHORS   Montuenga,L.M., Zhou,J., Avis,I., Vos,M., Martinez,A., Cuttitta,F.,
            Treston,A.M., Sunday,M. and Mulshine,J.L.
  TITLE     Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes
            with critical stages of mammalian lung development
  JOURNAL   Am J Respir Cell Mol Biol 19 (4), 554-562 (1998)
   PUBMED   9761751
REFERENCE   7  (bases 1 to 1777)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   8  (bases 1 to 1777)
  AUTHORS   Hoek,K.S., Kidd,G.J., Carson,J.H. and Smith,R.
  TITLE     hnRNP A2 selectively binds the cytoplasmic transport sequence of
            myelin basic protein mRNA
  JOURNAL   Biochemistry 37 (19), 7021-7029 (1998)
   PUBMED   9578590
REFERENCE   9  (bases 1 to 1777)
  AUTHORS   Burd,C.G., Swanson,M.S., Gorlach,M. and Dreyfuss,G.
  TITLE     Primary structures of the heterogeneous nuclear ribonucleoprotein
            A2, B1, and C2 proteins: a diversity of RNA binding proteins is
            generated by small peptide inserts
  JOURNAL   Proc Natl Acad Sci U S A 86 (24), 9788-9792 (1989)
   PUBMED   2557628
REFERENCE   10 (bases 1 to 1777)
  AUTHORS   Tockman,M.S., Gupta,P.K., Myers,J.D., Frost,J.K., Baylin,S.B.,
            Gold,E.B., Chase,A.M., Wilkinson,P.H. and Mulshine,J.L.
  TITLE     Sensitive and specific monoclonal antibody recognition of human
            lung cancer antigen on preserved sputum cells: a new approach to
            early lung cancer detection
  JOURNAL   J Clin Oncol 6 (11), 1685-1693 (1988)
   PUBMED   2846790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 3, 2020 this sequence version replaced NM_001104613.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1080335.1,
                                           SRR26360172.89805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000004.1  81875676-81875886   c
            212-247             JAXUCZ010000004.1  81873430-81873465   c
            248-358             JAXUCZ010000004.1  81873222-81873332   c
            359-505             JAXUCZ010000004.1  81872929-81873075   c
            506-716             JAXUCZ010000004.1  81872539-81872749   c
            717-818             JAXUCZ010000004.1  81872334-81872435   c
            819-899             JAXUCZ010000004.1  81872168-81872248   c
            900-962             JAXUCZ010000004.1  81871503-81871565   c
            963-1082            JAXUCZ010000004.1  81870729-81870848   c
            1083-1205           JAXUCZ010000004.1  81870405-81870527   c
            1206-1288           JAXUCZ010000004.1  81869661-81869743   c
            1289-1777           JAXUCZ010000004.1  81869012-81869500   c
FEATURES             Location/Qualifiers
     source          1..1777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1777
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /note="heterogeneous nuclear ribonucleoprotein A2/B1"
                     /db_xref="GeneID:362361"
                     /db_xref="RGD:1310403"
     exon            1..211
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1267
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /note="nuclear ribonucleoprotein particle A2 protein;
                     heterogeneous nuclear ribonucleoprotein A2; heterogeneous
                     nuclear ribonucleoprotein B1; heterogeneous nuclear
                     ribonucleoprotein B0a; heterogeneous nuclear
                     ribonucleoprotein B0b; hnRNP A2 / hnRNP B1; hnRNP A2/B1"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoproteins A2/B1"
                     /protein_id="NP_001098083.2"
                     /db_xref="GeneID:362361"
                     /db_xref="RGD:1310403"
                     /translation="MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQW
                     GKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREES
                     GKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTF
                     DDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGN
                     FGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGY
                     GNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGG
                     NYGPGGSGGSGGYGGRSRY"
     exon            212..247
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..358
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..505
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..716
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..818
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..899
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..962
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1082
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1205
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1288
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1777
                     /gene="Hnrnpa2b1"
                     /gene_synonym="hnRNP; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggttctag aaaagcggcg gtctcggctc cagcggcagt agcagcggcg ccggtcccgt
       61 gtgcaggtgc tccgtgcggc gcagtttctt ggccatcggc tgctctcacc acagcgtcag
      121 gacgagtccc gtgcgtgtcc gtccgcggag gtctttctct tctcgctcgg ctgcgggaaa
      181 tcgagctgaa gcgactgagt ccgcgatgga gaaaacttta gaaactgttc ctttggagag
      241 gaaaaagaga gaaaaggaac agttccgtaa gctctttatt ggtggcttaa gctttgaaac
      301 cacagaagaa agtttgagaa actactacga gcaatgggga aagctcacag actgtgtggt
      361 tatgcgggat cctgcaagca aaagatcaag aggatttggc tttgtaactt tctcatctat
      421 ggctgaggtt gatgctgcca tggctgcaag gcctcattcc attgatggca gggtggttga
      481 gccaaaacgt gctgtggcaa gagaggagtc tgggaaacca ggagcccatg tgactgtgaa
      541 gaaactgttc gttggtggaa ttaaggaaga tactgaggag catcacctta gagattactt
      601 tgaagaatat ggaaaaattg atactattga aataattact gataggcagt ctggaaaaaa
      661 aagaggcttt ggctttgtta cctttgatga ccatgatcct gtggataaga ttgtcttgca
      721 gaaatatcac accataaatg gtcacaatgc agaagttaga aaggcattgt ctagacaaga
      781 aatgcaggaa gtccaaagtt ctaggagtgg aagaggagga aactttggtt ttggagattc
      841 tcgaggtggc ggtggcaatt ttggaccagg accaggaagc aactttaggg ggggttctga
      901 tggatatgga agtggacgtg gatttgggga tggctataat gggtatggag gaggacctgg
      961 aggtggcaat tttggaggta gccctggtta tggaggagga agaggaggat atggtggtgg
     1021 aggacctgga tatggcaacc agggtggggg ctacggaggt ggttatgaca actatggagg
     1081 aggaaattat ggaagtggaa attacaatga ttttggaaat tataaccagc aaccttctaa
     1141 ctacggtcca atgaagagtg gaaactttgg tggtagcagg aacatgggag gaccatatgg
     1201 tggagggaac tatggtcctg gaggaagtgg aggaagtggg ggctatggtg gaaggagccg
     1261 atattgagct tcttcctact taccatgggc ttcactgtat aaataggaga ggatgagagc
     1321 ccagaggtaa cagaacagct tcaggttatc gaaataacaa tgttaaggaa actcttatct
     1381 cagtcatgca taaatatgca gtgatatggc agaagacacc agagcagatg cagagagcca
     1441 ttttgtgaat ggattggatt atttaatacc ttactgtgga ggaaggattg taaaaaaaaa
     1501 tgcctttgag acagtttctt agctttttaa ttgttgtttc tttctagtgg tctttgtaag
     1561 agtgtagaag cattccttct ttgataatgt taaatttgta agtttcaggt gacatgtgaa
     1621 acctttttta agatttttct caaaaagttt tgaaaagcta ttagccagga tcatggtgta
     1681 ataagacata acgtttttcc tttaaaaatt taagtgcgtg tgtagagtta agaagctgtt
     1741 gtacatttat gatttaataa aataattcta aaggaaa
//
