LOCUS       NM_001399274            1874 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein A1
            (Hnrnpa1), transcript variant 1, mRNA.
ACCESSION   NM_001399274 XM_006242384
VERSION     NM_001399274.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1874)
  AUTHORS   Huang,B., Liu,X., Zhang,T., Wu,Q., Huang,C., Xia,X.G. and Zhou,H.
  TITLE     Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in
            Transgenic Rats
  JOURNAL   Int J Mol Sci 24 (22), 16214 (2023)
   PUBMED   38003404
  REMARK    GeneRIF: Increase in hnRNPA1 Expression Suffices to Kill Motor
            Neurons in Transgenic Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1874)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 1874)
  AUTHORS   Liu,Q., Shu,S., Wang,R.R., Liu,F., Cui,B., Guo,X.N., Lu,C.X.,
            Li,X.G., Liu,M.S., Peng,B., Cui,L.Y. and Zhang,X.
  TITLE     Whole-exome sequencing identifies a missense mutation in hnRNPA1 in
            a family with flail arm ALS
  JOURNAL   Neurology 87 (17), 1763-1769 (2016)
   PUBMED   27694260
REFERENCE   4  (bases 1 to 1874)
  AUTHORS   Liu,X.Y., Li,H.L., Su,J.B., Ding,F.H., Zhao,J.J., Chai,F., Li,Y.X.,
            Cui,S.C., Sun,F.Y., Wu,Z.Y., Xu,P. and Chen,X.H.
  TITLE     Regulation of RAGE splicing by hnRNP A1 and Tra2beta-1 and its
            potential role in AD pathogenesis
  JOURNAL   J Neurochem 133 (2), 187-198 (2015)
   PUBMED   25689357
REFERENCE   5  (bases 1 to 1874)
  AUTHORS   Sangith,N., Srinivasaraghavan,K., Sahu,I., Desai,A., Medipally,S.,
            Somavarappu,A.K., Verma,C. and Venkatraman,P.
  TITLE     Discovery of novel interacting partners of PSMD9, a proteasomal
            chaperone: Role of an Atypical and versatile PDZ-domain motif
            interaction and identification of putative functional modules
  JOURNAL   FEBS Open Bio 4, 571-583 (2014)
   PUBMED   25009770
  REMARK    Erratum:[FEBS Open Bio. 2015 Jun 28;5:731-2. doi:
            10.1016/j.fob.2015.06.010.. PMID: 26448906]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1874)
  AUTHORS   Faura,M., Renau-Piqueras,J., Bachs,O. and Bosser,R.
  TITLE     Differential distribution of heterogeneous nuclear
            ribonucleoproteins in rat tissues
  JOURNAL   Biochem Biophys Res Commun 217 (2), 554-560 (1995)
   PUBMED   7503735
REFERENCE   7  (bases 1 to 1874)
  AUTHORS   Kumar,A. and Wilson,S.H.
  TITLE     Studies of the strand-annealing activity of mammalian hnRNP complex
            protein A1
  JOURNAL   Biochemistry 29 (48), 10717-10722 (1990)
   PUBMED   1703006
REFERENCE   8  (bases 1 to 1874)
  AUTHORS   Planck,S.R., Listerud,M.D. and Buckley,S.D.
  TITLE     Modulation of hnRNP A1 protein gene expression by epidermal growth
            factor in Rat-1 cells
  JOURNAL   Nucleic Acids Res 16 (24), 11663-11673 (1988)
   PUBMED   3062579
REFERENCE   9  (bases 1 to 1874)
  AUTHORS   Cobianchi,F., Karpel,R.L., Williams,K.R., Notario,V. and
            Wilson,S.H.
  TITLE     Mammalian heterogeneous nuclear ribonucleoprotein complex protein
            A1. Large-scale overproduction in Escherichia coli and cooperative
            binding to single-stranded nucleic acids
  JOURNAL   J Biol Chem 263 (2), 1063-1071 (1988)
   PUBMED   2447078
REFERENCE   10 (bases 1 to 1874)
  AUTHORS   Cobianchi,F., SenGupta,D.N., Zmudzka,B.Z. and Wilson,S.H.
  TITLE     Structure of rodent helix-destabilizing protein revealed by cDNA
            cloning
  JOURNAL   J Biol Chem 261 (8), 3536-3543 (1986)
   PUBMED   3005291
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 5, 2022 this sequence version replaced XM_006242384.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2309631.1,
                                           SRR22399492.1264002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000007.1  136254118-136254173
            57-173              JAXUCZ010000007.1  136254716-136254832
            174-320             JAXUCZ010000007.1  136255089-136255235
            321-531             JAXUCZ010000007.1  136255407-136255617
            532-624             JAXUCZ010000007.1  136255704-136255796
            625-717             JAXUCZ010000007.1  136255884-136255976
            718-792             JAXUCZ010000007.1  136256124-136256198
            793-951             JAXUCZ010000007.1  136256402-136256560
            952-1107            JAXUCZ010000007.1  136257080-136257235
            1108-1173           JAXUCZ010000007.1  136257426-136257491
            1174-1874           JAXUCZ010000007.1  136257719-136258419
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1874
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /note="heterogeneous nuclear ribonucleoprotein A1"
                     /db_xref="GeneID:29578"
                     /db_xref="RGD:69234"
     exon            1..56
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1163
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /note="isoform 1 is encoded by transcript variant 1; HDP;
                     hnRNP core protein A1; helix-destabilizing protein;
                     single-strand RNA-binding protein"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein A1
                     isoform 1"
                     /protein_id="NP_001386203.1"
                     /db_xref="GeneID:29578"
                     /db_xref="RGD:69234"
                     /translation="MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCV
                     VMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHL
                     TVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVD
                     KIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGR
                     GGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGN
                     QGSGYGGSGSYDSYNNGGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNF
                     GGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF"
     exon            57..173
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            174..320
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..531
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..624
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..717
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..792
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..951
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1107
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1173
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1874
                     /gene="Hnrnpa1"
                     /gene_synonym="hnRNP A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgaggaag catcgctgaa cgctctcatc atcctaccgt catgtctaag tcagagtccc
       61 ccaaggaacc ggaacagctg cggaagctct tcattggagg gctgagcttc gaaacaaccg
      121 acgagagtct gaggagccat tttgagcaat ggggaacact caccgactgt gtggtaatga
      181 gagatccaaa caccaaaaga tccagaggct ttgggtttgt cacatatgcc actgtggagg
      241 aagtggatgc tgccatgaat gcaagaccac acaaggtgga tggaagagtt gtggaaccta
      301 agagagctgt gtcaagagaa gattctcaga gaccaggtgc ccacttaact gtgaagaaga
      361 tctttgttgg cggtattaaa gaagacactg aagaacatca cctacgagat tattttgagc
      421 agtatgggaa aattgaagtg attgaaatta tgactgacag aggcagtgga aaaaagaggg
      481 gatttgcgtt tgtcaccttt gatgaccatg actctgtgga taagattgtt attcagaaat
      541 accatactgt gaatggccac aactgtgaag taagaaaggc tctgtcgaaa caagagatgg
      601 ctagtgcttc atccagccag agaggtcgaa gtggttccgg aaactttggt ggtggtcgtg
      661 gaggtggttt cggtggcaat gacaattttg gtcgaggagg gaacttcagt ggtcgtggtg
      721 gctttggtgg cagccgtggt ggtggtggat atggtggcag tggggatggc tataatggat
      781 ttggcaatga tggtggttat ggaggaggcg gccctggtta ctctggagga agcagaggct
      841 atggaagtgg tggacagggt tatggaaacc agggcagtgg ctatggcggg agtggcagct
      901 atgacagcta taacaacgga ggaggcggag gcggctttgg cggtggtagt ggaagcaatt
      961 ttggaggtgg tggaagctac aatgattttg gcaattacaa caaccagtca tcaaattttg
     1021 gaccgatgaa aggaggaaac tttggaggca ggagctctgg cccttatggt ggtggaggcc
     1081 agtactttgc taaaccacga aaccaaggtg gctatggagg ttccagcagc agcagtagct
     1141 atggcagtgg caggaggttc taattacagc caggaaacaa agcttagcag gagaggagag
     1201 ccagagaagt gacagggaag ctacaggtta caacagattt gtgaactcag ccaagcacag
     1261 tggtggcagg gcctagctgc tacaaagaag acatgtttta gacaatactc atgtgtgtgg
     1321 gcaaaaactc caggactgta tctgtgacta attgtataac aggttatttt agtttctgtt
     1381 ctgtggaaag tgtaaagcat tccaacgaag ggttttactg tagacctttt tcacccatgc
     1441 tgttgattgc taaatgtaaa agtctgatca tgacgctgaa taaatgtgtc tttttttttt
     1501 ttttttaatg tgctgtgtaa agttagtcta ctctgaagcc atcttggtaa acttccccaa
     1561 cagtgtgaag ttagaattcc ttcagggtgg tgccaaattc catttggaat ttatttatgg
     1621 ttgcttgggt ggagaagcca ttgtcttcaa aaaccttggt gttgctaaac tgccagttac
     1681 tgttgtaact taatgagttt caccatttaa agggtcatcc aagcaagatc acaatttggt
     1741 tataaaatgg ttgttggcac accctatgca atatcaaaat tgaataacgg tctcagataa
     1801 aataacagat gggaatgaag cttgtgtatc atccattatc atgtgtactc aataaacgat
     1861 ttaattctct tgaa
//
