LOCUS       NM_031044               1225 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus histamine N-methyltransferase (Hnmt), mRNA.
ACCESSION   NM_031044
VERSION     NM_031044.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Heidari,A., Tongsook,C., Najafipour,R., Musante,L., Vasli,N.,
            Garshasbi,M., Hu,H., Mittal,K., McNaughton,A.J., Sritharan,K.,
            Hudson,M., Stehr,H., Talebi,S., Moradi,M., Darvish,H., Arshad
            Rafiq,M., Mozhdehipanah,H., Rashidinejad,A., Samiei,S., Ghadami,M.,
            Windpassinger,C., Gillessen-Kaesbach,G., Tzschach,A., Ahmed,I.,
            Mikhailov,A., Stavropoulos,D.J., Carter,M.T., Keshavarz,S.,
            Ayub,M., Najmabadi,H., Liu,X., Ropers,H.H., Macheroux,P. and
            Vincent,J.B.
  TITLE     Mutations in the histamine N-methyltransferase gene, HNMT, are
            associated with nonsyndromic autosomal recessive intellectual
            disability
  JOURNAL   Hum Mol Genet 24 (20), 5697-5710 (2015)
   PUBMED   26206890
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   van Wamelen,D.J., Shan,L., Aziz,N.A., Anink,J.J., Bao,A.M.,
            Roos,R.A. and Swaab,D.F.
  TITLE     Functional increase of brain histaminergic signaling in
            Huntington's disease
  JOURNAL   Brain Pathol 21 (4), 419-427 (2011)
   PUBMED   21106039
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   Marasovic-Susnjara,I., Palada,V., Marinovic-Terzic,I., Mimica,N.,
            Marin,J., Muck-Seler,D., Mustapic,M., Presecki,P., Pivac,N.,
            Folnegovic-Smalc,V., Marinovic-Curin,J. and Terzic,J.
  TITLE     No association between histamine N-methyltransferase functional
            polymorphism Thr105Ile and Alzheimer's disease
  JOURNAL   Neurosci Lett 489 (2), 119-121 (2011)
   PUBMED   21138759
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Adachi,N., Liu,K., Ninomiya,K., Matsuoka,E., Motoki,A., Irisawa,Y.
            and Nishibori,M.
  TITLE     Reduction of the infarct size by simultaneous administration of
            L-histidine and diphenhydramine in ischaemic rat brains
  JOURNAL   Resuscitation 82 (2), 219-221 (2011)
   PUBMED   21131122
REFERENCE   6  (bases 1 to 1225)
  AUTHORS   Takemura,M., Tanaka,T., Taguchi,Y., Imamura,I., Mizuguchi,H.,
            Kuroda,M., Fukui,H., Yamatodani,A. and Wada,H.
  TITLE     Histamine N-methyltransferase from rat kidney. Cloning, nucleotide
            sequence, and expression in Escherichia coli cells
  JOURNAL   J Biol Chem 267 (22), 15687-15691 (1992)
   PUBMED   1639806
REFERENCE   7  (bases 1 to 1225)
  AUTHORS   Walajtys-Rode,E., Waskiewicz,J. and Rafalowska,U.
  TITLE     Effect of in vivo glucocorticoid administration on histamine
            metabolism in rat brain synaptosomes
  JOURNAL   Neurosci Lett 97 (3), 340-344 (1989)
   PUBMED   2717067
REFERENCE   8  (bases 1 to 1225)
  AUTHORS   Kierska,D., Sasiak,K., Bieganski,T. and Maslinski,C.
  TITLE     Causal relationship between a tumour growth and the changes in
            histamine metabolism in tissues of sarcoma-bearing rat
  JOURNAL   Agents Actions 20 (3-4), 314-316 (1987)
   PUBMED   3111198
REFERENCE   9  (bases 1 to 1225)
  AUTHORS   Verburg,K.M., Bowsher,R.R., Zerbe,R.L. and Henry,D.P.
  TITLE     The effect of hypertonic saline administration or stalk transection
            on histamine and histamine N-methyltransferase in the rat posterior
            pituitary
  JOURNAL   Agents Actions 18 (5-6), 494-498 (1986)
   PUBMED   2429527
REFERENCE   10 (bases 1 to 1225)
  AUTHORS   Kouvelas,E.D., Savakis,C.E., Tzebelikos,E.T., Bonatsos,G. and
            Mitrossilis,S.
  TITLE     Developmental characteristics of histamine methyltransferase and
            phenylethanolamine-N-methyl-transferase of rat brain
  JOURNAL   Experientia 32 (9), 1136-1138 (1976)
   PUBMED   971743
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D10693.1.
            
            On Jun 10, 2007 this sequence version replaced NM_031044.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10693.1, BC087635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984038 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1225
                     /gene="Hnmt"
                     /note="histamine N-methyltransferase"
                     /db_xref="GeneID:81676"
                     /db_xref="RGD:71049"
     exon            1..145
                     /gene="Hnmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..896
                     /gene="Hnmt"
                     /EC_number="2.1.1.8"
                     /note="HMT"
                     /codon_start=1
                     /product="histamine N-methyltransferase"
                     /protein_id="NP_112306.1"
                     /db_xref="GeneID:81676"
                     /db_xref="RGD:71049"
                     /translation="MASFMRSLFSDHSRYVESFRRFLNNSTEHQCMQEFMDKKLPGII
                     ARIGETKAEIKILSIGGGAGEIDLQILSKVQAQYPGICINNEVVEPNAEQIVKYKELV
                     AKTSNMENIKFAWHKETSSEYQKRVVEEDEEPPKWDFIHMIQMLYYVKDIPATLKFFH
                     GLLAANAKILIILVSGTSGWEKLWKKYGFRLPRDDLCQYVTSSDLAQILDDLGIKYEC
                     YDLLSTMDITDCFIDGNENGDLLWDFLTETCNFIKTAPLDLKEEIMKDLQEPEFSVKK
                     EGKVLFNNNLSFIVVEANV"
     exon            146..198
                     /gene="Hnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            199..306
                     /gene="Hnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            307..440
                     /gene="Hnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            441..534
                     /gene="Hnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            535..1225
                     /gene="Hnmt"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1225
                     /gene="Hnmt"
ORIGIN      
        1 aacccaatat ggcatctttc atgaggagct tattttctga ccacagcaga tatgttgaat
       61 cttttcggag atttctaaat aattcaacgg aacaccagtg catgcaggaa ttcatggata
      121 agaagcttcc aggcataata gcaaggattg gagaaacaaa agcagaaatt aagattctga
      181 gtataggcgg aggtgcaggt gaaattgacc ttcagattct ctccaaagtc caggctcagt
      241 acccaggaat ctgtattaac aatgaagttg tagagccaaa tgccgaacaa attgtcaagt
      301 acaaagagct tgtagcaaag acatcaaaca tggagaacat aaaatttgct tggcataagg
      361 agacatcatc tgaatatcaa aaacgtgtag tggaagaaga cgaagaacct ccaaagtggg
      421 actttattca tatgattcag atgctatatt atgtaaagga tatcccagcc accctgaaat
      481 tcttccacgg tctcttagct gccaatgcta aaattctcat tattcttgtg tcaggaacta
      541 gtggctggga aaagctatgg aaaaaatatg gattccgcct acccagggat gacctctgcc
      601 agtatgtcac atcttctgat cttgctcaga tactggacga cctgggtatt aagtatgaat
      661 gttacgacct tttgtccact atggacataa cagactgttt tattgatggt aatgaaaatg
      721 gagacctgct ttgggatttt ttgacagaaa cctgcaactt tatcaaaaca gcaccactgg
      781 acctcaaaga ggaaattatg aaagatcttc aagagcctga atttagtgtt aagaaagagg
      841 ggaaggtact tttcaacaac aatctgagtt ttatagtggt tgaggcaaat gtataagtca
      901 tgagtattca gaactcatat tttgaccaaa tgctgattta tttacatatt aaatacatat
      961 tatttaaata ttgaagttaa aattaatccc ataatagaat acaatattat ttcttataaa
     1021 tgaaatctac aagtttccaa gacaacttag actttctaag aactgagcca cttccagttg
     1081 tgaccttaaa agctaatact caggctaaac actgcccaac tggaaacatg agacttgagt
     1141 ttcattagct tactgatagt aaagttcttt ccattttctt agtgtactgg aaatttttag
     1201 aatagtaata aaatatgtgt catcc
//
